Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dihydrofolate reductase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| DfrA14 | Card DatabaseReference Gene CatalogReslit | 257 | Trimethoprim, TRIMETHOPRIM +2 |
| India|Mexico|Egypt|Morocco|Peru|Kenya|Senegal|Mali|South Africa|Vietnam|Nepal|Indonesia|Bolivia|Equatorial Guinea|Uganda|Cameroon|Guatemala|Philippines|Burkina-Faso, Madrid, Spain, Taiwan, Sweden, Iran, United States, South West London, UK, England, Italy, Chile|South America, United States|New York|Florida|Illinois|Gaza|Colombia|South America|Mediterranean region, South Korea, Norway, Zimbabwe, Kenya, United Kingdom|Africa, China, United Kingdom, UK|Latin America, Czechia|Czech Republic, Gothenburg, Africa|Ghana|Kenya|Tanzania, La Paz, Bolivia|La Paz River basin, Belgium, Chile, Sri Lanka, Ecuador, Vietnam, UK, Taiwan|Germany|Netherlands|United Kingdom|United States, Democratic Republic of the Congo, South Africa, Denmark|Japan, Germany, Greece, Italy|Far East countries, Germany|global, Brazil, Czech Republic, California|Arizona|South Carolina|Idaho|Maine, China|USA|Italy|Israel, Italy|Colombia|United States|South Africa|India|Greece|North Africa, Switzerland, Europe, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, Kenya|Malawi, Australia, Russia, Guadeloupe|French West Indies, Jakarta, Nigeria, Dominican Republic, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Myanmar, India|Pakistan|Bangladesh|Philippines|Democratic Republic of the Congo, California|Europe|North America|Republic of Congo, sub-Saharan Africa|Burkina Faso|Ghana|Guinea-Bissau|Kenya|Senegal, Portugal, Malaysia, Japan, England|Wales, Caribbean, Europe|Greece, Finland|Eastern Finland, The Gambia, Senegal, Europe|EU|China|Portugal|Germany, southern Ontario, Canada, Madagascar, India, central Adriatic Sea|Croatia|Croatian marine environment, Spain, Europe|Portugal, Australia|Melbourne, Australia, Hungary, Spain|Peru, Zambia, Germany|Poland|Denmark, Stellenbosch, South Africa, Abuja, Nigeria, Lebanon, South America|Australia|France|Vietnam|China, Guadeloupe, Egypt|United States|China, Al-Kharj, KSA, Thailand, Ontario, Canada, Serbia, Oxfordshire, UK, Saudi Arabia, Belgium|The Netherlands|Europe, Norway|Kenya|United Kingdom|Italy, Western Africa|Mali, Bangladesh, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, Pakistan|Karachi, Pakistan, Kuwait, Poland, Finland, Wales|Nigeria, Balochistan, Pakistan, Mozambique, Oman, Brazilian Amazon Region, Central Adriatic|Central Adriatic Sea, Ghana, New Zealand, Shanghai, China, Bangkok, Thailand, Croatia, Accra, Ghana|Ghana, Uruguay|Chile, Egypt, United States|Pakistan|Bangladesh|Nigeria|Iraq|India, California, Ethiopia, Pakistan, Rwanda, Fujian Province, Southeast China|China, Romania, Europe|Czech Republic, Armenia, Austria, Somali region, Ethiopia|Somali Region, Ethiopia, Europe|Asia|South America|Africa|Germany|Vietnam|USA|Ecuador|China, Europe|Africa|North America|South America|Asia|Oceania, Calabria|Italy, Europe|Italy, Northern Italy, Indonesia, Guangzhou, China, Ibadan, Nigeria, Greater Accra Region, Ghana|Ghana, North Carolina, USA, Northern Nigeria|Nigeria, southwestern Nigeria, Australia|France|Bangladesh|United States, Europe|China, East Africa|Tanzania|Uganda, United Arab Emirates, Kazakhstan |
| 1994, 2004, 2006, 2008, 2010, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 |
| DQ449578 |
| AHK10285.1 |
| dfrA14 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Escherichia coli, Salmonella enterica subsp. enterica serovar Typhimurium str. DT104, Salmonella enterica subsp. enterica serovar Typhimurium +1 | - | 2014 | KF921535, Z50805, Z50804, AF393510, DQ388123 | AHK10285.1 |
| dfrA14-like | Reslit | 3 | Trimethoprim | Escherichia coli | Germany, Pakistan, West Africa|Conakry, Guinea | 2017, 2018 | PDDP00000000|MG182343 | - |
| dfr A14 | Reslit | 10 | Trimethoprim, Trimethoprim-sulfamethoxazole | Klebsiella pneumoniae +10 | South Africa, Romania, Vietnam, Edo state, Nigeria, Southeast Nigeria, Denmark, United States, Portugal | 2019, 2020, 2021, 2022, 2023, 2025 | CP012043|NXKY01000005.1 | - |
| dfrA 14 | Reslit | 1 | Trimethoprim | Klebsiella pneumoniae | Iran | 2025 | JARGDG000000000|JARGDG010000000 | - |
Mechanism of resistance to several antimicrobial agents in Salmonella Clinical isolates causing traveler's diarrhea.
The study identified several AMR genes and mutations in Salmonella isolates causing traveler's diarrhea, including blaTEM, blaOXA-1, tetA, tetB, tetG, dfrA1, dfrA12, dfrA14, dfrA17, floR, cmlA, and a mutation in the gyrA gene. These genes and mutations contribute to resistance against ampicillin, tetracycline, trimethoprim, chloramphenicol, and quinolones.
Spread of Escherichia coli Strains with High-Level Cefotaxime and Ceftazidime Resistance between the Community, Long-Term Care Facilities, and Hospital Institutions.
The study identifies the spread of Escherichia coli strains with high-level resistance to cefotaxime and ceftazidime, primarily due to the presence of extended-spectrum beta-lactamases (ESBLs) such as CTX-M-15, CTX-M-14, and CTX-M-32. Additionally, other resistance genes like tetA, dfrA14, dfrA17, sul1, sul2, aac(6')Ib, and aac(3)IIb were found to contribute to multidrug resistance.
Complete nucleotide sequence of pK245, a 98-kilobase plasmid conferring quinolone resistance and extended-spectrum-beta-lactamase activity in a clinical Klebsiella pneumoniae isolate.
The study identifies the plasmid pK245 carrying the qnrS quinolone resistance gene and the blaSHV-2 extended-spectrum beta-lactamase gene, along with other resistance genes such as aacC2, strA, strB, catA2, sul2, tetD, and dfrA14, which confer resistance to multiple antimicrobial classes in Klebsiella pneumoniae.
Recovery of a functional class 2 integron from an Escherichia coli strain mediating a urinary tract infection.
Recovery of a functional class 2 integron from an Escherichia coli strain mediating a urinary tract infection.
Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two year intervention on trimethoprim use.
The study identified various dfr genes, including dfrA1, dfrA17, dfrA5, dfrA7, dfrA8, dfrA12, dfrA14, dfrA24, and dfrA26, as major contributors to trimethoprim resistance in E. coli and K. pneumoniae. The distribution of these genes remained largely unchanged during the intervention period.
Molecular clonality and antimicrobial resistance in Salmonella enterica serovars Enteritidis and Infantis from broilers in three Northern regions of Iran.
The study identified multiple antimicrobial resistance genes, including aadA1, floR, dfrA14, sulI, and tetA, in Salmonella enterica serovars Enteritidis and Infantis from broilers in Iran. These genes were associated with resistance to streptomycin, florfenicol, trimethoprim, sulfamethoxazole, and tetracycline, respectively. Additionally, a single mutation in the gyrA gene was found to confer resistance to nalidixic acid and ciprofloxacin.
Resistance determinants and mobile genetic elements of an NDM-1-encoding Klebsiella pneumoniae strain.
The study identifies multiple antibiotic resistance genes in the NDM-1-encoding Klebsiella pneumoniae strain, including eight beta-lactamase genes and various other resistance determinants, highlighting the complexity of its resistance profile.
The contribution of Escherichia coli from human and animal sources to the integron gene pool in coastal waters., Nucleotide sequence and genetic analysis of the type Ib trimethoprim-resistant, Tn4132-encoded dihydrofolate reductase., A novel Salmonella genomic island 1 and rare integron types in Salmonella Typhimurium isolates from horses in The Netherlands.
Antimicrobial resistance characteristics and fitness of Gram-negative fecal bacteria from volunteers treated with minocycline or amoxicillin.
The study identified various AMR genes, including bla TEM, dfr, strB, tet(A), and tet(B), in Gram-negative fecal bacteria from volunteers treated with amoxicillin, minocycline, or placebo. The prevalence of these genes increased significantly in the amoxicillin-treated group.
Identification of dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae.
The study identifies dfrA14 in two distinct plasmids conferring trimethoprim resistance in Actinobacillus pleuropneumoniae, marking the first description of this gene in the Pasteurellaceae family.
Emergence of a Clonal Lineage of Multidrug-Resistant ESBL-Producing Salmonella Infantis Transmitted from Broilers and Broiler Meat to Humans in Italy between 2011 and 2014.
The study identifies the emergence of a multidrug-resistant ESBL-producing Salmonella Infantis clone transmitting from broilers and broiler meat to humans in Italy, harboring the bla CTX-M-1 and bla CTX-M-65 genes, along with resistance genes tet(A), sul1, dfrA1, and dfrA14.
SSTAR, a Stand-Alone Easy-To-Use Antimicrobial Resistance Gene Predictor.
The study presents SSTAR, a software tool for identifying antimicrobial resistance (AR) genes from whole-genome sequencing data. It detects known AR genes and potential new variants, including truncated forms. The tool was applied to analyze resistance genes in Klebsiella pneumoniae ST437 and Escherichia coli ST44, revealing various beta-lactamases, aminoglycoside resistance genes, and porin mutations contributing to resistance.
Emergence of Plasmid-Borne dfrA14 Trimethoprim Resistance Gene in Shigella sonnei.
The study identifies the dfrA14 gene as a plasmid-borne trimethoprim resistance gene in Shigella sonnei, which was detected in strains during an outbreak in Chile.
Comprehensive Genome Analysis of Carbapenemase-Producing Enterobacter spp.: New Insights into Phylogeny, Population Structure, and Resistance Mechanisms.
The study identifies multiple carbapenemase genes (bla KPC-2, bla KPC-3, bla KPC-4, and bla NDM-1) and other resistance genes (such as qnrB19, qnrB2, qnrS1, bla TEM-1A, bla TEM-1B, bla OXA-9, bla SHV-12, aadA2, aac(6')-Ib, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ic, strA, strB, sul1, sul2, dfrA14, dfrA18, mph(A), catB3, arr-3, and tet(D)) in carbapenem-resistant Enterobacter spp. These genes are primarily located on plasmids and contribute to multidrug resistance.
Panel strain of Klebsiella pneumoniae for beta-lactam antibiotic evaluation: their phenotypic and genotypic characterization.
The study characterizes various AMR genes and mutations in K. pneumoniae panel strains, including beta-lactamases (bla SHV-11, bla TEM-1, bla CTX-M15, bla OXA-1, bla SHV-12, bla SHV-187, bla SHV-158, bla DHA-1, bla CMY-2), aminoglycoside modifying enzymes (aac(6')-Ib, strA, strB, aadA1, aadA2), quinolone resistance genes (qnrB66, qnrB4, oqxA, oqxB), tetracycline resistance (tet(A)), trimethoprim resistance (dfrA14), sulfonamide resistance (sul1, sul2), and porin genes (OmpK35, OmpK36).
Marine Bivalve Mollusks As Possible Indicators of Multidrug-Resistant Escherichia coli and Other Species of the Enterobacteriaceae Family.
The study identified multiple AMR genes in E. coli isolates from marine bivalves, including bla TEM-1, bla CTX-M-14, bla CTX-M-15, and various aminoglycoside, trimethoprim, sulfonamide, tetracycline, chloramphenicol, quinolone, and macrolide resistance genes. These findings highlight the potential risk of MDR Enterobacteriaceae in marine environments.
Day-to-Day Dynamics of Commensal Escherichia coli in Zimbabwean Cows Evidence Temporal Fluctuations within a Host-Specific Population Structure.
The study identified a few antibiotic-resistant E. coli clones in Zimbabwean cows, including resistance to tetracycline, penicillins, and trimethoprim, but these were rare and subdominant.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Public health surveillance in the UK revolutionises our understanding of the invasive Salmonella Typhimurium epidemic in Africa.
The study identified the presence of the blaCTX-M-15 gene in a UK-isolated lineage 2 strain of Salmonella Typhimurium, highlighting the potential for spread of extended-spectrum beta-lactamase resistance.
VIM-1 carbapenemase-producing Escherichia coli isolated from retail seafood, Germany 2016.
The study identifies a VIM-1 carbapenemase-producing E. coli isolate from retail seafood in Germany, highlighting the presence of multiple resistance genes including blaVIM-1, aacA4, aadA1, aph(3')-XV, catB2, qnrS1, blaSHV-12, blaACC-1, strA-like, strB-like, dfrA14-like, mph(A), sul1, and sul2.
