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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim-resistant dihydrofolate reductase DfrA12
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| DfrA12 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 237 | TRIMETHOPRIM, Trimethoprim +2 |
| India|Mexico|Egypt|Morocco|Peru|Kenya|Senegal|Mali|South Africa|Vietnam|Nepal|Indonesia|Bolivia|Equatorial Guinea|Uganda|Cameroon|Guatemala|Philippines|Burkina-Faso, India, Poland, Singapore|Colombia|Guyana|Brazil|Manaos, Sweden, Mexico, Australia, Global, Europe, Nebraska|United States, South West London, UK, Nepal, Netherlands, China, Europe|Portugal, Nepal|Japan, San Francisco|Seattle|Minnesota|Minneapolis|Sacramento|Dallas|Jackson, Delhi, India, Kenya, USA|Australia|Canada|Japan|France|Madagascar|China|Thailand|Germany, Norway, Pakistan, United Kingdom, UK|Latin America, France, Iran, United States, South Korea, Ghana, Japan, Chile, Egypt|Africa|Europe|Asia|Middle East|Indonesia|India|USA, Ecuador, UK, Brazil, South Africa, Vietnam, Italy|Far East countries, Lake Victoria, Tanzania, Italy, Shanghai, China, Thailand, West Cameroon, Stockholm|Sweden, Australia|India|Germany|USA|France|Portugal|Sweden|Israel|China|Turkey|Norway|Netherlands|Spain, Jakarta, Dominican Republic, Portugal, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Greece, Europe|Poland|USA|China|France, California|Europe|North America|Republic of Congo, Canada, Cambodia, India|United States, Europe|Greece, Finland|Eastern Finland, Taiwan, England, North-Western Mexico, Bangladesh, Georgia, USA|Georgia, Northern Ireland, Australia|Melbourne, Australia, North America|Asia|Europe|Middle East|Africa, Hong Kong, Basque Country, northern Spain|Basque Country, Southern Europe, Abuja, Nigeria, Peru, Khon Kaen province, Thailand, Germany, Zhejiang, China|China, Portugal|Spain|Italy|Morocco, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Ontario, Canada, Europe|Asia|North America|Western and South-Eastern Asia, Belgium|The Netherlands|Europe, Comunitat Valenciana|Spain, Russia|Switzerland|Italy|USA|Norway|Spain|Ghana, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, Pakistan|Karachi, Pakistan, Mozambique, China|Germany|USA, Oman, Central Adriatic|Central Adriatic Sea, Argentina, Spain, Bangkok, Thailand, Thailand|Pig|Pork, Fiji, Ethiopia, Bulgaria|Europe, Portugal|various regions, Fujian Province, Southeast China|China, Romania, Turkey, Alexandria, Egypt, Europe|Africa|North America|South America|Asia|Oceania, Shanghai, China|China, Calabria|Italy, Iowa, United States, Nigeria, Shanghai|Minhang District, Western Balkans|Hungary, Atlanta, Shenzhen, China, Australia|France|Bangladesh|United States, New York State, Europe|China, Asia|China, United Arab Emirates |
| 2004, 2006, 2007, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 |
| AY551331.1 |
| AAT45231.1 |
| dfrA12 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Escherichia coli, Aeromonas hydrophila, Aeromonas caviae, Salmonella enterica subsp. enterica serovar Choleraesuis, Enterococcus faecalis, Acinetobacter baumannii +1 | - | 2010 | FJ763641, KJ546436, KJ568502, EU650399, FR875302, AY551331, AB196348, AM040708, DQ995286, FM877486 | ADG84870.1 |
| dfr A12 | Reslit | 3 | Trimethoprim | Escherichia coli | Vietnam, Southeast Nigeria, Italy | 2021, 2022 | NCBI BioProject: PRJNA670213|PRJEB37980 | - |
| dfrA 12 | Reslit | 1 | Trimethoprim | Klebsiella pneumoniae | Iran | 2025 | JARGDG000000000|JARGDG010000000 | - |
Detection of mutations in the gyrA gene and class I integron from quinolone-resistant Salmonella enterica serovar Choleraesuis isolates in Taiwan.
Detection of mutations in the gyrA gene and class I integron from quinolone-resistant Salmonella enterica serovar Choleraesuis isolates in Taiwan.
Mechanism of resistance to several antimicrobial agents in Salmonella Clinical isolates causing traveler's diarrhea.
The study identified several AMR genes and mutations in Salmonella isolates causing traveler's diarrhea, including blaTEM, blaOXA-1, tetA, tetB, tetG, dfrA1, dfrA12, dfrA14, dfrA17, floR, cmlA, and a mutation in the gyrA gene. These genes and mutations contribute to resistance against ampicillin, tetracycline, trimethoprim, chloramphenicol, and quinolones.
Mechanisms of resistance in multiple-antibiotic-resistant Escherichia coli strains of human, animal, and food origins.
Incidence of class 1 integrons in multiple antibiotic-resistant Gram-negative copiotrophic bacteria from the River Torsa in India
The study identified various gene cassettes within class 1 integrons in multiple antibiotic-resistant Gram-negative bacteria from the River Torsa in India, including dfrA1, dfrA5, dfrA7, dfrA12, dfrA17, aac(6')-Ib, aadA1, aadA6, and a novel ORF with homology to dfrA1.
DNA sequence analysis of the genetic environment of various blaCTX-M genes.
DNA sequence analysis of the genetic environment of various blaCTX-M genes.
DNA sequence analysis of the genetic environment of various blaCTX-M genes.
Analysis of integrons in clinical isolates of Escherichia coli in China during the last six years.
Analysis of integrons in clinical isolates of Escherichia coli in China during the last six years.
Complete nucleotide sequence of the pCTX-M3 plasmid and its involvement in spread of the extended-spectrum beta-lactamase gene blaCTX-M-3.
The study characterizes the pCTX-M3 plasmid, which carries the blaCTX-M-3 gene, a extended-spectrum beta-lactamase, along with other resistance genes such as blaTEM-1, aadA2, aacC2, armA, dfrA12, and sul1, contributing to resistance against beta-lactams, aminoglycosides, and sulfonamides.
Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china.
Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china.
Molecular characterization of tetracycline-resistant genes and integrons from avirulent strains of Escherichia coli isolated from catfish.
Molecular characterization of tetracycline-resistant genes and integrons from avirulent strains of Escherichia coli isolated from catfish.
New complex class 1 integron carrying an ISCR1 element in Escherichia coli clinical isolates harbouring the blaCMY-11 gene., Molecular characterization of tetracycline-resistant genes and integrons from avirulent strains of Escherichia coli isolated from catfish., Detection of mutations in the gyrA gene and class I integron from quinolone-resistant Salmonella enterica serovar Choleraesuis isolates in Taiwan., Unnoticed spread of class 1 integrons in gram-positive clinical strains isolated in Guangzhou, China., DNA sequence analysis of the genetic environment of various blaCTX-M genes., Four novel resistance integron gene-cassette occurrences in bacterial isolates from zhenjiang, china.
High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.
The study identified a high prevalence of multidrug-tolerant bacteria and various antimicrobial resistance genes in ornamental fish and their carriage water, highlighting the potential risk of resistance gene spread through the aquatic environment.
Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two year intervention on trimethoprim use.
The study identified various dfr genes, including dfrA1, dfrA17, dfrA5, dfrA7, dfrA8, dfrA12, dfrA14, dfrA24, and dfrA26, as major contributors to trimethoprim resistance in E. coli and K. pneumoniae. The distribution of these genes remained largely unchanged during the intervention period.
Salmonella Typhimurium ST213 is associated with two types of IncA/C plasmids carrying multiple resistance determinants.
The study identifies bla CMY-2, dfrA12, orfF, aadA2, floR, and mer as resistance genes carried by IncA/C plasmids in Salmonella Typhimurium ST213, contributing to multidrug resistance.
Analysis of the resistome of a multidrug-resistant NDM-1-producing Escherichia coli strain by high-throughput genome sequencing.
