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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim-resistant dihydrofolate reductase DfrA1
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D27E | - | increased ligand dissociation rates while maintaining the enzyme’s ability to turnover substrate | Salmonella enterica, Escherichia coli | Trimethoprim | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries |
|---|
| Years |
|---|
| Sequence Accession |
|---|
| Protein Accession |
|---|
| DfrA1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 285 | TRIMETHOPRIM, Trimethoprim +2 | Escherichia coli +117 | India|Mexico|Egypt|Morocco|Peru|Kenya|Senegal|Mali|South Africa|Vietnam|Nepal|Indonesia|Bolivia|Equatorial Guinea|Uganda|Cameroon|Guatemala|Philippines|Burkina-Faso, Europe, India, Denmark, Bolivia, Ghana, Singapore|Colombia|Guyana|Brazil|Manaos, Sweden, South Africa, China, Europe|United States|Australia, Australia, Tunisia, Global, Haiti, Nigeria, Pakistan, Baltic Sea|Finland, Iran, Nebraska|United States, South West London, UK, Nepal, poultry, Poland, Italy, Europe|Italy, Portugal, Mexico, Saudi Arabia, Delhi, India, Kenya, Norway, Peru, France, United Kingdom, UK|Latin America, Scotland, South Asia|sub-Saharan Africa|The Gambia|Mali|Kenya|Mozambique|Bangladesh|India|Pakistan, Brazil, United States, South Korea, Argentina, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, Senegal, Egypt, Ecuador, UK, Germany, Greece, Japan, Belgium, mid-Adriatic coast, China|USA|Italy|Israel, Spain|France, Europe|Netherlands, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, Guadeloupe|French West Indies, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, England, North America|Asia|Europe|Australia|South America, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Ontario, Canada|North America, California|Europe|North America|Republic of Congo, Canada, sub-Saharan Africa|Burkina Faso|Ghana|Guinea-Bissau|Kenya|Senegal, Brasília, Brazil, United Kingdom|England|Australia, Europe|Poland, England|south-central England, North Carolina|USA, Assam, Northeast Tunisia, Europe|Greece, Finland|Eastern Finland, Spain, Romania|France, Europe|EU|China|Portugal|Germany, Bangladesh, Algeria, Northern Ireland, Abuja, Nigeria, Democratic Republic of Congo|Democratic Republic of the Congo, North Sea|Baltic Sea, South America|Chile, Quetta Balochistan, Iraq, Colombia, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Thailand, Ontario, Canada, Holtemme river, Saxony-Anhalt, Germany, Vietnam, Chile, Europe|Asia|North America|Western and South-Eastern Asia, Belgium|The Netherlands|Europe, Western Africa|Mali, Finland, Northern California|northern California|California, Pakistan|Karachi, Pakistan, West Texas, USA, Kuwait, Australia|South Australia, Sharkia Governorate, Egypt|Egypt, Central Greece, Finland|Iceland|Spain, Lebanon, Switzerland, Europe|United States|Asia|Africa|Australia|Bangladesh, Henan|Shaanxi, Ethiopia, Uruguay|Chile, Madagascar, Portugal|various regions, Asia|South America|North America|Europe|Africa, Fujian Province, Southeast China|China, Vancouver, Canada, Turkey, Austria, Somali region, Ethiopia|Somali Region, Ethiopia, Europe|Africa|North America|South America|Asia|Oceania, Taiwan, New Mexico, USA, Ibadan, Nigeria, Western Balkans|Hungary, Wuhan, Paraguay|Northern Spain, Europe|Croatia, Tianjin|Southern Karnataka, Australia|France|Bangladesh|United States, Europe|China, Middle East|Europe|Asia|South America|Peru|Egypt|Saudi Arabia|Denmark|Pakistan|Jordan|Iraq|Lebanon|China|Ghana, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia, Africa, northwest China|China | 1983, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AJ419168.1 | CAD11594.1 |
| dfrA1 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Escherichia coli, Acinetobacter baumannii, Laribacter hongkongensis, Campylobacter jejuni, Salmonella enterica subsp. enterica serovar Typhimurium, Shigella sonnei, Vibrio cholerae non-O1/non-O139, Aeromonas caviae, Salmonella sp. D76, Acinetobacter sp. PGS49 +1 | - | 2009 | FJ591049, HM055363, GU726913, AB188271, EU089668, FJ215857, AJ400733, X00926, AJ238350, AF203818, AJ419168, AY141977, DQ018382, AB199789, FM207631, FJ001872, FJ489928 | AAP74961.2 |
| dfrA1-aadA1 | Reslit | 3 | Trimethoprim | Escherichia coli +1 | India, Iran, China | 2014, 2018, 2024 | MF589545|MF589546|MF589547 | - |
| dfrA1/dfrA15/dfrA25/dfrA30 | Reslit | 1 | Trimethoprim | Escherichia coli +12 | India | 2014 | PRJEB6102 | - |
| dfr(A1) | Reslit | 1 | Trimethoprim | Escherichia coli | Egypt | 2018 | - | - |
| dfr A1 | Reslit | 10 | Trimethoprim | Enterobacteriaceae +11 | Portugal, India, Edo state, Nigeria, Southeast Nigeria, South Africa, Denmark, Italy, Germany, Spain, Egypt|Northern Egyptian governorates of Kafr El-Sheikh and Dakahlia | 2019, 2022, 2023, 2024, 2025 | MDDI00000000|MDDH00000000|MDGW00000000|MDJL00000000|MIIV00000000|MINP00000000|MINQ00000000|MINR00000000|MINU00000000|MDJJ00000000|MECX00000000|MDJI00000000|MECW00000000|MIIX00000000|MIIY00000000|MINS00000000|MINT00000000|MDJK00000000|MECT00000000|MINV00000000|NGWI00000000|NGWH00000000|NGWG00000000|NGWF00000000|NGWE00000000|NGWD00000000|NGWC00000000|NGWB00000000|NGWA00000000|NGVZ00000000|NGVY00000000|NGVX00000000|NGVW00000000|NMYB00000000|NMYA00000000|NMXZ00000000|NMXY00000000|NMXX00000000|NMXW00000000|NMXV00000000|NMXU00000000|NMXT00000000|NMXS00000000|NMXR00000000|NMXQ00000000|NMXP00000000|NMXO00000000|PDYE00000000|PDYD00000000|PDYC00000000|PDYB00000000|PDYA00000000|PDXZ00000000|PDXY00000000|PDXX00000000|PDXW00000000|PDXV00000000|PDXU00000000|PDXT00000000|PDXS00000000 | - |
| dfR A1 | Reslit | 1 | Trimethoprim | Vibrio cholerae | India|Malaysia|South China | 2021 | - | - |
| dfrA1/sul2 | Reslit | 1 | Trimethoprim/sulfamethoxazole | Escherichia coli | Denmark | 2022 | KP198616|U00096|CP001509|CP007491|MG591698 | - |
| dfrA1-like | Reslit | 1 | Trimethoprim | Escherichia ruysiae | - | 2023 | - | - |
Identification of class 1 integrons-associated gene cassettes in Escherichia coli isolated from Varanus spp. in Indonesia.
Mechanism of resistance to several antimicrobial agents in Salmonella Clinical isolates causing traveler's diarrhea.
The study identified several AMR genes and mutations in Salmonella isolates causing traveler's diarrhea, including blaTEM, blaOXA-1, tetA, tetB, tetG, dfrA1, dfrA12, dfrA14, dfrA17, floR, cmlA, and a mutation in the gyrA gene. These genes and mutations contribute to resistance against ampicillin, tetracycline, trimethoprim, chloramphenicol, and quinolones.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Cats as a risk for transmission of antimicrobial drug-resistant Salmonella.
The study identified several antimicrobial resistance genes in Salmonella isolates from cats, including blaTEM, cat, sul2, tet(A), and dfrA1, which confer resistance to ampicillin, chloramphenicol, sulfonamides, tetracycline, and trimethoprim, respectively.
Characterization of class 1 integrons-mediated antibiotic resistance among calf pathogenic Escherichia coli.
Incidence of class 1 integrons in multiple antibiotic-resistant Gram-negative copiotrophic bacteria from the River Torsa in India
The study identified various gene cassettes within class 1 integrons in multiple antibiotic-resistant Gram-negative bacteria from the River Torsa in India, including dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, aac(6')-Ib, aadA1, aadA6, and a novel ORF with homology to dfrA1.
Class 1 integrons and tetracycline resistance genes in alcaligenes, arthrobacter, and Pseudomonas spp. isolated from pigsties and manured soil.
The study identifies several tetracycline resistance genes (tet(A), tet(C), tet(33)) and gene cassettes (aadA1, aadA2, aadA9, aadA11, dfrA1, dfrB2a) associated with class 1 integrons in various bacterial species isolated from pigsties and manured soil.
Class 2 integrons in Vibrio cholerae.
Mechanism of drug resistance in clonally related clinical isolates of Vibrio fluvialis isolated in Kolkata, India.
Population structure and resistance genes in antibiotic-resistant bacteria from a remote community with minimal antibiotic exposure.
The study identified various acquired antibiotic resistance genes in commensal E. coli isolates from a remote community with minimal antibiotic exposure, including blaTEM, catI, cmlA6, tet(A), tet(B), dfrA1, dfrA7, dfrA8, dfrA17, sul1, sul2, aphA1, aadA1, aadA2, aadA5, aadB, and sat-1. These genes were found to be similar to those seen in antibiotic-exposed settings, indicating the dissemination of resistant bacteria and resistance genes from such environments.
Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant.
Vibrio cholerae O1 from Accra, Ghana carrying a class 2 integron and the SXT element.
The study identifies the presence of class 2 integrons carrying dfrA1, sat, and aadA1 cassettes in Vibrio cholerae O1 isolates from Accra, Ghana, which confer resistance to trimethoprim and streptomycin.
Occurrence of antibiotic resistance and class 1, 2 and 3 integrons in Escherichia coli isolated from a densely populated estuary (Seine, France).
Occurrence of antibiotic resistance and class 1, 2 and 3 integrons in Escherichia coli isolated from a densely populated estuary (Seine, France)., Local dissemination of multidrug-resistant Acinetobacter baumannii clones in a Thai hospital., Identification and characterization of integron-associated antibiotic resistant Laribacter hongkongensis isolated from aquatic products in China., Prevalence and characterization of integrons from bacteria isolated from a slaughterhouse wastewater treatment plant., An integron cassette carrying dfr1 with 90-bp repeat sequences located on the chromosome of trimethoprim-resistant isolates of Campylobacter jejuni., The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7., Characterization and chromosomal mapping of antimicrobial resistance genes in Salmonella enterica serotype typhimurium., Identification of class 1 integrons-associated gene cassettes in Escherichia coli isolated from Varanus spp. in Indonesia., Characterization of class 1 integrons-mediated antibiotic resistance among calf pathogenic Escherichia coli., Class 2 integrons in Vibrio cholerae., Prevalence of integrons and a new dfrA17 variant in Gram-negative bacilli which cause community-acquired infections.
High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.
The study identified a high prevalence of multidrug-tolerant bacteria and various antimicrobial resistance genes in ornamental fish and their carriage water, highlighting the potential risk of resistance gene spread through the aquatic environment.
Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two year intervention on trimethoprim use.
The study identified various dfr genes, including dfrA1, dfrA17, dfrA5, dfrA7, dfrA8, dfrA12, dfrA14, dfrA24, and dfrA26, as major contributors to trimethoprim resistance in E. coli and K. pneumoniae. The distribution of these genes remained largely unchanged during the intervention period.
