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Browse Genesblap99

blap99

class C beta-lactamase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

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Known alleles and reference sequences

Protein entries specific to blap99

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Validation StatusCandidate

Overview

Mechanism: hydrolysis of β-lactam antibiotics
Validation Method: site-directed mutagenesis and MIC testing
Drug Classes: cefepime
Organisms: Enterobacter cloacae P99, Escherichia coli JM83
Papers: 1
Databases: Reslit

Papers1

1

Mutational Replacement of Leu-293 in the Class C Enterobacter cloacae P99 beta-lactamase Confers Increased MIC of Cefepime.

PMID 12019116 · 2002

The Leu-293-Pro mutation in the class C Enterobacter cloacae P99 beta-lactamase increases the MIC of cefepime and ceftazidime.

Gene Information

Gene Name: blap99
Allele: blaP99
Encodes: class C beta-lactamase
Source Database: Reslit
Mechanism: hydrolysis of β-lactam antibiotics
Confers Resistance To: cefepime
Organisms Tested In: • Enterobacter cloacae P99
• Escherichia coli JM83
Validation Method: site-directed mutagenesis and MIC testing

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ResLit

A curated database of antimicrobial resistance genes and mutations extracted from scientific literature.

Browse

AMR Genes
AMR Mutations

Resources

About ResLit
Collaborators
PubMed
NCBI Pathogens
UniProt
CARD
ResFinder DB
PointFinder DB
AMR Rules

Curators

Curator Login
Dashboard

© 2026 ResLit. Data sourced from PubMed literature analysis.

Built for antimicrobial resistance research