Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

crrB

Enzyme IICBGlc

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to crrB

AMR Rules

Browse AMR rules for crrB

Validation StatusSupported

Overview

Mechanism: Lowers cAMP levels
Validation Method: Transposon insertion analysis
Drug Classes: Amikacin, Colistin, Polymyxin, COLISTIN, Polymyxin b
Organisms: Escherichia coli, Klebsiella pneumoniae
Geographic Location: Egypt
Alleles: 2
Papers: 20
Databases: Reslit
Mutations: 20

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S195N	-	HAMP domain-containing histidine kinase CrrB	Klebsiella pneumoniae	COLISTIN	Reference Gene Catalog	Established
Q10L	-	HAMP domain-containing histidine kinase CrrB	Klebsiella pneumoniae	ColistinCOLISTIN	Reference Gene CatalogReslit	Confirmed
G183V	-

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
crr	Reslit	1	Amikacin	Escherichia coli	-	2009	-	-
crrB	Reslit	5	Colistin, Polymyxin	Klebsiella pneumoniae	Egypt	2018, 2020, 2021, 2023, 2024	PRJNA393010\|ERP004913	-

Papers20

Genetic architecture of intrinsic antibiotic susceptibility.

PMID 19462005 · 2009

The study identifies multiple genes and mutations that contribute to antibiotic tolerance in E. coli, revealing a large mutational target size for increasing drug resistance. Key findings include the role of genes involved in electron transport, flagella synthesis, and efflux pumps in modulating susceptibility to various antibiotics.

Gene Information

Gene Name: crrB
Allele: crr
Encodes: Enzyme IICBGlc
Source Database: Reslit
Mechanism: Lowers cAMP levels
Confers Resistance To: Amikacin
Organisms Tested In: • Escherichia coli
Validation Method: Transposon insertion analysis

Morphological, genomic and transcriptomic responses of Klebsiella pneumoniae to the last-line antibiotic colistin.

PMID 29959380 · 2018

The study identifies mutations in phoQ and crrB genes that confer colistin resistance in Klebsiella pneumoniae, highlighting the genetic diversity in resistance mechanisms.

Gene Information

Gene Name: crrB
Allele: crrB
Encodes: Two-component system sensor kinase
Source Database: Reslit
Mechanism: Mutations in crrB lead to activation of the crrC gene and subsequent lipid A modifications, reducing colistin binding.
Confers Resistance To: Colistin
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: Whole genome sequencing and MIC testing
Sequence Accession: PRJNA393010|ERP004913

Predicting Phenotypic Polymyxin Resistance in Klebsiella pneumoniae through Machine Learning Analysis of Genomic Data.

PMID 32457240 · 2020

The study identifies several genes associated with polymyxin resistance in Klebsiella pneumoniae using machine learning analysis of genomic data, including known resistance determinants and potential novel genes.

Gene Information

Gene Name: crrB
Allele: crrB
Encodes: putative permease
Source Database: Reslit
Confers Resistance To: Polymyxin
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: machine learning model interpretation

Rapid high-resolution detection of colistin resistance in Gram-negative bacteria using flow cytometry: a comparison with broth microdilution, a commercial screening test and WGS.

PMID 34477846 · 2021

Gene Information

Gene Name: crrB
Allele: crrB
Encodes: two-component system response regulator
Source Database: Reslit
Confers Resistance To: Colistin
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: genotypic characterization using next-generation sequencing

Resistance evolution in Klebsiella pneumoniae under colistin pressure

PMID 38951173 · 2023

The study identified several mutations in genes such as pmrB, crrB, fimD, and BN373_30951 that confer resistance to colistin in Klebsiella pneumoniae.

Gene Information

Gene Name: crrB
Allele: crrB
Encodes: point mutations in the crrB gene
Source Database: Reslit
Confers Resistance To: Colistin
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: whole-genome sequencing and MIC testing

Efficacy of colistin-based combinations against pandrug-resistant whole-genome-sequenced Klebsiella pneumoniae isolated from hospitalized patients in Egypt: an in vitro/vivo comparative study.

PMID 39627871 · 2024

The study identified mutations in mgrB, PhoQ, PmrC, CrrB, ArnB, and ArnT as the primary mechanisms of colistin resistance in pandrug-resistant Klebsiella pneumoniae isolates.

Gene Information

Gene Name: crrB
Allele: crrB
Encodes: histidine kinase component of the CrrAB two-component system
Source Database: Reslit
Mechanism: amino acid substitution (A200Y)
Confers Resistance To: Colistin
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Egypt
Validation Method: whole-genome sequencing and functional analysis
Sequence Accession: CP154635|CP154636|CP154637|CP154638|CP154639