The study identified multiple AMR genes in a multidrug-resistant E. coli strain, including blaNDM-1, blaTEM-1, blaCTX-M-15, and others, along with chromosomal mutations in gyrA, parC, ompC, and ompF contributing to resistance.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Natural transformation facilitates transfer of transposons, integrons and gene cassettes between bacterial species.
The study demonstrates that natural transformation facilitates the transfer of transposons, integrons, and gene cassettes between bacterial species, leading to the acquisition of antibiotic resistance traits. Specific resistance genes such as aadB, blaIMP-5, blaOXA-30, dfrA12, aadA2, and aacA4 were identified and characterized.
DNA sequence analysis of plasmids from multidrug resistant Salmonella enterica serotype Heidelberg isolates.
The study identified multiple antimicrobial resistance genes in plasmids from multidrug-resistant Salmonella enterica serotype Heidelberg isolates, including bla CMY, aadA, aadB, aphA, strA, strB, sul1, sul2, tetA, floR, cmlA, dfrA1, dfrA12, and aacC.
Into the wild: dissemination of antibiotic resistance determinants via a species recovery program.
Class 1 integrons containing gene cassettes encoding resistance to streptomycin, spectinomycin, and trimethoprim were detected in captive brush-tailed rock wallabies, suggesting acquisition from human or domestic animal sources.
Diversity of plasmids encoding resistance and virulence functions in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains circulating in Europe.
The study identifies various AMR genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variant 4,[5],12:i:- strains, including aac(3)-IV, bla TEM-1, cmlA1, aadA1, aadA2, strA, sul1, sul2, sul3, tet(A), tet(B), and dfrA12, which confer resistance to multiple antibiotics.
Occurrence of Antimicrobial-Resistant Escherichia coli and Salmonella enterica in the Beef Cattle Production and Processing Continuum.
The study identified several AMR genes in E. coli and Salmonella, including beta-lactamase genes (blaCMY, blaCTX-M), sulfonamide resistance genes (sul1, sul2, sul3), and dihydrofolate reductase genes (dfrA1, dfrA5, dfrA7, dfrA12). These genes conferred resistance to various antibiotics such as ampicillin, ceftiofur, ceftriaxone, and trimethoprim-sulfamethoxazole.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Clinical epidemiology and molecular analysis of extended-spectrum-β-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types 131 and 648.
The study identified bla CTX-M-15, aac (3)-IIa, aadA1, aadA2, aadA5, qnrB4, qnrS1, aac (6')-Ib-cr, bla OXA-1, bla TEM-1B, bla SHV-12, bla CMY-42, bla DHA-1, mphA, ermB, catA1, catB3, sul1, sul2, dfrA12, dfrA17, dfrA1, dfrA5, tetA, tetB, and tetD as key AMR genes in ESBL-producing E. coli isolates in Nepal, highlighting the prevalence of multidrug resistance.
An outbreak of colistin-resistant Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae in the Netherlands (July to December 2013), with inter-institutional spread.
The study describes an outbreak of colistin-resistant KPC-producing K. pneumoniae ST258 in the Netherlands, highlighting the presence of multiple resistance genes including blaKPC-2, blaSHV-12, and various other AMR genes.
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Increase in the Prevalence of Resistance Determinants to Trimethoprim/Sulfamethoxazole in Clinical Stenotrophomonas maltophilia Isolates in China.
The study identified several resistance genes, including qacEΔ1-sul1, sul2, intI1, dfrA12, dfrA17, and dfrA27, which are associated with trimethoprim/sulfamethoxazole resistance in Stenotrophomonas maltophilia isolates in China.
Architecture of Class 1, 2, and 3 Integrons from Gram Negative Bacteria Recovered among Fruits and Vegetables.
The study identified several AMR genes in Gram-negative bacteria from fresh produce, including mcr-1, qnrA1, blaGES-11, mphA, and oqxAB, highlighting the presence of mobile genetic elements and clinically relevant resistance genes.
Comparative Genome Analysis of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Sequence Type 131 Strains from Nepal and Japan.
The study identified multiple AMR genes, including blaCTX-M-15, blaOXA-1, aac(6')-Ib-cr, tet(A), mphA, strA, strB, aadA5, sul1, sul2, dfrA12, dfrA17, catA1, and catB3, in ESBL-producing E. coli ST131 isolates from Nepal and Japan. These genes conferred resistance to various antibiotics, including β-lactams, aminoglycosides, tetracyclines, macrolides, sulfonamides, and chloramphenicol.
Genomic Analysis of Factors Associated with Low Prevalence of Antibiotic Resistance in Extraintestinal Pathogenic Escherichia coli Sequence Type 95 Strains.
The study identifies several AMR genes in ST95 E. coli strains, including blaTEM-1, blaCTX-M14, aadA1, aadA2, aadA5, aac3, strA, strB, tetA, tetB, tetD, sul1, sul2, dfrA5, dfrA12, dfrA17, mphA, and catA1, which confer resistance to various antibiotics such as ampicillin, cephalothin, streptomycin, tetracycline, sulfamethoxazole, trimethoprim, azithromycin, and chloramphenicol.
Distribution of Integrons and Phylogenetic Groups among Enteropathogenic Escherichia coli Isolates from Children <5 Years of Age in Delhi, India.
The study identified various AMR genes including dfrA1, dfrA7, dfrA12, aadA1, aadA2, sul1, tetA, aacC1, TEM, SHV, CTX-M, OXA, NDM-1, IMP, VIM, ACT, DHA, and CMY in E. coli isolates from children in Delhi, India. These genes were associated with resistance to multiple antibiotics such as trimethoprim, streptomycin, sulfonamides, tetracycline, gentamicin, and various beta-lactams.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Characterization of a blaNDM‑1‑harboring plasmid from a Salmonella enterica clinical isolate in China.
The study characterizes a blaNDM-1-harboring plasmid from a Salmonella enterica clinical isolate in China, identifying multiple resistance genes including blaNDM-1, blaCMY-6, dfrA12, aadA2, rmtC, qacEΔ1, sul1, and bleMBL.
Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.
The study characterized IncA/C2 plasmids carrying In809-like integrons from Enterobacteriaceae isolates of wildlife origin, identifying several AMR genes including blaIMP-4, blaIMP-26, blaIMP-38, sul2, floR, aac(3)-IId, qnrA1, arr-3, dfrA12, aphA1, aadA16, aadA2, blaOXA-1, blaTEM-1, and blaDHA-1.
Comparative Sequence Analysis of Multidrug-Resistant IncA/C Plasmids from Salmonella enterica.
The study identified multiple antimicrobial resistance genes on IncA/C plasmids from various Salmonella serovars, including bla_cmy-2, bla_tem-1, strA, strB, aadB, aph(3')-Ia, tetA, floR, cmlA, sul1, sul2, dfra12, quacE, sugE, merA, merB, merC, merD, and merE, which contribute to multidrug resistance.
Rapid Nanopore Sequencing of Plasmids and Resistance Gene Detection in Clinical Isolates.
The study demonstrates the feasibility of rapid nanopore sequencing for detecting plasmid-borne antimicrobial resistance (AMR) genes in clinical isolates. It identifies several AMR genes, including beta-lactamases, aminoglycoside-modifying enzymes, sulfonamide resistance genes, tetracycline resistance genes, macrolide resistance genes, and phenicol resistance genes, in both Escherichia coli and Klebsiella pneumoniae isolates.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
In vivo selection of a multidrug-resistant Aeromonas salmonicida during medicinal leech therapy.
The study identifies 13 antibiotic resistance genes in a multidrug-resistant Aeromonas salmonicida strain, including the ESBL CTX-M-3, TEM-1, and the unusual β-lactamase SCO-1, along with other resistance mechanisms such as aminoglycoside modification, sulfonamide resistance, tetracycline efflux, and chloramphenicol acetylation.
Porcine commensal Escherichia coli: a reservoir for class 1 integrons associated with IS26.
The study identified 17 antimicrobial resistance genes (ARGs) in 103 class 1 integron-positive Escherichia coli strains from porcine feces, highlighting the prevalence of multidrug-resistant commensal E. coli in pigs and their potential role in the dissemination of resistance genes.
