Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
iron transporter
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| W427Ter | - | catecholate siderophore receptor CirA | Klebsiella pneumoniae | CEFIDEROCOL | Reference Gene Catalog | Established |
| E465D | - | - | Escherichia coli | Cefiderocol | Reslit | Candidate |
| G465D | - | - | Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae | Cefiderocol |
Reslit |
| Candidate |
| R86S | - | catecholate siderophore receptor CirA | Escherichia coli | CEFIDEROCOL | Reference Gene Catalog | Established |
| S90YfsTer15 | - | catecholate siderophore receptor CirA | Escherichia coli | CEFIDEROCOL | Reference Gene Catalog | Established |
| Q42Ter | - | catecholate siderophore receptor CirA | Escherichia coli | CEFIDEROCOL | Reference Gene Catalog | Established |
| E388Ter | - | catecholate siderophore receptor CirA | Escherichia coli | CEFIDEROCOL | Reference Gene Catalog | Established |
| E133Ter | - | catecholate siderophore receptor CirA | Klebsiella pneumoniae | CEFIDEROCOL | Reference Gene Catalog | Established |
| Y253CfsTer5 | - | catecholate siderophore receptor CirA | Klebsiella pneumoniae | CEFIDEROCOL | Reference Gene Catalog | Established |
| G75W | - | catecholate siderophore receptor CirA | Klebsiella pneumoniae | CEFIDEROCOL | Reference Gene Catalog | Established |
| - | - | Klebsiella pneumoniae | Cefiderocol | Reslit | Candidate |
In Vitro Evolution of Cefiderocol Resistance in an NDM-Producing Klebsiella pneumoniae Due to Functional Loss of CirA.
Functional loss of the iron transporter gene cirA leads to high-level cefiderocol resistance in an NDM-producing Klebsiella pneumoniae strain, with reduced fitness.
New Delhi Metallo-Beta-Lactamase Facilitates the Emergence of Cefiderocol Resistance in Enterobacter cloacae.
The study shows that the presence of the New Delhi metallo-beta-lactamase (NDM) facilitates the emergence of cefiderocol resistance in Enterobacter cloacae through nonsynonymous mutations in the cirA gene, which encodes a catecholate siderophore receptor.
Emergence of High-Level Cefiderocol Resistance in Carbapenem-Resistant Klebsiella pneumoniae from Bloodstream Infections in Patients with Hematologic Malignancies in China.
High-level cefiderocol resistance in CRKP is mediated by the deficiency of CirA and the presence of NDM-5 beta-lactamase.
Occurrence of High Levels of Cefiderocol Resistance in Carbapenem-Resistant Escherichia coli before Its Approval in China: a Report from China CRE-Network.
High levels of cefiderocol resistance in carbapenem-resistant E. coli were observed, primarily due to the presence of NDM-5, mutations in pbp3, and a premature stop codon in cirA.
Convergent Klebsiella pneumoniae strains belonging to a sequence type 307 outbreak clone combine cefiderocol and carbapenem resistance with hypervirulence.
The study identifies mutations in the cirA gene, encoding the catecholate siderophore receptor, as a mechanism of cefiderocol resistance in Klebsiella pneumoniae ST307 strains. Additionally, mutations in ompK36 and the presence of carbapenemases were found to contribute to cefiderocol resistance.
Genotypic Evolution of Klebsiella pneumoniae Sequence Type 512 during Ceftazidime/Avibactam, Meropenem/Vaborbactam, and Cefiderocol Treatment, Italy.
The study identifies a novel KPC-154 beta-lactamase and a nonsense mutation in the cirA gene contributing to cefiderocol resistance in Klebsiella pneumoniae ST512. Additionally, a deletion in the ompK36 gene was linked to reduced meropenem/vaborbactam susceptibility.
Cefiderocol Resistance Conferred by Plasmid-Located Ferric Citrate Transport System in KPC-Producing Klebsiella pneumoniae.
The study identifies the plasmid-borne fec gene cluster as a novel mechanism of cefiderocol resistance in KPC-producing Klebsiella pneumoniae, demonstrating that the ferric citrate transport system reduces susceptibility to cefiderocol.
In vitro antimicrobial activity and resistance mechanisms of cefiderocol against clinical carbapenem-resistant gram-negative bacteria.
Cefiderocol showed high in vitro activity against carbapenem-resistant gram-negative bacteria, with resistance mechanisms involving beta-lactamase genes (bla OXA-66, bla OXA-23, bla SHV-12), mutations in envZ, cirA, nuoC, and ampC, and loss or altered expression of iron transporter genes (piuA, pirA, fepA).
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