Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
chloramphenicol acetyltransferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| catB6 | Reslit | 4 | Chloramphenicol, Phenicol | Escherichia coli +2 | Japan, China | 1999, 2011, 2024 | AJ223604 | - |
| catB | Reference Gene Catalog |
| 37 |
| CHLORAMPHENICOL, Chloramphenicol +1 |
| Clostridium butyricum +24 |
| Germany, United States|coastal wetlands, Dublin, United States, Mexico City, Madagascar|Cambodia|Senegal, Spain, desert plant, China, Vietnam, India|United States, Saudi Arabia, Brazil, France, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Khartoum, Sudan, India, India|Mahananda River, Gaza Strip, South India, South Africa, Thailand |
| 1992, 2010, 2012, 2013, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 |
| M93113 |
| AFJ11387.1 |
| catB-related | Reslit | 1 | Chloramphenicol | Vibrio metschnikovii +1 | Norway | 2020 | VHSL00000000|VHSN00000000|VHSK00000000|VHSM00000000|VHSO00000000|VHTC00000000|VHSI00000000|VHSR00000000|VHSS00000000|VHST00000000|VHSV00000000|VHSX00000000|VHSW00000000|VHSU00000000|VHSQ00000000|VHSY00000000|VHSP00000000|VMQP00000000 | - |
| catB11 | Card DatabaseReslit | 6 | Chloramphenicol, Phenicol | Pseudomonas mendocina Ps799 +5 | Europe, Europe|China|Pakistan|USA, Australia, New York Metropolitan area | 2021, 2022, 2024 | CP063358|CP063359 | AID93387.1 |
| Cbut_catB | Card Database | 1 | - | Clostridium butyricum | - | - | M93113.1 | AAA73865.1 |
| Paer_catB6 | Card Database | 1 | - | Pseudomonas aeruginosa | - | - | AJ223604.1 | CAA11473.1 |
Structure of In31, a blaIMP-containing Pseudomonas aeruginosa integron phyletically related to In5, which carries an unusual array of gene cassettes.
The study characterizes the blaIMP gene, which encodes the IMP-1 metallo-beta-lactamase, and identifies several other resistance genes including aacA4, catB6, and qacG, all of which were experimentally validated for their roles in antimicrobial resistance.
Comparative sequence analysis of the catB gene from Clostridium butyricum.
Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation.
The study identifies psiB as an anti-SOS factor that alleviates the SOS response in E. coli but not in V. cholerae, highlighting species-specific interactions.
Genomic analysis of the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06 widely spread in China.
The study identifies several AMR genes and mutations in the multidrug-resistant Acinetobacter baumannii strain MDR-ZJ06, including bla oxa-23, armA, and various efflux pumps, contributing to resistance against multiple antibiotics.
RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Characterization of Four Multidrug Resistance Plasmids Captured from the Sediments of an Urban Coastal Wetland.
Four multidrug resistance plasmids were captured from the sediments of an urban coastal wetland. These plasmids carried various resistance genes, including beta-lactamases, tetracycline resistance genes, sulfonamide resistance genes, and others, conferring resistance to multiple antibiotics.
Exploring the Genome and Phenotype of Multi-Drug Resistant Klebsiella pneumoniae of Clinical Origin.
The study identified multiple antimicrobial resistance genes in 11 multidrug-resistant Klebsiella pneumoniae isolates, including ESBL genes (blaCTX-M-15, blaSHV-12, blaTEM-1B), fluoroquinolone resistance genes (oqxAB, qnrB), and others such as catA, catB, tet, sul, dfr, and fosA. These genes contribute to resistance against various antibiotics, highlighting the complex resistance profile of these isolates.
Investigation of a Cluster of Sphingomonas koreensis Infections.
The study identified a chloramphenicol acetyltransferase gene (catB) in Sphingomonas koreensis isolates, indicating intrinsic resistance to chloramphenicol. The isolates showed resistance to multiple antibiotic classes, including aminoglycosides, beta-lactams, and fluoroquinolones, highlighting the challenges in treating these infections.
Genomic diversity of prevalent Staphylococcus epidermidis multidrug-resistant strains isolated from a Children's Hospital in México City in an eight-years survey.
The study identifies various AMR genes and mutations in multidrug-resistant Staphylococcus epidermidis strains isolated from a children's hospital in Mexico City, highlighting the presence of genes such as blaZ, mecA, and others, as well as mutations in gyrA and rpoB contributing to resistance.
Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.
The study identified various AMR genes and mutations in Klebsiella pneumoniae isolates from pregnant women in low-income countries, highlighting the prevalence of multidrug-resistant strains and the role of environmental factors in their carriage.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Vibrios from the Norwegian marine environment: Characterization of associated antibiotic resistance and virulence genes.
