Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

dck

deoxycytidine kinase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dck

AMR Rules

Browse AMR rules for dck

Validation StatusSupported

Overview

Mechanism: inactivation of dCK gene leads to resistance to purine nucleotide analogues
Validation Method: TALEN-mediated gene inactivation and in vitro resistance testing
Organisms: human, murine, Human
Alleles: 2
Papers: 4
Databases: Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
dCK	Reslit	1	-	-	-	2015	-	-
DCK	Reslit	3	-	human +2	-

Papers4

A Multidrug-resistant Engineered CAR T Cell for Allogeneic Combination Immunotherapy.

PMID 26061646 · 2015

The study demonstrates that TALEN-mediated inactivation of the dCK gene in primary T cells confers resistance to multiple purine nucleotide analogues, including clofarabine, fludarabine, and cytarabine, making them suitable for allogeneic immunotherapy.

Gene Information

Gene Name: dck
Allele: dCK
Encodes: deoxycytidine kinase
Source Database: Reslit
Mechanism: inactivation of dCK gene leads to resistance to purine nucleotide analogues
Validation Method: TALEN-mediated gene inactivation and in vitro resistance testing

Using genome-wide CRISPR library screening with library resistant DCK to find new sources of Ara-C drug resistance in AML.

PMID 27808171 · 2016

Gene Information

Gene Name: dck
Allele: DCK
Encodes: Deoxycytidine kinase
Source Database: Reslit
Mechanism: Loss of function leads to Ara-C resistance
Organisms Tested In: • human
• murine
Validation Method: CRISPR knockout and resistance assays

Transcriptional profiling of NCI/ADR-RES cells unveils a complex network of signaling pathways and molecular mechanisms of drug resistance.

PMID 29379303 · 2018

The study identifies multiple genes involved in drug resistance mechanisms in NCI/ADR-RES cells, including ABCB1, ABCC6, GALC, NNMT, CDA, DCK, DCDC2, TOP2A, LAMA4, NID2, COL4A4, MMP1, LOXL4, ITGB4, ITGB8, TGFBI, SEMA3D, FGFBP1, SLPI, and EpCAM, which contribute to resistance against various chemotherapeutic agents.

Gene Information

Gene Name: dck
Allele: DCK
Encodes: Deoxycytidine kinase
Source Database: Reslit
Organisms Tested In: • Human
Validation Method: Microarray and RT-qPCR analysis
Sequence Accession: GSE75494

Genome-scale CRISPR/Cas9 screen determines factors modulating sensitivity to ProTide NUC-1031.

PMID 31113993 · 2019

The study identifies DCK and DCTPP1 as critical factors in modulating sensitivity to NUC-1031, with DCK playing a significant role in gemcitabine resistance.

Gene Information

Gene Name: dck
Allele: DCK
Encodes: Deoxycytidine kinase
Source Database: Reslit
Validation Method: CRISPR/Cas9 knockdown and cytotoxicity assays