Impact of extensive antibiotic treatment on faecal carriage of antibiotic-resistant enterobacteria in children in a low resistance prevalence setting.
The study identified various AMR genes and mutations in E. coli isolates from children with cystic fibrosis, cancer, and healthy controls, highlighting differences in resistance profiles between groups.
A Novel IncA/C1 Group Conjugative Plasmid, Encoding VIM-1 Metallo-Beta-Lactamase, Mediates the Acquisition of Carbapenem Resistance in ST104 Klebsiella pneumoniae Isolates from Neonates in the Intensive Care Unit of V. Monaldi Hospital in Naples.
The study identifies a novel IncA/C1 conjugative plasmid, pIncAC_KP4898, which carries the blaVIM-1 gene and other resistance genes, mediating carbapenem resistance in ST104 Klebsiella pneumoniae isolates from neonates in the NICU of V. Monaldi Hospital in Naples.
High Prevalence of CTX-M-15-Type ESBL-Producing E. coli from Migratory Avian Species in Pakistan.
The study identified a high prevalence of CTX-M-15-type ESBL-producing E. coli in migratory avian species in Pakistan, highlighting the role of wild birds as reservoirs of multidrug-resistant bacteria and the potential for horizontal gene transfer of resistance determinants.
Impact of Wastewater Treatment on the Prevalence of Integrons and the Genetic Diversity of Integron Gene Cassettes.
The study identified various antibiotic resistance genes within integron gene cassettes in wastewater treatment plants, including aadA1, aadA2, aadA5, blaOXA-1, blaOXA-10, blaOXA-101, blaOXA-129, blaOXA-21, blaOXA-28, catB8, dfrA14, erm, qacE2, sul1, tet, orfD, and orfA, which confer resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, tetracyclines, and quaternary ammonium compounds.
Clinically Relevant ESBL-Producing K. pneumoniae ST307 and E. coli ST38 in an Urban West African Rat Population.
The study identifies clinically relevant ESBL-producing K. pneumoniae ST307 and E. coli ST38 in an urban West African rat population, highlighting the presence of multidrug-resistant strains carrying various resistance genes such as blaCTX-M-15, blaCTX-M-14, blaCTX-M-9, and others.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
An outbreak of a rare Shiga-toxin-producing Escherichia coli serotype (O117:H7) among men who have sex with men.
The study identified several AMR genes and mutations in STEC O117:H7 isolates, including the azithromycin resistance gene mphA, aadA1, aadA2, aadA5, blaTEM-1B, blaTEM-1C, dfrA1, dfrA12, dfrA14, dfrA, dfrA5, ermB, strA, strB, sul1, sul2, tet(A), tet(B), qnrs1, and a mutation in gyrA (S83L) associated with fluoroquinolone resistance.
Characterization of NDM-Encoding Plasmids From Enterobacteriaceae Recovered From Czech Hospitals.
The study characterized NDM-encoding plasmids from Enterobacteriaceae isolates in Czech hospitals, identifying blaNDM-1, blaNDM-4, and blaNDM-5 genes as the primary resistance determinants.
Draft genome sequence data of a tigecycline-resistant Enterobacter cloacae ST93 clinical strain isolated from bloodstream infection.
The study reports the draft genome sequence of a tigecycline-resistant Enterobacter cloacae ST93 clinical isolate, TREC1, which harbors multiple antimicrobial resistance genes, including those encoding resistance to beta-lactams, aminoglycosides, fluoroquinolones, fosfomycin, macrolides, lincosamides, streptogramin B, phenicols, sulfonamides, trimethoprim, and tetracyclines. The isolate is resistant to all antibiotics tested except colistin.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
The resistomes of six carbapenem-resistant pathogens - a critical genotype-phenotype analysis.
The study characterized the resistomes of six carbapenem-resistant pathogens, identifying various carbapenemase genes such as bla KPC-2, bla OXA-48, bla OXA-72, bla NDM-1, bla NDM-7, and bla VIM-1, along with other resistance genes like aac(6')-Ib-cr, aph(3")-Ib, aph(6)-Id, tet(B), erm(B), mph(A), sul1, sul2, dfrA17, dfrA14, bla CTX-M-15, bla CMY-6, bla OXA-1, bla SHV-200, bla OXA-10, and bla NDM-7.
The phylogeography and incidence of multi-drug resistant typhoid fever in sub-Saharan Africa.
The study identifies multiple AMR genes associated with multi-drug resistant (MDR) Salmonella Typhi in sub-Saharan Africa, including genes encoding resistance to aminoglycosides, beta-lactams, chloramphenicol, trimethoprim, sulfonamides, and tetracyclines. It also notes mutations in the gyrA gene associated with reduced susceptibility to fluoroquinolones.
Diarrheal bacterial pathogens and multi-resistant enterobacteria in the Choqueyapu River in La Paz, Bolivia.
The study identified multidrug-resistant Enterobacteriaceae in the Choqueyapu River, including E. coli and Enterobacter cloacae carrying bla CTX-M, bla KPC, bla NDM, bla VIM, and bla OXA-48 genes, highlighting the environmental spread of antibiotic resistance.
Quantitative contribution of efflux to multi-drug resistance of clinical Escherichia coli and Pseudomonas aeruginosa strains.
The study characterizes the role of efflux pumps in multidrug resistance of clinical E. coli and P. aeruginosa strains, showing that deletion of tolC and oprM significantly affects antibiotic susceptibility, but other resistance mechanisms persist.
Whole Genome Sequencing of Extended Spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae Isolated from Hospitalized Patients in KwaZulu-Natal, South Africa.
The study characterized multiple AMR genes in ESBL-producing K. pneumoniae isolates, including bla TEM-1B, bla CTX-M-15, bla SHV-1, bla OXA-1, aad AI6, aac (6′)Ib-cr, aph (6)Id, aph (3′)-Ib, oqx A, oqx B, fos A, ARR-3, sul 1, sul 2, dfr A14, dfr A27, cat A1, and cat B4.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Occurrence of Transferable Integrons and sul and dfr Genes Among Sulfonamide-and/or Trimethoprim-Resistant Bacteria Isolated From Chilean Salmonid Farms.
The study identified the presence of sul1, sul2, dfrA12, and dfrA14 genes in sulfonamide- and/or trimethoprim-resistant bacteria from Chilean salmonid farms, highlighting their potential for horizontal gene transfer through plasmids and integrons.
Whole-Genome Sequencing Analysis of Nontyphoidal Salmonella enterica of Chicken Meat and Human Origin Under Surveillance in Sri Lanka.
The study identified several AMR genes in nontyphoidal Salmonella enterica isolates from chicken meat and human sources in Sri Lanka, including blaCTX-M-15, fosA7, aph(6)-Id, tet(A), blaTEM-1B, qnrS1, sul3, and dfrA14.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Characterization of a carbapenem- and colistin-resistant Enterobacter cloacae carrying Tn6901 in bla (NDM-1) genomic context.
The study characterizes a carbapenem- and colistin-resistant Enterobacter cloacae strain, PIMB10EC27, which carries multiple resistance genes including blaNDM-1, blaSHV-12, and qnrS1, as well as mutations in pmrB and pmrC that may contribute to colistin resistance.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Commonality of Multidrug-Resistant Klebsiella pneumoniae ST348 Isolates in Horses and Humans in Portugal.
Emergence of Multidrug-Resistant Salmonella enterica Serovar Goldcoast Strains in Taiwan and International Spread of the ST358 Clone.
The study identifies multiple multidrug-resistant Salmonella enterica serovar Goldcoast strains in Taiwan, highlighting the emergence of an ST358 clone carrying various resistance genes, including blaCTX-M-55, mcr-1, and others, contributing to the rapid increase in infections.
Tracking Carbapenem-Producing Klebsiella pneumoniae Outbreak in an Intensive Care Unit by Whole Genome Sequencing.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CP-Kp) strains carrying various resistance genes, including blaKPC-2, blaNDM-1, and others, contributing to multidrug resistance. Plasmid analysis revealed the presence of resistance genes on different plasmids, highlighting the complexity of resistance mechanisms.
Clinical Resistome Screening of 1,110 Escherichia coli Isolates Efficiently Recovers Diagnostically Relevant Antibiotic Resistance Biomarkers and Potential Novel Resistance Mechanisms.
The study identifies several AMR genes including aac(3)-IIa, aac(6')-lb-cr, ant (2")-Ia, aph3'-1, dfrA14, dfrA17, sul1, and qnrB19, which confer resistance to Tobramycin, Ciprofloxacin, and Trimethoprim-Sulfamethoxazole. These genes were validated through cloning and MIC testing.
Evolution of Outbreak-Causing Carbapenem-Resistant Klebsiella pneumoniae ST258 at a Tertiary Care Hospital over 8 Years.
The study identifies various AMR genes in ST258 K. pneumoniae isolates, including blaKPC-2, blaKPC-3, aadA2, aadA1, blaTEM-1A, blaSHV-11, blaSHV-12, oqxA, oqxB, fosA, dfrA12, dfrA14, sul1, sul2, catA1, cml, and strAB, which confer resistance to multiple antibiotics.
Characterization of a Carbapenem-Resistant Kluyvera Cryocrescens Isolate Carrying Bla(ndm-1) from Hospital Sewage.
The study characterizes a carbapenem-resistant Kluyvera cryocrescens isolate carrying blaNDM-1 on a self-transmissible IncX3 plasmid, along with other resistance genes such as blaSHV-12, blaCTX-M-3, qnrS1, sul1, fosA, dfrA21, and dfrA14.
An African Salmonella Typhimurium ST313 sublineage with extensive drug-resistance and signatures of host adaptation.
The study identifies an extensively drug-resistant (XDR) sublineage II.1 of Salmonella Typhimurium ST313 in the Democratic Republic of the Congo, carrying resistance genes such as catA, blaTEM1, dfrA, blaSHV-2A, mphA, qnrS, and gyrA mutations, along with an IncHI2 plasmid pSTm-ST313-II.1.
The Resistome, Mobilome, Virulome and Phylogenomics of Multidrug-Resistant Escherichia coli Clinical Isolates from Pretoria, South Africa.
The study characterized the resistome, mobilome, and virulome of 20 multidrug-resistant E. coli isolates from Pretoria, South Africa. Key findings include the identification of various beta-lactamase genes (blaCTX-M-15, blaCTX-M-14, blaCTX-M-27, blaOXA-1, blaOXA-10, blaTEM-1B), aminoglycoside resistance genes (aac(3)-IIa, aac(3)-IId, aac(6')-Ib-cr, mph(A)), sulfonamide resistance genes (sul1, sul2, sul3), dihydrofolate reductase genes (dfrA17, dfrA14, dfrA1, dfrA5, dfrA7, dfrA12, dfrA23), tetracycline resistance genes (tet(A), tet(B)), chloramphenicol resistance genes (catB3, catA1), and fluoroquinolone resistance mutations in gyrA, gyrB, parC, and parE.
WGS based study of the population structure of Salmonella enterica serovar Infantis.
The study identified multiple resistance genes, including aadA1, sul1, tetA, and dfrA14, carried on a pESI-like plasmid in multidrug-resistant Salmonella enterica serovar Infantis strains.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
Evaluating the genome and resistome of extensively drug-resistant Klebsiella pneumoniae using native DNA and RNA Nanopore sequencing.
The study identified multiple AMR genes in extensively drug-resistant Klebsiella pneumoniae isolates, including beta-lactamases (blaSHV-11, blaTEM-1B, blaVEB-1, blaOXA-10, blaKPC-2, blaOXA-9, blaVIM-27, blaCTX-M-15, blaOXA-1, blaOXA-48), aminoglycoside resistance genes (aadA1, ant(2'')-Ia, aph(6)-Id, arr-2, aadA24, aph(3')-Ia, aph(6)-Id, aac(3)-IIa, aac(6')Ib-cr, aac(6')-Ib, aac(6')-Ib-cr), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet(A), tet(G)), trimethoprim resistance genes (dfrA1, dfrA14, dfrA23), chloramphenicol resistance genes (cmlA1, catB4), and others.
Complete Nucleotide Sequence of Plasmids of Two Escherichia coli Strains Carrying bla (NDM-) (5) and bla (NDM) (-) (5) and bla (OXA) (-) (181) From the Same Patient.
The study characterizes two carbapenemase-producing E. coli strains carrying blaNDM-5 and blaOXA-181, along with various other resistance genes such as qnrS1, blaCTX-M-15, aac(6')-lb-cr, catB3, sul1, dfrA17, qacEΔ1, aadA5, rmtB, ermB, mphA, tetB, catA1, dfrA14, dfrA12, blaTEM-1B, and blaCMY-42.
Whole Genome Sequencing of Escherichia coli From Store-Bought Produce.
The study identified various antimicrobial resistance genes in tetracycline-resistant E. coli strains from store-bought produce, highlighting the prevalence of multidrug resistance and the role of plasmids and integrons in the spread of resistance.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Exploration of risk factors for ceftriaxone resistance in invasive non-typhoidal Salmonella infections in western Kenya.
