Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
copper effluxing P1B-type ATPase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| copA | Reslit | 18 | Polymyxin |
| Spain, Ireland|United States|various, Argentina, China, France|United Kingdom, Switzerland, Tyrrhenian Sea|Panarea|Guaymas basin, Gulf of California, global, Austria, Malaysia |
| 2013, 2015, 2017, 2018, 2019, 2021, 2022, 2023, 2024, 2025 |
| HF583290|HF583291|HF583292 |
| - |
| CopA/CueO | Reslit | 1 | - | Acinetobacter baumannii | - | 2016 | NZ_CP008706.1 | - |
| copA* | Reslit | 1 | Ampicillin, Chloramphenicol +1 | Escherichia coli | - | 2021 | KY749247|PRJEB40537 | - |
| cop A | Reslit | 1 | - | E. coli | Lake Michigan|United States|North America | 2023 | - | - |
A new structural paradigm in copper resistance in Streptococcus pneumoniae.
The study identifies CupA as a copper chaperone and CopA as a copper effluxing P1B-type ATPase, both localized to the plasma membrane, playing critical roles in copper resistance in Streptococcus pneumoniae.
Molecular characterization of copper and cadmium resistance determinants in the biomining thermoacidophilic archaeon Sulfolobus metallicus.
The study identifies and characterizes two duplicated cop gene clusters in Sulfolobus metallicus, consisting of copA, copM, and copT genes, which are involved in copper and cadmium resistance.
Novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398 that also harbor cadmium and copper resistance determinants.
The study identifies novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398, which also harbor cadmium and copper resistance determinants.
Complete genome sequence and phenotype microarray analysis of Cronobacter sakazakii SP291: a persistent isolate cultured from a powdered infant formula production facility.
The study identified several AMR genes in Cronobacter sakazakii SP291, including tellurite resistance genes (terX, terW, terA, terB, terC, terD), heavy metal efflux genes (cusS, cusR, cusC, cusF, czcB, czcA, cusA, copG, pcoS, pcoB, pcoA), and oxidative stress resistance genes (yebA, yibP, hmp, grxB, grxC).
Living in an Extremely Polluted Environment: Clues from the Genome of Melanin-Producing Aeromonas salmonicida subsp. pectinolytica 34melT.
The study identifies several heavy metal resistance genes in Aeromonas salmonicida subsp. pectinolytica 34melT, including merA, copA, arsA, chrA, and zntA, which confer resistance to mercury, copper, arsenite, chromate, and heavy metals respectively.
Copper Resistance of the Emerging Pathogen Acinetobacter baumannii.
The study identifies several putative copper resistance genes in Acinetobacter baumannii, including ActP2/CopA1, CopA/CueO, CueR, CzcA, CzcB, CzcC, CzcD, PcoA, CopB, CopC, CopR/CusR, CopS/CusS, and ActP1/CopA2, which are involved in copper detoxification and efflux mechanisms.
Effects of Copper Addition on Copper Resistance, Antibiotic Resistance Genes, and intl1 during Swine Manure Composting.
The study found that copper addition affected the abundance of copper resistance genes (CRGs) and antibiotic resistance genes (ARGs) during swine manure composting. Specifically, the absolute abundances of pcoA, tcrB, erm(A), erm(B), and intI1 decreased, while those of copA and cusA increased. The high concentration of copper slowed down the dissipation of CRGs, ARGs, and intI1 during composting.
Genomic characterization of a local epidemic Pseudomonas aeruginosa reveals specific features of the widespread clone ST395.
The study identifies specific genomic islands (GIs) in the Pseudomonas aeruginosa ST395 clone, including GI-7, which contains genes for copper resistance (copA and copB). Additionally, chromosomal mutations in genes such as mexZ, gyrA, parC, ampR, ampD, mexR, mexS, and ampC contribute to multidrug resistance.
Genome sequencing and analysis of the first spontaneous Nanosilver resistant bacterium Proteus mirabilis strain SCDR1.
The study identifies several AMR genes in the Nanosilver-resistant Proteus mirabilis strain SCDR1, including those conferring resistance to tetracycline, fluoroquinolones, sulfonamides, daptomycin, rifamycin, elfamycins, chloramphenicol, and amikacin.
Resistance to Metals Used in Agricultural Production.
The paper discusses the resistance mechanisms of bacteria to copper and zinc, highlighting various genes such as pcoA, pcoD, copB, cueO, cusC, mco, czrC, czcD, and zntA that contribute to metal resistance. It also mentions the presence of a 20-gene copper pathogenicity island and the role of siderophores like yersiniabactin in copper resistance.
The Role of the CopA Copper Efflux System in Acinetobacter baumannii Virulence.
