dfr12

dihydrofolate reductase

Validation StatusCandidate

Overview

Mechanism: reduces trimethoprim binding
Validation Method: whole genome sequencing
Drug Classes: Trimethoprim
Organisms: Escherichia coli
Geographic Location: China, Tanzania
Papers: 2
Databases: Reslit

Papers2

First identification of bla (NDM-5) producing Escherichia coli from neonates and a HIV infected adult in Tanzania.

PMID 35225760 · 2022

The study identifies bla NDM-5 producing Escherichia coli in Tanzania, highlighting the presence of carbapenem resistance and other resistance genes on various plasmids.

Gene Information

Gene Name: dfr12
Allele: dfr12
Encodes: dihydrofolate reductase
Source Database: Reslit
Mechanism: reduces trimethoprim binding
Confers Resistance To: Trimethoprim
Organisms Tested In: • Escherichia coli
Geographic Location: Tanzania
Validation Method: whole genome sequencing
Sequence Accession: PRJNA756167|PRJNA756168|PRJNA756169

Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.

PMID 41232214 · 2025

The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.

Gene Information

Gene Name: dfr12
Allele: dfr12
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: Trimethoprim
Organisms Tested In: • Escherichia coli
Geographic Location: China
Validation Method: experimental validation in E. coli strains from food-producing animals

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dfr12

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