The study identified blaCTX-M-15, dfrA1, dfrA14, sul1, and sul2 as genes responsible for ceftriaxone resistance in invasive non-typhoidal Salmonella infections in western Kenya.
International clones of extended-spectrum β-lactamase (CTX-M)-producing Escherichia coli in peri-urban wild animals, Brazil.
The study identified various AMR genes in CTX-M-producing E. coli isolates from peri-urban wild animals in Brazil, including bla CTX-M-55, bla CTX-M-2, bla CTX-M-15, bla CTX-M-14, and others, indicating the presence of multidrug-resistant bacteria in wildlife.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Reservoirs of antimicrobial resistance genes in retail raw milk.
The study identifies multiple antimicrobial resistance genes in retail raw milk, including bla CMY-2, aph (3')-Ib, aph (6)-Id, bla TEM-1B, mdf(A), catA2, sul2, tet(B), and dfrA14, which confer resistance to various antibiotics. These genes were found in E. coli and other bacteria, and some were transferable between species.
Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae.
The study characterizes multidrug-resistant plasmids pA1705-qnrS, p911021-tetA, and p1642-tetA from Klebsiella pneumoniae, identifying several AMR genes including beta-lactamases (bla CTX-M-14, bla TEM-1, bla OXA-1, bla SHV-12, bla CTX-M-15, bla CTX-M-65), quinolone resistance gene qnrS1, tetracycline resistance genes tetA (A) and tetA (D), aminoglycoside resistance genes aacA4cr and aacC2, streptomycin resistance genes strA and strB, dihydrofolate reductase genes dfrA1 and dfrA14, sulfonamide resistance gene sul2, macrolide resistance gene mph (A), efflux pump gene oqxAB, chloramphenicol acetyltransferase gene catB3, and tunicamycin resistance gene tmrB.
Emerging Antimicrobial-Resistant High-Risk Klebsiella pneumoniae Clones ST307 and ST147.
The study identifies and characterizes the antimicrobial resistance genes and mutations associated with the high-risk Klebsiella pneumoniae clones ST307 and ST147, highlighting their global spread and the diversity of resistance mechanisms they employ.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans.
The study identifies a cluster of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae sequence type 101 isolated from food and humans, highlighting the potential role of food as a source of multidrug-resistant bacteria transmission to humans.
Using Therapeutic Drug Monitoring to Treat KPC-Producing Klebsiella pneumoniae Central Nervous System Infection With Ceftazidime/Avibactam.
The study identifies multiple AMR genes in a KPC-3-producing K. pneumoniae isolate, including blaKPC-3, aac(3)-Ib, aac(6')-Ib-cr, aph(3')-Ia, blaOXA-1, blaSHV-214, mphA, qacH, catB3, arr-3, sul1, and dfrA14, which confer resistance to various antibiotics.
Characterization of a New Transposon, Tn6696, on a bla (NDM-) (1)-Carrying Plasmid From Multidrug-Resistant Enterobacter cloacae ssp. dissolvens in China.
The study identifies a new transposon, Tn6696, on a blaNDM-1-carrying plasmid from a multidrug-resistant Enterobacter cloacae ssp. dissolvens strain, highlighting the role of this transposon in the horizontal transfer of carbapenem resistance.
The New Klebsiellapneumoniae ST152 Variants with Hypermucoviscous Phenotype Isolated from Renal Transplant Recipients with Asymptomatic Bacteriuria-Genetic Characteristics by WGS.
The study identified several AMR genes in two hypermucoviscous Klebsiella pneumoniae isolates from renal transplant recipients, including bla CTX-M-15, aac(6')-Ib-cr, and others, indicating resistance to various antibiotics.
Snapshot Study of Whole Genome Sequences of Escherichia coli from Healthy Companion Animals, Livestock, Wildlife, Humans and Food in Italy.
The study identified multiple antimicrobial resistance genes (ARGs) and mutations in Escherichia coli isolates from various sources in Italy, highlighting the prevalence of resistance to tetracycline, sulfonamide, penicillin, fluoroquinolone, and colistin. Key genes included tetA, sul2, blaTEM-1b, mcr-1, qnrS1, and others, along with mutations in gyrA, parC, parE, and pmrB.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
Salmonella identified in pigs in Kenya and Malawi reveals the potential for zoonotic transmission in emerging pork markets.
The study identified several AMR genes in Salmonella isolates from pigs in Kenya and Malawi, including dfrA14, sul2, aph(3''-1b), aph(6)-1d, blaTEM-1B, fosA7, tet(A), and tet(J). A single isolate with a gyrA(D87Y) mutation showed resistance to pefloxacin.
Whole-Genome Sequence Analysis of an Extensively Drug-Resistant Salmonella enterica Serovar Agona Isolate from an Australian Silver Gull (Chroicocephalus novaehollandiae) Reveals the Acquisition of Multidrug Resistance Plasmids.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Agona isolate from a silver gull, including bla CTX-M-55, dfrA14, sul3, qnrS1, tet(A), bla TEM-1, and others, indicating the acquisition of multidrug resistance plasmids.
Antimicrobial Resistance and Genomic Characterization of OXA-48- and CTX-M-15-Co-Producing Hypervirulent Klebsiella pneumoniae ST23 Recovered from Nosocomial Outbreak.
The study characterizes the AMR genes in a multidrug-resistant hypervirulent Klebsiella pneumoniae ST23 isolate, MAR14-456, which co-produces OXA-48 and CTX-M-15. The isolate shows resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Dissemination of Extended-Spectrum-β-Lactamase-Producing Enterobacter cloacae Complex from a Hospital to the Nearby Environment in Guadeloupe (French West Indies): ST114 Lineage Coding for a Successful IncHI2/ST1 Plasmid.
The study identifies the blaCTX-M-1 gene carried on an IncI1/ST3 plasmid in Enterobacter cloacae and Escherichia coli isolates from humans and wild animals in Guadeloupe, highlighting the dissemination of this resistance determinant in the environment.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
Colistin-resistant Enterobacter kobei carrying mcr-9.1 and bla(CTX-M-15) infecting a critically endangered franciscana dolphin (Pontoporia blainvillei), Brazil.
The study reports the emergence of the mcr-9.1 gene in a colistin-resistant Enterobacter kobei strain isolated from a critically endangered franciscana dolphin in Brazil, along with various other AMR genes.
Genomic Characterization of VIM and MCR Co-Producers: The First Two Clinical Cases, in Italy.
The study characterizes two clinical Enterobacter cloacae complex isolates co-producing VIM and MCR enzymes, identifying specific AMR genes and their resistance mechanisms.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
Resistome of a carbapenemase-producing novel ST232 Klebsiella michiganensis isolate from urban hospital effluent in South Africa.
The study reports the first carbapenemase-producing Klebsiella michiganensis isolate from South African hospital effluent, harboring multiple resistance genes including blaOXA-181, blaOXY-5-1, qnrB6, qnrS1, aadA16, aac(6')-Ib-cr, aph(6)-Id, arr-3, sul1, sul2, dfrA14, and dfrA27.
Distribution of Beta-Lactamase Producing Gram-Negative Bacterial Isolates in Isabela River of Santo Domingo, Dominican Republic.
The study identified several beta-lactamase genes, including bla TEM, bla OXA, bla SHV, and bla KPC, as well as other resistance genes such as CTX-M-15, CTX-M-55, OXA-1, OXA-72, OXA-132, KPC-3, QnrS1, QnrB19, sul2, sul1, dfrA12, dfrA14, dfrA17, mphA, aadA, aadA2, aadA5, ampC, ampC1, ampH, PmrF, bacA, and eptA, in various Gram-negative bacterial isolates from the Isabela River in the Dominican Republic.
Multidrug Resistant Klebsiella pneumoniae ST101 Clone Survival Chain From Inpatients to Hospital Effluent After Chlorine Treatment.
The study identifies multiple AMR genes and mutations in multidrug-resistant Klebsiella pneumoniae ST101 clone, including blaCTX-M-15, blaOXA-48, blaOXA-1, blaSHV-106, blaTEM-150, aac(3)-IIa, aac(6')-Ib-cr, oqxA10, oqxB17, fosA, catB3, dfrA14, tet(D), and mutations in mgrB, ompK35, gyrA, and parC.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Wild Boars Carry Extended-Spectrum β-Lactamase- and AmpC-Producing Escherichia coli.
Wild boars in Germany carry ESBL/AmpC-producing E. coli, with bla CTX-M-1, bla SHV-12, and bla CMY-2 being the most common beta-lactamase genes. Additional resistance genes include sul1, sul2, sul3, dfrA1, dfrA5, dfrA14, dfrA17, tet(A), cmlA, floR, and qnrS.
Investigating potential transmission of antimicrobial resistance in an open-plan hospital ward: a cross-sectional metagenomic study of resistome dispersion in a lower middle-income setting.
The study identified several AMR genes, including OXA-1, NDM-7, dfrA14, and catB3, which were associated with spatial distribution patterns in the hospital ward. These genes were linked to patient conditions such as tuberculosis and were influenced by factors like hospital length of stay and antibiotic use.
Antimicrobial Resistance Genes in ESBL-Producing Escherichia coli Isolates from Animals in Greece.
The study identified several AMR genes in ESBL-producing E. coli isolates from animals in Greece, including bla CTX-M-1/15, bla TEM, aadA1, aadA2, aphA, strA, strB, sul1, sul2, sul3, dfrA1, dfrA5, dfrA7, dfrA12, dfrA14, dfrA15, dfrA17, dfrA19, mph, mrx, intI1, tnpISE cp1, qnrS, and qnrB.
Characterization of beta-lactam-resistant Escherichia coli from Australian fruit bats indicates anthropogenic origins.
The study identified various beta-lactam-resistant Escherichia coli strains from Australian fruit bats, highlighting the presence of multiple AMR genes such as bla TEM-1A, bla TEM-1B, bla CTX-M-27, bla NDM-5, and others, indicating anthropogenic origins of these resistant strains.
Salmonella Typhi acquires diverse plasmids from other Enterobacteriaceae to develop cephalosporin resistance.
The study identifies plasmid-mediated cephalosporin resistance in Salmonella Typhi isolates from India, including bla SHV-12, bla TEM-1B, bla DHA-1, qnrB7, qnrB4, aac(6')Iaa, dfrA14, sul1, and sul2 genes. Chromosomal mutations in gyrA (S83F, D87N, S80I) and parC (S80I, E84K) contribute to fluoroquinolone resistance.
Presence of β-Lactamase-producing Enterobacterales and Salmonella Isolates in Marine Mammals.
The study identified various β-lactamase genes, including bla CMY-2, bla TEM-1, bla SHV-33, bla SHV-11, bla CTX-M-15, bla OXA-1, and bla DHA-1, along with non-β-lactamase resistance genes such as sul2, strA, strB, tet(A), and sul1, in Enterobacterales and Salmonella isolates from marine mammals.
Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.
The study reports an outbreak of NDM-1-producing Klebsiella pneumoniae in an ICU during the COVID-19 pandemic, highlighting the presence of multiple AMR genes including blaNDM-1, blaTEM-1, blaCTX-M-15, blaOXA-1, blaCMY-4, and others, along with mutations in ParC and GyrA contributing to quinolone resistance.
The genomic epidemiology of multi-drug resistant invasive non-typhoidal Salmonella in selected sub-Saharan African countries.
The study identified multiple AMR genes and mutations in invasive non-typhoidal Salmonella isolates from sub-Saharan Africa, highlighting the prevalence of multidrug resistance.
Emergence and Clonal Spread of CTX-M-65-Producing Escherichia coli From Retail Meat in Portugal.
The study identifies the blaCTX-M-65 gene in four multidrug-resistant Escherichia coli isolates from retail meat in Portugal, highlighting its chromosomal location and association with various resistance mechanisms.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Infective endocarditis caused by Enterobacteriaceae: phenotypic and molecular characterization of Escherichia coli and Klebsiella pneumoniae in Rio de Janeiro, Brazil.
The study identified several AMR genes in E. coli and K. pneumoniae isolates causing infective endocarditis, including genes conferring resistance to beta-lactams, aminoglycosides, sulfonamides, trimethoprim, fosfomycin, and fluoroquinolones. These genes were detected through molecular analysis and resistance profiling.
Antimicrobial Resistance and Type III Secretion System Virulotypes of Pseudomonas aeruginosa Isolates from Dogs and Cats in Primary Veterinary Hospitals in Japan: Identification of the International High-Risk Clone Sequence Type 235.
The study identifies various AMR genes and mutations in P. aeruginosa isolates from dogs and cats in Japan, highlighting the presence of high-risk clones like ST235 and the role of genetic factors in carbapenem and fluoroquinolone resistance.
Molecular Epidemiological Analysis of ST11-K64 Extensively Drug-Resistant Klebsiella pneumoniae Infections Outbreak in Intensive Care and Neurosurgery Units Based on Whole-Genome Sequencing.
The study identified multiple AMR genes in ST11-K64 XDRKp strains, including beta-lactamases, aminoglycoside resistance genes, and efflux pumps, contributing to extensive drug resistance.
Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales.
