Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
cadmium efflux transporter
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| cadA | Reslit | 4 | - | Staphylococcus aureus +5 | Oak Ridge, Tennessee, Canada|United Kingdom|Global | 2000, 2006, 2018, 2023 | AJ251015 | - |
| cad | Reslit |
| 1 |
| - |
| Staphylococcus aureus |
| Russia|Siberian Russia |
| 2015 |
| BBKC01000001-BBKC01000144|FN433596 |
| - |
| CAD | Reslit | 1 | - | human | - | 1994 | - | - |
Stenotrophomonas maltophilia D457R contains a cluster of genes from gram-positive bacteria involved in antibiotic and heavy metal resistance.
The study identified the mphBM gene, which confers erythromycin resistance, and the cadA gene, which confers cadmium resistance, in Stenotrophomonas maltophilia D457R. Both genes were experimentally validated.
Horizontal gene transfer of PIB-type ATPases among bacteria isolated from radionuclide- and metal-contaminated subsurface soils.
The study identified the horizontal transfer of PIB-type ATPases among bacteria isolated from radionuclide- and metal-contaminated subsurface soils, highlighting the role of these genes in heavy metal resistance.
Healthcare- and Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) and Fatal Pneumonia with Pediatric Deaths in Krasnoyarsk, Siberian Russia: Unique MRSA's Multiple Virulence Factors, Genome, and Stepwise Evolution.
The study identifies multiple antimicrobial resistance genes in MRSA strains from Krasnoyarsk, Siberian Russia, including mecA, blaZ, ermA, ermC, cat, aacA-aphD, aadD, tet, spc, ble, qacA, cad, and mer, which confer resistance to various antibiotics such as methicillin, ampicillin, erythromycin, clindamycin, chloramphenicol, gentamicin, kanamycin, tetracycline, spectinomycin, bleomycin, quaternary ammonium compounds, cadmium, and mercury.
Genomic Comparison of Highly Virulent, Moderately Virulent, and Avirulent Strains From a Genetically Closely-Related MRSA ST239 Sub-lineage Provides Insights Into Pathogenesis.
The study identifies dfrG, a gene encoding a trimethoprim-resistant dihydrofolate reductase, as a factor contributing to trimethoprim resistance in TW20, CMRSA6, and CMRSA3. M92 lacks this gene and is susceptible to trimethoprim.
Detecting patterns of accessory genome coevolution in Staphylococcus aureus using data from thousands of genomes.
The study identifies coevolving genes in Staphylococcus aureus, highlighting interactions among antibiotic resistance genes, mobile genetic elements, and virulence factors. Key findings include the coevolution of beta-lactam resistance genes (blaZ, blaI, blaR1), metal resistance genes (cadA, cadC, copB, mco), and plasmid replication genes (repD, repE, repN, pre).
The propensity for gene amplification: a comparison of protocols, cell lines, and selection agents.
The study identified that gene amplification plays a crucial role in drug resistance, particularly highlighting the amplification of DHFR, CAD, and MDR1 genes in response to methotrexate, phosphonacetyl-L-aspartate, and colcemid, respectively. Human cell lines showed reduced propensity for gene amplification compared to Chinese hamster ovary cells.
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