Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
efflux pump component
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| P108L | - | - | Clostridioides difficile | Fluoroquinolones | Reslit | Candidate |
Integrated genomic epidemiology and phenotypic profiling of Clostridium difficile across intra-hospital and community populations in Colombia.
The study identified several antimicrobial resistance molecular markers in Clostridium difficile isolates from Colombia, including cdeA, gyrA, folP, and rpoB, which are associated with resistance to fluoroquinolones, sulfonamides, and rifamycins.
Genomic characterization of nine Clostridioides difficile strains isolated from Korean patients with Clostridioides difficile infection.
Nine Clostridioides difficile strains isolated from Korean patients were analyzed, revealing diverse antibiotic resistance genes including those conferring resistance to erythromycin, clindamycin, glycopeptides, fluoroquinolones, aminoglycosides, and tetracyclines.
Detection and Genomic Characterisation of Clostridioides difficile from Spinach Fields.
The study identified various antimicrobial resistance genes in C. difficile isolates from spinach and soil samples, including vanB, tet(M), ant(6)-Ia, qacG, cdeA, SAT-4, vanXY, vanR, D19aph(3')-III_1, tet(40), and CDD-1, indicating resistance to vancomycin, tetracyclines, aminoglycosides, disinfectants, fluoroquinolones, nucleosides, and beta-lactams.
Antimicrobial Resistance of Clostridioides difficile in Children from a Tertiary Pediatric Hospital in Shanghai, China.
The study identifies various antimicrobial resistance genes in Clostridioides difficile isolates from children, including those conferring resistance to aminoglycosides, macrolides, fluoroquinolones, glycopeptides, lincosamides, tetracyclines, and others. Notably, the pCD-METRO plasmid and vanA/B were not detected, indicating alternative resistance mechanisms.
Phenotypic and genotypic antimicrobial resistance profiles of clinical Clostridioides difficile isolates collected from private and public health settings in South Africa.
The study identified a PnimB promoter mutation associated with reduced metronidazole susceptibility in ST1 strains, a Thr82Ile mutation in gyrA linked to fluoroquinolone resistance, and various efflux pump and resistance genes such as qacG, aac(6')-Ie-aph(2'')-Ia, ermB, tetM, and CDD-1/CDD-2. High multidrug resistance (MDR) was observed in ST1 and ST37 strains.
Epidemiology and genetic characteristics of Clostridioides difficile isolates in Northwest China.
The study identified 13 resistance genes, including cdeA, ermB, 23S rRNA, vanXYG, tetM, and tetB(P), along with mutations in gyrA, gyrB, and rpoB, conferring resistance to fluoroquinolones, macrolides, lincosamides, glycopeptides, tetracyclines, and rifamycins in Clostridioides difficile isolates from Northwest China.
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