ciaH

histidine kinase sensor

Validation StatusCandidate

Overview

Validation Method: genome-wide association study
Drug Classes: Beta-lactams, Cefotaxime
Organisms: Streptococcus pneumoniae
Geographic Location: Thailand|USA
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T230P	-	activates the CiaRH system	Streptococcus pneumoniae	Cefotaxime	Reslit	Candidate

Papers2

Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes.

PMID 25101644 · 2014

The study identifies 51 loci, including 301 SNPs, associated with beta-lactam non-susceptibility in Streptococcus pneumoniae, focusing on genes involved in peptidoglycan biosynthesis and other pathways.

Gene Information

Gene Name: ciaH
Allele: ciaH
Encodes: histidine kinase sensor
Source Database: Reslit
Confers Resistance To: Beta-lactams
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: Thailand|USA
Validation Method: genome-wide association study
Sequence Accession: ERP000435|ERP000483|ERP000485|ERP000487|ERP000598|ERP000599

Browse AMR Genes

ciaH

Mutations

Gene Information