Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
LysR-type regulator
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| C310R | - | activates BpeT such that gene expression occurs independently of co-inducer binding | Burkholderia pseudomallei | trimethoprimsulfamethoxazoletrimethoprim sulfamethoxazole | Reslit | Candidate |
| L265R | - | activates BpeT such that gene expression occurs independently of co-inducer binding | Burkholderia pseudomallei | trimethoprimsulfamethoxazoletrimethoprim sulfamethoxazole | Reslit | Candidate |
| T314AfsTer16 | - | efflux pump transcriptional regulator BpeT | Burkholderia pseudomallei | trimethoprim sulfamethoxazole | Reference Gene Catalog | Established |
Mechanisms of Resistance to Folate Pathway Inhibitors in Burkholderia pseudomallei: Deviation from the Norm.
Research Article
The study identifies mutations in bpeT, bpeS, folA, and folM that contribute to trimethoprim and co-trimoxazole resistance in Burkholderia pseudomallei. Specifically, bpeT mutations lead to overexpression of the BpeEF-OprC efflux pump, while bpeS mutations and folM mutations also play roles in co-trimoxazole resistance.
Development and validation of a triplex quantitative real-time PCR assay to detect efflux pump-mediated antibiotic resistance in Burkholderia pseudomallei.
Research Article
Taking the next-gen step: Comprehensive antimicrobial resistance detection from Burkholderia pseudomallei.
Research Article
The study presents ARDaP, a new tool for comprehensive antimicrobial resistance (AMR) detection in Burkholderia pseudomallei. ARDaP accurately identifies various AMR determinants, including mutations in genes such as penA, bpeT, ptr1, metF, dut, bpsl3085, and amrR, which confer resistance to antibiotics like ceftazidime, meropenem, co-trimoxazole, and doxycycline.
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