The study identified various antibiotic resistance genes in Vibrio isolates from the Norwegian marine environment, including beta-lactamases (blaCARB, blaampC, varG), tetracycline resistance genes (tet34, tet35), a multidrug efflux pump (adeF), a quinolone resistance gene (qnr), and a chloramphenicol resistance gene (catB-related).
Acinetobacter baumannii NCIMB8209: a Rare Environmental Strain Displaying Extensive Insertion Sequence-Mediated Genome Remodeling Resulting in the Loss of Exposed Cell Structures and Defensive Mechanisms.
The study identifies several AMR genes in the environmental strain Acinetobacter baumannii NCIMB8209, including blaOXA-78, blaADC-154, carO, oprD/occAB1, ant(3")-II, and catB, which confer resistance to carbapenems, beta-lactams, aminoglycosides, and chloramphenicol.
Biological Characteristics and Genetic Analysis of a Highly Pathogenic Proteus Mirabilis Strain Isolated From Dogs in China.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Proteus mirabilis strain CC15031, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and others.
Whole Genome Analysis of Environmental Pseudomonas mendocina Strains: Virulence Mechanisms and Phylogeny.
P. mendocina Ps799 exhibited a catB11 chloramphenicol resistance gene with a nucleotide deletion leading to a truncated protein, while no acquired resistance genes were found in Ps542.
Emerging carbapenem-resistant Klebsiella pneumoniae sequence type 16 causing multiple outbreaks in a tertiary hospital in southern Vietnam.
The study identifies carbapenem-resistant Klebsiella pneumoniae sequence type 16 causing multiple outbreaks in a hospital in Vietnam. Key AMR genes include blaOXA-181, blaOXA-48, and mutations in gyrA and parC contributing to fluoroquinolone resistance. Colistin resistance was due to disruption of the mgrB gene by an IS L3-like element.
Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1.
The study characterizes a Type B chloramphenicol acetyltransferase (CatB) from Elizabethkingia anophelis NUHP1, demonstrating its structural and functional similarities to clinically validated Type B CATs, suggesting its role in chloramphenicol resistance.
Emergence and Genetic Characterization of Plasmid-Encoded VIM-2-Producing Pseudomonas stutzeri with Novel Integron In1998 Isolated from Cerebrospinal Fluid.
The study identifies a novel plasmid-encoded VIM-2-producing Pseudomonas stutzeri strain, ZDHY95, with a complex genetic arrangement including a novel class I integron In1998 and various resistance genes such as blaVIM-2, aacA3, aadA13, cmlA8, blaOXA-246, arr3, dfrA27, qacEΔ1, sul1, aacA4'-30, aacA4', qnrVC1, catB11, blaCARB-4.
Metagenomic investigation of potential abortigenic pathogens in foetal tissues from Australian horses.
The study identified several potential abortigenic pathogens in equine abortion cases, including Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Streptococcus equi subsp. zooepidemicus, Acinetobacter lwoffii, and Acinetobacter calcoaceticus. It also detected antibiotic resistance genes such as strB, blaOXA-278, blaOXA-549, catB11, mcr9.1, and blaOXA-12.
The Integrative and Conjugative Element ICECspPOL2 Contributes to the Outbreak of Multi-Antibiotic-Resistant Bacteria for Chryseobacterium Spp. and Elizabethkingia Spp.
The study identifies the integrative and conjugative element ICE Csp POL2 in the multi-antibiotic-resistant strain Chryseobacterium sp. POL2, which carries several antibiotic resistance genes including those conferring resistance to carbapenems, chloramphenicol, florfenicol, macrolides, tetracycline, and aminoglycosides. The element was found to transfer horizontally to Elizabethkingia species, contributing to the spread of multiple antibiotic resistance genes.
Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
The study identifies multiple AMR genes and mutations in the pandrug-resistant K. pneumoniae strain DJ, including carbapenemases (bla NDM-5, bla OXA-181, bla CTX-M-15), aminoglycoside resistance genes (rmtB, rmtF, aac(6')-Ib, aadA2, strAB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase (dfrA12), polymyxin resistance gene (mgrB), tetracycline resistance gene (ramR), chloramphenicol resistance genes (catA2, catB), fosfomycin resistance gene (fosA), and macrolide resistance genes (mphA, ermB). Mutations in gyrA, parC, ompK35, ompK36, and ramR contribute to resistance to fluoroquinolones, polymyxins, tetracyclines, and other antibiotics.
Genomic Characterization of Carbapenem-Non-susceptible Pseudomonas aeruginosa Clinical Isolates From Saudi Arabia Revealed a Global Dissemination of GES-5-Producing ST235 and VIM-2-Producing ST233 Sub-Lineages.