The study characterizes a pESI-like plasmid harboring multiple resistance genes, including bla CTX-M-65, in multidrug-resistant Salmonella enterica Infantis isolates from England and Wales. The plasmid was associated with resistance to beta-lactams, aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, sulfonamides, fosfomycin, and heavy metals.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Transmission Dynamics of Carbapenem-Resistant Klebsiella pneumoniae Sequence Type 11 Strains Carrying Capsular Loci KL64 and rmpA/rmpA2 Genes.
The study identified multiple AMR genes and mutations in ST11-KL64 CRKP isolates, including bla KPC-2, rmtB, catA2, fosA, qnrS1, sul2, tet(A), aadA2, dfrA14, bla CTX-M-65, bla SHV-12, bla TEM-1B, iucABCD, iutA, rmpA2, and mutations in GyrA (S83I, D87G) and ParC (S80I).
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
One Health Genomic Study of Human and Animal Klebsiella pneumoniae Isolated at Diagnostic Laboratories on a Small Caribbean Island.
The study identified various AMR genes in Klebsiella pneumoniae isolates from humans and animals on St. Kitts, including bla CTX-M-15, bla TEM-1b, bla TEM-206, bla OXA-1, and others, highlighting host-specific differences in resistance profiles.
NDM-1 Introduction in Portugal through a ST11 KL105 Klebsiella pneumoniae Widespread in Europe.
The study characterizes the first recognized outbreak of NDM-1-producing K. pneumoniae in Portugal, highlighting the introduction of a new ST11 KL105 strain carrying blaNDM-1 in a unique genetic context. Several antibiotic resistance genes, including blaNDM-1, blaCTX-M-15, and others, were identified, along with chromosomal mutations conferring reduced susceptibility to fluoroquinolones and fosfomycin.
Plethora of Resistance Genes in Carbapenem-Resistant Gram-Negative Bacteria in Greece: No End to a Continuous Genetic Evolution.
The study identified a variety of resistance genes in carbapenem-resistant Gram-negative bacteria, including bla KPC, bla NDM, bla VIM, and others, highlighting the complex genetic diversity of these pathogens.
Whole-Genome Sequencing of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli From Human Infections in Finland Revealed Isolates Belonging to Internationally Successful ST131-C1-M27 Subclade but Distinct From Non-human Sources.
The study identified several beta-lactamase genes, including bla CTX-M-27, bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, bla CTX-M-3, bla SHV-12, and bla TEM-1, which confer resistance to beta-lactam antibiotics. Other resistance genes such as aadA5, aph(3")-Ib, aph(6)-Id, mph(A), sul1, sul2, tet(A), and dfrA17, dfrA12, dfrA1, and dfrA14 were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates in Finland.
First Description of Ceftazidime/Avibactam Resistance in a ST13 KPC-70-Producing Klebsiella pneumoniae Strain from Portugal.
The study reports the first description of ceftazidime/avibactam resistance in a ST13 KPC-70-producing Klebsiella pneumoniae strain from Portugal. The strain was found to harbor the blaKPC-70 gene, a variant of blaKPC-3 with two amino acid substitutions (D179Y and T263A), which conferred resistance to several β-lactam antibiotics.
Genetic Characterization of Antibiotic Resistant Enterobacteriaceae Isolates From Bovine Animals and the Environment in Nigeria.
The study characterizes antibiotic resistance genes in Enterobacteriaceae isolates from bovine animals and the environment in Nigeria, identifying several beta-lactamase, aminoglycoside modifying enzymes, qnr, sulfonamide, tetracycline, and trimethoprim resistance genes, highlighting the presence of multidrug-resistant strains.
Genomic diversity and antimicrobial resistance among non-typhoidal Salmonella associated with human disease in The Gambia.
The study identified various antimicrobial resistance (AMR) genes in non-typhoidal Salmonella isolates from The Gambia, including aac(6')-Iaa_1, aph_3_Ib, aph_6_Id, dfrA14, dfrA7, dfrA8, blaTEM-1B, catA1_1, fosA7_1, mph_A, sul1, sul2, tet_A, and tet_B. These genes confer resistance to aminoglycosides, trimethoprim, beta-lactams, chloramphenicol, fosfomycin, macrolides, sulfonamides, and tetracyclines. The study also found that multidrug resistance (MDR) was primarily associated with Salmonella serovar Enteritidis, especially in the eastern region.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2019-2020.
The report highlights the presence of various antimicrobial resistance genes such as blaVIM-1, blaTEM-1B, blaTEM-1C, and cfr in different bacterial isolates, indicating resistance to carbapenems, beta-lactams, and macrolides/lincosamides/streptogramin B.
Using whole-genome sequence data to examine the epidemiology of antimicrobial resistance in Escherichia coli from wild meso-mammals and environmental sources on swine farms, conservation areas, and the Grand River watershed in southern Ontario, Canada.
The study identified several AMR genes in E. coli isolates from wild meso-mammals and environmental sources, including blaTEM-1, tet(A), tet(B), sul1, sul2, aph(3”)-Ib, aph(6)-Id, blaCMY-2, qnrS1, and floR. These genes conferred resistance to various antibiotics such as beta-lactams, tetracyclines, sulfonamides, aminoglycosides, and quinolones.
The Current Landscape of Antibiotic Resistance of Salmonella Infantis in Italy: The Expansion of Extended-Spectrum Beta-Lactamase Producers on a Local Scale.
The study identified multiple antimicrobial resistance genes in Salmonella Infantis strains from Italy, including blaCTX-M-1, aadA1, dfrA1, dfrA14, sul1, and tet(A), which contribute to resistance against various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, sulfonamides, and tetracyclines.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Comparison of Two Distinct Subpopulations of Klebsiella pneumoniae ST16 Co-Occurring in a Single Patient.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae ST16 isolates, including bla NDM-4, bla OXA-181, and a frameshift mutation in acrR, contributing to carbapenem and fluoroquinolone resistance.
Characterization of Klebsiella pneumoniae isolated from patients suspected of pulmonary or bubonic plague during the Madagascar epidemic in 2017.
The study identified several AMR genes in K. pneumoniae isolates, including bla CTX-M-15, bla SHV-27, bla SHV-1, bla SHV-101, bla SHV-108, bla TEM-1B, qnrB66, aac(3)-IIa, dfrA14, strA, strB, sul2, and tet(A). These genes conferred resistance to various antibiotics such as beta-lactams, quinolones, aminoglycosides, sulfonamides, and tetracyclines.
Characterization of qnrB-carrying plasmids from ESBL- and non-ESBL-producing Escherichia coli.
The study characterized qnrB-carrying plasmids from ESBL- and non-ESBL-producing E. coli, identifying qnrB1, qnrB2, and qnrB19 as major quinolone resistance determinants. These plasmids were found to be self-transmissible and associated with various resistance genes.
Hybrid Plasmids Encoding Antimicrobial Resistance and Virulence Traits Among Hypervirulent Klebsiella pneumoniae ST2096 in India.
The study characterizes hybrid plasmids in MDR-HvKp ST2096 isolates from India, identifying multiple AMR genes such as bla NDM-5, bla OXA-232, aadA2, armA, and others, along with virulence genes like rmpA2 and iucABCD.
Submarine Outfalls of Treated Wastewater Effluents are Sources of Extensively- and Multidrug-Resistant KPC- and OXA-48-Producing Enterobacteriaceae in Coastal Marine Environment.
The study identified extensively drug-resistant (XDR) and multidrug-resistant (MDR) KPC- and OXA-48-producing Enterobacteriaceae in coastal marine environments, highlighting the presence of various AMR genes including bla KPC-2, bla OXA-48, and others.
Occurrence and Genomic Characterization of Clone ST1193 Clonotype 14-64 in Uncomplicated Urinary Tract Infections Caused by Escherichia coli in Spain.
The study identified the occurrence of fluoroquinolone-resistant ST1193 clone in uncomplicated urinary tract infections (uUTI) caused by Escherichia coli in Spain. Several AMR genes and mutations were characterized, including blaTEM-1B, aph(3')-Ib, aph(6)-Id, mdf(A), mph(A), sul2, dfrA14, dfrA17, sitABCD, and chromosomal mutations in gyrA (S83L, D87N), parC (S80I), and parE (L416F).
Genomic epidemiology and temperature dependency of hypermucoviscous Klebsiella pneumoniae in Japan.
The study identifies multiple AMR genes and mutations in hypermucoviscous Klebsiella pneumoniae isolates from Japan, highlighting the presence of ESBLs, carbapenemases, and other resistance determinants. It also reveals temperature-dependent variations in the HMV phenotype and the genetic diversity of the isolates.
KPC-3-, GES-5-, and VIM-1-Producing Enterobacterales Isolated from Urban Ponds.
The study identified bla KPC-3, bla GES-5, and bla VIM genes in various Enterobacterales isolates from urban ponds, highlighting their role in carbapenem resistance.
Genomic dissection of Klebsiella pneumoniae infections in hospital patients reveals insights into an opportunistic pathogen.
The study identifies multiple AMR genes and mutations in Klebsiella pneumoniae isolates, including bla CTX-M-15, bla IMP-4, bla OXA-48, qnrB1, qnrS1, aac(6')-Ib-cr, rmtB, aac(6')-Ib4, aadA2, ant(2")-Ia, ermB, arr-2, dfrA14, sul2, and sul1, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, aminoglycosides, and sulfonamides.
Epidemiological Characteristics of OXA-232-Producing Carbapenem-Resistant Klebsiella pneumoniae Strains Isolated during Nosocomial Clonal Spread Associated with Environmental Colonization.
The study identified OXA-232-producing carbapenem-resistant Klebsiella pneumoniae (CRKP) strains that exhibited multidrug resistance, including resistance to carbapenems, cephalosporins, aminoglycosides, and quinolones. The strains were part of a clonal spread within the ICU, showing genetic similarities and carrying resistance genes such as blaOXA-232, blaCTX-M-15, blaSHV-106, and others.
Cross-Sectional Survey of Antibiotic Resistance in Extended Spectrum β-Lactamase-Producing Enterobacteriaceae Isolated from Pigs in Greece.
The study identified a high prevalence of ESBL-producing Enterobacteriaceae in Greek pigs, with a focus on resistance mechanisms involving bla CTX-M1/15, bla TEM, and bla SHV genes, as well as resistance to fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and colistin.
Characterization of β-Lactamases and Multidrug Resistance Mechanisms in Enterobacterales from Hospital Effluents and Wastewater Treatment Plant.
The study identified several β-lactamase genes, including bla CTX-M-27, bla TEM-1, bla CTX-M-15, bla CTX-M-30, and bla SHV-12, along with a variety of other AMR genes such as aadA5, aph(3''-Ib), aph(6)-Id, aac(3)-IIa, sul1, sul2, dfrA17, dfrA14, qnrB1, tet(A), mph(A), qacE∆, and catB3, which confer resistance to various antibiotics in Enterobacterales isolated from hospital effluents and wastewater treatment plants.
Genomic Analysis of Two MDR Isolates of Salmonella enterica Serovar Infantis from a Spanish Hospital Bearing the bla(CTX-M-65) Gene with or without fosA3 in pESI-like Plasmids.
The study reports two multidrug-resistant (MDR) isolates of Salmonella enterica serovar Infantis from Spain carrying the blaCTX-M-65 gene on pESI-like plasmids, along with other resistance genes such as floR, aac(3)-IVa, aph(3′)-Ia, aph(4)-Ia, aadA1, tet(A), sul1, dfrA14, and fosA3. Mutations in gyrA and parC were associated with fluoroquinolone resistance, while truncations in nsfA and nsfB were linked to nitrofurantoin resistance.
Antimicrobial susceptibility and genomic profiling of Salmonella enterica from bloodstream infections at a tertiary referral hospital in Lusaka, Zambia, 2018-2019.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella enterica isolates, including blaTEM-1B, catA1, sul2, sul1, dfrA7, dfrA14, and mutations in gyrA, gyrB, and parC. These resistance mechanisms contribute to multidrug resistance and emerging resistance to ciprofloxacin and cephalosporins.
Proposal of a Method for Harmonized Broth Microdilution Antimicrobial Susceptibility Testing of Avibacterium gallinarum.
The study identified several antimicrobial resistance genes in Avibacterium gallinarum, including bla TEM, dfrA14, sul2, tet(B), and tet(H), which confer resistance to various antibiotics such as penicillin, trimethoprim, sulfamethoxazole, and tetracyclines.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.
The study identified multiple antibiotic resistance genes and mutations in invasive Salmonella isolates from Nigeria, highlighting the prevalence of multidrug-resistant S. Typhi 3.1.1 and other serovars carrying resistance determinants such as blaTEM-1, aph(3')-Ib, catA1, dfrA14, sul2, tetA, and qnrB19.
Spatiotemporal Investigation of Antibiotic Resistance in the Urban Water Cycle Influenced by Environmental and Anthropogenic Activity.
