catA1
diacetyl chloramphenicol esterase
Overview
- Drug Classes
- chloramphenicol
- Organisms
- Spirochaeta aurantia, Escherichia coli, Streptomyces coelicolor +5 more
- Alleles
- 2
- Papers
- 4
| Allele | Papers | Drug Classes | Organisms | Countries | Years | Status |
|---|---|---|---|---|---|---|
| cat | 2 | chloramphenicol | Spirochaeta aurantia +6 | Europe|North America|Asia | 2000, 2023 | Not Validated |
| catA1 | 2 | chloramphenicol | Escherichia coli +1 | Australia | 2002, 2003 | Not Validated |
Spirochaeta aurantia has diacetyl chloramphenicol esterase activity.
PMID 10714999 · 2000Spirochaeta aurantia possesses a cell-associated diacetyl chloramphenicol esterase that converts diacetyl chloramphenicol to chloramphenicol, reducing its effectiveness as an antibiotic.
Gene Information
- Gene Name
- catA1
- Allele
- cat
- Encodes
- diacetyl chloramphenicol esterase
- Validation Method
- conversion of diacetyl chloramphenicol to chloramphenicol as shown by HPLC, TLC, and microbiological assays
Confers Resistance To
Organisms Tested In
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- catA1
- Allele
- cat
- Encodes
- chloramphenicol acetyltransferase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
A multiresistant clone of Shiga toxin-producing Escherichia coli O118:[H16] is spread in cattle and humans over different European countries.
PMID 12450802 · 2002Gene Information
- Gene Name
- catA1
- Allele
- catA1
- Encodes
- chloramphenicol acetyltransferase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
In34, a complex In5 family class 1 integron containing orf513 and dfrA10.
PMID 12499211 · 2003The study identifies and characterizes the class 1 integron In34, which contains multiple antibiotic resistance genes including aadB, dfrA10, aphA1, catA1, blaTEM, and sul1. These genes confer resistance to various antibiotics such as gentamicin, kanamycin, tobramycin, trimethoprim, chloramphenicol, ampicillin, and sulfamethoxazole.
Gene Information
- Gene Name
- catA1
- Allele
- catA1
- Encodes
- chloramphenicol acetyltransferase
- Validation Method
- cloning and susceptibility testing
Confers Resistance To
Organisms Tested In
Isolation Details
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