ddcP

D-alanyl-D-alanine carboxypeptidase

Validation StatusCandidate

Overview

Mechanism: Contributes to ampicillin resistance by functioning as a low-molecular-weight penicillin-binding protein (LMW-PBP) and is essential for high-level ampicillin resistance.
Validation Method: Targeted mutant analysis and enzymatic activity assay
Drug Classes: Ampicillin
Organisms: Enterococcus faecium
Papers: 1
Databases: Reslit

Papers1

Genome-wide identification of ampicillin resistance determinants in Enterococcus faecium.

PMID 22761597 · 2012

This study identified ddcP, ldt fm, and pgt as intrinsic ampicillin resistance determinants in Enterococcus faecium. These genes are part of the core genome and contribute to ampicillin resistance through various mechanisms, including peptidoglycan cross-linking and cell wall synthesis.

Gene Information

Gene Name: ddcP
Allele: ddcP
Encodes: D-alanyl-D-alanine carboxypeptidase
Source Database: Reslit
Mechanism: Contributes to ampicillin resistance by functioning as a low-molecular-weight penicillin-binding protein (LMW-PBP) and is essential for high-level ampicillin resistance.
Confers Resistance To: Ampicillin
Organisms Tested In: • Enterococcus faecium
Validation Method: Targeted mutant analysis and enzymatic activity assay
Sequence Accession: JQ088279

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ddcP

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