High Prevalence of CTX-M-15-Type ESBL-Producing E. coli from Migratory Avian Species in Pakistan.
The study identified a high prevalence of CTX-M-15-type ESBL-producing E. coli in migratory avian species in Pakistan, highlighting the role of wild birds as reservoirs of multidrug-resistant bacteria and the potential for horizontal gene transfer of resistance determinants.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Polyphyletic Nature of Salmonella enterica Serotype Derby and Lineage-Specific Host-Association Revealed by Genome-Wide Analysis.
The study identified AMR genes aadA2, sul1, and tetA in Salmonella enterica serovar Derby strains, with a multidrug-resistant profile STR-SSS-TET in certain lineages.
Gene cassettes of class I integron-associated with antimicrobial resistance in isolates of Citrobacter spp. with multidrug resistance.
The study identified several gene cassettes associated with antimicrobial resistance in multidrug-resistant Citrobacter isolates, including aadA1, aadA2, dfrA1, dfrA12, dfrA15, dfrA1-aadA1, and dfrA12-orfF-aadA2.
A pan-genome-based machine learning approach for predicting antimicrobial resistance activities of the Escherichia coli strains.
The study identifies and characterizes several AMR genes in E. coli, including beta-lactamases (blaTEM-1, blaOXA-1, blaCMY-2, ampC), aminoglycoside modifying enzymes (aac(3')-Ia, aac(3')-VI), dihydrofolate reductases (dfrA1, dfrA5, dfrA12, dfrA15), quinolone resistance proteins (qnrB2, qnrB6, qnrS2), and others. These genes were validated through computational and wet lab methods, showing their roles in conferring resistance to various antibiotics.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms.
The study identified tetracycline resistance genes tet(A) and tet(B) as the most common in commensal E. coli isolates from cattle farms, along with gene cassettes such as aadA1, dfrA1, dfrA12, sul1, cat1, and floR associated with class 1 integrons.
Molecular characterisation of the NDM-1-encoding plasmid p2189-NDM in an Escherichia coli ST410 clinical isolate from Ghana.
The study identifies the NDM-1-producing E. coli strain EC2189 carrying the plasmid p2189-NDM, which contains multiple AMR genes including blaNDM-1, aadA1, aac(6')-Ib, sul3, dfrA12, cmlA1, blaCTX-M-15, blaTEM-1A, and blaOXA-9. The plasmid p2189-NDM exhibits a unique genetic structure and is phylogenetically distinct from previously identified blaNDM-1-positive plasmids.
Characterisation of antibiotic resistance of Salmonella isolated from dog treats in Japan.
The study identified the presence of antibiotic-resistant Salmonella in dog treats in Japan, including the blaTEM gene, aadA1, aadA2, tetB, floR, catA1, dfrA12, and intI1 genes, indicating multidrug resistance.
Occurrence of Transferable Integrons and sul and dfr Genes Among Sulfonamide-and/or Trimethoprim-Resistant Bacteria Isolated From Chilean Salmonid Farms.
The study identified the presence of sul1, sul2, dfrA12, and dfrA14 genes in sulfonamide- and/or trimethoprim-resistant bacteria from Chilean salmonid farms, highlighting their potential for horizontal gene transfer through plasmids and integrons.
Global phylogenomics of multidrug-resistant Salmonella enterica serotype Kentucky ST198.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serotype Kentucky ST198, including genes such as blaTEM-1, aacA4, aadA1, sul1, tetA, catA1, mph(A), blaCTX-M-1, blaOXA-48, blaNDM-1, blaCMY-2, and dfrA12, along with mutations in gyrA and parC that confer resistance to various antibiotics.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Nanopore metagenomics enables rapid clinical diagnosis of bacterial lower respiratory infection.
The study presents a nanopore metagenomics method for rapid detection of bacterial pathogens and antibiotic resistance genes in lower respiratory infections, achieving high sensitivity and specificity through host DNA depletion and real-time sequencing.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Molecular Epidemiology of Multidrug-Resistant Klebsiella pneumoniae Isolates in a Brazilian Tertiary Hospital.
The study identified various AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae isolates, including bla KPC, bla CTX-M, bla TEM, and mutations in ompk35, ompk36, gyrA, and parC. These findings highlight the complex resistance mechanisms contributing to the persistence of MDR-Kp in the hospital setting.
Tracking Carbapenem-Producing Klebsiella pneumoniae Outbreak in an Intensive Care Unit by Whole Genome Sequencing.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains carrying various resistance genes, including blaKPC-2, blaNDM-1, and others, contributing to multidrug resistance. Plasmid analysis revealed the presence of resistance genes on different plasmids, highlighting the complexity of resistance mechanisms.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Genetic characterization of a novel sequence type of multidrug-resistant Citrobacter freundii strain recovered from wastewater treatment plant.
The study reports the identification of a multidrug-resistant Citrobacter freundii strain R17 carrying 13 antibiotic-resistance genes, including blaCMY-85, aadA2, aac(3)-lld, blaDHA-1, blaTEM-1B, qnrB4, mph(A), catA2, sul1, sul2, tet(D), and dfrA12, which confer resistance to various antibiotic classes.
Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals.
The study identified blaNDM genes as the primary cause of carbapenem resistance in Escherichia coli isolates from humans, pigs, chickens, and flies in rural China, highlighting the transmission of these resistance genes between humans and backyard animals.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene.
The study identifies the chromosomally-encoded mcr-1 gene in a colistin-resistant E. coli ST695 strain, along with various other resistance genes such as bla NDM-1, aadA1, aadA2, aph(3')-Ia, aph(3')-VI, rmtB, cmlA1, floR, tet(A), tet(M), dfrA12, oqxA, oqxB, qnrS1, mph(A), bla TEM-105, and bla TEM-1B, contributing to its multidrug-resistant phenotype.
Complex Class 1 Integron in a Clinical Escherichia coli Strain From Vietnam Carrying Both mcr-1 and bla (NDM-1).
The study identifies a multidrug-resistant E. coli strain carrying both mcr-1 and bla NDM-1, highlighting the co-existence of colistin and carbapenem resistance genes in Vietnam.
First Report of Coexistence of Three Different MDR Plasmids, and That of Occurrence of IMP-Encoding Plasmid in Leclercia adecarboxylata.
The study reports the first identification of three different multidrug-resistant (MDR) plasmids in a single clinical isolate of Leclercia adecarboxylata, including the blaIMP-8 gene encoded on an IMP-encoding plasmid. These plasmids harbor various AMR genes such as blaIMP-8, aacC2, aadA2, mph(A), sul1, qacED1, mer, chrA, dfrA12, tmrB, catA1, catB8, tet(C), blaCTX-M-9, and blaTEM-1.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Genomic Characterization of New Variant of Hydrogen Sulfide (H(2)S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China †
The study reports the first detection of a hydrogen sulfide (H2S)-producing Escherichia coli variant isolated from a human in China, with multidrug resistance properties, including colistin resistance mediated by the mcr-1 gene, along with other resistance genes such as aadA1, aadA2, dfrA12, blaTEM-1B, oqxA, oqxB, floR, cmlA1, sul3, and tet(A).
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Genome-Based Analysis of Extended-Spectrum β-Lactamase-Producing Escherichia coli in the Aquatic Environment and Nile Perch (Lates niloticus) of Lake Victoria, Tanzania.
The study identified multiple AMR genes in ESBL-producing E. coli from Nile perch and water samples in Lake Victoria, including bla CTX-M-15, bla TEM-1B, aadA2, aac(3)-IId, sul1, sul2, dfrA12, qepA4, tetB, tetD, mphA, mdfA, catA1, strA, strB, nfaE, iss, vat, and lpfA.
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
The study identified 22 AMR genes in 10 ocular E. coli isolates, including bla CTX-M-15, dfrA17, aadA2, aadA5, bla OXA-1, bla NDM-5, dfrA12, bla TEM-1 B, mdfA, emrB, mphA, sul1, sul2, and aac(6')-1b-cr. Additionally, chromosomal mutations in parE, gyrA, and parC were found to confer resistance to fluoroquinolones.