Antibiotic susceptibility profiles of some Vibrio strains isolated from wastewater final effluents in a rural community of the Eastern Cape Province of South Africa.
The study identified several antibiotic resistance genes in Vibrio strains isolated from wastewater effluents, including dfrA1, dfr18, floR, sul2, strB, and tetA, which confer resistance to trimethoprim, chloramphenicol, sulfamethoxazole, streptomycin, and tetracycline.
Identification and characterization of integron-associated antibiotic resistant Laribacter hongkongensis isolated from aquatic products in China.
Local dissemination of multidrug-resistant Acinetobacter baumannii clones in a Thai hospital.
Identification and molecular characterization of antimicrobial-resistant shiga toxin-producing Escherichia coli isolated from retail meat products.
The study identified class 1 integrons carrying aadA1 and dfrA1 gene cassettes in Shiga toxin-producing Escherichia coli (STEC) isolates from retail meat products, contributing to multidrug resistance.
Diversity and evolution of AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I.
The study characterizes various AbaR genomic resistance islands in Acinetobacter baumannii strains of European clone I, identifying multiple AMR genes such as blaTEM-1, aacC1, aadA1, aacA4, dfrA1, catA1, sul1, and tetA, which confer resistance to beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
QRDR mutations, efflux system & antimicrobial resistance genes in enterotoxigenic Escherichia coli isolated from an outbreak of diarrhoea in Ahmedabad, India.
The study identified QRDR mutations in gyrA and parC, as well as the aac(6')-Ib-cr gene, class 1 and class 2 integrons, and various resistance genes including blaTEM-1, catA1, dfrA1, dfrA17, aadA1, aadA5, strA, tet, and aphA1-Ia in ETEC strains, contributing to multidrug resistance.
Phenotypic and genotypic characterization of Salmonella enterica recovered from poultry meat in Tunisia and identification of new genetic traits.
The study identified various AMR genes in Salmonella enterica isolates from poultry meat in Tunisia, including blaTEM, aadA1, aadA2, dfrA1, sul1, sul2, sul3, strA-strB, cmlA, and tet(A). These genes contribute to resistance against multiple antibiotics such as ampicillin, sulfonamides, streptomycin, trimethoprim, chloramphenicol, and tetracycline.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Drug-resistance mechanisms in Vibrio cholerae O1 outbreak strain, Haiti, 2010.
The study identified resistance genes strA, strB, sul2, dfrA1, and floR in the Haiti V. cholerae O1 outbreak strain, along with mutations in gyrA (Ser83Ile) and parC (Ser85Leu) contributing to quinolone resistance.
Molecular characterization of a 21.4 kilobase antibiotic resistance plasmid from an α-hemolytic Escherichia coli O108:H- human clinical isolate.
The study identifies a 21.4 kb plasmid pECTm80 carrying a class 2 integron with gene cassettes dfrA1, sat2, and ΔaadA1, which confer resistance to trimethoprim, streptothricin, and streptomycin/spectinomycin respectively.
DNA sequence analysis of plasmids from multidrug resistant Salmonella enterica serotype Heidelberg isolates.
The study identified multiple antimicrobial resistance genes in plasmids from multidrug-resistant Salmonella enterica serotype Heidelberg isolates, including bla CMY, aadA, aadB, aphA, strA, strB, sul1, sul2, tetA, floR, cmlA, dfrA1, dfrA12, and aacC.
Outbreak investigation using high-throughput genome sequencing within a diagnostic microbiology laboratory.
The study identified the blaCTX-M-15 gene, aadA1, tetA, and dfrA1 as resistance determinants in multidrug-resistant Escherichia coli strains during an outbreak. Additionally, quinolone resistance mutations in gyrA (S83L, D87N) and parC (S80I, E84V) were detected.
Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.
The study identifies multidrug-resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae strains in Nigeria, highlighting the presence of resistance genes such as floR, sul2, dfrA1, and strAB, along with quinolone resistance mutations in gyrA (Ser83Ile) and parC (Ser85Leu).
Occurrence and abundance of antibiotics and resistance genes in rivers, canal and near drug formulation facilities--a study in Pakistan.
The study identified the presence of antibiotic resistance genes sulI and dfrA1 in environmental samples, which are associated with sulfamethoxazole and trimethoprim resistance, respectively. These genes were found at high concentrations near drug formulation facilities and in areas with elevated antibiotic levels.
Sulphonamide and trimethoprim resistance genes persist in sediments at Baltic Sea aquaculture farms but are not detected in the surrounding environment.
The study identified the persistence of sulphonamide resistance genes (sul1, sul2) and trimethoprim resistance gene (dfrA1) in sediments at Baltic Sea aquaculture farms, while these genes were not detected in the surrounding environment.
Characterization of Escherichia coli virulence genes, pathotypes and antibiotic resistance properties in diarrheic calves in Iran.
The study identified several antibiotic resistance genes in E. coli isolates from diarrheic calves in Iran, including aadA1, sul1, aac[3]-IV, dfrA1, tetA, and tetB, which confer resistance to streptomycin, sulfonamide, gentamicin, trimethoprim, and tetracycline.
Within-population distribution of trimethoprim resistance in Escherichia coli before and after a community-wide intervention on trimethoprim use.
The study identified dfrA1, dfrA5, and dfrA17 as trimethoprim resistance genes in Escherichia coli, showing their distribution across different genetic subpopulations and changes in resistance frequencies after a community-wide intervention on trimethoprim use.
Occurrence of Antimicrobial-Resistant Escherichia coli and Salmonella enterica in the Beef Cattle Production and Processing Continuum.
The study identified several AMR genes in E. coli and Salmonella, including beta-lactamase genes (blaCMY, blaCTX-M), sulfonamide resistance genes (sul1, sul2, sul3), and dihydrofolate reductase genes (dfrA1, dfrA5, dfrA7, dfrA12). These genes conferred resistance to various antibiotics such as ampicillin, ceftiofur, ceftriaxone, and trimethoprim-sulfamethoxazole.
Phylogenetic distribution and prevalence of genes encoding class I Integrons and CTX-M-15 extended-spectrum β-lactamases in Escherichia coli isolates from healthy humans in Chandigarh, India.
The study identifies the presence of class 1 integrons and bla CTX-M-15 genes in commensal E. coli isolates from healthy individuals in Chandigarh, India. It also detects several gene cassettes conferring resistance to trimethoprim, streptomycin, spectinomycin, streptothricin, chloramphenicol, tetracycline, and sulfonamides.
Shotgun metagenomics reveals a wide array of antibiotic resistance genes and mobile elements in a polluted lake in India.
The study identified a diverse array of antibiotic resistance genes in a polluted lake in India, including sul2, qnrD, aph(6)-Id, aph(3′)-Ib, CMY2, qnrS, ant(3′)-Ia, dfrB1/dfrB5/dfrB6/dfrB8, GES, ere(A)/ere(C), qnrC, mph(E), dfrA1/dfrA15/dfrA25/dfrA30, erm(F), ant(2′)-Ia, cmlA, and tet(39). These genes conferred resistance to various classes of antibiotics, highlighting the significant presence of resistance mechanisms in the polluted environment.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
Draft Genome Sequence of a Pathogenic O86:H25 Sequence Type 57 Escherichia coli Strain Isolated from Poultry and Carrying 12 Acquired Antibiotic Resistance Genes.
The study reports the draft genome sequence of an E. coli strain carrying 12 acquired antibiotic resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, sulfonamide resistance, trimethoprim resistance, tetracycline resistance, and streptothricin resistance.
Environmental Isolate of Rahnella aquatilis Harbors Class 1 Integron.
The study reports the first description of a class 1 integron in an environmental isolate of Rahnella aquatilis, harboring the dfrA1-aadA1 gene cassette array and the blaTEM gene, contributing to resistance against trimethoprim, streptomycin, spectinomycin, ampicillin, and piperacillin.
Emergence of a Clonal Lineage of Multidrug-Resistant ESBL-Producing Salmonella Infantis Transmitted from Broilers and Broiler Meat to Humans in Italy between 2011 and 2014.
The study identifies the emergence of a multidrug-resistant ESBL-producing Salmonella Infantis clone transmitting from broilers and broiler meat to humans in Italy, harboring the bla CTX-M-1 and bla CTX-M-65 genes, along with resistance genes tet(A), sul1, dfrA1, and dfrA14.
Draft Genome Sequence of Proteus mirabilis NO-051/03, Representative of a Multidrug-Resistant Clone Spreading in Europe and Expressing the CMY-16 AmpC-Type β-Lactamase.
The draft genome sequence of Proteus mirabilis NO-051/03 reveals the presence of multiple acquired resistance genes, including blaCMY-16 and blaTEM-1b, which confer resistance to β-lactams, as well as genes for resistance to aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, and sulfonamides. Additionally, mutations in gyrA, gyrB, and parC contribute to fluoroquinolone resistance.
Draft Genomic Analysis of an Avian Multidrug Resistant Morganella morganii Isolate Carrying qnrD1.
The study reports the draft genome sequence of a multidrug-resistant Morganella morganii isolate carrying the qnrD1 gene, along with various other antibiotic resistance genes such as aadA1y, aph(3')-Ic, strA-strB, blaOXA-1, catA2, catB3, sul2, dfrA1, tetY, and sat2.
Multidrug- and Extensively Drug-Resistant Uropathogenic Escherichia coli Clinical Strains: Phylogenetic Groups Widely Associated with Integrons Maintain High Genetic Diversity.
The study identifies various AMR genes such as aadA1, aadB, aacC, ant1, dfrA1, and dfrA17 in MDR- and XDR-UPEC strains, which confer resistance to gentamicin and trimethoprim-sulfamethoxazole.
Prevalence, serotyping and antimicrobials resistance mechanism of Salmonella enterica isolated from clinical and environmental samples in Saudi Arabia.
The study identified several AMR genes and mutations in Salmonella enterica isolates from Saudi Arabia, including carb-like, dfrA1, floR, tetA, and mutations in gyrA and parC genes associated with resistance to beta-lactams, trimethoprim-sulfamethoxazole, chloramphenicol, tetracycline, and fluoroquinolones.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Genome sequence of Shigella flexneri strain SP1, a diarrheal isolate that encodes an extended-spectrum β-lactamase (ESBL).
The study identifies the presence of multiple antibiotic resistance genes in the Shigella flexneri strain SP1, including blaCTX-M-14, blaOXA-1, aadA24, strA, strB, catA1, tetD, sul2, and dfrA1, which contribute to its multidrug-resistant phenotype.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
Characterization of Salmonella enterica isolates causing bacteremia in Lima, Peru, using multiple typing methods.
The study identified aadA1 and dfrA1 genes in Salmonella isolates, which confer resistance to streptomycin, spectinomycin, and trimethoprim. These genes were found in Infantis and Dublin isolates, respectively.
Characterization of plasmids harboring blaCTX-M and blaCMY genes in E. coli from French broilers.
The study characterized blaCTX-M-1 and blaCMY-2 genes in E. coli isolates from French broilers, highlighting their roles in extended-spectrum cephalosporin resistance and the presence of virulence genes on blaCMY-2-containing plasmids.
Molecular analysis of multidrug resistance in clinical isolates of Shigella spp. from 2001-2010 in Kolkata, India: role of integrons, plasmids, and topoisomerase mutations.
The study identified several AMR genes including dfrV, dfrA1, aadA, blaOXA, sat, InsE, and InsO, as well as mutations in gyrA and parC contributing to quinolone resistance in Shigella isolates.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Gene cassettes of class I integron-associated with antimicrobial resistance in isolates of Citrobacter spp. with multidrug resistance.
