Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
CfxA family broad-spectrum class A beta-lactamase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| Y239D | - | associated with ceftazidime resistance | Prevotella | Ceftazidime | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years |
|---|
| Sequence Accession |
|---|
| Protein Accession |
|---|
| cfxA | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 27 | BETA-LACTAM, Cefoxitin +12 | Prevotella intermedia +38 | Japan, Michigan, USA, China, North America|Eastern Europe, Iran, Australia, St. Louis, MO, Norway, Mexico, Southern Germany|various, India, Belgium|Germany|Hungary|Slovenia|Turkey | 1993, 2001, 2003, 2006, 2008, 2013, 2014, 2015, 2019, 2020, 2021, 2022, 2023, 2024, 2026 | AF118110.1 | AAD23513.1 |
| cfx A | Reslit | 1 | Cefoxitin | Prevotella spp. | - | 2011 | - | - |
| CFX | Reslit | 1 | Beta-lactams | Proteobacteria +3 | Alberta, Canada | 2019 | - | - |
| cfx | Reslit | 1 | Piperacillin/tazobactam | non-fragilis Bacteroides species | St. Louis, MO | 2022 | GCF_000025985|GCF_000012825.1|GCF_013009555.1|PRJNA745162 | - |
| CfxA | Card DatabaseReference Gene CatalogResFinder Database | 3 | BETA-LACTAM, CEFOXITIN +1 | Phocaeicola vulgatus | - | 1993 | U38243.1 | AAB17891.1 |
Cloning and biochemical characterization of a class A beta-lactamase from Prevotella intermedia.
Cloning and biochemical characterization of a class A beta-lactamase from Prevotella intermedia.
Sequence analysis of cfxA2-like beta-lactamases in Prevotella species.
Sequence analysis of cfxA2-like beta-lactamases in Prevotella species.
Sequence analysis of cfxA2-like beta-lactamases in Prevotella species.
Sequence analysis of cfxA2-like beta-lactamases in Prevotella species.
Presence of the cfxA gene in Bacteroides distasonis.
The study identified the presence of the cfxA gene encoding a class A beta-lactamase in several strains of Bacteroides distasonis and Bacteroides vulgatus, which conferred resistance to cefoxitin and cefotaxime.
Detection of cfxA and cfxA2, the beta-lactamase genes of Prevotella spp., in clinical samples from dentoalveolar infection by real-time PCR.
The study identifies cfxA and cfxA2 as beta-lactamase genes responsible for penicillin resistance in Prevotella spp. isolates from dentoalveolar infections, demonstrating their prevalence and utility in molecular detection.
Genetic tools for studying Capnocytophaga canimorsus.
The study describes the development of genetic tools for Capnocytophaga canimorsus, including the identification of functional resistance genes ermF, cfxA, and tetQ, which can be used as selection markers for plasmid maintenance in C. canimorsus and other Capnocytophaga species.
Antibiotic resistance in primary and persistent endodontic infections.
The study identified bla TEM-1, cfx A, tet M, tet W, and tet Q as the most prevalent antibiotic resistance genes in endodontic infections. bla TEM-1 was more prevalent in primary infections, while tet M remained unchanged after treatment. Vancomycin resistance genes were not detected.
PCR-based detection of resistance genes in anaerobic bacteria isolated from intra-abdominal infections.
The study identified several resistance genes, including cepA, cfiA, cfxA, tetQ, ermF, and mefA, in anaerobic bacteria isolated from intra-abdominal infections in Japan. A mutation in the gyrA gene was also found to confer resistance to fluoroquinolones.
Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients.
Characterization of a multidrug-resistant, novel Bacteroides genomospecies.
Detection of critical antibiotic resistance genes through routine microbiome surveillance.
The study identifies various antibiotic resistance genes (ARGs) associated with multidrug resistance, including macrolide, beta-lactam, tetracycline, and methicillin resistance genes, highlighting the presence of these genes in postmortem microbiome samples.
Comparative diversity of microbiomes and Resistomes in beef feedlots, downstream environments and urban sewage influent.
The study identified several tetracycline, macrolide, aminoglycoside, beta-lactam, sulfonamide, mercury, and biocide resistance genes in beef feedlots, catch basin water, soil, and urban sewage influent. Tetracycline resistance was predominant in beef production systems, while urban sewage influent showed a diverse resistome with resistance to multiple antimicrobial classes.
Higher Prevalence of Multi-Antimicrobial Resistant Bacteroides spp. Strains Isolated at a Tertiary Teaching Hospital in China.
The study identifies the cfiA gene as the primary mechanism of carbapenem resistance in Bacteroides fragilis, along with other resistance genes such as cfxA, cepA, ermF, and nim. These genes contribute to resistance against various antibiotics including carbapenems, cefoxitin, clindamycin, and metronidazole.