The study identifies CopA as a key P-type ATPase involved in copper resistance and virulence in Acinetobacter baumannii, demonstrating its role in copper efflux and protection against oxidative stress.
Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans.
The study identifies a cluster of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type 101 isolated from food and humans, highlighting the potential role of food as a source of multidrug-resistant bacteria transmission to humans.
Comparison of Transcriptional Responses and Metabolic Alterations in Three Multidrug-Resistant Model Microorganisms, Staphylococcus aureus ATCC BAA-39, Escherichia coli ATCC BAA-196, and Acinetobacter baumannii ATCC BAA-1790, on Exposure to Iodine-Containing Nano-micelle Drug FS-1.
The study investigated the effects of the iodine-containing nano-micelle drug FS-1 on the transcriptional and metabolic responses of three multidrug-resistant microorganisms. FS-1 induced significant changes in gene expression, affecting central metabolism, respiration, and stress response pathways, indicating potential mechanisms of action involving cellular stress and metabolic disruption.
Increased copy number couples the evolution of plasmid horizontal transmission and plasmid-encoded antibiotic resistance.
The study identifies copA* mutations in the R1 plasmid that increase plasmid copy number, leading to enhanced horizontal transmission and antibiotic resistance.
Shallow-Water Hydrothermal Vents as Natural Accelerators of Bacterial Antibiotic Resistance in Marine Coastal Areas.
The study identifies multiple heavy metal resistance (HMR) genes in bacterial isolates from shallow-water hydrothermal vents, demonstrating co-selection for antibiotic resistance (AR) in these environments.
Global Antimicrobial Resistance Gene Study of Helicobacter pylori: Comparison of Detection Tools, ARG and Efflux Pump Gene Analysis, Worldwide Epidemiological Distribution, and Information Related to the Antimicrobial-Resistant Phenotype.
The study identified 42 antimicrobial resistance genes (ARG) in Helicobacter pylori, including 16 related to single antibiotic class resistance and 26 related to multidrug resistance. Key genes include hp1181, copA, msbA, vanT, vanTr, mepA, and several RND efflux pumps. These genes were validated through multiple detection tools and curation processes.
Impact of corrosion inhibitors on antibiotic resistance, metal resistance, and microbial communities in drinking water.
Zinc orthophosphate increased antibiotic resistant bacteria (ARB) and antibiotic-resistance genes (ARGs), while sodium silicate decreased ARB and ARGs. The study identified sul1, sul2, qacEΔ1, and intI1 as key ARGs influenced by corrosion inhibitors.
Antisense transcription is associated with expression of metal resistance determinants in Cupriavidus metallidurans CH34.
The study identifies several metal resistance genes in Cupriavidus metallidurans CH34, including merA, merT, arsC2, arsC1, arsB, arsR, czcC2, tauD, atoD, czcC, copF, copD, copC, copB, copA, copR, copS, cupR, cupA, cupC, silC, silB, silA, gshA, and gshB, which are up-regulated under metal stress conditions and are associated with antisense transcription activities.
Characterization of Bacteroides fragilis from the vagina of a giant panda (Ailuropoda melanoleuca) with vaginitis.
The study identifies three antibiotic resistance genes, cfxA, cepA, and copA, in a multidrug-resistant Bacteroides fragilis strain isolated from a giant panda with vaginitis.
Antimicrobial and Metal Resistance Genes in Bacteria Isolated from Mine Water in Austria.
The study identified a variety of antimicrobial and metal resistance genes in bacteria isolated from mine water in Austria, highlighting the prevalence of multidrug efflux pumps and beta-lactamase genes. It also noted the presence of specific metal resistance genes such as ruvB, copA, recGM, and mgtA, as well as co-resistance genes like arsBM, acrD, and the mer operon.
Genomic characterisation of nasal isolates of coagulase-negative Staphylococci from healthy medical students reveals novel Staphylococcal cassette chromosome mec elements.
The study identified novel Staphylococcal cassette chromosome mec (SCC mec ) elements in four methicillin-resistant coagulase-negative Staphylococci (CoNS) isolates from healthy medical students. The isolates harbored various antimicrobial resistance genes, including mecA, blaZ, mphC, msrA, tetK, fusC, fusF, qacA, qacB, qacC, norA, copB, arsC, cadC, cadD, copZ, copA, copR, and czcD, which conferred resistance to beta-lactams, macrolides, tetracyclines, fusidic acid, quaternary ammonium compounds, fluoroquinolones, and heavy metals.
No comments yet. Be the first to comment!
© 2026 ResLit. Data sourced from PubMed literature analysis.
Built for antimicrobial resistance research