The study identified several gene cassettes associated with antimicrobial resistance in multidrug-resistant Citrobacter isolates, including aadA1, aadA2, dfrA1, dfrA12, dfrA15, dfrA1-aadA1, and dfrA12-orfF-aadA2.
Gene cassettes of class I integron-associated with antimicrobial resistance in isolates of Citrobacter spp. with multidrug resistance.
The study identified several gene cassettes associated with antimicrobial resistance in multidrug-resistant Citrobacter isolates, including aadA1, aadA2, dfrA1, dfrA12, dfrA15, dfrA1-aadA1, and dfrA12-orfF-aadA2.
Genetic analysis of invasive Escherichia coli in Scotland reveals determinants of healthcare-associated versus community-acquired infections.
The study identified several antibiotic resistance genes in E. coli isolates, including blaCTX-M-15, blaCTX-M-9, aac(3)-II, aac(6')-Ib, aadA1, dfrA1, sul1, sul2, mphA, and mrxA, which contribute to resistance against various antibiotics such as third-generation cephalosporins, aminoglycosides, trimethoprim, sulfonamides, and macrolides.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Dynamics of antimicrobial resistance in intestinal Escherichia coli from children in community settings in South Asia and sub-Saharan Africa.
The study identified multiple AMR genes in aEPEC isolates from children in South Asia and sub-Saharan Africa, highlighting the prevalence of resistance to multiple antibiotics, including ampicillin, streptomycin, trimethoprim/sulphamethoxazole, and tetracycline.
Antimicrobial resistance genes in pathogenic Escherichia coli isolated from diseased broiler chickens in Egypt and their relationship with the phenotypic resistance characteristics.
The study identified multiple antimicrobial resistance genes in pathogenic E. coli isolates from broiler chickens in Egypt, including CITM, ere, aac(3)-(IV), tet(A), tet(B), dfr(A1), and aad(A1). These genes were associated with resistance to various antibiotics, highlighting the presence of multidrug-resistant E. coli in poultry.
A Fatal Bacteremia Caused by Hypermucousviscous KPC-2 Producing Extensively Drug-Resistant K64-ST11 Klebsiella pneumoniae in Brazil.
The study reports a fatal case of bacteremia caused by a hypermucoviscous KPC-2 producing extensively drug-resistant K64-ST11 Klebsiella pneumoniae. The isolate harbored multiple AMR genes including blaKPC-2, blaSHV-11, qnrS1, oqxA, oqxB, sul1, sul2, dfrA1, tetA, tetD, and fosA, contributing to its extensive drug resistance.
Draft genome sequence data of a tigecycline-resistant Enterobacter cloacae ST93 clinical strain isolated from bloodstream infection.
The study reports the draft genome sequence of a tigecycline-resistant Enterobacter cloacae ST93 clinical isolate, TREC1, which harbors multiple antimicrobial resistance genes, including those encoding resistance to beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, macrolides, lincosamides, streptogramin B, phenicols, sulfonamides, trimethoprim, and tetracyclines. The isolate is resistant to all antibiotics tested except colistin.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms.
The study identified tetracycline resistance genes tet(A) and tet(B) as the most common in commensal E. coli isolates from cattle farms, along with gene cassettes such as aadA1, dfrA1, dfrA12, sul1, cat1, and floR associated with class 1 integrons.
Genome sequence analysis of an extensively drug-resistant Acinetobacter baumannii indigo-pigmented strain depicts evidence of increase genome plasticity.
The study identifies multiple antibiotic resistance genes in the extensively drug-resistant Acinetobacter baumannii strain Ab33405, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, highlighting the genetic basis of its multidrug resistance.
High abundances of class 1 integrase and sulfonamide resistance genes, and characterisation of class 1 integron gene cassettes in four urban wetlands in Nigeria.
The study identified high abundances of class 1 integrase (intI1) and sulfonamide resistance genes (sul1 and sul2) in urban wetlands in Nigeria, along with various gene cassettes in class 1 integrons that confer resistance to trimethoprim, aminoglycosides, rifampicin, and fluoroquinolones.
Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain.
The study shows that Acinetobacter baumannii A118 can acquire antibiotic resistance genes from other species through natural transformation, leading to increased resistance to various antibiotics such as meropenem, imipenem, and sulfamethoxazole.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
Prevalence of Antibiotic Resistance Genes in Multidrug-Resistant Enterobacteriaceae on Portuguese Livestock Manure.
The study identified several antibiotic resistance genes in multidrug-resistant Enterobacteriaceae from Portuguese livestock manure, including cat I, cat II, qnr S, tet (A), tet (M), sul 3, and dfr Ia group.
Prevalence of antimicrobial resistance and potential pathogenicity, and possible spread of third generation cephalosporin resistance, in Escherichia coli isolated from healthy chicken farms in the region of Dakar, Senegal.
The study identified various AMR genes and mutations in E. coli isolates from healthy chicken farms in Senegal, including bla CTX-M, bla CMY-2, tetA, dfrA1, dfrA7, aadA1, qnrB, and bla TEM, as well as mutations in gyrA and parC genes contributing to ciprofloxacin resistance.
Draft Genome Sequence of an Enterococcus faecalis Strain (24FS) That Was Isolated from Healthy Infant Feces and Exhibits High Antibacterial Activity, Multiple-Antibiotic Resistance, and Multiple Virulence Factors.
The study reports the draft genome sequence of Enterococcus faecalis 24FS, highlighting its multiple-antibiotic resistance traits, including resistance to chloramphenicol, tetracycline, erythromycin, aminoglycosides, fluoroquinolones, trimethoprim, streptothricin, and streptomycin, along with potential virulence factors.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Associations between antimicrobial use and the faecal resistome on broiler farms from nine European countries.
The study identified several antimicrobial resistance genes associated with antimicrobial use on broiler farms, including bla TEM, erm (B), tet (W), aadA cluster, cmx, and dfrA1.
Antimicrobial resistance, virulence & plasmid profiles among clinical isolates of Shigella serogroups.
The study identified multiple antimicrobial resistance genes including bla OXA-1, bla TEM-1B, qnr S1, dfr A1, aad A1, sul II, tet B, and cat A1 in Shigella isolates. Additionally, novel mutations in gyr A, gyr B, par C, and par E genes were observed, contributing to quinolone resistance.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Phenotypic and genotypic characterization of antibiotic-resistant in Escherichia coli isolates from patients with diarrhea.
The study identified several antibiotic resistance genes in E. coli isolates from patients with diarrhea, including dfrA1, sul1, citm, tetA, and qnr, which contribute to resistance against trimethoprim, sulfamethoxazole, ampicillin, tetracycline, and ciprofloxacin, respectively.
Trimethoprim and other nonclassical antifolates an excellent template for searching modifications of dihydrofolate reductase enzyme inhibitors.
The study identifies the dfrA1 gene as a contributor to trimethoprim resistance in Klebsiella pneumoniae and Escherichia coli.
Molecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance.
The study identifies blaKPC-2 as the dominant carbapenemase gene in clinical CRKP isolates, along with various ESBLs and other resistance genes such as blaCTX-M, blaTEM, blaSHV, aac(3)-IId, rmtB, QnrS1, oqxA, oqxB, fosA, catA1, catA2, dfrA1, and dfrA17.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Effects of a Four-Week High-Dosage Zinc Oxide Supplemented Diet on Commensal Escherichia coli of Weaned Pigs.
The study identifies several antibiotic resistance genes (ARGs) and zinc tolerance genes in commensal Escherichia coli from weaned pigs, highlighting the impact of high-dose zinc oxide diets on selecting for resistant strains.
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
Resistance to change: AMR gene dynamics on a commercial pig farm with high antimicrobial usage.
The study identified multiple AMR genes, including tetB, tetQ, ermA, ermB, and dfrA1, which were associated with tetracycline, macrolide, and trimethoprim resistance in porcine fecal samples. These genes were found to be prevalent and diverse, with no significant changes in their abundance despite antimicrobial treatments.
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Research Note: Longitudinal monitoring of chicken houses in a commercial layer farm for antimicrobial resistance in Escherichia coli with special reference to plasmid-mediated quinolone resistance.
The study identified qnrS1, qnrS2, and qnrS13 genes as plasmid-mediated quinolone resistance genes in E. coli isolates from a commercial layer farm. Additionally, blaTEM, aadA, tetA, and dfrA1 genes were found to confer resistance to ampicillin, dihydrostreptomycin, oxytetracycline, and trimethoprim, respectively.
Genotypic and Phenotypic-Based Assessment of Antibiotic Resistance and Profile of Staphylococcal Cassette Chromosome mec in the Methicillin-Resistant Staphylococcus aureus Recovered from Raw Milk.
The study identified several AMR genes in MRSA isolates from raw milk, including blaZ, tetK, dfrA1, aacA-D, ermA, and gyrA, which confer resistance to various antibiotics such as penicillin, tetracycline, trimethoprim-sulfamethoxazole, gentamicin, erythromycin, and fluoroquinolones.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Exploration of risk factors for ceftriaxone resistance in invasive non-typhoidal Salmonella infections in western Kenya.
The study identified blaCTX-M-15, dfrA1, dfrA14, sul1, and sul2 as genes responsible for ceftriaxone resistance in invasive non-typhoidal Salmonella infections in western Kenya.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Emergence of a Multidrug-Resistant Enterobacter hormaechei Clinical Isolate from Egypt Co-Harboring mcr-9 and bla(VIM-4).
The study reports the first complete genomic sequence of an mcr-9 and bla VIM-4 -carrying multidrug-resistant Enterobacter hormaechei clinical isolate from Egypt, highlighting the coexistence of these resistance genes on an IncHI2 plasmid and their potential for dissemination.
Genomic profiling of antimicrobial resistance genes in clinical isolates of Salmonella Typhi from patients infected with Typhoid fever in India.
The study identified several AMR genes and mutations in Salmonella Typhi isolates, including beta-lactamases (blaTEM-1B, blaTEM-116), chloramphenicol resistance gene (catA1), trimethoprim resistance genes (dfrA7, dfrA15), sulfamethoxazole resistance genes (sul1, sul2), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE genes.
Metagenomic Diagnosis for a Culture-Negative Sample From a Patient With Severe Pneumonia by Nanopore and Next-Generation Sequencing.
The study identified several AMR genes in a culture-negative sample from a patient with severe pneumonia, including bla SHV-12, bla KPC-2, bla TEM-1, bla CTX-M-65, aac(3)-IIa, aadA1, dfrA1, sul1, aph(3')-Ia, catA1, fosA, acrA, and rmtB, which confer resistance to various antibiotics.
Plasmid Replicon Typing of Antibiotic-Resistant Escherichia coli From Clams and Marine Sediments.
The study identified various antibiotic resistance genes in E. coli isolates from clams and marine sediments, including blaTEM, blaSHV, blaCTX-M, tet(A), dfrA1, aadA, strA, strB, and ant(3"). These genes were associated with resistance to beta-lactams, tetracycline, trimethoprim/sulfamethoxazole, and streptomycin.
Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae.
The study characterizes multidrug-resistant plasmids pA1705-qnrS, p911021-tetA, and p1642-tetA from Klebsiella pneumoniae, identifying several AMR genes including beta-lactamases (bla CTX-M-14, bla TEM-1, bla OXA-1, bla SHV-12, bla CTX-M-15, bla CTX-M-65), quinolone resistance gene qnrS1, tetracycline resistance genes tetA (A) and tetA (D), aminoglycoside resistance genes aacA4cr and aacC2, streptomycin resistance genes strA and strB, dihydrofolate reductase genes dfrA1 and dfrA14, sulfonamide resistance gene sul2, macrolide resistance gene mph (A), efflux pump gene oqxAB, chloramphenicol acetyltransferase gene catB3, and tunicamycin resistance gene tmrB.