Unusual accumulation of a wide array of antimicrobial resistance mechanisms in a patient with cytomegalovirus-associated hemophagocytic lymphohistiocytosis: a case report.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
Novel Insights and Features of the NDM-5-Producing Escherichia coli Sequence Type 167 High-Risk Clone.
The study identifies the NDM-5-producing Escherichia coli sequence type 167 clone, highlighting its resistance mechanisms and the presence of various resistance genes such as blaNDM-5, aadA2, dfrA12, sul1, tet(A), mphA, rmtB, and aac(3)-IIa.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Whole Genome Sequencing Analysis of Porcine Faecal Commensal Escherichia coli Carrying Class 1 Integrons from Sows and Their Offspring.
The study identified multiple antimicrobial resistance genes in porcine faecal commensal E. coli, including blaTEM-1, strA, strB, tetA, dfrA12, aadA1, aadA2, cmlA, aph(3')-Ia, sul2, and sul3, which confer resistance to beta-lactams, streptomycin, tetracyclines, trimethoprim, aminoglycosides, chloramphenicol, neomycin, kanamycin, and sulfonamides.
Genomic Characterisation of a Multiple Drug Resistant IncHI2 ST4 Plasmid in Escherichia coli ST744 in Australia.
The study describes the first complete sequence of a multiple drug-resistant IncHI2 ST4 plasmid, pTZ41_1P, from a commensal E. coli in Australia. The plasmid carries genes conferring resistance to heavy metals, beta-lactams, aminoglycosides, and sulfonamides.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
Antimicrobial Resistance in Swine Fecal Specimens Across Different Farm Management Systems.
The study identified several AMR genes associated with different antimicrobial classes in swine fecal samples from farms with varying antimicrobial usage levels. These genes included beta-lactamases, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, macrolide resistance markers, polymyxin resistance genes, phenicol resistance genes, and trimethoprim resistance genes.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Development of an NGS-Based Workflow for Improved Monitoring of Circulating Plasmids in Support of Risk Assessment of Antimicrobial Resistance Gene Dissemination.
The study developed an optimized NGS-based workflow for plasmid reconstruction, enabling the identification of AMR genes such as mcr-1.1, blaTEM-1B, and others, which are critical for understanding the dissemination of antimicrobial resistance.
Novel IncFII plasmid harbouring blaNDM-4 in a carbapenem-resistant Escherichia coli of pig origin, Italy.
The study identifies a novel IncFII plasmid, pMOL412_FII, carrying the blaNDM-4 gene, which mediates resistance to carbapenems in a carbapenem-resistant E. coli isolate from a pig in Italy. Additional resistance genes include blaTEM-1B, sul1, sul3, and dfrA12, contributing to resistance against beta-lactams, sulfamethoxazole, and trimethoprim.
Profiling Virulence and Antimicrobial Resistance Markers of Enterovirulent Escherichia Coli from Fecal Isolates of Adult Patients with Enteric Infections in West Cameroon.
The study identified several AMR genes and mutations in enterovirulent E. coli isolates from adult patients in Cameroon, including blaTEM, blaOxa, cat1, cat2, tetB, tetA, tetG, sul2, and dfrA12, along with mutations in gyrA and parC contributing to quinolone resistance.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Revealing antimicrobial resistance in stormwater with MinION.
The study identified several AMR genes in stormwater samples from Stockholm, including aac(3)-X, aac(6')-I, aph(3')-I, aph(3')-IIb, bacA, chloramphenicol, rosA, ermO, abeS, major facilitator superfamily transporter, mexE, mexX, ompR, opcM, oprA, oprN, qacG, puromycin, ADP-ribosylating, dfrA12, vanH, vanR, and vanS, which confer resistance to various antibiotics such as aminoglycosides, beta-lactams, chloramphenicol, fosmidomycin, MLS, multidrug, puromycin, rifamycin, trimethoprim, and vancomycin.
Genome Characterization of mcr-1-Positive Escherichia coli Isolated From Pigs With Postweaning Diarrhea in China.
The study identifies multiple antimicrobial resistance genes, including mcr-1.1 and mcr-3.1, in multidrug-resistant E. coli isolates from pigs with postweaning diarrhea in China.
Characterization of Multidrug Resistance Patterns of Emerging Salmonella enterica Serovar Rissen along the Food Chain in China.
The study identified multiple AMR genes in Salmonella enterica serovar Rissen isolates, including tet(A), blaTEM-1B, aadA2, aadA1, aac(6')-Iaa, aph(3")-lld, sul3, and dfrA12, which confer resistance to various antibiotics such as tetracycline, ampicillin, streptomycin, sulfisoxazole, and trimethoprim-sulfamethoxazole.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Genomic analysis of trimethoprim-resistant extraintestinal pathogenic Escherichia coli and recurrent urinary tract infections.
The study identified seven trimethoprim-resistance genes, including dfrA17 and dfrA12, along with bla CTX-M-15 and bla CTX-M-14, which are associated with extended-spectrum beta-lactam resistance. Additionally, the study found chrA, qacEΔ1, and other resistance genes in the analyzed isolates.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Distribution of Beta-Lactamase Producing Gram-Negative Bacterial Isolates in Isabela River of Santo Domingo, Dominican Republic.
The study identified several beta-lactamase genes, including bla TEM, bla OXA, bla SHV, and bla KPC, as well as other resistance genes such as CTX-M-15, CTX-M-55, OXA-1, OXA-72, OXA-132, KPC-3, QnrS1, QnrB19, sul2, sul1, dfrA12, dfrA14, dfrA17, mphA, aadA, aadA2, aadA5, ampC, ampC1, ampH, PmrF, bacA, and eptA, in various Gram-negative bacterial isolates from the Isabela River in the Dominican Republic.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Molecular investigation of an outbreak associated with total parenteral nutrition contaminated with NDM-producing Leclercia adecarboxylata.
The study identified NDM-1, TEM-1B, and SHV-12 carbapenemase genes along with various other AMR genes in Leclercia adecarboxylata isolates causing an outbreak linked to contaminated TPN.
An Update on Wastewater Multi-Resistant Bacteria: Identification of Clinical Pathogens Such as Escherichia coli O25b:H4-B2-ST131-Producing CTX-M-15 ESBL and KPC-3 Carbapenemase-Producing Klebsiella oxytoca.
The study identifies several AMR genes, including bla CTX-M-15, bla KPC-3, aac(6')-Ib-cr5, and various dfr and aad genes, in wastewater isolates, highlighting the prevalence of multidrug-resistant bacteria in wastewater treatment plants.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
pCTX-M3-Structure, Function, and Evolution of a Multi-Resistance Conjugative Plasmid of a Broad Recipient Range.
The study characterizes the pCTX-M3 plasmid, highlighting its role in the dissemination of antibiotic resistance genes, including bla CTX-M-3, armA, aadA2, dfrA12, sul1, and bla TEM-1. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, and trimethoprim.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Genomic analysis and phylogenetic position of the complex IncC plasmid found in the Spanish monophasic clone of Salmonella enterica serovar Typhimurium.
The study identifies various AMR genes in the IncC plasmid pUO-STmRV1, including blaTEM-1, cmlA1, aac(3)-IV, aadA1, aadA2, sul1, sul2, sul3, tet(A), dfrA12, arsR2, arsH, merRTPCADE, and silESRCBAP, which confer resistance to antibiotics and heavy metals.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions.
The study characterizes the mcr-1 gene and various other resistance genes in Escherichia coli isolates from animal organs with lesions, highlighting their multidrug resistance profiles and the genetic features of plasmids carrying these genes.
Genomic Characterization of Multidrug-Resistant Salmonella Serovars Derby and Rissen From the Pig Value Chain in Vietnam.
