Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
CepA family extended-spectrum class A beta-lactamase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| cepA | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 23 | Unknown beta-lactam, Cephalosporin, Penicillin, Ampicillin, Cephalosporins, Chlorhexidine, Beta lactams, Ampicillin sulbactam, Amoxicillin clavulanic acid, Piperacillin tazobactam | Bacteroides fragilis, Bacteroides xylanisolvens DSM 23964, Klebsiella pneumoniae, Escherichia coli, Bacteroides thetaiotaomicron, Bacteroides fragilis sensu stricto | Japan, China, North America, Eastern Europe, Iran, St. Louis, MO, Norway, India | 1993, 1994, 2004, 2012, 2013, 2020, 2021, 2022, 2023, 2024 | FR688022.1 | CBX07047.1 |
| CepA-29 | Card DatabaseReference Gene CatalogResFinder Database | 5 | Cephalosporin, Unknown beta-lactam | Bacteroides fragilis | - | 1994 | NG_050385.1 | WP_063865204.1 |
| CepA-44 | Card DatabaseReference Gene CatalogResFinder Database | 5 | Cephalosporin, Unknown beta-lactam | Bacteroides fragilis | - | 1994 | NG_050386.1 | WP_032579291.1 |
| CepA-49 | Card DatabaseReference Gene CatalogResFinder Database | 5 | Cephalosporin, Unknown beta-lactam | Bacteroides fragilis | - | 1994 | NG_050387.1 | WP_008659027.1 |
Plasmid-related beta-lactamase production in Bacteroides fragilis strains.
Research Article
The study identified the cfiA and cepA genes associated with beta-lactamase production in Bacteroides fragilis strains, highlighting their role in penicillin resistance.
Preliminary safety evaluation of a new Bacteroides xylanisolvens isolate.
Research Article
The study identified the cepA gene in Bacteroides xylanisolvens DSM 23964, which confers resistance to penicillin and ampicillin. The gene was experimentally validated through PCR and antibiotic susceptibility testing.
PCR-based detection of resistance genes in anaerobic bacteria isolated from intra-abdominal infections.
Research Article
The study identified several resistance genes, including cepA, cfiA, cfxA, tetQ, ermF, and mefA, in anaerobic bacteria isolated from intra-abdominal infections in Japan. A mutation in the gyrA gene was also found to confer resistance to fluoroquinolones.
Determining the susceptibility of carbapenem resistant Klebsiella pneumoniae and Escherichia coli strains against common disinfectants at a tertiary hospital in China.
Research Article
The study identified the presence of qacEΔ1 and cepA genes in carbapenem-resistant Klebsiella pneumoniae and Escherichia coli strains, which are associated with increased resistance to chlorhexidine and PVP-I.
Metatranscriptomics Reveals Antibiotic-Induced Resistance Gene Expression in the Murine Gut Microbiota.
Research Article
The study identifies specific AMR genes, including beta-lactamase genes (cepA, bl2e_cepA) and tetracycline resistance genes (tet32, tet44, tetW), that are upregulated in response to amoxicillin and doxycycline treatments in the murine gut microbiota.
Higher Prevalence of Multi-Antimicrobial Resistant Bacteroides spp. Strains Isolated at a Tertiary Teaching Hospital in China.
Research Article
The study identifies the cfiA gene as the primary mechanism of carbapenem resistance in Bacteroides fragilis, along with other resistance genes such as cfxA, cepA, ermF, and nim. These genes contribute to resistance against various antibiotics including carbapenems, cefoxitin, clindamycin, and metronidazole.
Ribaxamase, an Orally Administered beta-lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone.
Research Article
The study identified several beta-lactamase and vancomycin resistance genes that were significantly increased in placebo-treated patients compared to ribaxamase-treated patients following ceftriaxone exposure.
Antibiotic resistance pattern of Bacteroides fragilis isolated from clinical and colorectal specimens.
Research Article
The study identified high resistance rates in Bacteroides fragilis isolates, particularly to penicillin G, tetracycline, clindamycin, and cefoxitin. Key resistance genes included tetQ, ermF, cepA, cfxA, and cfiA.
Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction.
Research Article
The study identifies cfiA and cepA as key carbapenem resistance genes in Bacteroides fragilis sensu stricto, and bla and cfx as important beta-lactam resistance genes in non-fragilis Bacteroides species. It also highlights the role of insertion sequences in activating cfiA-mediated carbapenem resistance.
Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.
Research Article
The study identified OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that exhibited multidrug resistance, including resistance to carbapenems, cephalosporins, aminoglycosides, and quinolones. The strains were part of a clonal spread within the ICU, showing genetic similarities and carrying resistance genes such as blaOXA-232, blaCTX-M-15, blaSHV-106, and others.
Molecular epidemiological characteristics of carbapenem-resistant Klebsiella pneumoniae among children in China.
Research Article
The study identified KPC-2, NDM-1, and IPM-4 carbapenemase genes as the primary contributors to carbapenem resistance in Klebsiella pneumoniae isolates from children in China. Additionally, qacE and cepA genes were found to confer resistance to disinfectants.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
Research Article
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Anaerobic Gram-Negative Bacteria: Role as a Reservoir of Antibiotic Resistance.
Research Article
The study identifies several AMR genes in anaerobic Gram-negative bacteria, including nimE for metronidazole resistance, ermF for clindamycin resistance, cfiA for imipenem resistance, cepA for piperacillin-tazobactam resistance, and cfxA for cefoxitin resistance.
Characterization of the Disinfectant Resistance Genes qacEΔ1 and cepA in Carbapenem-Resistant Klebsiella pneumoniae Isolates.
Research Article
The study identified the disinfectant resistance genes qacEΔ1 and cepA in carbapenem-resistant Klebsiella pneumoniae isolates, highlighting their association with increased antimicrobial resistance.
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
Cloning and characterization of the endogenous cephalosporinase gene, cepA, from Bacteroides fragilis reveals a new subgroup of Ambler class A beta-lactamases., Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
Research Article
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