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Comparative Genomics of Acinetobacter baumannii Clinical Strains From Brazil Reveals Polyclonal Dissemination and Selective Exchange of Mobile Genetic Elements Associated With Resistance Genes.
The study identifies multiple beta-lactamase genes, including blaTEM-1, blaADC-182, and blaOXA-253, as well as aminoglycoside resistance genes such as aph3 and aadB, which contribute to the multidrug resistance profile of Acinetobacter baumannii clinical strains in Brazil.
Phenotypic and Genotypic Properties of Vibrio cholerae non-O1, non-O139 Isolates Recovered from Domestic Ducks in Germany.
Mechanisms Protecting Acinetobacter baumannii against Multiple Stresses Triggered by the Host Immune Response, Antibiotics and Outside-Host Environment.
This review discusses the mechanisms that protect Acinetobacter baumannii against multiple stresses, including those from the host immune response, antibiotics, and the outside environment. It highlights the role of surface glycoconjugates, outer membrane components, and various virulence factors in evading immune defenses and surviving adverse conditions.
First Genomic Characterization of bla(VIM-1) and mcr-9-Coharbouring Enterobacter hormaechei Isolated from Food of Animal Origin.
The study reports the first genomic characterization of a multidrug-resistant Enterobacter hormaechei isolate coharboring bla(VIM-1) and mcr-9 genes from food of animal origin. The isolate was resistant to carbapenems and other antibiotics, but susceptible to colistin. The bla(VIM-1) and mcr-9 genes were located on the same IncHI2 plasmid, along with other resistance genes.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Outbreak of multi-drug-resistant (MDR) Shigella flexneri in northern Australia due to an endemic regional clone acquiring an IncFII plasmid.
The study identifies several AMR genes in a multi-drug-resistant Shigella flexneri strain, including bla DHA, bla OXA-1, tet(B), catA1, dfrA1, mph(A), ermB, qnrB, aadA, and qacEΔ1, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, trimethoprim, macrolides, quinolones, aminoglycosides, and quaternary ammonium compounds.
The New Klebsiellapneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
The study identified several AMR genes in two hypermucoviscous Klebsiella pneumoniae isolates from renal transplant recipients, including bla CTX-M-15, aac(6')-Ib-cr, and others, indicating resistance to various antibiotics.
Biological Characteristics and Genetic Analysis of a Highly Pathogenic Proteus Mirabilis Strain Isolated From Dogs in China.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Proteus mirabilis strain CC15031, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and others.
Molecular Characteristics of Extraintestinal Pathogenic E. coli (ExPEC), Uropathogenic E. coli (UPEC), and Multidrug Resistant E. coli Isolated from Healthy Dogs in Spain. Whole Genome Sequencing of Canine ST372 Isolates and Comparison with Human Isolates Causing Extraintestinal Infections.
The study identified several AMR genes in canine ST372 isolates, including blaTEM-1A, sul1, aadA1, dfrA1, and mdf(A), which confer resistance to beta-lactams, sulfonamides, aminoglycosides, trimethoprim, and tetracyclines respectively. These genes were found in the genomes of the isolates through whole genome sequencing and in silico analysis.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
A Multifactorial Approach for Surveillance of Shigella spp. and Entero-Invasive Escherichia coli Is Important for Detecting (Inter)national Clusters.
The study identified several AMR genes and mutations in Shigella spp. and EIEC isolates, including beta-lactamases (blaTEM-1b, blaOXA-1, blaCTX-M-15, blaCTX-M-32, blaCTX-M-55, blaDHA-1), dihydrofolate reductase variants (dfrA1, dfrA14, dfrA17, dfrA7, dfrA8), sulfonamide resistance genes (sul1, sul2), macrolide resistance genes (erm(B), mphA), and chromosomal mutations in gyrA, parC, and parE associated with ciprofloxacin resistance.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
Clinical and microbiological characteristics of patients colonized or infected by Stenotrophomonas maltophilia : is resistance to sulfamethoxazole/trimethoprim a problem?
The study identified the sul1, sul2, and dfrA1 genes as key mechanisms of sulfamethoxazole/trimethoprim resistance in Stenotrophomonas maltophilia, with sul1 being the most prevalent.
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
Collateral sensitivity associated with antibiotic resistance plasmids.
The study identifies several AMR genes carried by clinically relevant plasmids, including blaOXA-48, qnrS1, blaSHV-12, aac(6')-Ib3, blaVEB-9, qnrVC-1, sul1, tetA', tetC, dfrA1, dfrA23, blaVIM-1, aadA1, qacEΔ1, blaBEL-1, blaGES-5, blaIMP-8, and blaFOX-8. These genes confer resistance to various antibiotics, and the study highlights the collateral sensitivity associated with the acquisition of these plasmids.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Utility of whole-genome sequencing during an investigation of multiple foodborne outbreaks of Shigella sonnei.
The study identified multiple antimicrobial resistance genes in the Shigella sonnei outbreak strain, including blaCTX-M-15, qnrS1, strA, strB, dfrA1, tetA, and sul2, which conferred resistance to various antibiotics such as ceftazidime, ciprofloxacin, streptomycin, trimethoprim, tetracycline, and sulfamethoxazole.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Wild boars in Germany carry ESBL/AmpC-producing E. coli, with bla CTX-M-1, bla SHV-12, and bla CMY-2 being the most common beta-lactamase genes. Additional resistance genes include sul1, sul2, sul3, dfrA1, dfrA5, dfrA14, dfrA17, tet(A), cmlA, floR, and qnrS.
An Update on Wastewater Multi-Resistant Bacteria: Identification of Clinical Pathogens Such as Escherichia coli O25b:H4-B2-ST131-Producing CTX-M-15 ESBL and KPC-3 Carbapenemase-Producing Klebsiella oxytoca.
The study identifies several AMR genes, including bla CTX-M-15, bla KPC-3, aac(6')-Ib-cr5, and various dfr and aad genes, in wastewater isolates, highlighting the prevalence of multidrug-resistant bacteria in wastewater treatment plants.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
A Real-Time Thermal Sensor System for Quantifying the Inhibitory Effect of Antimicrobial Peptides on Bacterial Adhesion and Biofilm Formation.
The study identified several AMR genes in E. coli and S. aureus isolates, including beta-lactamases (blaOXA-1, blaTEM-1A), chloramphenicol acetyltransferase (catA1), trimethoprim resistance gene (dfrA1), fluoroquinolone resistance gene (floR), sulfonamide resistance genes (sul1, sul2), methicillin resistance gene (mecA), beta-lactamase (blaZ-like), and tetracycline efflux pumps (tet(K), tet(M)).
On-Farm Anaerobic Digestion of Dairy Manure Reduces the Abundance of Antibiotic Resistance-Associated Gene Targets and the Potential for Plasmid Transfer.
The study found that anaerobic digestion of dairy manure significantly reduced the abundance of antibiotic resistance genes, including various ESBL genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla PER-1, as well as other resistance genes like aac(6')-Ib-cr, aph(3')-Ib, aph(6)-Id, bla OXA-1, catB4, dfrA1, floR, lnu(G), sul2, aadA2, mph(E), msr(E), tet(C), tet(E), and tet(X).
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Molecular Analysis of Antimicrobial Resistance among Enterobacteriaceae Isolated from Diarrhoeic Calves in Egypt.
The study identified multiple antimicrobial resistance genes, including blaTEM, floR, dfrA1, dfrA17, aadA1, aadA2, aadA5, catB3, sat1, and blaPse1, in Enterobacteriaceae isolates from diarrhoeic calves in Egypt. These genes confer resistance to various antibiotics such as ampicillin, tetracycline, chloramphenicol, and others.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
The study identified multiple AMR genes and mutations in invasive non-typhoidal Salmonella isolates from sub-Saharan Africa, highlighting the prevalence of multidrug resistance.
Genomic insights into the diversity, virulence and resistance of Klebsiella pneumoniae extensively drug resistant clinical isolates.
The study identified various beta-lactamase genes, including blaSHV-11, blaKPC-2, and blaNDM-1, along with qnrS1, aadA1, dfrA1, and sul1, which contribute to multidrug resistance in extensively drug-resistant Klebsiella pneumoniae isolates.
Acquisition and loss of CTX-M plasmids in Shigella species associated with MSM transmission in the UK.
The study identifies the presence of bla CTX-M-27, erm(B), mph(A), aph(3')-Ib, aph(6)-Id, sul2, and tet(A) in Shigella isolates associated with MSM transmission in the UK, highlighting the role of plasmids in the spread of antimicrobial resistance.
Antimicrobial Resistance and Whole-Genome Characterisation of High-Level Ciprofloxacin-Resistant Salmonella Enterica Serovar Kentucky ST 198 Strains Isolated from Human in Poland.
The study identified several AMR genes and mutations in high-level ciprofloxacin-resistant Salmonella Enterica serovar Kentucky ST198 strains isolated from humans in Poland, including blaTEM-1B, qnrS1, aac(3)-Id, aac(3)-IId, aac(6')-Iaa, aac(6')-Iid, aph(3")-Ib, aph(3")-Id, aadA1, sul1, dfrA1, and tetA, along with mutations in gyrA and parC that confer resistance to quinolones and beta-lactams.
A genomic epidemiological study shows that prevalence of antimicrobial resistance in Enterobacterales is associated with the livestock host, as well as antimicrobial usage.
The study identified various AMR genes in Enterobacterales isolates from livestock, highlighting the association between AMR prevalence and antimicrobial usage, with pigs being a major reservoir of AMR genes.
Phylogenetic and antimicrobial drug resistance analysis of Vibrio cholerae O1 isolates from Ghana.
The study identified multiple antimicrobial resistance genes in Vibrio cholerae O1 isolates from Ghana, including strA, strB, catB5, floR, sul2, and dfrA1, which confer resistance to streptomycin, chloramphenicol, florfenicol, sulfonamides, and trimethoprim/sulfamethoxazole. Additionally, mutations in gyrA (S83I) and parC (S85L) were found to contribute to fluoroquinolone resistance.
Deciphering Multidrug-Resistant Acinetobacter baumannii from a Pediatric Cancer Hospital in Egypt.
The study identified various AMR genes and mutations in multidrug-resistant Acinetobacter baumannii isolates from a pediatric cancer hospital in Egypt, highlighting the presence of bla NDM, bla OXA-23-like, bla OXA-51-like, and other resistance genes, along with mutations in pmrA and lptF contributing to colistin resistance.
Stepwise Evolution of a Klebsiella pneumoniae Clone within a Host Leading to Increased Multidrug Resistance.
The study identifies the acquisition of multiple AMR genes and mutations in a Klebsiella pneumoniae clone, leading to increased multidrug resistance. Key findings include the role of blaCTX-M-14, aac(3)-Iid, tet(A), qnrS1, sul1, dfrA1, acrAB-TolC, ompK35, and mgrB in conferring resistance to various antibiotics, along with mutations in ramR that contribute to resistance.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Prevalence of genotypic antimicrobial resistance in clinical Shiga toxin-producing Escherichia coli in Norway, 2018 to 2020.
The study identified a low prevalence of genotypic antimicrobial resistance in clinical STEC in Norway, with aminoglycoside resistance being the most common. Key resistance genes included strA, strB, aadA1, sul1, sul2, tetA, blaTEM-1B, and dfrA1.
