blatem−141

beta-lactamase

Validation StatusCandidate

Overview

Mechanism: hydrolyzes beta-lactam antibiotics
Validation Method: genomic analysis
Drug Classes: Ampicillin, Cephalosporin, Ceftazidime, Cefotaxime, Cefepime, Piperacillin/tazobactam, Imipenem, Doripenem, Meropenem, Ertapenem
Organisms: Salmonella enterica subsp. enterica, Klebsiella pneumoniae
Geographic Location: China, South Africa
Papers: 2
Databases: Reslit

Papers2

Comparative genomics analysis of Salmonella Enteritidis isolated from clinical cases associated with chicken.

PMID 39587491 · 2024

Five Salmonella Enteritidis isolates were analyzed, revealing multiple antimicrobial resistance genes and chromosomal mutations. Key resistance genes included bla CTX−M−55, bla TEM−141, bla TEM−1B, aac(6')-Iaa, aph(3’)-IIa, aph(3’’)-Ib, aph(6)-Id, tet(A), floR, fosA3, and sul2. Chromosomal mutations in gyrA (D87G/D87Y) and acrB (F28L/L40P) were also identified, contributing to fluoroquinolone and multidrug resistance.

Gene Information

Gene Name: blatem−141
Allele: blaTEM−141
Encodes: beta-lactamase
Source Database: Reslit
Mechanism: hydrolyzes beta-lactam antibiotics
Confers Resistance To: AmpicillinCephalosporin
Organisms Tested In: • Salmonella enterica subsp. enterica
Geographic Location: China
Validation Method: genomic analysis
Sequence Accession: CP084532.1|CP102669.1|NC_003197.2|NC_003198.1|CP026327.1

Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?

PMID 40350461 · 2025

The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.

Gene Information

Gene Name: blatem−141
Allele: blaTEM−141
Encodes: Beta-lactamase
Source Database: Reslit
Confers Resistance To: CeftazidimeCefotaximeCefepimePiperacillin/tazobactamImipenemDoripenemMeropenemErtapenem
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: South Africa
Validation Method: whole genome sequencing
Sequence Accession: PRJNA1143548

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blatem−141

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