Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

dam

DNA methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dam

AMR Rules

Browse AMR rules for dam

Validation StatusSupported

Overview

Mechanism: regulation of gene expression
Validation Method: comparison of dam-positive and dam-negative strains
Drug Classes: Nalidixic acid
Organisms: Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium, Klebsiella pneumoniae
Alleles: 2
Papers: 4
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
dam	Reslit	3	Nalidixic acid	Escherichia coli +1	-	2008, 2018, 2022	-	-
Dam	Reslit	1	-

Papers4

Epigenetic inheritance based evolution of antibiotic resistance in bacteria.

PMID 18282299 · 2008

The study identifies AmpC, GadA, and GadB as genes involved in epigenetic-based antibiotic resistance in E. coli, demonstrating that gene expression changes can lead to resistance without DNA mutations. Additionally, the DNA methyltransferase dam was found to influence resistance to nalidixic acid.

Gene Information

Gene Name: dam
Allele: dam
Encodes: DNA methyltransferase
Source Database: Reslit
Mechanism: regulation of gene expression
Confers Resistance To: Nalidixic acid
Organisms Tested In: • Escherichia coli
Validation Method: comparison of dam-positive and dam-negative strains

Using a Chemical Genetic Screen to Enhance Our Understanding of the Antibacterial Properties of Silver.

PMID 29986482 · 2018

This study identifies several genes involved in silver resistance in E. coli through a chemical genetic screen, highlighting the roles of genes related to cell membrane proteins, sulfur metabolism, and NAD+ biosynthesis in conferring resistance to silver.

Gene Information

Gene Name: dam
Allele: dam
Encodes: DNA methyltransferase
Source Database: Reslit
Mechanism: involved in DNA repair and resistance to silver
Organisms Tested In: • Escherichia coli
Validation Method: gene deletion and resistance assay

Prospects of Indole derivatives as methyl transfer inhibitors: antimicrobial resistance managers.

PMID 32366298 · 2020

The study identifies ZINC04899565 and ZINC49171024 as potential broad-spectrum antimicrobial agents targeting multiple methyl transfer enzymes, including MetK, CobA, Dam, and TrmD, which are crucial for bacterial survival and resistance mechanisms.

Gene Information

Gene Name: dam
Allele: Dam
Encodes: DNA adenosine methylase
Source Database: Reslit
Mechanism: inhibition of Dam
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Validation Method: molecular docking

Antimicrobial resistance in Klebsiella pneumoniae: identification of bacterial DNA adenine methyltransferase as a novel drug target from hypothetical proteins using subtractive genomics.

PMID 36617654 · 2022

The study identifies DNA adenine methyltransferase (Dam) as a novel drug target in K. pneumoniae through subtractive genomics and in silico analysis, highlighting its role in bacterial virulence and potential for targeting in antibiotic development.

Gene Information

Gene Name: dam
Allele: dam
Encodes: DNA adenine methyltransferase
Source Database: Reslit
Organisms Tested In: • Klebsiella pneumoniae
Validation Method: subtracted genomics and in silico analysis