Molecular characterization of Vibrio cholerae O1 strains circulating in Assam: a north eastern state of India.
The study identified the presence of antibiotic resistance genes sulII, dfrA1, strB, and the SXT element in Vibrio cholerae O1 strains circulating in Assam, highlighting the emergence of multidrug-resistant strains.
Recurring outbreaks by the same Escherichia coli ST10 clone in a broiler unit during 18 months.
The study identifies multiple antimicrobial resistance genes, including blaTEM-1B, tetA, dfrA1/sul2, and floR, in E. coli ST10 isolates causing recurrent outbreaks in a broiler unit over 18 months.
Prevalence, Risk Factors, Antimicrobial Resistance and Molecular Characterization of Salmonella in Northeast Tunisia Broiler Flocks.
The study identified the bla CTX-M gene in extended-spectrum beta-lactamase (ESBL)-producing Salmonella strains, along with tetA, tetB, and dfrA1 genes in tetracycline and trimethoprim-resistant strains. High levels of multidrug resistance were observed.
Plethora of Resistance Genes in Carbapenem-Resistant Gram-Negative Bacteria in Greece: No End to a Continuous Genetic Evolution.
The study identified a variety of resistance genes in carbapenem-resistant Gram-negative bacteria, including bla KPC, bla NDM, bla VIM, and others, highlighting the complex genetic diversity of these pathogens.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Decreasing the abundance of tetracycline-resistant Escherichia coli in pig feces during nursery using flavophospholipol as a pig feed additive.
Flavophospholipol (FPL) effectively reduced the abundance of tetracycline-resistant Escherichia coli in pig feces by inhibiting conjugational transfer and growth of resistant plasmids carrying tetA, tetB, blaTEM-1B, mdfA, aph(3')-I, sul2, aadA1, and dfrA1.
Distribution and Molecular Characterization of Functional Class 2 Integrons in Clinical Proteus mirabilis Isolates.
The study identified functional class 2 integrons in three Proteus mirabilis isolates, containing gene cassettes dfrA1-sat2-aadA1 and four novel open reading frames. The internal stop codons in intI2 genes were mutated, indicating functional intI2 genes.
Genomic characterization of multidrug-resistant Salmonella serovar Kentucky ST198 isolated in poultry flocks in Spain (2011-2017).
The study identified multiple antimicrobial resistance genes in multidrug-resistant Salmonella serovar Kentucky ST198 isolates from Spain, including genes conferring resistance to aminoglycosides, beta-lactams, sulfonamides, tetracyclines, trimethoprim, and colistin.
Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.
The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Pathogenic E. coli from Cattle as a Reservoir of Resistance Genes to Various Groups of Antibiotics.
The study identified various AMR genes in pathogenic E. coli strains from cattle in Romania and France, highlighting the presence of multidrug-resistant (MDR) strains and the diversity of resistance mechanisms.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.
The report highlights the presence of various antimicrobial resistance genes such as blaVIM-1, blaTEM-1B, blaTEM-1C, and cfr in different bacterial isolates, indicating resistance to carbapenems, beta-lactams, and macrolides/lincosamides/streptogramin B.
The Current Landscape of Antibiotic Resistance of Salmonella Infantis in Italy: The Expansion of Extended-Spectrum Beta-Lactamase Producers on a Local Scale.
The study identified multiple antimicrobial resistance genes in Salmonella Infantis strains from Italy, including blaCTX-M-1, aadA1, dfrA1, dfrA14, sul1, and tet(A), which contribute to resistance against various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, sulfonamides, and tetracyclines.
Identifying the Sources of Intestinal Colonization With Extended-Spectrum β-Lactamase-Producing Escherichia coli in Healthy Infants in the Community.
The study identifies several AMR genes, including blaCTX-M-15, qnrS1, ermB, aadA1, aph(3')-Ib, aph(6)-Id, dfrA1, catA1, aadA2, dfrA5, dfrA12, qnrS13, aac(6')-Ib-cr5, blaTEM-1, blaOXA-1, sul1, and dfrA17, associated with ESBL-Ec in children, mothers, and drinking water in rural Bangladesh.
Epidemiology of Klebsiella michiganensis Carrying Multidrug-Resistant IncHI5 Plasmids in the Southeast Coastal Area of China.
The study identified multiple AMR genes on IncHI5 plasmids in Klebsiella michiganensis, including beta-lactamases (blaCTX-M-3, blaTEM-1, blaSHV-12, blaIMP-4, blaNDM-1, blaOXA-1, blaOXA-16, blaSFO-1, blaSIM-1), aminoglycoside modifying enzymes (aacA4, arr3, aadA5, gcu37, dfrA1), chloramphenicol acetyltransferase (catA2), streptomycin resistance genes (strA, strB), macrolide resistance genes (msrAB, mph(A)), and quaternary ammonium compound resistance gene (qacG2).
Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).
The study identifies several AMR genes, including blaTEM-1, dfrA1, tetA, sul1, floR, aac(6')-laa, qnrE1, aadA1, and aac(6')-ly, in non-typhoidal Salmonella enterica strains. It also reports mutations in mgrB, pmrB, and pmrC associated with colistin resistance.
Antimicrobial Resistance in Escherichia coli from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.
The study identifies SHV-12-producing Escherichia coli isolates in a broiler farm environment, highlighting the presence of various antimicrobial resistance genes such as bla SHV-12, cmlA, tet (A), aac(6′)-Ib-cr, and others. These genes confer resistance to multiple antibiotics, emphasizing the need for monitoring and controlling AMR in agricultural settings.
Genetic Characterization of Four Groups of Chromosome-Borne Accessory Genetic Elements Carrying Drug Resistance Genes in Providencia.
This study characterizes four groups of chromosome-borne accessory genetic elements (AGEs) in Providencia, highlighting the diversity and complexity of multidrug resistance (MDR) regions within these elements. It identifies numerous drug resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others, contributing to the understanding of AMR mechanisms in Providencia.
Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
The study identifies D27E and L28Q substitutions in DfrA1 and DfrA5 as key determinants of trimethoprim resistance, revealing a common mechanism of resistance in plasmid-encoded dihydrofolate reductases.
Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018.
The 2018 cholera outbreak in Algeria involved Vibrio cholerae O1 El Tor isolates with resistance to streptomycin, sulfamethoxazole, trimethoprim, and sulfamethoxazole/trimethoprim, decreased susceptibility to ciprofloxacin, and intermediate resistance to chloramphenicol and nitrofurantoin. Mutations in gyrA (S83I), parC (S85L), nfsA (R169C), nfsB (Q5Stop), and vprA (D89N) were identified as contributing to the resistance profiles.
Antimicrobial resistance in urinary pathogens and culture-independent detection of trimethoprim resistance in urine from patients with urinary tract infection.
The study identifies dfrA1, dfrA5, dfrA7, dfrA12, and dfrA17 as trimethoprim resistance genes in urinary pathogens, demonstrating their utility in predicting phenotypic resistance without culture.
Clinical and Genomic Investigation of an International Ceftriaxone- and Azithromycin-Resistant Shigella sonnei Cluster among Men Who Have Sex with Men, Montréal, Canada 2017-2019.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
mcr-1-Mediated Colistin Resistance and Genomic Characterization of Antimicrobial Resistance in ESBL-Producing Salmonella Infantis Strains from a Broiler Meat Production Chain in Italy.
The study identified mcr-1.1 and mcr-1.2 variants on IncX4 plasmids in colistin-resistant Salmonella Infantis strains, along with other resistance genes such as blaCTX-M-1, aac(6')-Iaa, tet(A), dfrA1, sul1, and qacE.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Molecular characterisation of Acinetobacter baumannii isolates from bloodstream infections in a tertiary-level hospital in South Africa.
The study identified colistin-resistant Acinetobacter baumannii isolates with resistance genes including bla OXA-23, bla NDM-1, lps B, and various efflux pumps. These isolates exhibited extensive drug resistance (XDR) and were associated with sequence types ST1 and ST2.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Urban rats as carriers of invasive Salmonella Typhimurium sequence type 313, Kisangani, Democratic Republic of Congo.
The study identified multidrug-resistant Salmonella Typhimurium ST313 in urban rats in Kisangani, Democratic Republic of Congo, highlighting their potential role as reservoirs of invasive Salmonella. The resistant isolates carried genes such as blaTEM-1, strA, strB, ant(3')-Ia, aac(3')-IId, sul1, sul2, dfrA1, tetB, and catA10, conferring resistance to multiple antibiotics.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Phylotypic Profiling, Distribution of Pathogenicity Island Markers, and Antimicrobial Susceptibility of Escherichia coli Isolated from Retail Chicken Meat and Humans.
The study identified several antimicrobial resistance genes, including sul2, blaTEM, qnrA, dfrA1, and aphA1, in Escherichia coli isolates from retail chicken meat and human urinary tract infections. These genes conferred resistance to various antibiotics such as penicillin, sulfonamides, quinolones, and aminoglycosides.
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Epidemiology, Mechanisms of Resistance and Treatment Algorithm for Infections Due to Carbapenem-Resistant Gram-Negative Bacteria: An Expert Panel Opinion.
The paper discusses the mechanisms of resistance in carbapenem-resistant Gram-negative bacteria, highlighting the role of various beta-lactamases such as blaOXA-51, blaOXA-23, blaOXA-24, blaOXA-48, blaKPC, blaNDM, blaVIM, and blaIMP, as well as aminoglycoside modifying enzymes like aac(6')-Ib and aadA, and quinolone resistance genes such as qnrS1.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
Hospital Acquired Pathogenic Escherichia coli from Clinical and Hospital Water Samples of Quetta Balochistan.
The study identified ESBL blaCTX-M-15, tetracycline resistance gene tetA, and TMP-SMX resistance gene dfrA1 in E. coli isolates from clinical and hospital water samples, highlighting the presence of multidrug-resistant strains.
Occurrence of virulence factors and carbapenemase genes in Salmonella enterica serovar Enteritidis isolated from chicken meat and egg samples in Iraq.
The study identified carbapenemase genes blaIMP, blaOXA-48-like, and blaNDM, along with tetracycline resistance genes tetA and tetB, and trimethoprim-sulfamethoxazole resistance genes dfrA1 and sul1 in Salmonella enterica serovar Enteritidis isolates from chicken meat and eggs in Iraq.
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Molecular Characterization of Salmonella spp. Isolates from Wild Colombian Babilla (Caiman crocodilus fuscus) Isolated In Situ.
The study identified multiple antibiotic resistance genes in Salmonella isolates from wild Colombian babilla, including blaTEM, strB, sul1, blaCMY2, blaCTX-M, sul2, dfrA1, floR, and qnrD, indicating the potential of these reptiles as carriers of multidrug-resistant bacteria.
In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.
The study identifies several AMR genes in E. coli strains, including aadA, strA/strB, aphA1, aphA2, tetA, tetB, sul1, sul2, sul3, dfrA1, dfrA10, dfrA12, floR, and blaSHV, which confer resistance to various antibiotics such as streptomycin, neomycin, tetracycline, sulfonamides, trimethoprim, chloramphenicol, and cephalosporins.
A Cross-Validated Feature Selection (CVFS) approach for extracting the most parsimonious feature sets and discovering potential antimicrobial resistance (AMR) biomarkers.
The study presents a Cross-Validated Feature Selection (CVFS) approach for identifying the most parsimonious gene sets for predicting antimicrobial resistance (AMR) from bacterial pan-genomes. The CVFS approach was able to extract both known and novel AMR genes, demonstrating its effectiveness in selecting relevant features for AMR prediction.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Phylogenetic analysis and antibiotic resistance of Escherichia coli isolated from wild and domestic animals at an agricultural land interface area of Salaphra wildlife sanctuary, Thailand.