Ribaxamase, an Orally Administered beta-lactamase, Diminishes Changes to Acquired Antimicrobial Resistance of the Gut Resistome in Patients Treated with Ceftriaxone.
The study identified several beta-lactamase and vancomycin resistance genes that were significantly increased in placebo-treated patients compared to ribaxamase-treated patients following ceftriaxone exposure.
Antibiotic resistance pattern of Bacteroides fragilis isolated from clinical and colorectal specimens.
The study identified high resistance rates in Bacteroides fragilis isolates, particularly to penicillin G, tetracycline, clindamycin, and cefoxitin. Key resistance genes included tetQ, ermF, cepA, cfxA, and cfiA.
Comparative Genomics of Bacteroides fragilis Group Isolates Reveals Species-Dependent Resistance Mechanisms and Validates Clinical Tools for Resistance Prediction.
The study identifies cfiA and cepA as key carbapenem resistance genes in Bacteroides fragilis sensu stricto, and bla and cfx as important beta-lactam resistance genes in non-fragilis Bacteroides species. It also highlights the role of insertion sequences in activating cfiA-mediated carbapenem resistance.
Genomic diversity and antimicrobial resistance of Prevotella species isolated from chronic lung disease airways.
The study identified ermF, tetQ, and cfxA as key AMR genes in Prevotella species, showing strong correlations with resistance to azithromycin, clindamycin, doxycycline, and ceftazidime. All isolates were resistant to tobramycin.
Acute and persistent effects of commonly used antibiotics on the gut microbiome and resistome in healthy adults.
The study identified increased resistance gene burden in healthy volunteers after antibiotic treatment, particularly with cfxA, tetO, and tet40 genes associated with β-lactam and tetracycline resistance.
Differential response to prolonged amoxicillin treatment: long-term resilience of the microbiome versus long-lasting perturbations in the gut resistome.
The study found that prolonged amoxicillin treatment leads to an increase in the abundance and diversity of antimicrobial resistance genes (ARGs) in the gut microbiome, particularly beta-lactamase genes such as cfxA and its variants, as well as tetracycline and macrolide resistance genes.
Root canal microbiota as an augmented reservoir of antimicrobial resistance genes in type 2 diabetes mellitus patients.
The study identifies that root canal microbiota in T2DM patients harbor a higher prevalence of antimicrobial resistance genes (ARGs) compared to non-diabetic patients, particularly for tetW, tetM, ermB, ermC, cfxA, and tetQ.
The oral microbiota is a reservoir for antimicrobial resistance: resistome and phenotypic resistance characteristics of oral biofilm in health, caries, and periodontitis.
The study identified various antimicrobial resistance genes (ARGs) in the oral microbiota, including mefA, msrD, ermB, ermF, cfxA, blaCSP(1), tetM, tetQ, and pgpB, which confer resistance to antibiotics such as erythromycin, azithromycin, penicillin, ampicillin, tetracycline, and colistin. These genes were found in multiple bacterial species and were associated with different resistotypes in healthy, caries, and periodontitis groups.
Anaerobic Gram-Negative Bacteria: Role as a Reservoir of Antibiotic Resistance.
The study identifies several AMR genes in anaerobic Gram-negative bacteria, including nimE for metronidazole resistance, ermF for clindamycin resistance, cfiA for imipenem resistance, cepA for piperacillin-tazobactam resistance, and cfxA for cefoxitin resistance.
Recovery of the gut microbiome following enteric infection and persistence of antimicrobial resistance genes in specific microbial hosts.
The study identified several extended-spectrum beta-lactamase (ESBL) genes during enteric infection, with some persisting post-recovery, indicating potential gene transfer within the community. The research highlights the persistence of antimicrobial resistance genes in specific microbial hosts, emphasizing the need for further investigation into the dynamics of resistance gene transmission.
Detection of the antibiotic resistance genes content of intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients from European countries.
The study identified and compared the prevalence of antibiotic resistance genes in intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients in European countries, highlighting differences in gene carriage between gut microbiota and clinical strains.
Characterization of Bacteroides fragilis from the vagina of a giant panda (Ailuropoda melanoleuca) with vaginitis.
The study identifies three antibiotic resistance genes, cfxA, cepA, and copA, in a multidrug-resistant Bacteroides fragilis strain isolated from a giant panda with vaginitis.
Effect of surgical antimicrobial prophylaxis duration for colic surgery on complications and resistome.
The study found that extending surgical antimicrobial prophylaxis beyond 24 hours did not increase postoperative complications but led to a higher abundance of beta-lactam resistance genes, including TEM, BlaZ, SHV, CfxA, and PBP2, as well as aminoglycoside-modifying enzymes like AAC(6'), ANT(3"), ANT(6), APH(2"), APH(3'), APH(3"), and APH(6) in the fecal resistome of horses.
Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species.
Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species.
Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species.
Genetic and biochemical analysis of a novel Ambler class A beta-lactamase responsible for cefoxitin resistance in Bacteroides species.
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