ctpC

P-1B-ATPase metal exporter

Validation StatusCandidate

Overview

Mechanism: mediates zinc efflux
Validation Method: mutant generation and complementation, growth assays, fluorescence microscopy
Drug Classes: Rifampicin
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium leprae
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
G667R	-	-	Mycobacterium leprae	Rifampicin	Reslit	Candidate

Papers2

Mycobacterial resistance to zinc poisoning requires assembly of P-ATPase-containing membrane metal efflux platforms.

PMID 35961955 · 2022

PacL1 and CtpC are critical for mycobacterial resistance to zinc poisoning, with PacL1 acting as a zinc-binding chaperone and CtpC functioning as a metal exporter.

Gene Information

Gene Name: ctpC
Allele: ctpC
Encodes: P-1B-ATPase metal exporter
Source Database: Reslit
Mechanism: mediates zinc efflux
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium smegmatis
Validation Method: mutant generation and complementation, growth assays, fluorescence microscopy

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ctpC

Mutations

Gene Information