The study identified several AMR genes, including carbapenemases (cphA5, cphA7, imiH, ESP-1), colistin resistance gene mcr-7.1, aminoglycoside resistance genes (aadA, aph(6)-Id, aph(3')-Ib), sulfonamide/trimethoprim resistance genes (sul1, dfrA15, dfrA14), and multidrug efflux pumps (MexB, OpmH, MexK) in various bacterial isolates from urban water samples.
Molecular characterization of multi drug resistant Escherichia coli isolates at a tertiary hospital in Abuja, Nigeria.
The study identified several AMR genes in multi-drug resistant E. coli isolates, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-27, bla CTX-M-65, bla OXA-1, bla OXA-2, bla CMY-2, bla NDM-1, bla NDM-5, aac(3)-IId, aac(3)-IIe, aac(6')-Ib-cr, aad A5, ant(2′′)-Ia, aph(3′′)-Ib, aph(3′′)-VI, aph(6)-Id, ermB, ermD, fosA3, fosA7, mdtM, emrD, sul1, sul2, sul3, tetA, tetB, tetM, dfrA1, dfrA7, dfrA8, dfrA12, dfrA14, dfrA17, dfrA82, dfrB4, qepA, qepA1, qepA2, qepA4, qnrB19, qnrS1, qacE, catA1, catA2, catB3, cmlA1, mphA.
Clinical Efficacy, Antibiotic Resistance Genes, Virulence Factors and Outcome of Hospital-Acquired Pneumonia Induced by Klebsiella pneumoniae Carbapenemase 2-Producing with Tigecycline Treatment in the ICU.
The study identified several antibiotic resistance genes, including blaKPC-2, blaSHV, blaCTX-M, blaTEM, and aac3iia, which are associated with resistance to various antibiotics. Additionally, virulence factors such as AREO-iutA and Capsule-wzc were found to be independently associated with mortality in patients with KPC-KP infections.
Draft Genome Sequences of Multidrug-Resistant Escherichia coli Isolated from River Water.
The study reports the draft genome sequences of seven multidrug-resistant Escherichia coli strains isolated from river water, identifying various antibiotic resistance genes and mutations associated with resistance to multiple antibiotics.
Whole genome sequencing of OXA-232-producing wzi93-KL112-O1 carbapenem-resistant Klebsiella pneumoniae in human bloodstream infection co-harboring chromosomal ISEcp1-based bla (CTX-M-15) and one rmpA2-associated virulence plasmid.
The study characterizes an OXA-232-producing ST15 CRKP strain with a multidrug-resistant profile, harboring chromosomal bla CTX-M-15 and plasmid-mediated bla OXA-232, along with other resistance genes such as strAB, rmtF, sul2, dfrA14, qnrB1, arr-2, and catB. Mutations in gyrA (S83F) and parC (S80I) contribute to fluoroquinolone resistance.
Human pandemic K27-ST392 CTX-M-15 extended-spectrum β-lactamase-positive Klebsiella pneumoniae: A one health clone threatening companion animals.
The study identifies a multidrug-resistant K. pneumoniae strain (LCKp01) carrying the bla CTX-M-15 gene and other clinically important AMR genes, highlighting the global spread of this clone in both human and animal populations.
Emergence of a Novel Lineage and Wide Spread of a bla(CTX-M-15)/IncHI2/ST1 Plasmid among Nosocomial Enterobacter in Guadeloupe.
The study identifies the bla CTX-M-15 gene as the most prevalent ESBL determinant in ESBL-producing Enterobacter cloacae complex isolates, along with the IncHI2/ST1 plasmid. It also reports the presence of other resistance genes such as mcr-9, aac(3)-IIa, aac(6′)-Ib-cr, aph(3″)-Ib, aph(6)-Id, bla OXA-1, bla TEM-1B, qnrB1, fosA, sul2, tet(A), dfrA14, ars, mer, tni, and the ter operon.
Whole genome sequencing and characteristics of extended-spectrum beta-lactamase producing Escherichia coli isolated from poultry farms in Banaskantha, India.
The study identified multiple extended-spectrum beta-lactamase (ESBL) genes, including bla TEM, bla SHV, bla OXA, and bla CTX-M subtypes, along with plasmid-mediated AMR genes such as qnrS1, tetA, dfrA14, sul2, aph(3")-lb, aph(6)-ld, and Aph(3')-la in ESBL-producing E. coli isolates from poultry farms in India.
Pathogenome comparison and global phylogeny of Escherichia coli ST1485 strains.
The study identifies multiple antibiotic resistance genes, including blaTEM-1, aph(3')-Ib, aph(6)-Id, sul2, dfrA14, and mcr-1, in Escherichia coli ST1485 strains, highlighting their multidrug-resistant nature and potential zoonotic risk.
Genomic Study of Chromosomally and Plasmid-Mediated Multidrug Resistance and Virulence Determinants in Klebsiella Pneumoniae Isolates Obtained from a Tertiary Hospital in Al-Kharj, KSA.
The study identified several AMR genes in K. pneumoniae isolates, including blaOXA-1, blaCTX-M-3, blaOXA-232, catB3, aac(6')-Ib-cr, dfrA14, IntI1, IS1, RepE, qnrB4, qnrB55, qnrS1, aph(3")-Ib, sul2, aadA2, SHV-190, SHV-26, SHV-11, tet(A), fosA, OqxA, and OqxB, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, trimethoprim, quinolones, sulfonamides, and fosfomycin.
Vaginal Bacteria in Mares and the Occurrence of Antimicrobial Resistance.
The study identified several AMR genes in E. coli isolates from mares, including dfrA14 for trimethoprim resistance, mdf(A) for chloramphenicol resistance, sul2 for sulfonamide resistance, blaEC for beta-lactam resistance, and aph(6)-Id for streptomycin resistance.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Characterization of Escherichia coli and other bacteria isolated from condemned broilers at a Danish abattoir.
The study identified several AMR genes in E. coli isolates from condemned broiler carcasses, including beta-lactamase genes (bla TEM-1B, bla TEM-1C, bla TEM-220, bla TEM-106, bla TEM-135, bla TEM-126, bla TEM-127), sulfonamide resistance gene (sul 2), aminoglycoside resistance genes (aph (6)-Id, aph (3")-Ib, aph (3')-Ia, aad A1, aad A5, aac (3)- Via), trimethoprim resistance genes (dfr A1, dfr A14, dfr A15, dfr A17), tetracycline resistance genes (tet (A), tet (B)), and a macrolide resistance gene (mdf (A)).
Coexistence of Multidrug Resistance and Virulence in a Single Conjugative Plasmid from a Hypervirulent Klebsiella pneumoniae Isolate of Sequence Type 25.
The study identifies a conjugative plasmid pCY814036-iucA carrying multidrug resistance genes and virulence factors, and another plasmid pCY814036-KPC2 harboring bla KPC-2 and rmtB, contributing to carbapenem resistance and hypervirulence in a Klebsiella pneumoniae isolate.
A Cross-Validated Feature Selection (CVFS) approach for extracting the most parsimonious feature sets and discovering potential antimicrobial resistance (AMR) biomarkers.
The study presents a Cross-Validated Feature Selection (CVFS) approach for identifying the most parsimonious gene sets for predicting antimicrobial resistance (AMR) from bacterial pan-genomes. The CVFS approach was able to extract both known and novel AMR genes, demonstrating its effectiveness in selecting relevant features for AMR prediction.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Whole-Genome Sequencing Snapshot of Clinically Relevant Carbapenem-Resistant Gram-Negative Bacteria from Wastewater in Serbia.
The study identified several AMR genes and mutations in carbapenem-resistant Gram-negative bacteria from wastewater in Serbia, highlighting the presence of multidrug-resistant isolates with resistance to various antibiotics, including carbapenems, aminoglycosides, fluoroquinolones, and colistin.
Epidemiological characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic analysis of Aeromonas caviae isolated from extra-intestinal infections.
The study identified multiple antimicrobial resistance genes in Aeromonas caviae isolates from extra-intestinal infections, including blaMOX, blaPER-3, blaOXA, blaNDM, blaCphA, qnrS2, qnrVC, aac(6')-Ib-cr, tet(A), tet(E), tet(31), dfrA1, dfrA12, dfrA14, dfrA15b, floR, catB3, catII, and catI, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, tetracyclines, trimethoprim, and chloramphenicol.
Enterobacterales plasmid sharing amongst human bloodstream infections, livestock, wastewater, and waterway niches in Oxfordshire, UK.
The study identifies various AMR genes, including bla TEM-1, aph(3'')-Ib, aph(6)-Id, dfrA5, sul2, and robA, which are associated with plasmids shared among human bloodstream infections, livestock, wastewater, and waterways in Oxfordshire, UK.
Analysis of Antimicrobial Resistance Genes (ARGs) in Enterobacterales and A. baumannii Clinical Strains Colonizing a Single Italian Patient.
The study identified various antimicrobial resistance genes in Enterobacterales and A. baumannii clinical strains from a single patient, highlighting the presence of blaNDM-1, qnrS1, aadA1, strA-strB, sul2, tet(J), catA1, blaACT-15, blaTEM-1B, dfrA14, oqxB, fosA, blaLEN-22, blaOXA-23, blaADC-25, blaOXA-66, armA, mph(E), msr(E), and tetB, indicating multidrug resistance and potential for horizontal gene transfer.
Antimicrobial Resistance in Vaginal Bacteria in Inseminated Mares.
The study identified several AMR genes in E. coli, S. equisimilis, and S. simulans, including sul1, sul2, dfrA1, dfrA14, tet(A), mdf(A), blaEC-5, blaTEM-1, blaTEM-1B, blaEC, catB3, aadA5, aph(6)-ld, lsaC, and blaZ, which conferred resistance to various antibiotics.
Mobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production line.
The study identifies multiple antimicrobial resistance genes in Salmonella isolates from a poultry production line, highlighting the role of mobile genetic elements in the spread of multidrug resistance.
The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China.
The study identifies multiple antimicrobial resistance genes in Salmonella enterica isolates from China, highlighting the increasing prevalence of resistance to beta-lactams, quinolones, tetracyclines, and sulfonamides. Key genes include blaTEM-1B, blaCTX-M-14, aac(3)-IV, and mcr-1.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Within-patient and global evolutionary dynamics of Klebsiella pneumoniae ST17.
The study identified the presence of the bla CTX-M-15 gene, which confers resistance to extended-spectrum beta-lactams, along with other AMR genes such as aac(3)-IIa, bla TEM1-D, strAB, dfrA14, sul2, and catA2 in Klebsiella pneumoniae ST17. The yersiniabactin gene was also found to be present in the genomes.
Molecular epidemiology of enterically colonizing Escherichia coli with resistance against third-generation cephalosporins isolated from stool samples of European soldiers with concomitant diarrhea on deployment in Western African Mali.
The study identified bla CTX-M-15 and bla TEM-1b as the primary genes responsible for third-generation cephalosporin resistance in E. coli isolates from European soldiers in Mali. Additionally, several quinolone resistance genes including qnrS1, gyrA S83L, gyrA D87N, parE S458T, parE S458A, and parC S80I were found. Trimethoprim-sulfamethoxazole resistance was mediated by sul1, sul2, dfrA1, dfrA5, dfrA14, and dfrA17. Gentamicin resistance was associated with aph6-Id, aph3-Ib, aac3-IId, aadA5, and aac6-Ib-cr5. Tetracycline resistance was conferred by tetA, tetB, and tetD.
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
The study identified multidrug-resistant non-typhoidal Salmonella in migratory birds in Bangladesh, highlighting the presence of various AMR genes such as blaCARB-2, floR, sul1, tet(G), dfrA1, and mutations in gyrA and parC associated with quinolone resistance.
Whole-genome sequencing and phylogenetic analysis capture the emergence of a multi-drug resistant Salmonella enterica serovar Infantis clone from diagnostic animal samples in the United States.
The study identifies a multidrug-resistant Salmonella infantis clone harboring a pESI-like megaplasmid with the blaCTX-M-65 gene, which confers resistance to ceftriaxone and ampicillin. Several other AMR genes, including aac(3)-IVa, aadA1, aph(4)-Ia, sul1, tetA, floR, dfrA14, and fosA, were also characterized.
Role of multidrug resistance and co-resistance on a high percentage of streptomycin resistance in Escherichia coli isolated from chicken meats in Japan.
The study identifies multiple AMR genes, including strA/strB, blaTEM, tetB, aphA1, dfrA14, dfrA17, and cat1, which contribute to multidrug resistance in Escherichia coli isolated from chicken meats in Japan.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
From Farm to Fork: Persistence of Clinically Relevant Multidrug-Resistant and Copper-Tolerant Klebsiella pneumoniae Long after Colistin Withdrawal in Poultry Production.
The study identified silA and pcoD genes associated with copper tolerance in Klebsiella pneumoniae isolates from poultry, and numerous chromosomal mutations linked to colistin resistance.
Case report: A successfully treated case of community-acquired urinary tract infection due to Klebsiella aerogenes in Bangladesh.
The study identifies several AMR genes in a multidrug-resistant Klebsiella aerogenes strain, including genes conferring resistance to aminoglycosides, beta-lactams, fluoroquinolones, and others. The strain was found to be susceptible to carbapenems and polymyxins.
