dfr18

Dihydrofolate reductase

Validation StatusSupported

Overview

Validation Method: cloning and sequencing
Drug Classes: Trimethoprim
Organisms: Vibrio cholerae O1, Vibrio vulnificus, Vibrio metschnikovii, Vibrio fluvialis, Vibrio parahaemolyticus, Vibrio cholerae
Geographic Location: Asia, Eastern Cape Province, South Africa|Eastern Cape, South Africa
Papers: 3
Databases: Reslit

Papers3

Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.

PMID 11600347 · 2001

The study identifies the antibiotic resistance genes in Vibrio cholerae O139 and O1 SXT constins, including floR, strA, strB, sulII, and dfr18, which confer resistance to chloramphenicol, streptomycin, sulfamethoxazole, and trimethoprim, respectively.

Gene Information

Gene Name: dfr18
Allele: dfr18
Encodes: Dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: Trimethoprim
Organisms Tested In: • Vibrio cholerae O1
Geographic Location: Asia
Validation Method: cloning and sequencing
Sequence Accession: AY034138|AY035340|AF375956

Antibiotic susceptibility profiles of some Vibrio strains isolated from wastewater final effluents in a rural community of the Eastern Cape Province of South Africa.

PMID 20470419 · 2010

The study identified several antibiotic resistance genes in Vibrio strains isolated from wastewater effluents, including dfrA1, dfr18, floR, sul2, strB, and tetA, which confer resistance to trimethoprim, chloramphenicol, sulfamethoxazole, streptomycin, and tetracycline.

Gene Information

Gene Name: dfr18
Allele: dfr18
Encodes: trimethoprim resistance
Source Database: Reslit
Confers Resistance To: Trimethoprim
Organisms Tested In: • Vibrio vulnificus
• Vibrio metschnikovii
• Vibrio fluvialis
• Vibrio parahaemolyticus
Geographic Location: South Africa
Validation Method: PCR and antibiotic susceptibility testing

Antibiotic resistance and virulence genes profiling of Vibrio cholerae and Vibrio mimicus isolates from some seafood collected at the aquatic environment and wet markets in Eastern Cape Province, South Africa.

PMID 37616193 · 2023

The study identified various antibiotic resistance genes and virulence genes in Vibrio cholerae and Vibrio mimicus isolates from seafood samples in South Africa, highlighting the presence of resistance to multiple antibiotics including polymyxin B, ampicillin, and fluoroquinolones.

Gene Information

Gene Name: dfr18
Allele: dfr18
Encodes: dihydrofolate reductase
Source Database: Reslit
Organisms Tested In: • Vibrio cholerae
Geographic Location: Eastern Cape Province, South Africa|Eastern Cape
Validation Method: PCR detection and phenotypic resistance testing

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