The study identified several AMR genes in E. coli isolates from wild and domestic animals in Thailand, including blaTEM, blaSHV, blaCMY-2, aac(3)-IV, aadA, tetA, tetB, qnrA, sul3, dfrA1, dfrA5, and dfrA7, which conferred resistance to various antibiotics such as ampicillin, gentamicin, tetracycline, ciprofloxacin, and trimethoprim-sulfamethoxazole.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
The fate of sulfonamide resistance genes and anthropogenic pollution marker intI1 after discharge of wastewater into a pristine river stream.
The study identifies and characterizes several sulfonamide resistance genes (sul1, sul2), the integrase gene intI1, and various other antibiotic resistance genes (ARGs) such as aadA2, aadA11, blaOXA-2, blaOXA-4, blaOXA-10, blaOXA-33, blaOXA-36, blaOXA-129, blaOXA-392, blaOXA-824, blaBEL-1, blaGES-11, ereA2, cmlA5, dfrA1, and qacL. These genes were found in the class 1 integron gene cassettes in the Holtemme river, highlighting the persistence of ARGs downstream from wastewater treatment plant discharge.
In silico analyses of diversity and dissemination of antimicrobial resistance genes and mobile genetics elements, for plasmids of enteric pathogens.
The study identifies a diverse array of antimicrobial resistance (AMR) genes across various plasmid replicon types in enteric pathogens, highlighting the prevalence of resistance genes in plasmids such as IncHI2, IncN, IncA/C, IncP, IncHI1, and IncFIA. Key AMR genes include aac(3)-IId, aac(3)-IIg, aac(6')-Ib3, aadA1, aadA5, aph(3'')-Ib, bla CMY-2, bla CTX-M-27, bla NDM-1, mcr-9.1, and others, which confer resistance to antibiotics such as gentamicin, cephalosporins, carbapenems, colistin, and tetracycline.
Metagenomic Insight into Microbiome and Antibiotic Resistance Genes of High Clinical Concern in Urban and Rural Hospital Wastewater of Northern India Origin: a Major Reservoir of Antimicrobial Resistance.
The study identified several clinically relevant antibiotic resistance genes (ARGs) in hospital wastewater samples from northern India, including bla NDM-1, mcr-5.1, aac(6')-Ib, aph(3')-I, erm, and sul1. These genes were found to confer resistance to various antibiotics such as carbapenems, colistin, aminoglycosides, macrolides, lincosamides, streptogramin B, and sulfonamides.
Aeromonas hydrophila ST251 and Aeromonas dhakensis are major emerging pathogens of striped catfish in Vietnam.
The study identifies antibiotic resistance genes such as sul1, dfrA1, tetA, qnrS2, aac(6')-Ib4, arr-2, blaAQU, blaOXA-726, cphA3, and cepH in Aeromonas dhakensis and Aeromonas hydrophila isolates from striped catfish in Vietnam, highlighting the emergence of multidrug-resistant strains.
Emergence of colistin resistance and characterization of antimicrobial resistance and virulence factors of Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia cage culture.
The study identified several AMR genes in Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia. Notably, mcr-3 was found in A. hydrophila, and qnrS, tetA, blaTEM, and floR were prevalent in Salmonella spp. No colistin resistance genes were detected in V. cholerae.
Epidemiological characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic analysis of Aeromonas caviae isolated from extra-intestinal infections.
The study identified multiple antimicrobial resistance genes in Aeromonas caviae isolates from extra-intestinal infections, including blaMOX, blaPER-3, blaOXA, blaNDM, blaCphA, qnrS2, qnrVC, aac(6')-Ib-cr, tet(A), tet(E), tet(31), dfrA1, dfrA12, dfrA14, dfrA15b, floR, catB3, catII, and catI, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, tetracyclines, trimethoprim, and chloramphenicol.
Serotype Occurrence, Virulence Profiles, Antimicrobial Resistance and Molecular Characterization of Salmonella Isolated from Hospitalized Patients with Gastroenteritis in Great Tunisia between 2010 and 2020.
The study identified qnrB and dfrA1 genes as contributors to fluoroquinolone and trimethoprim-sulfamethoxazole resistance in Salmonella isolates from Tunisia.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Mobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production line.
The study identifies multiple antimicrobial resistance genes in Salmonella isolates from a poultry production line, highlighting the role of mobile genetic elements in the spread of multidrug resistance.
Genome profiling of uropathogenic E. coli from strictly defined community-acquired UTI in paediatric patients: a multicentric study.
The study identified multiple AMR genes in E. coli isolates from pediatric UTI cases, including bla CTX-M-15, bla NDM-5, bla OXA-1, and others, highlighting the presence of high-risk clones like ST131 and ST167.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Antibiotic-Resistant Vibrio cholerae O1 and Its SXT Elements Associated with Two Cholera Epidemics in Kenya in 2007 to 2010 and 2015 to 2016.
The study identified antibiotic resistance genes dfrA1, sul2, strA, strB, and floR in Vibrio cholerae O1 strains from two cholera epidemics in Kenya. Chromosomal mutations in gyrA (Ser83Ile) and parC (Ser85Leu) were associated with nalidixic acid resistance.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Molecular epidemiology of enterically colonizing Escherichia coli with resistance against third-generation cephalosporins isolated from stool samples of European soldiers with concomitant diarrhea on deployment in Western African Mali.
The study identified bla CTX-M-15 and bla TEM-1b as the primary genes responsible for third-generation cephalosporin resistance in E. coli isolates from European soldiers in Mali. Additionally, several quinolone resistance genes including qnrS1, gyrA S83L, gyrA D87N, parE S458T, parE S458A, and parC S80I were found. Trimethoprim-sulfamethoxazole resistance was mediated by sul1, sul2, dfrA1, dfrA5, dfrA14, and dfrA17. Gentamicin resistance was associated with aph6-Id, aph3-Ib, aac3-IId, aadA5, and aac6-Ib-cr5. Tetracycline resistance was conferred by tetA, tetB, and tetD.
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
The study identified multidrug-resistant non-typhoidal Salmonella in migratory birds in Bangladesh, highlighting the presence of various AMR genes such as blaCARB-2, floR, sul1, tet(G), dfrA1, and mutations in gyrA and parC associated with quinolone resistance.
Genomic epidemiology of nosocomial carbapenemase-producing Citrobacter freundii in sewerage systems in the Helsinki metropolitan area, Finland.
The study identified bla KPC-2 and bla VIM-1 carbapenemase genes, along with various other AMR genes such as aac(6′)-If, aph(6)-Id, aac(3)-IIa, aadA1, dfrA1, sul2, sat2, qnrB, cmlA5, bla OXA-9, bla CMY-79, bla CMY-116, bla TEM-1A, bla CMY-117, bla OXA-10, bla CFE, bla CMY-100, aac(6′)-Ib, aadA2, sul1, qnrS1, qnrB9, mph(E), msr(E), aac(6′)-Iic, and dfrA16 in carbapenemase-producing Citrobacter freundii isolates from hospital environments and municipal wastewater in Finland.
Escherichia ruysiae May Serve as a Reservoir of Antibiotic Resistance Genes across Multiple Settings and Regions.
Prevalence and antimicrobial resistance profiles of Vibrio spp. and Enterococcus spp. in retail shrimp in Northern California.
The study identified 27 unique antimicrobial resistance genes (ARGs) in Vibrio isolates, including qnrVC6, dfrA31, dfrA6, and qnrVC1, which conferred resistance to various antibiotics such as cephalosporins, chloramphenicol, gentamicin, and tetracycline.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Case of Extensively Drug-Resistant Shigella sonnei Infection, United States
The study reports a case of extensively drug-resistant Shigella sonnei infection in an immunocompromised patient, highlighting the challenge of identifying XDR strains using traditional microbiological methods and emphasizing the need for whole-genome sequencing for accurate diagnosis. The isolate exhibited resistance to all first-line antimicrobials, including ciprofloxacin, azithromycin, and ceftriaxone, and carried several AMR genes such as blaCTX-M-27, qnrB19, mph(A), sul1, sul2, dfrA1, dfrA17, and tet(A).
Occurrence of ESBL- and AmpC-Producing E. coli in French Griffon Vultures Feeding on Extensive Livestock Carcasses.
The study identified ESBL-producing E. coli carrying the bla CTX-M-15 gene in French griffon vultures, highlighting the spread of multidrug-resistant bacteria through scavenging behavior.
Genomic Characterization of Fecal Escherichia coli Isolates with Reduced Susceptibility to Beta-Lactam Antimicrobials from Wild Hogs and Coyotes.
The study identified beta-lactamase genes (blaCMY-2, blaCTX-M-55, blaCTX-M-27), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aac(3)-IId, aadA5, ant(3")-Ia, aph(3')-Ia, aph(3")-lb, aph(6)-ld), sulfonamide resistance genes (sul1, sul2, sul3), amphenicol resistance gene (floR), trimethoprim resistance genes (dfrA1, dfrA17), and MLS resistance genes (Inu(F), erm(B), mph(A)) in E. coli isolates from coyotes and wild hogs. Additionally, chromosomal mutations in ampC, gyrA, parC, and parE were found to confer resistance to beta-lactam and quinolone antibiotics.
Whole Genome Sequencing and Pan-Genomic Analysis of Multidrug-Resistant Vibrio cholerae VC01 Isolated from a Clinical Sample.
The study identified multiple AMR genes in the multidrug-resistant V. cholerae VC01 strain, including catB9, floR, tet(34), sul2, and dfrA1, which confer resistance to chloramphenicol, florfenicol, oxytetracycline, sulfonamide, and trimethoprim, respectively.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment.
This review discusses the molecular basis of challenges to effective treatment of UPEC-associated urinary tract infections, focusing on virulence factors and antibiotic resistance mechanisms.
The scope of antimicrobial resistance in residential aged care facilities determined through analysis of Escherichia coli and the total wastewater resistome.
The study identified several AMR genes in E. coli isolates from residential aged care facilities, including blaCTX-M-15, blaCTX-M-27, blaCTX-M-62, blaOXA-1, blaOXA-181, blaTEM-1, qnrS, aac(6')-Ib-cr, sul1, sul2, and dfrA1, which confer resistance to various antibiotics such as cephalosporins, fluoroquinolones, and sulfonamides.
Pathognomonic features of Pasteurella multocida isolates among various avian species in Sharkia Governorate, Egypt.
The study identified several AMR genes in Pasteurella multocida isolates, including ermX (erythromycin resistance), blaROB-1 (beta-lactam resistance), mcr-1 (colistin resistance), sul1 (sulfonamide resistance), dfrA1 (trimethoprim resistance), and tetH (tetracycline resistance).
Genetic Characterization of Extensively Drug-Resistant Shigella sonnei Infections, Spain, 2021-2022.
The Molecular Characterization of bla(NDM-1)-Positive Acinetobacter baumannii Isolated in Central Greece.
The study identifies multiple AMR genes in blaNDM-1-positive Acinetobacter baumannii isolates, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, macrolide resistance genes, tetracycline resistance genes, trimethoprim resistance genes, and quaternary ammonium resistance genes.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Deciphering the Role of WWTPs in Cold Environments as Hotspots for the Dissemination of Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes (ARGs) in wastewater treatment plants (WWTPs) in cold environments, highlighting their role as hotspots for the dissemination of ARGs. Key genes included aadA, aadB, ampC, blaSHV, blaTEM, dfrA1, ermB, fosA, qnrS, and tetA(A).