Investigation of multidrug-resistant plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates from Pakistan.
The study identified 34 antimicrobial resistance genes (ARGs) in multidrug-resistant (MDR) plasmids from carbapenemase-producing Klebsiella pneumoniae clinical isolates in Pakistan, including bla NDM-1, bla OXA-48, and various beta-lactamases, aminoglycoside resistance genes, and others.
The impact of applying various de novo assembly and correction tools on the identification of genome characterization, drug resistance, and virulence factors of clinical isolates using ONT sequencing.
The study evaluates the impact of various de novo assembly and read correction tools on the identification of antimicrobial resistance (AMR) genes, plasmids, and virulence factors in clinical Escherichia coli isolates using Oxford Nanopore sequencing. It highlights the effectiveness of Flye and Canu in detecting AMR genes and the importance of read correction tools like Medaka and Racon in improving assembly quality and AMR gene detection.
Poultry production as the main reservoir of ciprofloxacin- and tigecycline-resistant extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198.2-2 causing human infections in China.
The study identifies several AMR genes and mutations in Salmonella enterica serovar Kentucky ST198.2-2, including blaCTX-M-14b, blaCTX-M-55, blaTEM-1B, aadA7, aph(3')-Ia, aac(3)-IId, rmtB, tet(A), sul1, dfrA14, floR, lnu(F), mph(A), arr-2, and fosA3, which confer resistance to various antibiotics. Mutations in gyrA and parC also contribute to fluoroquinolone resistance.
Isolation and characterization of multidrug resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens.
The study identified 25 different antimicrobial resistance genes in multidrug-resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens, including tetB, blaTEM-1, blaROB-1, floR, sul2, sul3, dfrK, aadA1, aadA2, aph(3)-la, aph(3)-lb, aph(6)-ld, sat2, dfrA14, dfrA32, merC, merP, merR, merT, qacL, and cmlA1.
Co-localization of clinically relevant antibiotic- and heavy metal resistance genes on plasmids in Klebsiella pneumoniae from marine bivalves.
The study identifies multiple antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) co-localized on plasmids in Klebsiella pneumoniae isolated from marine bivalves, highlighting the potential for co-selection of these genes in the marine environment.
Plasmids conferring resistance to extended-spectrum beta-lactamases including a rare IncN+IncR multireplicon carrying bla(CTX-M-1) in Escherichia coli recovered from migrating barnacle geese ( Branta leucopsis).
The study identified several AMR genes in ESBL/AmpC-producing E. coli isolates from barnacle geese, including bla(CTX-M-1), bla(CTX-M-15), bla(CMY-2), aadA2b, lnu(F), and qnrS1, which confer resistance to various beta-lactams, aminoglycosides, lincomycin, and quinolones.
Clonal expansion and rapid characterization of Klebsiella pneumoniae ST1788, an otherwise uncommon strain spreading in Wales, UK.
The study identified several AMR genes in Klebsiella pneumoniae ST1788, including blaSHV-232, blaCTX-M-15, blaCTX-M-266, blaOXA-1, blaTEM-1, aac(3')-lla, aac(6')-lb-cr, strA, strB, qnrB1, dfrA14, sul2, and blaOXA-48. These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, trimethoprim, sulfamethoxazole, and carbapenems.
Outbreak of OXA-232-producing carbapenem-resistant Klebsiella pneumoniae ST15 in a Chinese teaching hospital: a molecular epidemiological study.
The study identified the presence of multiple AMR genes, including blaOXA-232, blaCTX-M-15, blaSHV-28, fosA, oqxA, oqxB, tet(E), AAC(6')-Ib, APH(3'')-Ib, APH(6)-Id, TEM-1, sul2, QnrB17, QnrB1, dfrA14, arr-2, AAC(6')-Ib9, and rmtF, in OXA-232-producing CRKP isolates from a hospital outbreak in China.
Virulence Factors and Antimicrobial Resistance of Uropathogenic Escherichia coli EQ101 UPEC Isolated from UTI Patient in Quetta, Balochistan, Pakistan.
The study identified multiple antimicrobial resistance genes in the E. coli EQ101 isolate, including genes involved in antibiotic efflux, inactivation, and drug replacement. Key resistance genes include TolC, emrR, evgA, qacEdelta1, H-NS, cpxA, mdtM, aadA5, mphA, CTX-M-15, sul1, and dfrA14.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Polyclonal Multidrug ESBL-Producing Klebsiella pneumoniae and Emergence of Susceptible Hypervirulent Klebsiella pneumoniae ST23 Isolates in Mozambique.
The study identified multiple AMR genes in Klebsiella isolates, including bla CTX-M-15, bla TEM-1, bla SHV, and bla OXA-1, which confer resistance to beta-lactams. Other genes like aac(3)-IIa, aac(6')-Ib-cr, qnrB1, qnrB6, catA1, catA2, catB3, dfrA5, dfrA7, dfrA12, dfrA14, dfrA27, sul1, sul2, mph(A), tet(A), tet(D), fosA, ARR-3, and oqxAB were also found, contributing to resistance against aminoglycosides, quinolones, chloramphenicol, trimethoprim, sulfamethoxazole, macrolides, tetracycline, fosfomycin, rifampicin, and quinolones respectively. Mutations in ompK36, ompK37, and acrR were associated with resistance to cephalosporins and fluoroquinolones, while mutations in RamR were linked to tigecycline resistance.
Comparative Genomic Analysis Reveals the Emergence of ST-231 and ST-395 Klebsiella pneumoniae Strains Associated with the High Transmissibility of bla(KPC) Plasmids.
The study identifies multiple AMR genes, including blaOXA-232, blaCTX-M-15, dfrA14, aac(6')-Ib-cr, and others, in K. pneumoniae isolates, highlighting the role of integrons and plasmids in the dissemination of resistance.
Unveiling the genome of a high-risk pandrug-resistant Klebsiella pneumoniae emerging in the Brazilian Amazon Region, 2022.
The study identified a pandrug-resistant Klebsiella pneumoniae strain (Kp196) with a complex resistome comprising numerous acquired and intrinsic resistance mechanisms, including multiple beta-lactamases, aminoglycoside-modifying enzymes, quinolone resistance proteins, and mutations in genes involved in colistin, tigecycline, and fluoroquinolone resistance.
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Occurrence and temporal distribution of extended-spectrum β-lactamase-producing Escherichia coli in clams from the Central Adriatic, Italy.
The study identified several β-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla SHV12, bla CMY-2, bla TEM-1B, bla TEM-106, and bla TEM-126, which confer resistance to various β-lactam antibiotics. Other resistance genes such as aac(6′)-Ib-cr, qnrS1, tet(A), tet(B), tet(M), aadA5, aadA2b, sul1, sul2, sul3, dfrA17, dfrA5, dfrA14, dfrA12, mph(A), cmlA1, catA2, aac(3)-IIa, aac(3)-IId, and lnu(F) were also characterized, providing insights into the multidrug resistance profiles of ESBL-producing E. coli isolates from clams in the Central Adriatic.
Prevalence and genomic characterization of Salmonella isolates from commercial chicken eggs retailed in traditional markets in Ghana.
The study identified several AMR genes and mutations in Salmonella isolates from chicken eggs in Ghana, including aadA1, aph(3")-Ib, aph(6)-Id, catA1, dfrA1, dfrA14, fosA7.2, qnrB19, sul1, sul2, and tet(A), as well as mutations in gyrA (D87N) and gyrA (S83Y).
Within-host genetic diversity of extended-spectrum beta-lactamase-producing Enterobacterales in long-term colonized patients.
The study characterizes various AMR genes, including bla CTX-M-15, bla TEM-1B, bla OXA-1, qnrB1, qnrS1, aph(6)-Id, aph(3”)-Ib, aac(3)-IIa, ant(3”)-Ia, dfrA14, dfrA1, aac(6’)-Ib-cr, tet(A), tet(D), sul2, sul1, fosA6, fosA_5, fosA_3, bla CTX-M-1, bla CTX-M-14, bla CTX-M-14b, bla CTX-M-8, bla CMY-2, bla TEM-190, aac(3)-IVa, aph(4)-Ia, and catB3_2, in ESBL-producing Enterobacterales isolates from long-term colonized patients.
Impact of systemic antimicrobial therapy on the faecal microbiome in symptomatic dairy cows.
The study identified AmpC-producing Escherichia coli strains carrying the blaCMY-2 gene, which conferred resistance to third-generation cephalosporins. Other resistance genes such as aph(6)-Id, dfrA14, and sul2 were also detected, providing resistance to streptomycin, trimethoprim, and sulfonamides, respectively.
Metagenomic identification of pathogens and antimicrobial-resistant genes in bacterial positive blood cultures by nanopore sequencing.
The study identified various antimicrobial resistance (AMR) genes in bacterial positive blood cultures using nanopore sequencing, demonstrating the effectiveness of this method in detecting resistance mechanisms and pathogens quickly.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
In-depth characterization of multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates from Italian hospital patients.
The study characterized multidrug-resistant NDM-1 and KPC-3 co-producing Klebsiella pneumoniae bloodstream isolates, identifying several AMR genes and mutations associated with resistance to various antibiotics.
Outbreak of NDM-5-producing Klebsiella pneumoniae ST307: an emerging high-risk antimicrobial resistance clone in Shanghai, China.
The study reports an outbreak of NDM-5-producing Klebsiella pneumoniae ST307 in Shanghai, China, highlighting the presence of multiple resistance genes including bla NDM-5, bla CTX-M-15, and bla DHA-1, which confer resistance to carbapenems, cephalosporins, and other antibiotics.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease.
The study characterizes three ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198 strains from a single patient with inflammatory bowel disease, highlighting their multidrug-resistant profile and potential epidemiological links to strains from chicken meat.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Multidrug-Resistant Bacteria in Surgical Intensive Care Units: Antibiotic Susceptibility and β-Lactamase Characterization.
The study identified OXA-48 carbapenemase in 82.9% of K. pneumoniae isolates and NDM in 7.3%. bla CTX-M-15, bla SHV, and bla OXA-1 were also detected. Additionally, aac(6")-Ib, dfrA14, oqxA, and oqxB were found to confer resistance to aminoglycosides, trimethoprim, and fluoroquinolones.
Genomic analysis of multidrug-resistant Escherichia coli from Urban Environmental water sources in Accra, Ghana, Provides Insights into public health implications.
The study identified several AMR genes in multidrug-resistant E. coli isolates from urban environmental water sources in Accra, Ghana, highlighting the presence of beta-lactamases (blaTEM-1B, blaCTX-M-15, blaTEM-1C, blaDHA-1, blaOXA-1, blaOXA-181), sulfonamide resistance genes (sul2, sul1), aminoglycoside resistance genes (aph(6)-Id, aadA2, mph(A)), quinolone resistance gene (qnrS1), tetracycline resistance gene (tet(B)), chloramphenicol resistance gene (catA1), dihydrofolate reductase (dfrA14), and others.
Genetics of resistance to trimethoprim in cotrimoxazole resistant uropathogenic Escherichia coli: integrons, transposons, and single gene cassettes.
The study identifies various dfrA gene cassettes, including dfrA1, dfrA5, dfrA7, dfrA8, and dfrA14, as the primary genetic determinants of trimethoprim resistance in cotrimoxazole-resistant uropathogenic E. coli strains. These genes are found in class 1 and 2 integrons, as well as in transposons.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Pathogenomics analysis of high-risk clone ST147 multidrug-resistant Klebsiella pneumoniae isolated from a patient in Egypt.
The study identifies multiple AMR genes in the MDR-KP isolate WSF99, including various beta-lactamases, carbapenemase, aminoglycoside modifying enzymes, fluoroquinolone resistance genes, and others, highlighting the complex resistance profile of this high-risk clone.
A newly identified IncY plasmid from multi-drug-resistant Escherichia coli isolated from dairy cattle feces in Poland.
The study identifies two IncY plasmids from multi-drug-resistant E. coli isolated from dairy cattle feces in Poland, carrying resistance genes against beta-lactams, aminoglycosides, tetracyclines, trimethoprim/sulfamethoxazole, and fluoroquinolones.
Mobile genetic elements define the non-random structure of the Salmonella enterica serovar Typhi pangenome.
The study identifies multiple AMR genes, including blaTEM-1B, qnrS1, sul2, tet(A), aph(3'')-Ib, aph(6)-Id, dfrA14, blaCTX-M-15, blaCTX-M-88, catA1, qacE, sul1, and tet(B), which are associated with multidrug-resistant and extensively drug-resistant Salmonella enterica serovar Typhi strains.
Host species shapes genotype, antimicrobial resistance, and virulence profiles of enterotoxigenic Escherichia coli (ETEC) from livestock in the United States.
The study identifies distinct antimicrobial resistance (AMR) gene profiles in bovine and swine enterotoxigenic Escherichia coli (ETEC) isolates, highlighting differences in the prevalence of specific AMR genes and plasmid replicons between the two host species.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
The ISVsa3-ORF2-abh-tet(X4) circular intermediate-mediated transmission of tigecycline resistance in Escherichia coli isolates from duck farms.
