cydA

cytochrome d ubiquinol oxidase

Validation StatusSupported

Overview

Mechanism: oxidative phosphorylation
Validation Method: barcode-based selection and enrichment analysis
Drug Classes: Beta-lactams, Clofazimine
Organisms: Escherichia coli, Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium abscessus
Papers: 3
Databases: Reslit

Papers3

Parallel Mapping of Antibiotic Resistance Alleles in Escherichia coli.

PMID 26771672 · 2016

The study identified multiple genes and alleles associated with antibiotic resistance in Escherichia coli through a genome-scale barcoded library and enrichment analysis, highlighting the role of multi-drug resistance alleles in laboratory selections.

Gene Information

Gene Name: cydA
Allele: cydA
Encodes: cytochrome d ubiquinol oxidase
Source Database: Reslit
Mechanism: oxidative phosphorylation
Confers Resistance To: Beta-lactams
Organisms Tested In: • Escherichia coli
Validation Method: barcode-based selection and enrichment analysis

Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis.

PMID 31511370 · 2019

The study identifies 4-amino-thieno[2,3-d]pyrimidines as novel QcrB inhibitors that inhibit Mycobacterium tuberculosis growth. Mutations in the qcrB gene were found to confer resistance to these compounds.

Gene Information

Gene Name: cydA
Allele: cydA
Encodes: cytochrome bd complex subunit
Source Database: Reslit
Mechanism: respiratory chain compensation
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium smegmatis
Validation Method: genetic deletion and complementation
Sequence Accession: PRJNA561987

RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus.

PMID 34633851 · 2022

The study identifies several genes involved in antibiotic resistance in Mycobacterium abscessus, including erm(41) for macrolide resistance, WhiB7 for general resistance to ribosome-targeting antibiotics, sigH for tigecycline resistance, cydA for clofazimine tolerance, and various aminoglycoside-modifying enzymes like aac(2'), aph(3'), and eis2.

Gene Information

Gene Name: cydA
Allele: cydA
Encodes: subunit of the bd-type quinol oxidase
Source Database: Reslit
Confers Resistance To: Clofazimine
Organisms Tested In: • Mycobacterium abscessus
Validation Method: CRISPR interference and time-kill kinetic analysis
Sequence Accession: PRJNA655109|GSE163621

Comments (0)

No comments yet. Be the first to comment!

Browse AMR Genes

cydA

Gene Information

Gene Information

Gene Information