cfac

CAMP factor

Validation StatusCandidate

Overview

Mechanism: confers resistance to erythrocyte lysis by interacting with Staphylococcus aureus sphingomyelinase C
Validation Method: cloning and expression in E. coli, detection of CAMP activity
Drug Classes: Ampicillin
Organisms: Streptococcus pyogenes, Escherichia coli, Shigella
Papers: 2
Databases: Reslit

Papers2

Identification, cloning, and expression of the CAMP factor gene (cfa) of group A streptococci.

PMID 10456923 · 1999

The study identifies and characterizes the CAMP factor gene (cfa) in group A streptococci, demonstrating its role in erythrocyte lysis through interaction with Staphylococcus aureus sphingomyelinase C.

Gene Information

Gene Name: cfac
Allele: cfa
Encodes: CAMP factor
Source Database: Reslit
Mechanism: confers resistance to erythrocyte lysis by interacting with Staphylococcus aureus sphingomyelinase C
Organisms Tested In: • Streptococcus pyogenes
• Escherichia coli
Validation Method: cloning and expression in E. coli, detection of CAMP activity
Sequence Accession: AF079502

The role of cfa gene in ampicillin tolerance in Shigella.

PMID 31686867 · 2019

The study identifies the cfa gene as being associated with ampicillin tolerance in Shigella, with increased expression observed in the tolerant strain.

Gene Information

Gene Name: cfac
Allele: cfa
Encodes: cyclopropane-fatty-acyl-phospholipid synthase
Source Database: Reslit
Mechanism: Increased expression of cfa gene is associated with ampicillin tolerance
Confers Resistance To: Ampicillin
Organisms Tested In: • Shigella
Validation Method: RT-PCR showing 7.56-fold higher expression in tolerant strain

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