The study identifies the tet(X4) gene in E. coli isolates from duck farms, demonstrating its presence in a circular intermediate and its ability to transfer via conjugation, highlighting the potential for widespread tigecycline resistance.
Geneticand phenotypic characterization of a novel ST45-K43 carbapenem-resistant Klebsiella pneumoniae strain causing bloodstream infection: a potential clinical threat.
The study identifies a novel ST45-K43 carbapenem-resistant Klebsiella pneumoniae strain, 18SHX166, carrying multiple antimicrobial resistance genes including bla KPC-2, oqxA, oqxB, fosA7, bla SHV26, aph(3′)-Ia, bleO, tet(A), dfrA14, and bla TEM1B. The strain exhibits multidrug resistance and high transmissibility.
Genomic Characteristics of a Carbapenem-Resistant Klebsiella pneumoniae Co-Carrying bla (NDM-5) and bla (KPC-2) Capsular Type KL25 Recovered from a County Level Hospital in China.
The study reports the genomic characteristics of a multidrug-resistant ST11 Klebsiella pneumoniae isolate SM117 with capsular serotype KL25, co-carrying bla NDM-5, two copies of bla KPC-2, and multiple plasmid-borne virulence genes. The isolate shows resistance to all antibiotics except polymyxin.
Molecular characterization, virulence and antimicrobial and biocidal susceptibility of selected bacteria isolated from the cloaca of nestling ospreys (Pandion haliaetus) from Mono Lake, California, USA.
The study identified several AMR genes and mutations in bacteria isolated from the cloaca of nestling ospreys, including bla CTX-M-55, bla EC, tet (A), floR, sul3, dfrA14, aac(3)-IIa, ampC, fosA5, sal (A), blaZ, tet (M), and pbp5. Mutations in gyrA, parC, parE, ompK36, ompK37, rpoB, and pbp5 were also detected, contributing to resistance against various antibiotics.
Genomic Characterization of Extended-Spectrum β-Lactamase-Producing and Third-Generation Cephalosporin-Resistant Escherichia coli Isolated from Stools of Primary Healthcare Patients in Ethiopia.
The study identified multiple antimicrobial resistance genes in E. coli isolates, including bla CTX-M-15, bla TEM-1B, tet(A), qnrS1, and others, highlighting the prevalence of multidrug resistance in the region.
Comprehensive Genomic Analysis of Uropathogenic E. coli: Virulence Factors, Antimicrobial Resistance, and Mobile Genetic Elements.
The study identified numerous antimicrobial resistance genes and mutations in uropathogenic E. coli isolates, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and quinolone resistance genes. Mutations in gyrA, parC, parE, and marR were associated with fluoroquinolone resistance, while mutations in PmrB, CyaA, GlpT, PtsI, and UhpT were linked to fosfomycin resistance.
Genomic analysis of Enterobacteriaceae from colorectal cancer patients at a tertiary hospital in Ghana: a case-control study.
The study identified various antimicrobial resistance genes in Enterobacteriaceae isolated from colorectal cancer patients and healthy controls, including ampC2, ampH, strA, strB, mphA, sul1, sul2, tetA, tetR, and dfrA14.
Analyzing Antibiotic Resistance in Bacteria from Wastewater in Pakistan Using Whole-Genome Sequencing.
The study identifies several AMR genes and mutations in wastewater isolates from Pakistan, highlighting the presence of carbapenemases like blaNDM-5 and blaOXA-1, as well as quinolone resistance determinants such as gyrA and parC mutations. These findings emphasize the role of wastewater as a reservoir for clinically relevant AMR genes.
Antimicrobial Resistance in Wastewater Samples from Kumasi, Ghana: A Genomic and Metagenomic Analysis
The study identified several AMR genes and mutations in P. aeruginosa and K. pneumoniae isolates from wastewater samples in Kumasi, Ghana, highlighting the presence of multidrug-resistant strains carrying genes such as blaCTX-M-15, blaOXA-488, and qnrVC1, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
A nosocomial outbreak of colistin and carbapenem-resistant hypervirulent Klebsiella pneumoniae in a large teaching hospital.
Survey in ruminants from Rwanda revealed high diversity and prevalence of extended-spectrum cephalosporin-resistant Enterobacterales.
The study identified various extended-spectrum cephalosporin-resistant Enterobacterales in ruminants from Rwanda, including multiple beta-lactamase genes such as bla CTX-M-15, bla TEM-1, and others, along with non-beta-lactam resistance genes like tet(A), sul2, and qnrS1.
Genome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
The study identified various AMR genes in Shigella isolates from Fujian Province, including beta-lactamases (bla TEM-1, bla OXA-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-55, bla CTX-M-64), macrolide resistance genes (mphA, ermB), tetracycline resistance genes (tetA, tetB), aminoglycoside resistance genes (aadA, aph(3')-Ib, aac(3)-IId), chloramphenicol resistance gene (catA1), and sulfonamide/trimethoprim resistance genes (sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA17).
Genomic surveillance detects interregional spread of New Delhi metallo-beta-lactamase-1-producing Providencia stuartii in hospitals, Romania, December 2021 to September 2023.
The study identifies the spread of NDM-1-producing Providencia stuartii in Romania, highlighting the presence of multiple resistance genes including bla NDM-1, bla OXA-10, bla CMY-4, bla CMY-16, bla CMY-194, qnrD2, armA, aph(3')-VI, aac(6')-Ib3, rmtC, dfrA14, dfrA12, sul1, and sul2.
Multidrug-resistant ESBL-producing Klebsiella pneumoniae complex in Czech hospitals, wastewaters and surface waters.
The study identified multidrug-resistant Klebsiella pneumoniae complex isolates carrying various beta-lactamase genes such as bla CTX-M-15, bla GES-51, bla OXA-48, bla NDM-1, and bla KPC-3, along with other resistance genes like oqxA, oqxB, sul2, aph(6)-Id, dfr14, qnrB1, and aac(6')-Ib-cr.
Two outbreak cases involving ST65-KL2 and ST11-KL64 hypervirulent carbapenem-resistant Klebsiella pneumoniae: similarity and diversity analysis.
The study identifies two outbreak cases of hypervirulent carbapenem-resistant Klebsiella pneumoniae (hvCRKP) strains, ST65-KL2 and ST11-KL64, highlighting their distinct resistance mechanisms and virulence profiles.
Emergence of mcr-8.1-bearing MDR-hypervirulent Klebsiella pneumoniae ST307.
The study identifies the colistin resistance gene mcr-8.1 in multidrug-resistant Klebsiella pneumoniae ST307 isolates from Armenia, highlighting the emergence of this gene in the region.
Characterizing Methicillin-Resistant Staphylococcus spp. and Extended-Spectrum Cephalosporin-Resistant Escherichia coli in Cattle.
The study identified several AMR genes in E. coli and MRSA isolates from cattle in Austria, including bla CTX-M-1/15, bla CTX-M-9, bla TEM, tet (A), tet (B), dfrA1, dfrA5, dfrA14, dfrA17, sul2, sul3, aadA1, aadA2, floR, cmlA, aphA, and bla ACT. Additionally, the MRSA isolate carried the mecA gene, indicating methicillin resistance.
Fecal carriage of ESBL-producing E. coli and genetic characterization in rural children and livestock in the Somali region, Ethiopia: a one health approach.
The study identified bla CTX-M-15 as the most prevalent ESBL gene in both human and animal E. coli isolates, along with other resistance genes such as bla TEM-1B, bla OXA-1, and various aminoglycoside, sulfonamide, and trimethoprim resistance genes. Mutations in gyrA, parC, and parE were also associated with fluoroquinolone resistance.
Phenotypic and Genomic Characterization of ESBL- and AmpC-β-Lactamase-Producing Enterobacterales Isolates from Imported Healthy Reptiles.
The study identified multiple ESBL and AmpC β-lactamase genes, including bla CTX-M-15, bla CTX-M-55, bla CTX-M-3, bla CTX-M-27, bla CTX-M-65, bla SHV-12, bla SHV-42, bla DHA-1, bla CMY-2, bla CMY-3, bla CMY-46, bla CMY-101, bla ACT-16, bla CMH-like, and bla MIR-9, along with other AMR genes such as mcr-1, qnrS1, aac(6')-Ib-cr5, and various tetracycline, aminoglycoside, sulfonamide, chloramphenicol, macrolide, lincosamide, and rifampicin resistance genes in Enterobacterales isolates from imported healthy reptiles.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Multidrug-resistant ST11-KL64 hypervirulent Klebsiella pneumoniae with multiple bla- genes isolated from children's blood.
An exploration of unusual antimicrobial resistance phenotypes in Salmonella Typhi from Blantyre, Malawi reveals the ongoing role of IncHI1 plasmids.
Highly drug resistant clone of Salmonella Kentucky ST198 in clinical infections and poultry in Zimbabwe.
The study identifies multiple AMR genes and mutations in Salmonella Kentucky ST198 strains from Zimbabwe, highlighting their multidrug resistance and the presence of specific resistance mechanisms such as blaCTX-M-14.1 and mutations in gyrA and parC.
Assessment of Antibiotic Resistance Among Isolates of Klebsiella spp. and Raoultella spp. in Wildlife and Their Environment from Portugal: A Positive Epidemiologic Outcome.
The study identified a single multidrug-resistant (MDR) and extended-spectrum beta-lactamase (ESBL)-producing K. pneumoniae isolate from soil samples carrying multiple resistance genes, including bla CTX-M-15, bla TEM-1, bla SHV-28, bla OXA-1, qnr B1, oqx A, oqx B19, aac (6′)-Ibcr, sul 2, dfr A14, tet A, aph (6)-Id, aph (3″)-Ib, acr D, cat B3, and Int I1.
Circulation of a Unique Klebsiella pneumoniae Clone, ST147 NDM-1/OXA-48, in Two Diverse Hospitals in Calabria (Italy).
The study identifies multiple AMR genes, including bla OXA-48, bla NDM-1, bla CTX-M-15, and bla SHV, in K. pneumoniae strains from two hospitals in Calabria, Italy, highlighting the presence of multidrug-resistant clones.
Wastewater based genomic surveillance key to population level monitoring of AmpC/ESBL producing Escherichia coli.
The study identified various AMR genes and mutations in AmpC/ESBL-producing E. coli from wastewater samples in Finland, highlighting the prevalence of blaCTX-M-15, blaCTX-M-27, and other resistance determinants.
Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinical Aeromonas complex.
The study identified multiple beta-lactamase genes, including bla NDM-1, bla PER-3, and bla OXA-1, along with other resistance genes such as aac(6′)-Ib-cr6, aph(3″)-Ib, and floR, which contribute to resistance against various antibiotics in Aeromonas isolates.
Carbapenem-Resistant, Virulence Plasmid-Harboring Klebsiella pneumoniae, United States.
The study identifies six pVir-CRKP isolates from the United States, highlighting their multidrug resistance and enhanced virulence traits. These isolates exhibit resistance to various antibiotics, including carbapenems, cephalosporins, fluoroquinolones, and aminoglycosides, due to the presence of specific AMR genes and mutations.
Broiler litter moisture and trace metals contribute to the persistence of Salmonella strains that harbor large plasmids carrying siderophores.
The study identified several antimicrobial resistance genes in Salmonella strains isolated from broiler litter, including aadA1, aac(3)-IV, aph(3′)-Ia, aph(4)-Ia, dfrA14, floR, sul1, tetA, sul2, merRTPCA, qacE, aph(3″)-Ib, aph(6)-Id, pcoABCDRE, silP, and silE. These genes were found on various plasmids and contributed to resistance against multiple antibiotics such as streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, mercury, quaternary ammonium compounds, copper, and silver.
Next-generation diagnostics of bloodstream infections enabled by rapid whole-genome sequencing of bacterial cells purified from blood cultures.
The study presents a rapid whole-genome sequencing workflow (LC-WGS) for diagnosing bloodstream infections, demonstrating accurate identification of bacterial pathogens and detection of clinically relevant resistance markers within 4.2 hours. The workflow successfully identified various AMR genes, including bla CTX-M-15, bla DHA-1, bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-23, armA, mecA, vanRSHAXYZ, aac(6')-Ie/aph(2'')-Ia, aph(3')-IIIa, aac(6')-I, sul1, and dfrA17.
Whole-Genome Sequencing of Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae Isolated from Human Bloodstream Infections.
The study identified multiple AMR genes in ESBL-producing K. pneumoniae isolates, including blaCTX-M-15, blaKPC-3, and others conferring resistance to β-lactams, aminoglycosides, fluoroquinolones, sulfonamides, tetracyclines, and chloramphenicol.
Polyclonal carbapenemase-producing Escherichia coli in Northern Italy: the emergence of NDM-7.
The study identifies the emergence of NDM-7 in polyclonal carbapenemase-producing E. coli in Northern Italy, highlighting the presence of various carbapenemase genes such as bla KPC-3, bla VIM-1, and bla NDM-7, along with other resistance genes.
Recent emergence of cephalosporin-resistant Salmonella Typhi in India due to the endemic clone acquiring IncFIB(K) plasmid encoding bla (CTX-M-15) gene.
