Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| cepA | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 26 | Penicillin, Ampicillin +8 |
| Japan, China, North America|Eastern Europe, Iran, St. Louis, MO, Camden, NJ, USA, Norway, India |
| 1993, 1994, 2004, 2012, 2013, 2020, 2021, 2022, 2023, 2024 |
| PRJNA504846|PRJNA515074 |
| AAA22905.1 |
| CepA-49 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Bacteroides fragilis | - | 1994 | U05886.1 | AAA21535.1 |
| CepA-44 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Bacteroides fragilis | - | 1994 | U05885.1 | AAA21534.1 |
| cepA-49 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Bacteroides fragilis | - | 1994 | U05886 | - |
| cepA-44 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Bacteroides fragilis | - | 1994 | U05885 | - |
| cepA-29 | ResFinder Database | 1 | UNKNOWN BETA-LACTAM | Bacteroides fragilis | - | 1994 | U05884 | - |
| CepA-29 | Card DatabaseReference Gene CatalogResFinder Database | 4 | UNKNOWN BETA-LACTAM, CEPHALOSPORIN | Bacteroides fragilis | - | 1994 | U05884.1 | AAA21533.1 |
Plasmid-related beta-lactamase production in Bacteroides fragilis strains.
The study identified the cfiA and cepA genes associated with beta-lactamase production in Bacteroides fragilis strains, highlighting their role in penicillin resistance.
Preliminary safety evaluation of a new Bacteroides xylanisolvens isolate.
The study identified the cepA gene in Bacteroides xylanisolvens DSM 23964, which confers resistance to penicillin and ampicillin. The gene was experimentally validated through PCR and antibiotic susceptibility testing.
PCR-based detection of resistance genes in anaerobic bacteria isolated from intra-abdominal infections.
The study identified several resistance genes, including cepA, cfiA, cfxA, tetQ, ermF, and mefA, in anaerobic bacteria isolated from intra-abdominal infections in Japan. A mutation in the gyrA gene was also found to confer resistance to fluoroquinolones.
Determining the susceptibility of carbapenem resistant Klebsiella pneumoniae and Escherichia coli strains against common disinfectants at a tertiary hospital in China.
The study identified the presence of qacEΔ1 and cepA genes in carbapenem-resistant Klebsiella pneumoniae and Escherichia coli strains, which are associated with increased resistance to chlorhexidine and PVP-I.
Metatranscriptomics Reveals Antibiotic-Induced Resistance Gene Expression in the Murine Gut Microbiota.
The study identifies specific AMR genes, including beta-lactamase genes (cepA, bl2e_cepA) and tetracycline resistance genes (tet32, tet44, tetW), that are upregulated in response to amoxicillin and doxycycline treatments in the murine gut microbiota.
Higher Prevalence of Multi-Antimicrobial Resistant Bacteroides spp. Strains Isolated at a Tertiary Teaching Hospital in China.
The study identifies the cfiA gene as the primary mechanism of carbapenem resistance in Bacteroides fragilis, along with other resistance genes such as cfxA, cepA, ermF, and nim. These genes contribute to resistance against various antibiotics including carbapenems, cefoxitin, clindamycin, and metronidazole.
Ribaxamase, an Orally Administered beta-lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone.
The study identified several beta-lactamase and vancomycin resistance genes that were significantly increased in placebo-treated patients compared to ribaxamase-treated patients following ceftriaxone exposure.
Antibiotic resistance pattern of Bacteroides fragilis isolated from clinical and colorectal specimens.
The study identified high resistance rates in Bacteroides fragilis isolates, particularly to penicillin G, tetracycline, clindamycin, and cefoxitin. Key resistance genes included tetQ, ermF, cepA, cfxA, and cfiA.
Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction.
The study identifies cfiA and cepA as key carbapenem resistance genes in Bacteroides fragilis sensu stricto, and bla and cfx as important beta-lactam resistance genes in non-fragilis Bacteroides species. It also highlights the role of insertion sequences in activating cfiA-mediated carbapenem resistance.
Evaluating the Effectiveness of Hospital Antiseptics on Multidrug-Resistant Acinetobacter baumannii: Understanding the Relationship between Microbicide and Antibiotic Resistance.
The study identified the presence of microbicide-resistance genes qacE, qacEΔ1, and cepA in Acinetobacter baumannii strains, which conferred higher tolerance to microbicides, particularly bleach. The presence of these genes was more prevalent in pan-susceptible strains.
Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.
The study identified OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that exhibited multidrug resistance, including resistance to carbapenems, cephalosporins, aminoglycosides, and quinolones. The strains were part of a clonal spread within the ICU, showing genetic similarities and carrying resistance genes such as blaOXA-232, blaCTX-M-15, blaSHV-106, and others.
Molecular epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae among children in China.
The study identified KPC-2, NDM-1, and IPM-4 carbapenemase genes as the primary contributors to carbapenem resistance in Klebsiella pneumoniae isolates from children in China. Additionally, qacE and cepA genes were found to confer resistance to disinfectants.
Disinfectant Susceptibility of Third-Generation-Cephalosporin/Carbapenem-Resistant Gram-Negative Bacteria Isolated from the Oral Cavity of Residents of Long-Term-Care Facilities.
The study identifies qacE Δ 1 as a gene associated with resistance to cetylpyridinium chloride (CPC) and benzalkonium chloride (BZK) in Pseudomonas aeruginosa, Enterobacter hormaechei, and Proteus mirabilis. It also identifies smvA as a gene associated with resistance to chlorhexidine chloride (CHX) in Proteus mirabilis, and cepA as a gene associated with resistance to CHX in Klebsiella pneumoniae.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Anaerobic Gram-Negative Bacteria: Role as a Reservoir of Antibiotic Resistance.
The study identifies several AMR genes in anaerobic Gram-negative bacteria, including nimE for metronidazole resistance, ermF for clindamycin resistance, cfiA for imipenem resistance, cepA for piperacillin-tazobactam resistance, and cfxA for cefoxitin resistance.
Characterization of the Disinfectant Resistance Genes qacEΔ1 and cepA in Carbapenem-Resistant Klebsiella pneumoniae Isolates.
The study identified the disinfectant resistance genes qacEΔ1 and cepA in carbapenem-resistant Klebsiella pneumoniae isolates, highlighting their association with increased antimicrobial resistance.
Characterization of Bacteroides fragilis from the vagina of a giant panda (Ailuropoda melanoleuca) with vaginitis.
The study identifies three antibiotic resistance genes, cfxA, cepA, and copA, in a multidrug-resistant Bacteroides fragilis strain isolated from a giant panda with vaginitis.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases., Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
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