The study identified multiple antimicrobial resistance genes in Salmonella serovars Derby and Rissen from Vietnam, highlighting the presence of multidrug-resistant strains along the pig value chain.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
Insight Into Whole Genome of Aeromonas veronii Isolated From Freshwater Fish by Resistome Analysis Reveal Extensively Antibiotic Resistant Traits.
The study identified 17 AMR genes in Aeromonas veronii isolates from tilapia, highlighting extensive antibiotic resistance traits, including resistance to beta-lactams, aminoglycosides, tetracyclines, and others.
IS1294 Reorganizes Plasmids in a Multidrug-Resistant Escherichia coli Strain.
The study identifies and characterizes various AMR genes, including blaCTX-M-55, rmtB, oqxAB, blaTEM-1b, floR, tet(A), strA, strB, sul1, sul2, aac(3)-IId, aadA2, dfrA12, and aph(3′)-IIa, in a multidrug-resistant E. coli strain. These genes contribute to resistance against multiple antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and trimethoprim.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
High-Resolution Genomic Profiling of Carbapenem-Resistant Klebsiella pneumoniae Isolates: A Multicentric Retrospective Indian Study.
The study identifies various carbapenem resistance genes such as blaOXA232, blaNDM1, blaNDM5, blaOXA181, and others in Klebsiella pneumoniae isolates from India. It also characterizes mutations in ompK35 and ompK36 contributing to carbapenem resistance.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
Genomic evolution of the globally disseminated multidrug-resistant Klebsiella pneumoniae clonal group 147.
The study identifies multiple AMR genes and mutations in the pandrug-resistant K. pneumoniae strain DJ, including carbapenemases (bla NDM-5, bla OXA-181, bla CTX-M-15), aminoglycoside resistance genes (rmtB, rmtF, aac(6')-Ib, aadA2, strAB), sulfonamide resistance genes (sul1, sul2), dihydrofolate reductase (dfrA12), polymyxin resistance gene (mgrB), tetracycline resistance gene (ramR), chloramphenicol resistance genes (catA2, catB), fosfomycin resistance gene (fosA), and macrolide resistance genes (mphA, ermB). Mutations in gyrA, parC, ompK35, ompK36, and ramR contribute to resistance to fluoroquinolones, polymyxins, tetracyclines, and other antibiotics.
The Darkest Place Is under the Candlestick-Healthy Urogenital Tract as a Source of Worldwide Disseminated Extraintestinal Pathogenic Escherichia coli Lineages.
The study identified several AMR genes and mutations in E. coli strains from the urogenital microbiome of healthy women, including blaTEM-30, tet(A), aac(3)-IId, sul1, dfrA12, and a gyrA mutation (S83L) conferring resistance to various antibiotics.
Plethora of Resistance Genes in Carbapenem-Resistant Gram-Negative Bacteria in Greece: No End to a Continuous Genetic Evolution.
The study identified a variety of resistance genes in carbapenem-resistant Gram-negative bacteria, including bla KPC, bla NDM, bla VIM, and others, highlighting the complex genetic diversity of these pathogens.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
Anti-microbial resistance of Salmonella isolates from raw meat-based dog food in Japan.
Prevalence, Antimicrobial Resistance, and Whole Genome Sequencing Analysis of Shiga Toxin-Producing Escherichia coli (STEC) and Enteropathogenic Escherichia coli (EPEC) from Imported Foods in China during 2015-2021.
The study identified several antimicrobial resistance genes in STEC and EPEC isolates from imported foods in China, including blaTEM-1B, tetA, tetB, catA1, cmlA1, aadA1, aph(4)-Ia, aac(3)-IV, aph(6)-Id, aph(3")-Ib, sul3, dfrA12, and qnrS1, which conferred resistance to various antibiotics such as ampicillin, tetracycline, chloramphenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Comparison of Reference-Based Assembly and De Novo Assembly for Bacterial Plasmid Reconstruction and AMR Gene Localization in Salmonella enterica Serovar Schwarzengrund Isolates.
The study identified various AMR genes in Salmonella enterica serovar Schwarzengrund isolates, including aadA2, AAC(3)-IV, AAC(6')-Iy, APH(4)-Ia, cmlA1, dfrA12, floR, sul1, sul2, sul3, TEM-1, and tet(A). These genes were located on both the chromosome and plasmids, highlighting the importance of plasmid-mediated AMR gene transmission.
HAM-ART: An optimised culture-free Hi-C metagenomics pipeline for tracking antimicrobial resistance genes in complex microbial communities.
The study identified various AMR genes, including aadA1, aadA2, blaCFE-1, cmlA1, dfrA12, mdf(A), sul3, tet(34), and lnu(A), in pig fecal microbiomes. Notably, the lnu(A) gene was exclusively found in conventional farms and associated with Lactobacillus species.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
The study identified multidrug-resistant Escherichia coli isolates from surface water in north-western Mexico, including international high-risk lineages ST410 and ST617. These isolates carried various AMR genes such as blaTEM-1B, blaCTX-M-15, aadA1, aadA2, aadA5, aac(3)-IIa, aac(3)-IId, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, floR, cmlA1, lnu(F), mdf(A), sul2, sul3, tet(A), tet(B), dfrA12, and dfrA17. Additionally, mutations in gyrA (S83L, D87N), parC (S80I), and parE (S458A) were found to contribute to fluoroquinolone resistance.
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.
The study identified various AMR genes in E. coli isolates from a low antimicrobial usage pig farm, highlighting the persistence of multidrug-resistant strains despite minimal selective pressure.
IncFIB-4.1 and IncFIB-4.2 Single-Replicon Plasmids: Small Backbones with Large Accessory Regions.
The study characterizes several AMR genes and mutations in IncFIB-4.1 and IncFIB-4.2 plasmids, highlighting their role in conferring resistance to various antibiotics.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Identifying the Sources of Intestinal Colonization With Extended-Spectrum β-Lactamase-Producing Escherichia coli in Healthy Infants in the Community.
The study identifies several AMR genes, including blaCTX-M-15, qnrS1, ermB, aadA1, aph(3')-Ib, aph(6)-Id, dfrA1, catA1, aadA2, dfrA5, dfrA12, qnrS13, aac(6')-Ib-cr5, blaTEM-1, blaOXA-1, sul1, and dfrA17, associated with ESBL-Ec in children, mothers, and drinking water in rural Bangladesh.
Antimicrobial Resistance in Escherichia coli from the Broiler Farm Environment, with Detection of SHV-12-Producing Isolates.
The study identifies SHV-12-producing Escherichia coli isolates in a broiler farm environment, highlighting the presence of various antimicrobial resistance genes such as bla SHV-12, cmlA, tet (A), aac(6′)-Ib-cr, and others. These genes confer resistance to multiple antibiotics, emphasizing the need for monitoring and controlling AMR in agricultural settings.
Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from a mixed-use watershed in Georgia, USA, including bla CMY-2, aadA2, strA, strB, sul1, sul2, tetA, tetC, floR, and dfrA12, which conferred resistance to various antibiotics such as ceftiofur, ceftriaxone, streptomycin, sulfisoxazole, tetracycline, chloramphenicol, and trimethoprim.
Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India.
The study characterizes hybrid plasmids in MDR-HvKp ST2096 isolates from India, identifying multiple AMR genes such as bla NDM-5, bla OXA-232, aadA2, armA, and others, along with virulence genes like rmpA2 and iucABCD.
Antimicrobial resistance in urinary pathogens and culture-independent detection of trimethoprim resistance in urine from patients with urinary tract infection.
The study identifies dfrA1, dfrA5, dfrA7, dfrA12, and dfrA17 as trimethoprim resistance genes in urinary pathogens, demonstrating their utility in predicting phenotypic resistance without culture.
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
Escherichia coli ST1193: Following in the Footsteps of E. coli ST131
The paper characterizes Escherichia coli ST1193 as an emerging multidrug-resistant clone with various AMR determinants, including beta-lactamases (bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-55, bla OXA-1, bla TEM-1, bla CMY-42, bla CMY-2), aminoglycoside-modifying enzymes (aac(3)-IIa, aac(3)-IId, aac(6′)-Ib-cr, aadA1, aadA2, aadA5, aph(3′′)-Ib, aph(6)-Id), and other resistance genes (mcr-1, mph(A), erm(B), dfrA8, dfrA12, dfrA17, sul1, sul2, tetA, tetB).
