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ResLit

cmlA4

chloramphenicol efflux MFS transporter CmlA4

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to cmlA4

AMR Rules

Browse AMR rules for cmlA4

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic efflux
Validation Method: PCR confirmation
Drug Classes: CHLORAMPHENICOL, Chloramphenicol
Organisms: Klebsiella pneumoniae, Salmonella enterica subsp. enterica serovar Agona, Acinetobacter baumannii, Pandoraea oxalativorans DSM 23570 T
Geographic Location: Europe|Asia, United States
Alleles: 2
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
CmlA4	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	7	CHLORAMPHENICOL, Chloramphenicol	Klebsiella pneumoniae +3	United States, Europe\|Asia

Papers4

Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

PMID 10681329 · 2000

Gene Information

Gene Name: cmlA4
Allele: CmlA4
Encodes: chloramphenicol efflux MFS transporter CmlA4
Source Database: Reference Gene Catalog
Mechanism: antibiotic efflux
Confers Resistance To: CHLORAMPHENICOL
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AF156486.1
Protein Accession: AAF27726.1
Notes: ARO:3002694

Biochemical sequence analyses of GES-1, a novel class A extended-spectrum beta-lactamase, and the class 1 integron In52 from Klebsiella pneumoniae.

PMID 10681329 · 2000

Gene Information

Gene Name: cmlA4
Allele: CmlA4
Encodes: chloramphenicol efflux MFS transporter CmlA4
Source Database: Card Database
Mechanism: antibiotic efflux
Confers Resistance To: CHLORAMPHENICOL
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AF156486.1
Protein Accession: AAF27726.1
Notes: ARO:3002694

Class 1 integron-associated gene cassettes in Salmonella enterica subsp. enterica serovar Agona isolated from pig carcasses in Brazil.

PMID 15761062 · 2005

Gene Information

Gene Name: cmlA4
Allele: CmlA4
Source Database: ResFinder Database
Mechanism: Increased efflux
Confers Resistance To: CHLORAMPHENICOL
Sequence Accession: 47651

Class 1 integron-associated gene cassettes in Salmonella enterica subsp. enterica serovar Agona isolated from pig carcasses in Brazil.

PMID 15761062 · 2005

Gene Information

Gene Name: cmlA4
Allele: CmlA4
Encodes: chloramphenicol efflux MFS transporter CmlA4
Source Database: Reference Gene Catalog
Confers Resistance To: CHLORAMPHENICOL
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Agona
Sequence Accession: AJ867237.1
Protein Accession: CAI29522.1

Antimicrobial resistance determinants in Acinetobacter baumannii isolates taken from military treatment facilities.

PMID 24247131 · 2014

The study identified multiple antimicrobial resistance genes in Acinetobacter baumannii isolates from military treatment facilities, including bla OXA-51-like, bla OXA-23, bla GES-11, aac(6')-Ib, aacC1, aadB, aphA6, and others, highlighting the complex resistome of these isolates.

Gene Information

Gene Name: cmlA4
Allele: CmlA4
Encodes: chloramphenicol acetyltransferase
Source Database: Reslit
Confers Resistance To: Chloramphenicol
Organisms Tested In: • Acinetobacter baumannii
Geographic Location: United States
Validation Method: PCR confirmation
Sequence Accession: KF057029|KF057030|KF057031|KF057032|KF057033|KF057034

Characterization and Comparative Overview of Complete Sequences of the First Plasmids of Pandoraea across Clinical and Non-clinical Strains.

PMID 27790203 · 2016

The study characterizes plasmids from various Pandoraea strains, identifying several antibiotic resistance genes including beta-lactamases, tetracycline resistance genes, aminoglycoside resistance genes, fluoroquinolone resistance genes, macrolide resistance genes, chloramphenicol resistance genes, and lincomamide resistance genes.

Gene Information

Gene Name: cmlA4
Allele: CmlA4
Encodes: chloramphenicol acetyltransferase
Source Database: Reslit
Confers Resistance To: Chloramphenicol
Organisms Tested In: • Pandoraea oxalativorans DSM 23570 T
Geographic Location: Europe|Asia
Validation Method: homology search against CARD database
Sequence Accession: CP011808|CP011809|CP013482|CP011518|CP011519|CP011520|CP011521|CP010898

PMID N/A

Gene Information

Gene Name: cmlA4
Allele: CmlA4
Encodes: chloramphenicol efflux MFS transporter CmlA4
Source Database: Reference Gene Catalog
Confers Resistance To: CHLORAMPHENICOL
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: EU622856.1
Protein Accession: ACC95408.1

PMID N/A

Gene Information

Gene Name: cmlA4
Allele: cmlA4
Encodes: major facilitator superfamily (MFS) antibiotic efflux pump
Source Database: Card Database
Mechanism: antibiotic efflux
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: AF156486.1
Protein Accession: AAF27726.1
Notes: ARO:3002694