The study identified GES-5-producing ST235 and VIM-2-producing ST233 sub-lineages of Pseudomonas aeruginosa in Saudi Arabia, highlighting their global dissemination and the presence of various resistance genes including blaGES-5, blaVIM-2, and others.
Chloramphenicol-borate/boronate complex for controlling infections by chloramphenicol-resistant bacteria.
The study identified the catB gene encoding chloramphenicol acetyl transferase as responsible for chloramphenicol resistance in Pseudomonas aeruginosa strain EXR1. The synthesized chloramphenicol-borate derivative showed improved antibacterial activity against resistant strains by preventing acetylation by CAT.
Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.
The study identified OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that exhibited multidrug resistance, including resistance to carbapenems, cephalosporins, aminoglycosides, and quinolones. The strains were part of a clonal spread within the ICU, showing genetic similarities and carrying resistance genes such as blaOXA-232, blaCTX-M-15, blaSHV-106, and others.
Whole genome sequencing of the multidrug-resistant Chryseobacterium indologenes isolated from a patient in Brazil.
The study identified multiple antibiotic resistance genes and mutations in a multidrug-resistant Chryseobacterium indologenes strain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and efflux pumps, contributing to resistance against various antibiotics.
Phage-Plasmids Spread Antibiotic Resistance Genes through Infection and Lysogenic Conversion.
Phage-plasmids (P-Ps) carry a variety of antibiotic resistance genes (ARGs), including beta-lactamases, aminoglycoside-modifying enzymes, and carbapenemases. These genes are often located in integrons and are associated with transposable elements. P-Ps can be induced by mitomycin C and can transfer resistance genes through lysogenic conversion.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla (CTX-M-15) and one rmpA2-associated virulence plasmid.
The study characterizes an OXA-232-producing ST15 CRKP strain with a multidrug-resistant profile, harboring chromosomal bla CTX-M-15 and plasmid-mediated bla OXA-232, along with other resistance genes such as strAB, rmtF, sul2, dfrA14, qnrB1, arr-2, and catB. Mutations in gyrA (S83F) and parC (S80I) contribute to fluoroquinolone resistance.
Identification of a Multidrug Resistant Pseudomonas aeruginosa Isolate Harboring Infrequent Red Fluorescence Plasmid from COPD Patient.
The study identifies a multidrug-resistant Pseudomonas aeruginosa isolate L1a harboring an infrequent red fluorescence plasmid. The isolate shows resistance to several antibiotics including levofloxacin, cefepime, aztreonam, and imipenem, and carries multiple drug resistance genes and efflux pump-related genes.
Antimicrobial Resistance and Genetic Diversity of Pseudomonas aeruginosa Strains Isolated from Equine and Other Veterinary Samples.
The study identified several AMR genes in Pseudomonas aeruginosa strains isolated from equine and other veterinary samples, including beta-lactamases, aminoglycoside modifying enzymes, quinolone resistance genes, sulfonamide resistance genes, phenicol resistance genes, tetracycline resistance genes, and efflux pumps. Additionally, genes conferring resistance to quaternary ammonium compounds were detected.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Molecular insights into novel environmental strains of Klebsiella quasipneumoniae harboring different antimicrobial-resistance genes.
The study identified multiple antimicrobial resistance genes in novel environmental strains of Klebsiella quasipneumoniae, including fosA, bla OKP, oqxB, oqxA, bla SHV−1, bla OXA−1, aac(6')-Ib-cr, catB, and aph(3”)-Ia, which confer resistance to various antibiotics such as fosfomycin, beta-lactams, aminoglycosides, and chloramphenicol.
A nosocomial Pseudomonas aeruginosa ST3495 isolated from a wild Burmese python (Python bivittatus) with suppurative pneumonia and bacteremia in Hainan, China.
The study identified Pseudomonas aeruginosa ST3495 isolated from a wild Burmese python with suppurative pneumonia and bacteremia, highlighting its resistance genes catB, blaTEM, ant(3'')-I, and tetA, along with virulence factors.
Antimicrobial resistance heterogeneity among multidrug-resistant Gram-negative pathogens: Phenotypic, genotypic, and proteomic analysis.
The study identified various AMR genes in multidrug-resistant Gram-negative pathogens, highlighting the prevalence of bla CTX-M-15, bla CMY-42, bla NDM-5, aadA, bla TEM-1B, bla OXA-232, bla NDM-1, rmtB, rmtC, bla VEB, bla VIM-2, aph(3'), strA/B, bla OXA-23, aph (3′), catB, dfrB, bla VIM-2, fosA, oqxA, oqxB, bla OXA-23, bla CARB, bla OXA-91, bla OXA-51, bla PAO, bla SHV, aph (3′)-Ib, aph (6)-Id, mphE, msrE, ermB, mphA, aadA, rmtB, qnrB, dfrA, sul1, sul2, and fosA7.
Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens.