Genomic Characterization of an O101:H9-ST167 NDM-5-Producing Escherichia coli Strain from a Kitten in Italy.
The study characterizes an NDM-5-producing Escherichia coli ST167 strain from a kitten in Italy, highlighting the presence of multiple AMR genes including blaNDM-5, bla_ble, blaAmpH, blaAmpC1, and others, along with mutations in gyrA, parC, and parE contributing to fluoroquinolone resistance.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Within-farm dynamics of ESBL-producing Escherichia coli in dairy cattle: Resistance profiles and molecular characterization by long-read whole-genome sequencing.
The study identified multiple ESBL-encoding genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, and bla SHV-12, as well as carbapenemase gene bla NDM-1, in ESBL-producing E. coli isolates from dairy cattle farms. These genes were associated with resistance to various beta-lactam antibiotics. Additionally, several other AMR genes such as aadA2, ant(3")-Ia, aph(3')-Ia, dfrA12, sul3, cmlA1, and others were identified, contributing to resistance against aminoglycosides, trimethoprim, sulfamethoxazole, and chloramphenicol. Mutations in gyrA, parC, and parE were linked to fluoroquinolone resistance.
Identification and Characterisation of pST1023 A Mosaic, Multidrug-Resistant and Mobilisable IncR Plasmid.
The study identifies and characterizes the mosaic, multidrug-resistant, and mobilizable IncR plasmid pST1023, which carries several AMR genes including cmlA1, aadA1, aadA2, sul3, tetA(B), dfrA12, and a sil operon conferring resistance to various antibiotics and silver.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Genome-associations of extended-spectrum ß-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand.
The study identifies various AMR genes in ESBL and/or AmpC-producing E. coli from small and medium pig farms in Thailand, highlighting the co-occurrence of resistance genes conferring resistance to critically important antimicrobials.
Longitudinal Study on Extended-Spectrum Beta-Lactamase-E. coli in Sentinel Mallard Ducks in an Important Baltic Stop-Over Site for Migratory Ducks in Germany.
The study identified bla CTX-M-1, dfrA12, and mcr-9 as the primary AMR genes in ESBL-producing E. coli isolates from sentinel mallard ducks, highlighting the presence of multidrug-resistant strains in wild bird populations.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Aeromonas species isolated from aquatic organisms, insects, chicken, and humans in India show similar antimicrobial resistance profiles.
The study identified multiple antimicrobial resistance (AMR) genes in Aeromonas species isolated from various hosts in India, including beta-lactamases (bla OXA-12, bla OXA-427, bla OXA-724, bla OXA-780, bla FOX-2, bla FOX-4, bla FOX-5, bla FOX-7, bla AQU-2, bla MOX-7), metallo-beta-lactamases (cphA3, cphA4, cphA5, cphA8, ImiH), and other resistance genes (dfrA12, aadA2, ANT(3")-IIa, sul1). Additionally, multidrug efflux pump genes (mdtH, zntA, emrD, blR, crp) were found to contribute to AMR in these isolates.
In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.
The study identifies several AMR genes in E. coli strains, including aadA, strA/strB, aphA1, aphA2, tetA, tetB, sul1, sul2, sul3, dfrA1, dfrA10, dfrA12, floR, and blaSHV, which confer resistance to various antibiotics such as streptomycin, neomycin, tetracycline, sulfonamides, trimethoprim, chloramphenicol, and cephalosporins.
Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region.
The study identified various AMR genes in L. monocytogenes, Salmonella enterica, and S. aureus isolates from artisanal food production chains in the Mediterranean region, highlighting the presence of fosfomycin, aminoglycoside, beta-lactam, trimethoprim, sulfonamide, tetracycline, and streptomycin resistance mechanisms.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Epidemiological characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic analysis of Aeromonas caviae isolated from extra-intestinal infections.
The study identified multiple antimicrobial resistance genes in Aeromonas caviae isolates from extra-intestinal infections, including blaMOX, blaPER-3, blaOXA, blaNDM, blaCphA, qnrS2, qnrVC, aac(6')-Ib-cr, tet(A), tet(E), tet(31), dfrA1, dfrA12, dfrA14, dfrA15b, floR, catB3, catII, and catI, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, tetracyclines, trimethoprim, and chloramphenicol.
Integrative omics identifies conserved and pathogen-specific responses of sepsis-causing bacteria.
The study identified various AMR genes in sepsis-causing bacteria, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others, highlighting the complexity of AMR in these pathogens.
The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China.
The study identifies multiple antimicrobial resistance genes in Salmonella enterica isolates from China, highlighting the increasing prevalence of resistance to beta-lactams, quinolones, tetracyclines, and sulfonamides. Key genes include blaTEM-1B, blaCTX-M-14, aac(3)-IV, and mcr-1.
Phylogenomics of Globally Spread Clonal Groups 14 and 15 of Klebsiella pneumoniae.
The study characterizes various AMR genes and mutations in K. pneumoniae clonal groups 14 and 15, highlighting the prevalence of bla CTX-M-15, bla OXA-232, bla NDM-1, and other beta-lactamases, along with quinolone resistance mechanisms.
Antimicrobial resistance, Extended-Spectrum β-Lactamase production and virulence genes in Salmonella enterica and Escherichia coli isolates from estuarine environment.
The study identified several AMR genes in Salmonella and E. coli isolates from estuarine environments, including bla TEM, cmlA, sul3, tetA, dfrA12, and bla CTX-M-55, highlighting the presence of multidrug-resistant and ESBL-producing bacteria in these environments.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Genomic Surveillance of Salmonella from the Comunitat Valenciana (Spain).
The study identified multiple antimicrobial resistance genes including mcr-1, tet(A), aadA2, dfrA12, sul1, sul3, and ant(3")-Ia, along with mutations in gyrA that confer resistance to various antibiotics in Salmonella isolates from the Comunitat Valenciana, Spain.
The First Report of Escherichia coli and Klebsiella pneumoniae Strains That Produce Both NDM-5 and OXA-181 in Jiangsu Province, China.
The study reports the first identification of Escherichia coli and Klebsiella pneumoniae strains producing both NDM-5 and OXA-181 carbapenemases in pediatric patients in China, highlighting the potential for rapid dissemination of these resistance genes.
Whole-Genome Sequencing Revealed the Fusion Plasmids Capable of Transmission and Acquisition of Both Antimicrobial Resistance and Hypervirulence Determinants in Multidrug-Resistant Klebsiella pneumoniae Isolates.
The study identified multiple antimicrobial resistance genes and hypervirulence determinants in multidrug-resistant Klebsiella pneumoniae isolates, highlighting the role of fusion plasmids in the transmission of these traits.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
The study identified silA and pcoD genes associated with copper tolerance in Klebsiella pneumoniae isolates from poultry, and numerous chromosomal mutations linked to colistin resistance.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
The study identified multidrug-resistant, hydrogen sulfide-producing variants of Escherichia coli from Bangladesh, highlighting the presence of various AMR genes such as bla TEM1B, bla CTX-M-55, bla CTX-M-65, bla CTX-M-123, aadA1, aadA2, aph (3')-Ia, aph (3'')-Ib, aph (6)-Id, tet(A), tet(M), sul3, sul2, dfrA12, mph(A), floR, cmlA1, qacL, and qnrS1.
Genomic epidemiology and antibiotic susceptibility profiling of uropathogenic Escherichia coli among children in the United States.
The study identified AMR genes blaCTX-M-15, sul1, dfrA12, and dfrA17 in ST131 E. coli isolates from children with UTIs, and mutations in gyrA and parC that confer fluoroquinolone resistance.
Genomic traits of multidrug resistant enterotoxigenic Escherichia coli isolates from diarrheic pigs.
The study identified 53 resistance genes and 13 categories of 195 virulence factors in multidrug-resistant ETEC isolates from diarrheic pigs, including tet(A), floR, aph(3')-Ia, aadA2, bleO, sul3, dfrA12, QnrS1, and tet(X4).
