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Explore antimicrobial resistance genes from the literature
23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(B)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| cfr(B) | Card DatabaseResFinder Database | 2 | CLINDAMYCIN, LINCOMYCIN +7 | Clostridioides difficile, Enterococcus faecium +1 | - | 2015 | KM359438, KM359439, KR610408 |
| CDF47262.1 |
| Cfr(B) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 18 | FLORFENICOL, STREPTOGRAMIN B +18 | Clostridioides difficile +7 | United States, Germany, Japan, Latin America, Egypt, Europe|Canada, Nigeria, USA|United Kingdom|Mexico|China | 2015, 2016, 2018, 2019, 2020, 2023, 2024, 2025 | HG002389.1 | CDF47163.1 |
| cfrB | Reslit | 1 | Oxazolidinone | Clostridioides difficile | Asia|Europe|North America|Australia/New Zealand | 2021 | BK013348 | - |
Clostridium difficile isolates with high linezolid MICs harbor the multiresistance gene cfr.
A cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene.
A cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene.
A cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene.
Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program.
Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program.
Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program.
Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program.
Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program.
Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program.
The study reports the first detection of the cfr gene in E. faecium clinical isolates in the United States and characterizes a new variant, cfr(B), which confers resistance to multiple antibiotic classes including phenicols, oxazolidinones, pleuromutilins, macrolides, and streptogramin A.
Detection of a cfr(B) Variant in German Enterococcus faecium Clinical Isolates and the Impact on Linezolid Resistance in Enterococcus spp.
The study identifies a cfr(B) variant in Enterococcus faecium clinical isolates that confers linezolid and chloramphenicol resistance. The cfr(B) gene is located on the transposon Tn6218 and shows high similarity to cfr from Clostridium difficile. Despite experimental efforts, the cfr(B) variant did not consistently confer resistance in transformant strains.
Complete Genome Sequence and Characterization of Linezolid-Resistant Enterococcus faecalis Clinical Isolate KUB3006 Carrying a cfr(B)-Transposon on Its Chromosome and optrA-Plasmid.
The study identifies the presence of the cfr(B) gene on a chromosomal Tn 6218-like element and the optrA gene on a plasmid in the linezolid-resistant E. faecalis isolate KUB3006, contributing to its resistance to linezolid and chloramphenicol.
cfr(B), cfr(C), and a New cfr-Like Gene, cfr(E), in Clostridium difficile Strains Recovered across Latin America.
The study identifies cfr(B), cfr(C), and a new cfr-like gene, cfr(E), in Clostridium difficile strains from Latin America, demonstrating their ability to confer resistance to multiple antibiotics through hypermethylation of 23S rRNA.
Effects of Low-Dose Antibiotics on Gut Immunity and Antibiotic Resistomes in Weaned Piglets.
The study identified two transferrable ARGs, Erm(T) and tcr3, which conferred resistance to macrolide and tetracycline, respectively, in weaned piglets exposed to low-dose antibiotics.
A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile.
This study identifies multiple AMR genes and mutations in Clostridioides difficile, including ermB, tetM, mefH, and various mutations in gyrA, gyrB, rpoB, pbp1, and pbp3. These findings highlight the widespread nature of AMR in C. difficile and its potential role in the spread of the bacterium.
Phenotypic and genotypic characterization of linezolid resistance and the effect of antibiotic combinations on methicillin-resistant Staphylococcus aureus clinical isolates.
The study identified linezolid resistance mechanisms in MRSA isolates, including mutations in domain V of 23 S rRNA (A2338T, T2504C, G2576T) and genes such as cfr(B), optrA, msrA, mecA, and vanA.
Emergence of linezolid-resistant Enterococcus faecium in a tertiary hospital in Copenhagen.
Florfenicol administration in piglets co-selects for multiple antimicrobial resistance genes.
Florfenicol administration in piglets leads to the selection of multiple antimicrobial resistance genes, including those conferring resistance to phenicols, aminoglycosides, beta-lactams, sulfonamides, and oxazolidinones.
Clostridioides difficile recovered from hospital patients, livestock and dogs in Nigeria share near-identical genome sequences.
The study identified several AMR genes and mutations in C. difficile isolates from Nigeria, including erm(B) for clindamycin resistance, tet(M) for tetracycline resistance, cfr(B) for linezolid resistance, and erm(A) for MLSB resistance. Additionally, gyrA-Thr82Ile mutation was found to confer fluoroquinolone resistance.
Genomic Characterization of Linezolid-Resistant Clostridioides difficile Harboring cfr Variants.
The study identifies cfr gene variants (cfr(B), cfr(C), and cfr(E)) in linezolid-resistant Clostridioides difficile strains, highlighting their association with resistance and the presence of specific mutations in these genes.
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