The study identifies numerous antibiotic resistance genes (ARGs) that are transferred between plasmids, particularly beta-lactamases (bla TEM-1, bla NDM-4, bla KPC-2, bla SHV-1), aminoglycoside resistance gene aacC1, and colistin resistance gene mcr-1. These genes are shown to transfer between compatible plasmids in clinical pathogens, accelerating the spread of antibiotic resistance.
Whole-genome sequencing and analysis of Chryseobacterium arthrosphaerae from Rana nigromaculata.
The study identified 10 antibiotic resistance genes in Chryseobacterium arthrosphaerae strain FS91703, including genes conferring resistance to folate pathway inhibitors, penicillins, cephalosporins, carbapenems, phenicols, tetracyclines, and erythromycin. Additionally, two multidrug-resistant efflux pump genes, adeG and farA, were detected.
Characterization of a hemolytic and antibiotic-resistant Pseudomonas aeruginosa strain S3 pathogenic to fish isolated from Mahananda River in India.
The study identified multiple antibiotic resistance genes in Pseudomonas aeruginosa strain S3, including beta-lactamases, fosfomycin resistance gene fosA, aminoglycoside resistance gene aph, chloramphenicol resistance gene catB, and multiple efflux pump genes such as mexAB-oprM, mexCD-oprJ, mexEF-oprN, mexXY, mexVW-oprM, mexJK-oprM, mexHI-opmD, mexPQ-opmE, acrAB-tolC, oqxAB, and mcr. Additionally, hemolysin genes like plcH, choE, and papA were also identified.
Comparative resistomics analysis of multidrug-resistant Chryseobacteria.
The study identifies several AMR genes in multidrug-resistant Chryseobacteria, including aadS, blaCGA, blaCGB, blaIND, catB11, ranA, ranB, rosA, and tetX, which confer resistance to various antibiotics. These genes are potentially intrinsic and show high transmissibility among Chryseobacteria and other Bacteroidota species.
First report of carbapenems encoding multidrug-resistant gram-negative bacteria from a pediatric hospital in Gaza Strip, Palestine.
The study identified multiple carbapenem resistance genes, including bla KPC-2, bla PDC-36/12, and bla POM-1, in multidrug-resistant Gram-negative bacteria isolated from a pediatric hospital in the Gaza Strip. These genes were found in various bacterial species such as Escherichia coli and Klebsiella pneumoniae.
The expression of integron arrays is shaped by the translation rate of cassettes.
The study demonstrates that the identity of the first cassette in an integron array significantly influences the expression of downstream cassettes, thereby affecting the resistance phenotype. Specifically, aacA54, aacA61, and aacA8 were shown to reduce resistance to β-lactams and aminoglycosides, while blaVIM-1 and catB3 conferred resistance to carbapenems and chloramphenicol, respectively.
Essential oils modulate virulence phenotypes in a multidrug-resistant pyomelanogenic Pseudomonas aeruginosa clinical isolate.
The study identifies multiple AMR genes in the MDR P. aeruginosa strain U804, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, which contribute to its resistance against various antibiotics.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Occurrence and Genotypic Characterization of Selected Multidrug-resistant ESKAPE-E Pathogens Isolated from Integrated Smallholder Fresh Produce Farms.
The study identified several AMR genes, including mcr-9 (colistin resistance), blaOXA-like and blaPAO-like (beta-lactam resistance), catB (chloramphenicol resistance), sul (sulfonamide resistance), tet(A) (tetracycline resistance), mdf(A)_1 (macrolide resistance), and formA (formaldehyde resistance) in various ESKAPE-E pathogens isolated from smallholder farms in South Africa.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Retrospective analysis of antimicrobial resistance of Salmonella spp. isolated from livestock and its environment in Thailand.
The study identified several AMR genes in Salmonella isolates from livestock and their environment in Thailand, including aadA1, aadA2, aadB, aac(6')-Ia, blaTEM, tetA, tetB, catA, catB, cmlA, sulI, and dfrA1, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, chloramphenicol, sulfamethoxazole, and trimethoprim.
Acquisition of novel antibiotic resistance genes by the bacterial predator Bacteriovorax sp. As-1.
Bacteriovorax sp. As-1 exhibits resistance to multiple antibiotics, primarily due to mutations in the gyrA gene, specifically S90Y and G94R, which are associated with reduced fluoroquinolone susceptibility.
Antibiotic contamination and antimicrobial resistance dynamics in the urban sewage microbiome in India.
The study identifies multiple antibiotic resistance genes (ARGs) in urban sewage samples from India, highlighting the presence of genes such as blaTEM, catB, aac(6')-Ib, sul1, ermB, dfrA1, mphA, sul2, blaOXA, blaCTX-M, and qnrS, which confer resistance to various antibiotic classes.
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