Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
nonessential low molecular mass PBP4
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| W273X | - | inactivation | Pseudomonas aeruginosa | ceftazidimecefepimepiperacillin+1 more | Reslit | Candidate |
| T79P | - | inactivation | Pseudomonas aeruginosa | ceftazidimecefepimepiperacillin+1 more | Reslit | Candidate |
| T428P | - | inactivation, D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | ceftazidimecephalosporins | Reference Gene CatalogReslit | Confirmed |
| G109D | - | - | Pseudomonas aeruginosa | ceftazidime | Reslit | Candidate |
| G115S | - | - | Pseudomonas aeruginosa | ceftazidime | Reslit | Candidate |
| A394P | - | - | Pseudomonas aeruginosa | ceftazidime avibactam | Reslit | Candidate |
| W388L | - | - | Pseudomonas aeruginosa | ceftazidime avibactam | Reslit | Candidate |
| E234K | - | - | Pseudomonas aeruginosa | cephalosporinspenicillin | Reslit | Candidate |
| T27S | - | - | - | ceftazidimecefepimepiperacillin+2 more | Reslit | Candidate |
| S230I | - | - | - | ceftazidimecefepimepiperacillin+2 more | Reslit | Candidate |
| F438L | - | - | - | ceftazidimecefepimepiperacillin+2 more | Reslit | Candidate |
| W92R | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Established |
| L145P | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Established |
| L204P | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Established |
| N317H | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | aztreonamceftazidime avibactamcephalosporins | Reference Gene Catalog | Established |
| I356A | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Established |
| L402P | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Established |
| G437D | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Established |
| W459* | - | D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine endopeptidase DacB | Pseudomonas aeruginosa | cephalosporins | Reference Gene Catalog | Established |
| - | - | Pseudomonas aeruginosa | cephalosporinscarbapenems | Reslit | Candidate |
Beta-lactam resistance response triggered by inactivation of a nonessential penicillin-binding protein.
Research Article
Inactivation of dacB leads to high-level β-lactam resistance.
Evolution of Habitat-Dependent Antibiotic Resistance in Pseudomonas aeruginosa.
Research Article
Molecular Mechanisms of Resistance to Ceftazidime/Avibactam in Clinical Isolates of Enterobacterales and Pseudomonas aeruginosa in Latin American Hospitals.
Research Article
Multifactorial resistance mechanisms associated with resistance to ceftazidime-avibactam in clinical Pseudomonas aeruginosa isolates from Switzerland.
Research Article
The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research.
Review
Mutations in dacB lead to hyperproduction of AmpC β-lactamase, resulting in resistance to cephalosporins and penicillins.
Keeping up with the pathogens: improved antimicrobial resistance detection and prediction from Pseudomonas aeruginosa genomes.
Research Article
missense mutation
Mutant prevention concentrations and phenotypic and genomic profiling of first-step resistance mechanisms to classical and novel β-lactams in Pseudomonas aeruginosa.
Research Article
dacB
Restoring ceftolozane susceptibility: a role for diazabicyclooctane β-lactamase inhibitors?
Research Article
dacB
Simultaneous and divergent evolution of resistance to cephalosporin/β-lactamase inhibitor combinations and imipenem/relebactam following ceftazidime/avibactam treatment of MDR Pseudomonas aeruginosa infections.
Research Article
dacB
Deciphering β-lactamase-independent β-lactam resistance evolution trajectories in Pseudomonas aeruginosa.
Research Article
dacB
Single-layer end-on continuous suture of colonic anastomoses.
Research Article
dacB
Infective endocarditis of a native aortic valve due to Pseudomonas aeruginosa complicated by progressive multi-drug resistance.
Research Article
Mutation in dacB gene leads to increased ampC expression, contributing to resistance