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ResLit

cdsA

phosphatidate cytidylyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cdsA

AMR Rules

Browse AMR rules for cdsA

Validation StatusSupported

Overview

Mechanism: loss-of-function single nucleotide polymorphisms (SNPs)
Validation Method: microarray and real-time RT-PCR
Drug Classes: Macrolide, Daptomycin, DAPTOMYCIN
Organisms: Staphylococcus aureus, Streptococcus mitis, Streptococcus oralis, S. oralis
Papers: 5
Databases: Reslit
Mutations: 3

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
Q31*	-	loss of function	Streptococcus mitis, Streptococcus oralis	Daptomycin	Reslit	Candidate
G221V	-	-	Streptococcus mitis, S. oralis	Daptomycin	Reslit	Candidate
D222N	-	phosphatidate cytidylyltransferase CdsA, single resistance variant	Streptococcus oralis	DAPTOMYCIN

Papers5

Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cryptotanshinone.

PMID 19707532 · 2009

Cryptotanshinone (CT) shows bacteriostatic activity against Staphylococcus aureus, affecting genes involved in resistance to trimethoprim, bacitracin, and macrolides.

Gene Information

Gene Name: cdsA
Allele: cdsA
Encodes: phosphatidate cytidylyltransferase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Staphylococcus aureus
Validation Method: microarray and real-time RT-PCR
Sequence Accession: GSE13203

Impact of High-Level Daptomycin Resistance in the Streptococcus mitis Group on Virulence and Survivability during Daptomycin Treatment in Experimental Infective Endocarditis.

PMID 28264848 · 2017

The study identifies that high-level daptomycin resistance in the Streptococcus mitis group is mediated by loss-of-function mutations in the cdsA and pgsA genes, which are involved in cardiolipin biosynthesis. These mutations lead to reduced cardiolipin and phosphatidylglycerol production, contributing to daptomycin resistance.

Gene Information

Gene Name: cdsA
Allele: cdsA
Encodes: enzyme which is critical in the biosynthetic pathway for cardiolipin
Source Database: Reslit
Mechanism: loss-of-function single nucleotide polymorphisms (SNPs)
Confers Resistance To: Daptomycin
Organisms Tested In: • Streptococcus mitis
• Streptococcus oralis
Validation Method: genetic analysis and functional testing

Mutations in cdsA and pgsA Correlate with Daptomycin Resistance in Streptococcus mitis and S. oralis.

PMID 30509945 · 2019

Mutations in cdsA and pgsA correlate with daptomycin resistance in Streptococcus mitis and S. oralis. Substitutions in CdsA and PgsA were identified, which are involved in the cardiolipin biosynthesis pathway and lead to the loss of phosphatidylglycerol and cardiolipin from cell membranes, resulting in daptomycin resistance.

Gene Information

Gene Name: cdsA
Allele: cdsA
Encodes: phosphatidate cytidylyltransferase
Source Database: Reslit
Mechanism: substitution in CdsA, a phosphatidate cytidylyltransferase that is a key enzyme for the first committed biosynthetic step within the cardiolipin (CL) biosynthesis pathway
Confers Resistance To: Daptomycin
Organisms Tested In: • Streptococcus mitis
• Streptococcus oralis
Validation Method: whole-genome sequencing and experimental validation of mutations in CdsA and PgsA