Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
outer membrane protein
Overview
| D389V | - | - | - | Tetracycline | Reslit | Candidate |
Channel formation by CarO, the carbapenem resistance-associated outer membrane protein of Acinetobacter baumannii.
CarO, a 25/29-kDa outer membrane protein of Acinetobacter baumannii, forms ion channels in lipid bilayers and is associated with carbapenem resistance.
Genomic analysis of Acinetobacter baumannii A118 by comparison of optical maps: identification of structures related to its susceptibility phenotype.
The study identifies the absence of the AbaR-type resistance island and the tet(A) gene in Acinetobacter baumannii A118, which may explain its susceptibility to various antibiotics. It also characterizes genes such as cat, bla_ADC, bla_OXA-51-like, carO, and pbp2, which are involved in resistance to chloramphenicol, cephalosporins, carbapenems, and other antibiotics.
Carbapenem-resistant Acinetobacter baumannii from Brazil: role of carO alleles expression and blaOXA-23 gene.
The study identifies blaOXA-23 as a major carbapenem resistance determinant in Brazilian Acinetobacter baumannii isolates, along with variations in the carO gene affecting imipenem resistance.
Draft Genome Sequence of Acinetobacter bereziniae HPC229, a Carbapenem-Resistant Clinical Strain from Argentina Harboring blaNDM-1.
The draft genome sequence of Acinetobacter bereziniae HPC229, a carbapenem-resistant clinical strain from Argentina, reveals the presence of blaNDM-1, ampC, a new blaOXA-229-like variant, and a new carO allele, along with other resistance genes such as aphA6 and various efflux pump systems.
Mutation of CarO participates in drug resistance in imipenem-resistant Acinetobacter baumannii.
The study identifies mutations in the carO gene as a molecular mechanism contributing to imipenem resistance in Acinetobacter baumannii, with structural changes in the CarO protein affecting outer membrane permeability.
Can Insertion Sequences Proliferation Influence Genomic Plasticity? Comparative Analysis of Acinetobacter baumannii Sequence Type 78, a Persistent Clone in Italian Hospitals.
The study identified several carbapenem-resistant genes, including blaOXA-58, blaOXA-23, and blaOXA-90, along with insertion sequences ISAb1, ISAb25, and IS66, which contribute to genomic plasticity and resistance mechanisms in the SMAL clone of Acinetobacter baumannii.
Human pleural fluid triggers global changes in the transcriptional landscape of Acinetobacter baumannii as an adaptive response to stress.
The study identifies that human pleural fluid (PF) induces changes in the transcriptional landscape of Acinetobacter baumannii, affecting genes related to motility, biofilm formation, efflux pumps, and antibiotic resistance. Specifically, PF leads to reduced expression of beta-lactamase genes (carO, blaADC-99, blaOXA-89) and altered susceptibility to several antibiotics.
Interplay between Meropenem and Human Serum Albumin on Expression of Carbapenem Resistance Genes and Natural Competence in Acinetobacter baumannii.
The study identifies that human serum albumin (HSA) enhances the expression of carbapenem resistance genes such as bla OXA-51-like, bla OXA-23-like, and carO in Acinetobacter baumannii, leading to increased resistance to carbapenems like meropenem, imipenem, and doripenem.
Histone-like nucleoid-structuring protein (H-NS) regulatory role in antibiotic resistance in Acinetobacter baumannii.
The study shows that H-NS regulates the expression of antibiotic resistance genes in Acinetobacter baumannii, leading to increased resistance to beta-lactam antibiotics, aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfonamides, and colistin.
Therapeutic Effects of Inhibitor of ompA Expression against Carbapenem-Resistant Acinetobacter baumannii Strains.
Compound 62520 inhibits ompA expression and biofilm formation in carbapenem-resistant Acinetobacter baumannii strains, demonstrating therapeutic potential against these pathogens.
Global genomic epidemiology of chromosomally mediated non-enzymatic carbapenem resistance in Acinetobacter baumannii: on the way to predict and modify resistance.
The study identifies several genes and mutations associated with carbapenem resistance in Acinetobacter baumannii, including efflux pump components (AdeB, AdeC, AdeS), penicillin-binding proteins (PBP1a), and outer membrane porins (OprB, OprD, CarO). Mutations in these genes are linked to altered carbapenem susceptibility.
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