Genomic analysis of Shigella isolates from Lebanon reveals marked genetic diversity and antimicrobial resistance.
The study identified multiple antimicrobial resistance genes and mutations in Shigella isolates from Lebanon, including bla CTX-M-15 and bla CTX-M-3 for extended-spectrum beta-lactamase resistance, and gyrA mutations for quinolone resistance.
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Serovars, Virulence and Antimicrobial Resistance Genes of Non-Typhoidal Salmonella Strains from Dairy Systems in Mexico.
Genomic Insights into the Adaptation and Antibiotic Resistance Mechanisms of Williamsia chitiniclastica
The study identifies several AMR genes in Wohlfahrtiimonas chitiniclastica, including macA, macB, tehB, tet(H), tet(B), ant(2″)-Ia, aac(6′)-Ib, ant(3″)-Ib, bla VEB-1, bla OXA-1, aph(3′)-Ib, sul2, strA, and dfrA1, which confer resistance to various antibiotics such as macrolides, tetracycline, aminoglycosides, beta-lactams, sulfonamides, and trimethoprim.
Low temperatures do not impair the bacterial plasmid conjugation on poultry meat.
The study demonstrates that non-pathogenic E. coli can acquire an IncB/O-plasmid carrying multiple antimicrobial resistance genes through conjugation on poultry meat, even at low temperatures. This highlights the potential risk of antimicrobial resistance spread through food products.
Mechanism for transmission and pathogenesis of carbapenem-resistant Enterobacterales harboring the carbapenemase IMP and clinical countermeasures.
The study identifies blaIMP-4 and blaIMP-26 as carbapenemase genes responsible for carbapenem resistance in Enterobacterales. Additionally, various other AMR genes such as aac(6')-lb3, armAC, aph(3'')-lb, aph(6)-ld, aadA5, aac(6')-llc, aac(3)-IId, dfrA19, dfrA1, sul1, tet(D), tet(A), qnrS1, qnrB4, msr(E), mph(E), ere(A), mph(A), mcr-9, and ARR-3 were characterized for their roles in resistance to different antibiotics.
Emergence of multidrug resistant, ctx negative seventh pandemic Vibrio cholerae O1 El Tor sequence type (ST) 69 in coastal water of Kerala, India.
The study identifies multidrug-resistant Vibrio cholerae O1 El Tor sequence type 69 in coastal waters of Kerala, India, which lacks the ctx gene but contains several antimicrobial resistance genes including sul2, dfrA1, strA, strB, parC, parE, catB9, and floR.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Inter-plasmid transfer of antibiotic resistance genes accelerates antibiotic resistance in bacterial pathogens.
The study identifies numerous antibiotic resistance genes (ARGs) that are transferred between plasmids, particularly beta-lactamases (bla TEM-1, bla NDM-4, bla KPC-2, bla SHV-1), aminoglycoside resistance gene aacC1, and colistin resistance gene mcr-1. These genes are shown to transfer between compatible plasmids in clinical pathogens, accelerating the spread of antibiotic resistance.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Prevalence and molecular characterization of multi-resistant Escherichia coli isolates from clinical bovine mastitis in China.
The study identified multiple AMR genes and mutations in E. coli isolates from bovine mastitis, including blaTEM, blaCTX, dfrA1, dfrA1-aadA1, dfrA1-catB2-aadA1, dfrA17-aadA5, aadA1, aadA5, catB2, catB3, and mutations in gyrA, parC, gyrB, and parE associated with fluoroquinolone resistance.
Prevalence and molecular characterization of multi-resistant Escherichia coli isolates from clinical bovine mastitis in China.
The study identified multiple AMR genes and mutations in E. coli isolates from bovine mastitis, including blaTEM, blaCTX, dfrA1, dfrA1-aadA1, dfrA1-catB2-aadA1, dfrA17-aadA5, aadA1, aadA5, catB2, catB3, and mutations in gyrA, parC, gyrB, and parE associated with fluoroquinolone resistance.
Emergence of carbapenem resistant gram-negative pathogens with high rate of colistin resistance in Egypt: A cross sectional study to assess resistance trends during the COVID-19 pandemic.
The study identified high prevalence of carbapenem resistance in Gram-negative pathogens in Egypt, with bla NDM and bla OXA-48-like being the most prevalent carbapenemase genes. Plasmid-mediated quinolone resistance genes qnrS and qnrB were also detected. Additionally, several aminoglycoside resistance genes and integron-associated gene cassettes were characterized.
Horizontal transfer characterization of ColV plasmids in bla(CTX-M)-bearing avian Escherichia coli.
The study characterizes the horizontal transfer of ColV plasmids in bla(CTX-M)-bearing avian E. coli, identifying multiple resistance genes and virulence factors associated with these plasmids.
A review of the mechanisms that confer antibiotic resistance in pathotypes of E. coli.
The review discusses the mechanisms of antibiotic resistance in pathotypes of E. coli, focusing on the role of beta-lactamases, carbapenemases, and other resistance genes. It highlights the importance of understanding these mechanisms to combat the growing problem of antibiotic resistance.
Novel Providencia xianensis sp. nov.: A multidrug-resistant species identified in clinical infections.
The study identifies a novel multidrug-resistant species, Providencia xianensis, which shows resistance to several antibiotics including tetracycline, trimethoprim/sulfamethoxazole, lincosamide, rifamycin, and beta-lactams.
Design and Validation of Primer Sets for the Detection and Quantification of Antibiotic Resistance Genes in Environmental Samples by Quantitative PCR.
The study presents eleven novel primer sets for the detection and quantification of antibiotic resistance genes (ARGs) in environmental samples using qPCR. These primers target genes such as aadA, aadB, ampC, blaTEM, blaSHV, dfrA1, ermB, fosA, mecA, qnrS, and tetA(A), which are responsible for resistance to various antibiotics including aminoglycosides, beta-lactams, trimethoprim, macrolides, fosfomycin, quinolones, and tetracyclines.
Occurrence, molecular characterization, and antimicrobial susceptibility of sorbitol non-fermenting Escherichia coli in lake water, fish and humans in central Oromia, Ethiopia.
The study identified multiple antimicrobial resistance genes in sorbitol non-fermenting E. coli strains, including blaTEM-1B, tet(A), dfrA1, dfrA5, sul1, fos7, catA1, qnrS1, gyrA, and blaCTX-M15, which conferred resistance to various antibiotics such as ampicillin, tetracycline, trimethoprim, sulfamethoxazole, fosfomycin, chloramphenicol, ciprofloxacin, nalidixic acid, and extended-spectrum beta-lactams.
Occurrence and genomic characterization of antimicrobial-resistant and potential pathogenic Escherichia coli from Italian artisanal food productions of animal origin.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from Italian artisanal food products, including beta-lactamases, aminoglycoside-modifying enzymes, trimethoprim resistance genes, macrolide resistance genes, quinolone resistance proteins, sulfonamide resistance proteins, and tetracycline resistance genes. These genes were primarily carried on plasmids and contributed to multidrug resistance.
Genetics of resistance to trimethoprim in cotrimoxazole resistant uropathogenic Escherichia coli: integrons, transposons, and single gene cassettes.
The study identifies various dfrA gene cassettes, including dfrA1, dfrA5, dfrA7, dfrA8, and dfrA14, as the primary genetic determinants of trimethoprim resistance in cotrimoxazole-resistant uropathogenic E. coli strains. These genes are found in class 1 and 2 integrons, as well as in transposons.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
Metagenome-wide characterization of shared antimicrobial resistance genes in sympatric people and lemurs in rural Madagascar.
The study identified five tetracycline resistance genes (tet(32), tet(40), tet(W), tet(Q)) and one trimethoprim resistance gene (dfrF) that were significantly more abundant in human microbiomes compared to lemur microbiomes. These genes were found to be highly conserved between human and lemur microbiomes.
Genomic Evaluation of Multidrug-Resistant Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli from Irrigation Water and Fresh Produce in South Africa: A Cross-Sectional Analysis.
The study identified several AMR genes in multidrug-resistant ESBL-producing E. coli isolates from irrigation water and fresh produce in South Africa, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, aph(6)-Id, ant(3″)-Ia, aadA2, aph(3″)-Ib, sul2, sul3, dfrA1, fosA3, cmlA1, and floR.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
Antibiotic Resistance Genes and Plasmid Characteristics in Enterobacteriaceae Isolated from Fresh Produce
The study identified several antibiotic resistance genes on plasmids and chromosomes of Enterobacteriaceae strains isolated from fresh produce, highlighting the diversity of resistance mechanisms and the potential for horizontal gene transfer.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
A single amplified genome catalog reveals the dynamics of mobilome and resistome in the human microbiome.
The study identifies numerous AMR genes in oral and fecal SAGs, highlighting the presence of resistance mechanisms such as efflux pumps, quinolone resistance proteins, dihydrofolate reductases, erythromycin ribosome methyltransferases, and aminoglycoside phosphotransferases.
Analyzing Antibiotic Resistance in Bacteria from Wastewater in Pakistan Using Whole-Genome Sequencing.
The study identifies several AMR genes and mutations in wastewater isolates from Pakistan, highlighting the presence of carbapenemases like blaNDM-5 and blaOXA-1, as well as quinolone resistance determinants such as gyrA and parC mutations. These findings emphasize the role of wastewater as a reservoir for clinically relevant AMR genes.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Analysis of Acinetobacter P-type type IV secretion system-encoding plasmid diversity uncovers extensive secretion system conservation and diverse antibiotic resistance determinants.
This study identified 17 distinct antibiotic resistance genes across 53 P-type T4SS-encoding plasmids in Acinetobacter species, including various beta-lactamases, aminoglycoside modifying enzymes, and others, highlighting the significant diversity of resistance determinants carried by these plasmids.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Increased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
The study identifies a clonal expansion of multidrug-resistant Shigella sonnei (genotype 3.6.1.1.2) with resistance to multiple antibiotics, including ampicillin, trimethoprim-sulfamethoxazole, ciprofloxacin, and azithromycin.
Resistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
The study identified multiple AMR genes and mutations in multidrug-resistant Shigella strains, including beta-lactamases, macrolide resistance genes, quinolone resistance genes, and chromosomal mutations contributing to fluoroquinolone resistance.
Investigation of integron gene cassettes in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.
The study identified dfrA12 and aadA2 genes in class I integrons, and dfrA1 and sat2 genes in class II integrons in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.
Characterizing Methicillin-Resistant Staphylococcus spp. and Extended-Spectrum Cephalosporin-Resistant Escherichia coli in Cattle.
The study identified several AMR genes in E. coli and MRSA isolates from cattle in Austria, including bla CTX-M-1/15, bla CTX-M-9, bla TEM, tet (A), tet (B), dfrA1, dfrA5, dfrA14, dfrA17, sul2, sul3, aadA1, aadA2, floR, cmlA, aphA, and bla ACT. Additionally, the MRSA isolate carried the mecA gene, indicating methicillin resistance.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Genomic insights into the dynamic antibiotic resistance landscape of Vibrio cholerae during the Cholera outbreak 2022 in Odisha, India.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Whole-genome sequencing-based characterization of Salmonella enterica Serovar Enteritidis and Kentucky isolated from laying hens in northwest of Iran, 2022-2023.
The study identified the presence of a multidrug-resistant (MDR) Salmonella enterica serovar Kentucky ST198 clone with high-level ciprofloxacin resistance due to double mutations in gyrA (S83F, D87N) and parC (T57S, S80I) genes. The aminoglycoside resistance gene aac(6′)-Iaa was the most frequently detected gene, but it did not confer resistance to aminoglycosides. Other resistance genes included tetA, floR, sul1, dfrA1, and aph(3′)-Ia.
The rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
The study identifies several AMR genes and mutations in Shigella clones associated with men who have sex with men (MSM) in Taiwan, highlighting the emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) strains.
Genomic insights into plasmid mediated AMR genes, virulence factors and mobile genetic elements in raw milk Escherichia coli from Gujarat, India.
The study identified multiple antibiotic resistance genes in E. coli isolates from raw milk in Gujarat, India, including beta-lactamases, quinolone resistance genes, efflux pumps, folate pathway antagonists, aminoglycoside resistance genes, and tetracycline resistance genes.
Exogenous plasmid capture to characterize tetracycline-resistance plasmids in sprouts obtained from retail in Germany.
The study identified tetracycline resistance genes tet(A) and tet(D), along with quinolone, sulfonamide, and trimethoprim resistance genes qnrS1, sul1, and dfrA1 in plasmids from sprout samples.
Molecular epidemiology of Salmonella Enteritidis in humans and animals in Spain.
The study identified various AMR genes and mutations in Salmonella Enteritidis isolates from Spain, including beta-lactamases, quinolone resistance genes, tetracycline resistance genes, and aminoglycoside resistance genes. Chromosomal mutations in the gyrA gene were also found to contribute to quinolone resistance.
Molecular epidemiology of a multidrug-resistant Shigella sonnei outbreak in Tunisia (2022-2023) using whole-genome sequencing.
The study identifies multiple AMR genes and mutations in a multidrug-resistant Shigella sonnei outbreak in Tunisia, including blaCTX-M-15, dfrA1, qnrS1, sul2, tet(A), mph(A), and blaTEM-35, along with the D87Y mutation in gyrA.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
Whole-genome-based characterization of Escherichia albertii strains isolated from paediatric diarrhoeal cases in Kolkata, India.
The study identified several antimicrobial resistance genes in Escherichia albertii isolates, including beta-lactamases (bla CTX-M-55, bla TEM-105), quinolone resistance genes (qnrS1, qnrB32), sulfonamide resistance gene (sul2), tetracycline resistance genes (tetA, tetR), and trimethoprim resistance gene (dfrA1).
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
First report of multidrug-resistant and pathogenic Plesiomonas shigelloides from endangered crested ibis (Nipponia nippon).
The study reports the first isolation of multidrug-resistant and pathogenic Plesiomonas shigelloides from the endangered crested ibis, highlighting the presence of resistance genes such as blaTEM, aac(6')-Ib3, aac(6')-Ib-cr, mph(A), arr-2, tet(A), qacEΔ1, dfrA1, and sulI.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
Multidrug-resistant Shigella flexneri outbreak affecting humans and non-human primates in New Mexico, USA.
The study identifies multidrug-resistant Shigella flexneri serotype 2a strains in both human and non-human primate populations in New Mexico, USA, carrying resistance genes such as blaOXA-1, blaTEM-1, sul2, dfrA1, and dfrA5, along with fluoroquinolone resistance-conferring mutations in parC and gyrA.
Transmissible antimicrobial resistance in Escherichia coli isolated from household drinking water in Ibadan, Nigeria.
The study identified several AMR genes in E. coli isolates from household water in Ibadan, Nigeria, including blaTEM-1B, dfrA14, tetA, qnrS1, and mcr-1, highlighting the potential for horizontal gene transfer and the risk of AMR spread in the environment.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Trimethoprim resistance in Escherichia coli exhibits an allele-specific growth advantage.
The study identifies that specific dfrA alleles, such as dfrA1, dfrA5, dfrA7, dfrA14, and dfrA17, confer trimethoprim resistance in E. coli. The growth behavior of isolates carrying these alleles varies, with some showing a faster growth phenotype in the presence of trimethoprim.
Retrospective analysis of antimicrobial resistance of Salmonella spp. isolated from livestock and its environment in Thailand.
The study identified several AMR genes in Salmonella isolates from livestock and their environment in Thailand, including aadA1, aadA2, aadB, aac(6')-Ia, blaTEM, tetA, tetB, catA, catB, cmlA, sulI, and dfrA1, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, chloramphenicol, sulfamethoxazole, and trimethoprim.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Analyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications.
The study identified multiple AMR genes and mutations in Shigella flexneri isolates from Wuhan, including blaCTX-M, blaOXA, blaTEM, dfrA1, sul2, tetB, aadA1, and qnrS, along with specific mutations in gyrA, parC, and parE that confer resistance to various antibiotics.
Genomic characterization of multidrug-resistant clinical Acinetobacter baumannii isolates from a hospital in Paraguay.
The study identified multiple AMR genes in multidrug-resistant Acinetobacter baumannii isolates from Paraguay, including blaOXA-23, blaOXA-66, blaOXA-65, blaADC-73, blaADC-5, blaTEM-1, and various aminoglycoside, macrolide, sulfonamide, chloramphenicol, tetracycline, and trimethoprim resistance genes.
Outbreak Caused by VIM-1- and VIM-4-Positive Proteus mirabilis in a Hospital in Zagreb.
The study reports an outbreak of carbapenem-resistant Proteus mirabilis in a psychiatric hospital in Zagreb, Croatia, characterized by the presence of VIM-1 and VIM-4 carbapenemases, along with other resistance genes such as bla CTX-M-15, bla TEM, and aminoglycoside resistance genes.
Navigating an evolving microbial landscape: emerging antimicrobial resistance trends and precision stewardship in Tianjin tertiary hospitals (2021-2023).
The study identified significant trends in antimicrobial resistance (AMR) patterns among clinical isolates from hospitals in Tianjin, highlighting the increasing resistance of Klebsiella pneumoniae to various antibiotics, including carbapenems, and the notable decline in ceftazidime/avibactam resistance in E. coli. Additionally, it noted the emergence of resistance in Acinetobacter baumannii and Pseudomonas aeruginosa to several antimicrobials.
Insights into the Metabolic Adaptations of a Carbapenem-Resistant Klebsiella pneumoniae Strain on Exposure to Sublethal Concentrations of Ertapenem.
The study identified VIM-1, AAC(6')-Ib, APH(3')-Ia, ANT(3'')-Ia, Sul1, and DfrA1 as genes with significant differential abundance in a carbapenem-resistant K. pneumoniae strain exposed to sublethal concentrations of ertapenem, indicating their roles in antibiotic resistance.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Azithromycin resistance in nontyphoidal Salmonella in an urban informal settlement in Nairobi, Kenya.
The study identified several AMR genes in nontyphoidal Salmonella isolates, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, ant(3")-Ia, sul1, sul2, dfrA1, dfrA8, tetA, mph(A), bla CTX-M-3, bla TEM-135, bla TEM-1B, and bla TEM-1C. These genes conferred resistance to various antibiotics such as aminoglycosides, sulfonamides, tetracycline, macrolides, and beta-lactams.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
The study identifies several AMR genes and mutations in the novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate BB-7, including bla CTX-M-15, bla SHV-28, bla TEM-1, bla OXA-1, bla OXA-232, armA, aadA2, baeR, tetD, adeF, emrR, AAC(6')-Ib-cr6, catI, sul1, mphE, msrE, dfrA1, oqxA, and fosA, as well as mutations in GyrA, ParC, OmpA, OmpK37, and ArnT that confer resistance to multiple antibiotics.
An integrated phenotypic and genomic approach to characterize MBL-producing Enterobacterales strains circulating in a Sicilian transplant center.
The study characterizes MBL-producing Enterobacterales strains, identifying NDM-1, NDM-5, and VIM-1 as the most prevalent metallo-beta-lactamases. It also identifies various aminoglycoside, quinolone, and sulfonamide resistance genes, highlighting the multidrug-resistant nature of these isolates.
Global emergence of Acinetobacter baumannii International Clone 12 predominantly found in the Middle East.
The study identifies multiple acquired antimicrobial resistance genes in Acinetobacter baumannii International Clone 12, including bla OXA-23, bla GES-11, bla GES-12, bla GES-22, bla GES-35, bla CARB-16, bla CARB-49, aphA6a, aadB, strA, strB, cmlA1, aadA2b, sul1, drfA7, dfrA1, qacE, tet(B), tet(X3), msr(E), mph(E), bla TEM-1B, and aacC3. These genes contribute to resistance against various antibiotics, highlighting the complexity of resistance mechanisms in this clone.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Chitosan mitigates pan drug resistance in citrobacter freundii exhibiting AmpC and ESBL from Egyptian livestock.
The study identified multiple AMR genes in Citrobacter freundii isolates from Egyptian livestock, including bla TEM, bla CTX-M, bla OXA-10, bla CMY-2, qnrA, aadA1, sul2, dfrA1, ermB, tet(M), int1, and mcr-1, which confer resistance to various antibiotics.
Genomic diversity and antimicrobial resistance of Vibrio cholerae isolates from Africa: a PulseNet Africa initiative using nanopore sequencing to enhance genomic surveillance.
The study identified a high prevalence of trimethoprim resistance genes (dfrA1, dfrA15, dfrA31) and other resistance genes such as floR, strA, strB, varG, blaCARB-2, aadA1, aadA2, sul1, sul2, catB9, tet(C), tet(G), tet(59), qacEdelta, and blaCMY-4 in Vibrio cholerae isolates from Africa. Fluoroquinolone resistance mutations (gyrA_S83I and parC_S85L) and nitrofuran resistance mutations (nfsA_R169C and nfsB_Q5*) were also prevalent.
Genomic Characterization and Resistance Mechanisms of Carbapenem-Resistant Klebsiella pneumoniae ST101 Isolates from Saudi Arabia.
The study identifies bla_OXA-48 and bla_NDM-1 carbapenemase genes in CRKP ST101 isolates from Saudi Arabia, highlighting their role in carbapenem resistance and the complexity of resistance mechanisms in high-risk clones.
Antibiotic contamination and antimicrobial resistance dynamics in the urban sewage microbiome in India.
The study identifies multiple antibiotic resistance genes (ARGs) in urban sewage samples from India, highlighting the presence of genes such as blaTEM, catB, aac(6')-Ib, sul1, ermB, dfrA1, mphA, sul2, blaOXA, blaCTX-M, and qnrS, which confer resistance to various antibiotic classes.
Plasmid-Mediated Spread of Antibiotic Resistance by Arsenic and Microplastics During Vermicomposting.
Arsenic and microplastics significantly influenced the spread of antibiotic resistance genes (ARGs) during vermicomposting, with specific genes like bla ampC, bla LRA-1, bla FEZ-1, aph(3′)-II, ermB, vanY, mefA, catA, tetX4, bla IMP-11, aadK, ant(3′)-Ih-aac(6′)-Id, ermG, bla OXA-119, tetR, vatE, smeE, mexD, bla OXA-3, amrB, tetY, class A beta-lactamase, dfrA1, alanine adenosyltransferase JOHN-1, mdtB, mdtE, and erm-41 being enriched under various treatment conditions.
Unveiling Equine Abortion Pathogens: A One Health Perspective on Prevalence and Resistance in Northwest China.
The study identified multiple antibiotic resistance genes in equine abortion pathogens, including CTX-M, TEM-1, TetM, ermA/B/C, qnrA/B, sul1/2, dfrA1/5, SHV, OXA-1, OXA-23/48/58, mecA/B/C, IMP-1/2, NDM-1, VIM-1/2, and vanA/B/C, highlighting the widespread resistance to various antibiotics among these pathogens.
The nucleotide sequence of the trimethoprim-resistant dihydrofolate reductase gene harbored by Tn7.
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