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
SHIP: identifying antimicrobial resistance gene transfer between plasmids.
SHIP identifies horizontally transferred antimicrobial resistance (AMR) gene regions between plasmids, including a multi-resistant complex class 1 integron in Escherichia coli and Klebsiella pneumoniae, and a tetracycline resistance region in Enterococcus faecalis.
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Genomic Characterization of Two NDM-5-Producing Isolates of Klebsiella pneumoniae ST11 from a Single Patient.
The study identified two NDM-5-producing K. pneumoniae ST11 isolates from a single patient, highlighting the presence of multiple acquired antimicrobial resistance genes, including blaNDM-5, blaCTX-M-15, and rmtB, along with other resistance determinants.
Genomic investigation unveils high-risk ESBL producing Enterobacteriaceae within a rural environmental water body.
The study identifies several AMR genes and mutations in ESBL-producing Enterobacteriaceae isolated from a rural environmental water body in India, highlighting the presence of multidrug-resistant strains with genes such as bla VEB-6, bla SHV-12, bla NDM-1, bla CTX-M, and mcr-9, along with mutations in ompK 36 and gyrA.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients.
The study characterized multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates, identifying several AMR genes and mutations associated with resistance to various antibiotics.
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum β-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
The study identified several AMR genes and mutations in Salmonella enterica and Escherichia coli isolated from retail produce in Bangkok, Thailand. Key findings include the presence of bla TEM, qnrS, tetA, tetB, strA, and strB genes, as well as gyrA and parC mutations associated with ciprofloxacin resistance.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Tracking antimicrobial resistance transmission in urban and rural communities in Bangladesh: a One Health study of genomic diversity of ESBL-producing and carbapenem-resistant Escherichia coli.
The study identified various beta-lactamase genes, including bla CTX-M-15, bla TEM-1b, bla OXA-1, and carbapenem resistance genes like bla NDM-5, bla NDM-7, and bla NDM-1, in ESBL-producing and carbapenem-resistant E. coli isolates from Bangladesh.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Unveiling the genetic architecture and transmission dynamics of a novel multidrug-resistant plasmid harboring bla(NDM-5) in E. Coli ST167: implications for antibiotic resistance management.
The study identifies a novel multidrug-resistant plasmid pNDM-5-0083 carrying bla NDM-5, bla TEM-1B, aadA2, rmtB, dfrA12, and sul1, which contributes to resistance against multiple antibiotics in E. coli ST167.
Molecular basis of the persistence of chloramphenicol resistance among Escherichia coli and Salmonella spp. from pigs, pork and humans in Thailand.
The study identifies catA and cmlA as the primary genes responsible for chloramphenicol resistance in E. coli and Salmonella isolates from Thailand, highlighting their persistence through co-selection and horizontal gene transfer.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Antimicrobial resistance profiles and genome characteristics of Klebsiella isolated from the faeces of neonates in the neonatal intensive care unit.
The study identified multiple antimicrobial resistance genes in Klebsiella isolates from neonates in the NICU, including bla NDM-1, bla CTX-M-15, bla SHV-67, aac(6')-Ib-cr, aadA16, aph(3'')-Ib, and others. These genes confer resistance to various antibiotics such as carbapenems, cephalosporins, aminoglycosides, and fluoroquinolones. Additionally, the study found a multidrug-resistant Klebsiella pneumoniae strain carrying several resistance genes and plasmids.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Analyzing Antibiotic Resistance in Bacteria from Wastewater in Pakistan Using Whole-Genome Sequencing.
The study identifies several AMR genes and mutations in wastewater isolates from Pakistan, highlighting the presence of carbapenemases like blaNDM-5 and blaOXA-1, as well as quinolone resistance determinants such as gyrA and parC mutations. These findings emphasize the role of wastewater as a reservoir for clinically relevant AMR genes.
Genomic Characterization of 16S rRNA Methyltransferase-Producing Enterobacterales Reveals the Emergence of Klebsiella pneumoniae ST6260 Harboring rmtF, rmtB, bla(NDM-5), bla(OXA-232) and bla(SFO-1) Genes in a Cancer Hospital in Bulgaria.
The study identifies the emergence of Klebsiella pneumoniae ST6260 harboring multiple AMR genes, including rmtF, rmtB, bla(NDM-5), bla(OXA-232), and bla(SFO-1), highlighting the complexity of resistance mechanisms in Enterobacterales.
Molecular Characterization of Multidrug-Resistant Escherichia coli from Fecal Samples of Wild Animals.
The study identified multiple AMR genes in E. coli isolates from wild animals, including beta-lactamases (bla TEM-1B, bla CTX-M-65, bla CTX-M-55, bla EC-1982), aminoglycoside resistance genes (aac(3)-IIa, aadA2, aadA5, ant(3")-Ia, aph(3")-Ib, aph(3′)-Ia, aph(6)-Id), tetracycline resistance genes (tetB, tetA), trimethoprim resistance genes (dfrA17, dfrA1, dfrA5, dfrA12), sulfonamide resistance genes (sul1, sul2, sul3), macrolide/lincosamide/streptogramin resistance genes (mphB, lnuF, ermC, mefC), quinolone resistance genes (qnrB19, qnrB5, qnrS1, qnrS2), and others. Additionally, point mutations in gyrA, parC, and parE were associated with fluoroquinolone resistance.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Genomic epidemiology and phenotypic characterisation of Salmonella enterica serovar Panama in Victoria, Australia.
The study identifies the first plasmid-mediated colistin-resistant Salmonella enterica serovar Panama in Australia, highlighting the emergence of multidrug resistance in this invasive non-typhoidal Salmonella serovar.
Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023.
The study identifies the spread of NDM-1-producing Providencia stuartii in Romania, highlighting the presence of multiple resistance genes including bla NDM-1, bla OXA-10, bla CMY-4, bla CMY-16, bla CMY-194, qnrD2, armA, aph(3')-VI, aac(6')-Ib3, rmtC, dfrA14, dfrA12, sul1, and sul2.
Investigation of integron gene cassettes in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.
The study identified dfrA12 and aadA2 genes in class I integrons, and dfrA1 and sat2 genes in class II integrons in trimethoprim-sulfamethoxazole-resistant Acinetobacter baumannii isolates.
Tracking Multidrug Resistance in Gram-Negative Bacteria in Alexandria, Egypt (2020-2023): An Integrated Analysis of Patient Data and Diagnostic Tools.
The study identified bla NDM-5 as the most prevalent carbapenemase gene in E. coli isolates from Alexandria, Egypt, along with other resistance genes such as bla OXA-48, bla VIM, bla CTX-M-15, aadA2, aac(6')-Ib, qnrS1, dfrA12, sul1, and sul2.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Clonal Spread and Genetic Mechanisms Underpinning Ciprofloxacin Resistance in Salmonella enteritidis.
The study identified multiple plasmid-mediated quinolone resistance (PMQR) genes, including aac(6')-Ib-cr, qnrA, qnrS, and oqxAB, as well as GyrA mutations (S83Y, D87Y, S83Y-D87Y, S83R, D87N, D87G) in ciprofloxacin-resistant Salmonella enteritidis isolates. These genes and mutations were found to contribute to ciprofloxacin resistance through various mechanisms, including efflux pump overexpression and enzymatic modification of antibiotics.
Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail markets in Yichun city, China, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, trimethoprim, and extended-spectrum beta-lactamases.
Tracing the evolution: the rise of Salmonella Thompson co-resistant to clinically important antibiotics in China, 1997-2020.
The study identifies the IncC plasmid as a major driver of co-resistance to ciprofloxacin, cefotaxime, and azithromycin in Salmonella Thompson isolates in China, with specific resistance genes including qnrS1, qepA4, blaCMY-2, and mph(A).
Circulation of a Unique Klebsiella pneumoniae Clone, ST147 NDM-1/OXA-48, in Two Diverse Hospitals in Calabria (Italy).
