Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
23S rRNA (adenine(2503)-C(8))-methyltransferase Cfr(C)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Cfr(C) | Reference Gene CatalogResFinder DatabaseReslit | 14 | Clindamycin, Lincomycin, Linezolid, Tiamulin, Chloramphenicol, Florfenicol, Pristinamycin iia, Dalfopristin, Virginiamycin m, Streptogramin +5 more | Clostridioides difficile T10, Campylobacter coli, Campylobacter jejuni, Clostridium difficile, Bacillus anthracis, Porphyromonas gingivalis, Prevotella, Bacteroides, Staphylococcus, Oscillibacter +13 more | United States, Latin America, Europe, EU/EEA, China, Spain, USA, Denmark, Sweden, Belgium +21 more | 2014, 2017, 2018, 2019, 2021, 2022, 2023, 2025, 2026 | CANB01000378, KX686749 | AQM75611.1 |
| cfrC | Card Database | 1 | Chloramphenicol, Phenicol antibiotic, Florfenicol, Lincosamide antibiotic, Streptogramin a, Tiamulin, Linezolid, Streptogramin antibiotic, Clindamycin, Oxazolidinone antibiotic | Clostridium botulinum A str. ATCC 3502 | - | - | AM412317.1 | CAL84423.1 |
Sequence similarity of Clostridium difficile strains by analysis of conserved genes and genome content is reflected by their ribotype affiliation., Emergence of a plasmid-borne multidrug resistance gene cfr(C) in foodborne pathogen Campylobacter.
Research Article
Emergence of a plasmid-borne multidrug resistance gene cfr(C) in foodborne pathogen Campylobacter.
Research Article
Emergence of a plasmid-borne multidrug resistance gene cfr(C) in foodborne pathogen Campylobacter.
Research Article
Genomic Analysis of Emerging Florfenicol-Resistant Campylobacter coli Isolated from the Cecal Contents of Cattle in the United States.
Research Article
The study identifies the cfr(C) gene as a key determinant of florfenicol resistance in Campylobacter coli isolates, along with other resistance genes and a mutation in gyrA contributing to multidrug resistance.
cfr(B), cfr(C), and a New cfr-Like Gene, cfr(E), in Clostridium difficile Strains Recovered across Latin America.
Research Article
The study identifies cfr(B), cfr(C), and a new cfr-like gene, cfr(E), in Clostridium difficile strains from Latin America, demonstrating their ability to confer resistance to multiple antibiotics through hypermethylation of 23S rRNA.
The European Union summary report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2016.
Research Article
The report highlights high levels of antimicrobial resistance in zoonotic bacteria such as Salmonella and Campylobacter, with specific emphasis on resistance to fluoroquinolones, tetracyclines, and sulfonamides. It also notes the emergence of multidrug-resistant strains and the presence of ESBL-producing and carbapenemase-producing E. coli in poultry and meat.
The roles of antimicrobial resistance, phage diversity, isolation source and selection in shaping the genomic architecture of Bacillus anthracis.
Research Article
The study identifies ten AMR genes in B. anthracis, highlighting their distribution across global isolates and their association with population genomic structure. Key genes include mph L, bla 1, fos B, bla 2, vml R, bcII, tem -116, cfr C, dfr G, and oxa -59, each with distinct resistance mechanisms and geographic prevalence.
Withdrawal of antibiotic growth promoters in China and its impact on the foodborne pathogen Campylobacter coli of swine origin.
Research Article
The study found that the withdrawal of antibiotic growth promoters in China led to an increase in antibiotic resistance in Campylobacter coli, particularly for gentamicin and florfenicol. Several resistance genes, including aadE-Cc, aac(6')-aph(2"), ant(6)-la, aph(3")-lll, aph(2")-lf, tet(O), tet(M), tet(O/32/O), cat, fexA, cfr(C), optrA, blaOXA-193, blaOXA-489, and blaOXA-61, were identified. Mutations in 23S rRNA and gyrA were also associated with resistance to erythromycin and ciprofloxacin, respectively.
Metagenomic analysis reveals patterns and hosts of antibiotic resistance in different pig farms.
Research Article
The study identified various antibiotic resistance genes (ARGs) in pig manure samples from different regions of Shanxi, China, highlighting the prevalence of tetracycline, aminoglycoside, macrolide, and phenicol resistance genes. Key ARGs included tet(W), tet(40), tet(Q), erm(B), erm(F), mef(A), aph(3')-III, ant(6)-Ia, cfr(C), floR, blaACI-1, optrA, cat, cfxA4, cfxA5, blaCTX-M-105, blaCTX-M-65, fexB, erm(T), mdf(A), and ole(B).
Antimicrobial Resistance in Salmonella spp. from Food-Producing Animals and Human Cases in the EU
Research Article
The study identifies several AMR genes, including bla CTX-M-1, bla CTX-M-14b, bla SHV-12, tet(X3), and tet(X4), in Salmonella isolates from food-producing animals and human cases in the EU. These genes confer resistance to various antibiotics, highlighting the spread of multidrug-resistant Salmonella strains.
Size Distribution and Pathogenic Potential of Culturable Airborne Clostridium spp. in a Suburb of Toyama City, Japan.
Research Article
The study identified several antimicrobial resistance genes in Clostridium perfringens isolates, including mprF, tetA[P], tetB[P], erm[Q], cfrC, and mef[A]. These genes confer resistance to defensin, tetracycline, erythromycin, linezolid, phenicol, and macrolide antibiotics.
Virulence and resistance gene analysis of Rothia nasimurium by whole gene sequencing.
Research Article
The study identified multiple AMR genes in Rothia nasimurium Y1, including vanA, vanC, vanB, vanE, vanD, vanG, vanF, vanM, vanL, vanO, vanN, mtrA, vanRA, arlR, vanRI, vanRB, vanRC, vanRD, vanRF, vanRG, CpxR, kdpE, vanRM, vanRN, baeR, adeR, vanRL, smeR, gyrA, gyrB, parC, Mfd, mfd, PBP2, PBP2x, EF-Tu, dfrE, pncA, tetB(P), tetQ, tet44, tetT, tetW, tetS, tetM, tetO, otr(A), tet36, tet32, clbC, clbB, clbA, cipA, cfrA, cfrC, sul3, ParY, murA, cls, and ileS, which confer resistance to various antibiotics such as glycopeptides, beta-lactams, fluoroquinolones, tetracyclines, sulfonamides, aminoglycosides, lincosamides, phenicols, macrolides, and others.
Genomic Characterization of Linezolid-Resistant Clostridioides difficile Harboring cfr Variants.
Research Article
The study identifies cfr gene variants (cfr(B), cfr(C), and cfr(E)) in linezolid-resistant Clostridioides difficile strains, highlighting their association with resistance and the presence of specific mutations in these genes.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
Research Article
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
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