The study identifies the emergence of a new clone of ceftriaxone-resistant Salmonella Typhi in India, which acquired an IncFIB(K) plasmid encoding the bla(CTX-M-15) gene, along with other resistance determinants such as qnrS1, sul2, dfrA14, tet(A), aph(3"), and aph(6').
Genomic characterization of extended-spectrum β-lactamase-producing Escherichia coli spread among chickens and healthy residents in Lombok, Indonesia.
The study identifies bla CTX-M-55, bla CTX-M-15, bla CTX-M-1, bla CMY-2, and bla DHA-1 as the most prevalent extended-spectrum β-lactamase genes in E. coli isolates from chickens and humans in Lombok, Indonesia. Additionally, the study characterizes a 200 kb IncHI1 plasmid carrying multiple resistance genes, including aac(3)-IId, aph(6)-Id, aph(3’’)-Ib, aadA17, mph(A), Inu(F), qnrS1, sul2, and dfrA14, contributing to multidrug resistance.
Antimicrobial susceptibility trends of S. Typhi and S. Paratyphi in a post-COVID-19 pandemic India, from a multicenter surveillance network.
The study identified several antimicrobial resistance genes including blaCTX-M-15, qnrS1, sul2, dfrA14, and tet(A) in ceftriaxone-resistant S. Typhi isolates. A S83F mutation in gyrA was associated with reduced susceptibility to ciprofloxacin.
Genomic Characterization of NDM-1 Harboring Extensively-Drug Resistance Klebsiella pneumoniae Isolate From ICU-Admitted Patient With COVID-19.
The study identified multiple antimicrobial resistance genes in an extensively drug-resistant Klebsiella pneumoniae isolate, including bla NDM-1, armA, msrE, mphE, BRP, bla OXA-1, aadA2, dfrA12, qnrB1, bla CTX-M-15, and cat1, highlighting the complex resistance mechanisms in this isolate.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
Genome-Based Molecular Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Plasmid-Mediated Co-Occurrence of mcr-1.1 in Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli Isolated From the Indigenous Seminomadic Community in Malaysia.
The study identifies the presence of mcr-1.1, bla TEM, bla CTX-M−15, bla CTX-M−55, and other resistance genes in ESBL-producing E. coli isolates from the Jehai community in Malaysia, highlighting the co-occurrence of multiple antibiotic resistance mechanisms.
Drug resistant Klebsiella pneumoniae from patients and hospital effluent: a correlation?
The study identified multiple antibiotic resistance genes in clinical Klebsiella pneumoniae isolates, including bla TEM, bla SHV, bla CTX-M, and bla OXA families, as well as aminoglycoside, fluoroquinolone, and sulfonamide resistance genes. Effluent isolates showed fewer resistance genes and lower resistance levels compared to clinical isolates.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
Molecular characterization of multidrug-resistant E. coli recovered from diarrheagenic children under 5 years from Mukuru Informal Settlement, Nairobi, Kenya, based on whole-genome sequencing analysis.
The study identified multiple AMR genes and mutations in multidrug-resistant E. coli isolates from diarrheagenic children in Nairobi, Kenya, highlighting the presence of blaTEM-1B, blaCTX-M-15, qnrS1, qnrB4, aac(6')-Ib-cr, and other resistance mechanisms.
The pet café is a neglected site for transmission of antimicrobial-resistant Escherichia coli in urban life.
The study identifies multiple antimicrobial resistance genes (ARGs) in Escherichia coli isolates from pet cafés, highlighting the role of plasmids in the transmission of these genes. Key ARGs include tet(X4), sul2, sul3, strA, strB, dfrA14, qnrS1, qnrS2, oqxB, blaCTX-M-15, blaCTX-M-14, blaCTX-M-65, floR, and tet(A).
Transmissible antimicrobial resistance in Escherichia coli isolated from household drinking water in Ibadan, Nigeria.
The study identified several AMR genes in E. coli isolates from household water in Ibadan, Nigeria, including blaTEM-1B, dfrA14, tetA, qnrS1, and mcr-1, highlighting the potential for horizontal gene transfer and the risk of AMR spread in the environment.
Molecular characterization of multidrug-resistant Escherichia coli in the Greater Accra Region, Ghana: a 'One Health' approach.
The study identified multidrug-resistant Escherichia coli isolates carrying various AMR genes, including blaTEM-1B, tetA, sul2, aph(3'')-Id, dfrA14, qnrS1, and blaCTX-M-15, highlighting the spread of resistance mechanisms in the Greater Accra Region.
Comprehensive analysis of extensive drug-resistant Salmonella Typhi in Gujarat region, India: genomic findings and prospective alternative therapy.
The study identified multiple AMR genes and mutations in extensive drug-resistant Salmonella Typhi isolates from Gujarat, India, including aph(3'')-Ib, aph(6)-Id, bla CTX-M, dfrA14, qnrS1, sul2, tet(A), mdtK, and gyrA mutations, contributing to resistance against various antibiotics such as tetracycline, fluoroquinolones, and beta-lactams.
Clonal dissemination and persistence of Carbapenem-resistant bla (KPC-2) harbouring Klebsiella pneumoniae ST307 in a Tertiary Hospital in the Republic of Korea.
Emergence and characteristics of multidrug-resistant Salmonella enterica subspecies enterica serovar Infantis harboring the pESI plasmid in chicken slaughterhouses in South Korea.
The study identifies multidrug-resistant Salmonella enterica subsp. enterica serovar Infantis isolates harboring the pESI plasmid, which carries genes such as bla CTX-M-65, aadA1, dfrA14, sul1, tetA, and floR, leading to resistance against multiple antibiotics including third-generation cephalosporins.
Trimethoprim resistance in Escherichia coli exhibits an allele-specific growth advantage.
The study identifies that specific dfrA alleles, such as dfrA1, dfrA5, dfrA7, dfrA14, and dfrA17, confer trimethoprim resistance in E. coli. The growth behavior of isolates carrying these alleles varies, with some showing a faster growth phenotype in the presence of trimethoprim.
Dogs fed raw meat-based diets are vectors of drug-resistant Salmonella infection in humans.
Multidrug-resistant Klebsiella pneumoniae ST70 harboring bla(NDM) in a migratory Penguin.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Klebsiella pneumoniae ST70 isolate from a Magellanic Penguin, highlighting the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms.
Whole-Genome Sequencing and Bioinformatics Analysis of ESBL-producing Klebsiella pneumoniae in a Ghanaian teaching hospital.
The study identified multiple beta-lactamase genes, including bla SHV, bla CTX-M-15, bla TEM-1B, and bla OXA-1, as well as a variety of other resistance genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3'')-Ib, aph(6)-Id, aadA1, qnrB1, qnrB4, qnrB2, qnrB19, sul2, sul1, dfrA14, dfrA15, OqxA, OqxB, fosA, qacE, tetA, and tetD. Mutations in ompK36 and ompK37 were also found to contribute to reduced susceptibility to cephalosporins and carbapenems.
Antimicrobial resistance and biofilm formation in rarely reported Salmonella enterica serovars from patients presenting with gastroenteritis in Nairobi, Kenya.
Three Salmonella Newport isolates carried acquired antimicrobial resistance genes, including bla TEM −1 , tet(A), aph(6)-Id, dfrA14, and sul2. These genes conferred resistance to ampicillin, tetracycline, trimethoprim-sulfamethoxazole, and gentamicin.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars detected in poultry retail meat in North Carolina, USA.
The study identifies the clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars in poultry retail meat in North Carolina, USA. It characterizes the resistance profiles of these isolates, including the presence of bla(CTX-M-65), aac(3)-Iva, aadA1, aph(4)-Ia, floR, mdsA, mdsB, sul1, tet(A), dfrA14, aph(3')-Ia, sul2, aph(3'')-Ib, and fosA3.
Genomic characterization of an ESBL-producing Klebsiella pneumoniae ST37 recovered from a hospitalized patient in Armenia.
The study identified several AMR genes in the ESBL-producing K. pneumoniae ST37 isolate ARM02, including blaTEM-1D, blaSHV-11, dfrA14, sul2, strA, strB, and blaCTX-M-15, which were directly linked to the observed resistance phenotypes.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Clonal Dissemination of Pandrug-Resistant Klebsiella pneumoniae ST392KL27 in a Tertiary Care Hospital in Mexico.
Research note: Emergence of bla(NDM-13) producing Escherichia coli from a broiler chicken and farm environment in Jiangsu Province, China.
The study identified blaNDM-13-producing E. coli strains in a chicken farm in Jiangsu Province, China, which exhibit multidrug resistance, including resistance to carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and florfenicol. The study also characterizes the plasmids carrying blaNDM-13 and confirms their ability to transfer between bacteria.
Molecular epidemiology of pESI-carrying Salmonella Infantis in Korea: insights from a one health framework.
The study identifies multiple antimicrobial resistance genes and a quinolone resistance mutation in pESI-carrying Salmonella Infantis isolates from the Korean poultry production chain, highlighting the potential for zoonotic transmission.
Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria.
The study identified various AMR genes in Klebsiella spp. isolates from human, animal, and food sources, including strB, qnrS1, sul2, tetA, dfrA14, blaTEM-1, and blaSHV-11, which conferred resistance to multiple antibiotics.
Multidrug-Resistant pESI-Harboring Salmonella enterica Serovar Muenchen Sequence Type 82 in Poultry and Humans, Israel, 2020-2023.
Whole-genome sequencing reveals Enterobacter hormaechei as a key bloodstream pathogen in six tertiary care hospitals in southwestern Nigeria.
The study identifies several AMR genes in Enterobacter hormaechei and Enterobacter cloacae, including bla ACT-45, bla CTX-M-15, bla NDM-1, dfrA14, mcr10.1, aac(3)-Ile, aph(3′)-Ib, qnrB1, sul1, sul2, tet(A), catA1, and mphA, highlighting the prevalence of multidrug resistance in these species.
Genomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
The study identified high levels of antimicrobial resistance in Shigella boydii, with over 60% of isolates classified as multidrug-resistant. Key resistance genes included blaCTX-M-15, blaCTX-M-3, blaDHA-1, mphA, sul1, sul2, dfrA1, dfrA14, dfrA5, dfrA12, dfrA17, dfrA7, aadA1, aph(3’’)-Ib, aph(6)-Id, tet(A), and tet(B). Mutations in gyrA and parC were associated with ciprofloxacin resistance and reduced susceptibility.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Genomic characterization of Klebsiella pneumoniae clinical isolates from cancer patients: resistance profiles, virulence factors, and sequence typing.
The study identified several AMR genes in K. pneumoniae isolates from cancer patients, including genes conferring resistance to trimethoprim-sulfamethoxazole, tobramycin, levofloxacin, and carbapenems. Key resistance genes included sul1, sul2, dfrA1, dfrA12, dfrA14, dfrA27, aadA16, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aph(4)-Ia, ACC(3)-IId, ACC(3)-IIV, AAC(6')-Ib-cr, QnrS1, QnrB17, QnrB20, QnrB4, CTX-M, SHV, TEM, DHA-1, LAP-2, bla_kpc-1, bla_ndm-5, and bla_oxa-10.
Multidrug resistant hypervirulent ST307 clone from genomic surveillance of extended spectrum beta-lactamase-producing Klebsiella pneumoniae species complex in East Africa.
The study identifies multiple AMR genes, including blaCTX-M-15, blaTEM-1D, aac(6')-Ib-cr, aadA16, strB, qnrS1, sul2, sul1, catII.2, tet(A), dfrA14, arr-3, and mphA, in ESBL-KpSC isolates from East Africa, highlighting the prevalence of multidrug resistance.
Genomic characterization of two distinct Klebsiella pneumoniae strains in a fatal case of relapsed acute myelogenous leukemia: a case report.
The study identified two distinct Klebsiella pneumoniae strains, ST147 and ST967, with varying resistance profiles. ST147 isolates harbored multiple resistance genes including bla OXA−181, aadA, aadA5, bla CTX−M−15, bla OXA−1, bla SHV−11, bla TEM−1, sul1, qnrS1, and tet(A), while ST967 had a more limited resistome with aac(3)-IIa, bla SHV−27, and dfrA14.
Genomic Characterization and Resistance Mechanisms of Carbapenem-Resistant Klebsiella pneumoniae ST101 Isolates from Saudi Arabia.
The study identifies bla_OXA-48 and bla_NDM-1 carbapenemase genes in CRKP ST101 isolates from Saudi Arabia, highlighting their role in carbapenem resistance and the complexity of resistance mechanisms in high-risk clones.
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
Detection and Preliminary Genomic Characterization of Poultry-Derived Salmonella enterica from Southern Kazakhstan.
The study identified multidrug-resistant Salmonella enterica isolates from poultry farms in southern Kazakhstan, with universal fluoroquinolone resistance and plasmid-borne AMR genes such as blaTEM-116, tet(A), sul1, ant(3")-Ia, and dfrA14.
Nucleotide sequence and genetic analysis of the type Ib trimethoprim-resistant, Tn4132-encoded dihydrofolate reductase.
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