The study identifies multiple AMR genes, including bla OXA-48, bla NDM-1, bla CTX-M-15, and bla SHV, in K. pneumoniae strains from two hospitals in Calabria, Italy, highlighting the presence of multidrug-resistant clones.
Epidemic trend of Salmonella from swines and broilers in China from 2014 to 2023 and genetic evolution analysis of ESBLs-producing strains.
The study identified several AMR genes in ESBL-producing Salmonella strains from swines and broilers in China, including blaCTX-M-14, blaTEM-1B, blaCTX-M-65, aac(6')-Iaa, floR, sul2, tet(B), arr-2, fosA3, dfrA12, mph(A), lnu(F), blaCTX-M-55, blaOXA-1, sul1, tet(A), catB3, qnrS1, and mcr-1.1. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, tetracyclines, rifampicin, fosfomycin, trimethoprim, macrolides, lincomycin, quinolones, and colistin.
Detection of a genetically related carbapenemase-producing Escherichia coli ST167 in clinical and environmental isolates: Evidence for clonal spread of carbapenemase-producing Enterobacteriaceae in humans and the environment in Iowa, United States.
The study identifies a carbapenemase-producing E. coli strain BO1 carrying bla NDM-5, along with other resistance genes, highlighting the clonal spread of carbapenemase-producing Enterobacteriaceae between humans and the environment in Iowa.
Genomic Characterization of NDM-1 Harboring Extensively-Drug Resistance Klebsiella pneumoniae Isolate From ICU-Admitted Patient With COVID-19.
The study identified multiple antimicrobial resistance genes in an extensively drug-resistant Klebsiella pneumoniae isolate, including bla NDM-1, armA, msrE, mphE, BRP, bla OXA-1, aadA2, dfrA12, qnrB1, bla CTX-M-15, and cat1, highlighting the complex resistance mechanisms in this isolate.
Isolation, Antimicrobial Susceptibility, and Genotypes of Three Pasteurellaeae Species Prevalent on Pig Farms in China Between 2021 and 2023.
The study identified 18 antimicrobial resistance genes in three Pasteurellaeae species, including tetracycline, beta-lactam, sulfonamide, aminoglycoside, and macrolide resistance genes. High frequencies of tet(L), tet(M), tet(A), blaTEM, sul2, aph(3')-Ia, dfrA12, qnrS1, strA, sul3, and mef(B) were observed.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.
The study identifies multiple antibiotic resistance genes and mutations in non-typhoidal Salmonella isolates from Minhang District, Shanghai, highlighting the prevalence of multidrug-resistant strains and the role of specific genetic elements in resistance mechanisms.
Genomic insights into multidrug - resistant Salmonella enterica isolates from pet dogs and cats.
The study identified multiple AMR genes in multidrug-resistant Salmonella enterica isolates from pet dogs and cats, including aac(6')-Iaa, aadA1, aadA2, blaTEM-1B, qacL, sul3, tet(A), qnrS1, fosA7, dfrA12, cmlA1, aph(3')-Ib, aph(6)-Id, blaCTX-M-55, blaTEM-215, and floR, which confer resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole, ciprofloxacin, and chloramphenicol.
Acquired antibiotic resistance of Pseudomonas spp., Escherichia coli and Acinetobacter spp. in the Western Balkans and Hungary with a One Health outlook.
The study identifies various acquired antibiotic resistance genes in Pseudomonas spp., Escherichia coli, and Acinetobacter spp. in the Western Balkans and Hungary, including beta-lactamases like bla VIM-2-like, bla NDM-1, bla OXA-23, and bla OXA-66, aminoglycoside resistance genes such as aacA4, aadA2, and aphA, sulfonamide resistance gene sul1, and others. These genes confer resistance to multiple antibiotics, highlighting the complexity of antimicrobial resistance in the region.
Emergence of highly virulent Aeromonas dhakensis in channel catfish aquaculture: Genomic insights into pathogenicity and antimicrobial resistance.
The study identified 60 antibiotic resistance genes in the highly virulent Aeromonas dhakensis strain CWH5, including genes conferring resistance to multiple drug classes such as beta-lactams, tetracyclines, sulfonamides, and macrolides.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Emergence of carbapenem-resistant Salmonella Mbandaka through IS26-driven bla(NDM-1) mobilization and chromosomal structural variation.
The study reports the first documented isolation of a carbapenem-resistant Salmonella Mbandaka strain, highlighting the role of IS26 in the mobilization of blaNDM-1 and chromosomal structural variation.
Nanopore Sequencing-Driven Mapping of Antimicrobial Resistance Genes in Selected Escherichia coli Isolates from Pigs and Poultry Layers in Nigeria.
The study identified 95 antimicrobial resistance genes in 10 E. coli isolates from pigs and poultry in Nigeria, including genes such as qnrS1, qnrS10, qnrS15, kdpE, cmlA1, MIR-14, sul3, dfrA12, blaEc15, blaACT58, and blaEc18, which confer resistance to various antibiotics.
No evidence of multidrug-resistant Enterobacterales transmission between healthy companion animals and pet owners in the greater Atlanta area: a pilot study.
The study identified several AMR genes and mutations in E. coli isolates from both humans and pets, including blaCMY-2, blaCTX-M-15, blaTEM-1B, and mutations in gyrA and parC. These findings highlight the presence of multidrug-resistant Enterobacterales in healthy individuals and their companion animals.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Antibiotic resistance in mastitis-causing bacteria: Exploring antibiotic-resistance genes, underlying mechanisms, and their implications for dairy animal and public health.
The study identifies several AMR genes and mutations in Staphylococcus aureus and coagulase-negative staphylococci associated with mastitis, including blaZ, mecA, tetK, tetM, aphA3, aacA-aphD, aadD, ermA, msrA, mphC, lnuB, and vanA, which confer resistance to various antibiotics such as β-lactams, tetracyclines, aminoglycosides, macrolides, and glycopeptides.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Genomic epidemiology reveals statewide dispersal of clinical Shiga toxin-producing Escherichia coli and their antimicrobial resistome.
The study identifies 93 unique antimicrobial resistance (AMR) determinants in 1,655 clinical Shiga toxin-producing Escherichia coli (STEC) isolates from New York State, revealing extensive diversity in AMR genes and plasmid replicon types. Key AMR genes include blaEC, mdtM, acrF, ermD, sul2, sul1, aph(3")-Ib, aph(6)-Id, tet(A), tet(B), aadA1, aph(3′)-Ia, blaTEM-1, floR, dfrA1, dfrA8, aac(3)-IId, aadA2, aadA22, blaCARB-2, blaCMY-2, blaCTX-M-1/15/27/55, blaHER-3, blaLAP-2, ampC C11T, fosA7.5, lnu(F), catA1, gyrA S83L, qnrA1/S1, sul3, dfrA7/8/12/14/51, arr-2, erm(B), aph(3′)-IIa, aph (6)-Ic, blaCMY-2, blaCTX-M-14/27, blaHER-3, ble, mef(C), mph(ABG), gyrA D87Y/S83L, qnrB19/S1, dfrA51, and erm(F).
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Characterization of Enterobacter cloacae complex clinical isolates: comparative genomics and the role of the efflux pump AcrAB-TolC over-expression and NDM-1 production.
The study characterizes carbapenem-resistant Enterobacter cloacae complex isolates, highlighting the roles of the AcrAB-TolC efflux pump over-expression and the bla NDM-1 carbapenemase in conferring resistance. Multiple resistance genes, including bla NDM-1, acrAB-tolC, and various beta-lactamases, aminoglycoside-modifying enzymes, and sulfonamide resistance genes, were identified and validated.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
An integrated phenotypic and genomic approach to characterize MBL-producing Enterobacterales strains circulating in a Sicilian transplant center.
The study characterizes MBL-producing Enterobacterales strains, identifying NDM-1, NDM-5, and VIM-1 as the most prevalent metallo-beta-lactamases. It also identifies various aminoglycoside, quinolone, and sulfonamide resistance genes, highlighting the multidrug-resistant nature of these isolates.
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
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