cydab

terminal oxidase

Validation StatusCandidate

Overview

Mechanism: upregulated upon iron supplementation in kanamycin treatment, involved in altered respiration leading to antibiotic resistance
Validation Method: expression in mutant strains and suppression of TBO growth defect
Organisms: Escherichia coli, Streptomyces coelicolor, Mycobacterium smegmatis
Papers: 2
Databases: Reslit

Papers2

Cytochrome d but not cytochrome o rescues the toluidine blue growth sensitivity of arc mutants of Escherichia coli.

PMID 19897650 · 2010

The study shows that cytochrome d, but not cytochrome o, rescues the toluidine blue growth sensitivity of arc mutants in Escherichia coli by providing an anoxic intracellular environment.

Gene Information

Gene Name: cydab
Allele: cydAB
Encodes: terminal oxidase
Source Database: Reslit
Organisms Tested In: • Escherichia coli
Validation Method: expression in mutant strains and suppression of TBO growth defect

Iron-Induced Respiration Promotes Antibiotic Resistance in Actinomycete Bacteria.

PMID 35357210 · 2022

Iron promotes antibiotic resistance in Streptomyces coelicolor and Mycobacterium smegmatis by altering respiration, particularly through upregulation of cydAB and sdh2 genes.

Gene Information

Gene Name: cydab
Allele: cydAB
Encodes: two subunits of cytochrome bd oxidase
Source Database: Reslit
Mechanism: upregulated upon iron supplementation in kanamycin treatment, involved in altered respiration leading to antibiotic resistance
Organisms Tested In: • Streptomyces coelicolor
• Mycobacterium smegmatis
Validation Method: transcriptomic analysis and growth experiments

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