dat

d-alanine aminotransferase

Validation StatusCandidate

Overview

Mechanism: resistance to β-chloro-d-alanine via antibiotic inactivation
Validation Method: expression in wild-type, enzyme activity assays, structural modeling
Drug Classes: Beta-lactam
Organisms: Staphylococcus aureus
Papers: 2
Databases: Reslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
S180F	-	-	-	Beta-lactam	Reslit	Candidate

Papers2

A D-alanine aminotransferase S(180)F substitution confers resistance to β-chloro-D-alanine in Staphylococcus aureus via antibiotic inactivation.

PMID 40894697 · 2025

A S180F substitution in the d-alanine aminotransferase Dat confers resistance to β-chloro-D-alanine (BCDA) in Staphylococcus aureus by reducing enzymatic activity and altering PLP-BCDA adduct affinity.

Gene Information

Gene Name: dat
Allele: dat
Encodes: d-alanine aminotransferase
Source Database: Reslit
Mechanism: resistance to β-chloro-d-alanine via antibiotic inactivation
Organisms Tested In: • Staphylococcus aureus
Validation Method: expression in wild-type, enzyme activity assays, structural modeling
Sequence Accession: NCBI: SAUSA300_1696|9PXS

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Mutations

Gene Information