Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
deazaflavin-dependent nitroreductase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| G81S | - | likely to confer resistance | Mycobacterium tuberculosis | delamanidpretomanid | Reslit | Supported |
| L49P | - | single resistance variant | Mycobacterium tuberculosis | delamanidpretomanidmultiple antibiotics | Card DatabaseReslit | Confirmed |
| T79R | - | - | Mycobacterium avium | delamanid | Reslit | Candidate |
| R112W | - | - | - | pretomanid | Reslit | Candidate |
| C149Y | - | - | - | pretomanid | Reslit | Candidate |
| L64P | - | - | - | pretomanid | Reslit | Candidate |
| W88R | - | - | - | pretomanid | Reslit | Candidate |
| Y133C | - | - | - | pretomanid | Reslit | Candidate |
| S78Y | - | - | - | pretomaniddelamanid | Reslit | Candidate |
| W20* | - | nonsense mutation | Mycobacterium tuberculosis | delamanidpretomanidmultiple antibiotics | Card DatabaseReslit | Confirmed |
| G81D | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| R23P | - | - | - | delamanid | Reslit | Candidate |
| G53C | - | - | - | delamanid | Reslit | Candidate |
| P63Q | - | - | - | delamanid | Reslit | Candidate |
| E118K | - | - | - | delamanid | Reslit | Candidate |
| R142F | - | - | - | delamanid | Reslit | Candidate |
| W88* | nonsense mutation, loss-of-function | Mycobacterium tuberculosis | delamanidmultiple antibioticspretomanid | Card DatabaseReslit | Confirmed | |
| Y65L | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
| A76V | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
| Y133F | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
| V75L | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
| Q125K | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
| V148I | - | - | Mycobacterium smegmatis | pa 824 | Reslit | Candidate |
| L107P | - | - | - | delamanid | Reslit | Candidate |
| T40P | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| T51P | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| A77P | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| Y89S | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| D108A | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| T110P | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| T115P | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| D116E | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| T140P | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| D141A | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| C149W | - | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate |
| W139* | - | nonsense mutation | Mycobacterium tuberculosis | multiple antibiotics | Card Database | Established |
| M1Var | - | single resistance variant | Mycobacterium tuberculosis | multiple antibiotics | Card Database | Established |
| E35K | - | Mycobacterium tuberculosis | delamanid | Reslit | Candidate | |
| R536L | - | Mycobacterium tuberculosis | pretomanid | Reslit | Candidate |
Predicting nitroimidazole antibiotic resistance mutations in Mycobacterium tuberculosis with protein engineering.
Research Article
The study identifies mutations in the ddn gene that lead to resistance to pretomanid in Mycobacterium tuberculosis without completely losing the native menaquinone reductase activity. These mutations include L49P, S78Y, W88R, and Y133C.
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.
Review
This study identifies numerous mutations in genes associated with resistance to bedaquiline, clofazimine, linezolid, delamanid, and pretomanid in Mycobacterium tuberculosis, highlighting the genetic basis of resistance to these drugs.
Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.
Research Article
The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.
Leveraging large language models to predict antibiotic resistance in Mycobacterium tuberculosis.
Research Article
The study introduces LLMTB, a large language model that predicts antibiotic resistance in Mycobacterium tuberculosis by analyzing genomic data. It identifies key resistance genes and intergenic regions associated with various antibiotics, demonstrating superior performance compared to existing methods.
Genomic decoding of drug-resistant tuberculosis transmission in Thailand over three decades.
Research Article
The study identifies the ddn Gly81Ser mutation associated with delamanid resistance in Mycobacterium tuberculosis isolates from Thailand.
No comments yet. Be the first to comment!