Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dihydrofolate reductase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrA20 | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Pasteurella multocida | - | 2005 | AJ605332 | CAE53424.1 |
| DfrA20 |
Card DatabaseReference Gene CatalogResFinder DatabaseReslit |
| 9 |
| Trimethoprim, TRIMETHOPRIM |
| Pasteurella multocida +7 |
| France, Europe, Kenya, Nigeria |
| 2005, 2016, 2020, 2021, 2025 |
| AJ605332 |
| CAE53424.1 |
dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.
dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.
The study identifies dfrA20, a novel trimethoprim resistance gene from Pasteurella multocida, which confers resistance to trimethoprim through a plasmid-mediated mechanism.
dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.
dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.
dfrA20, A novel trimethoprim resistance gene from Pasteurella multocida.
Comparative genomics of Clostridium bolteae and Clostridium clostridioforme reveals species-specific genomic properties and numerous putative antibiotic resistance determinants.
The study identified numerous antibiotic resistance genes in Clostridium bolteae and Clostridium clostridioforme, including beta-lactamases, glycopeptide resistance operons, macrolide and lincosamide resistance genes, and efflux pumps. Notably, C. bolteae 90B3 exhibited resistance to linezolid, chloramphenicol, florfenicol, and tiamulin due to the presence of the 23S rRNA methyltransferase gene cfr. Additionally, C. clostridioforme 90A8 possessed a VanB-type operon conferring vancomycin resistance.
Exploration into the origins and mobilization of di-hydrofolate reductase genes and the emergence of clinical resistance to trimethoprim.
The study identifies novel trimethoprim-resistance determinants in Acinetobacter clinical isolates, including dfrA38, dfrA39, dfrA40, and dfrA41, which confer resistance to trimethoprim. It also reveals that chromosomal folA genes can confer resistance to trimethoprim, indicating that resistance to trimethoprim predates clinical use.
Detection of diverse carbapenem and multidrug resistance genes and high-risk strain types among carbapenem non-susceptible clinical isolates of target gram-negative bacteria in Kenya.
The study identified various carbapenemase genes (blaNDM-1, blaNDM-5, blaVIM-1, blaVIM-6, blaOXA-23, blaOXA-58, blaOXA-66, blaOXA-69, blaOXA-91, blaOXA-181, blaOXA-50) and other resistance genes (such as armA, rmtC, rmtF, aac(3)-I, aadA1, aph(3')-Ia, aph(3')-VI, aph(3')-Via, aph(6')-Id, mphE, msrE, mphA, ereA, dfrA1, dfrA12, dfrA14, dfrA17, dfrA20, sul1, sul2, tetB, tetD, tetG, tet39, qnrVC1, qnrS1, qnrB4, floR, catA1, catA2, catB3, catB7, cmlA1, cmlA5, arr-3, arr-2, sat2, acrF, mdtM, emrD, mexA, mexE, mexX, kdeA, oxa-10, oxa-395, oxa-396, oxa-846, adc-25, dha-1, act-16, cmY, ctx-m-15, shv-67, tem-1b) in carbapenem non-susceptible clinical isolates of gram-negative bacteria in Kenya, highlighting the diversity and prevalence of multidrug resistance.
Comprehensive molecular epidemiology of Acinetobacter baumannii from diverse sources in Nigeria.
The study identified 168 AMR genes in 189 Nigerian A. baumannii isolates, including blaADC-79, blaOXA-23, aph(3")-Ib, and others, highlighting the widespread presence of multidrug resistance.
Acquisition of novel antibiotic resistance genes by the bacterial predator Bacteriovorax sp. As-1.
Bacteriovorax sp. As-1 exhibits resistance to multiple antibiotics, primarily due to mutations in the gyrA gene, specifically S90Y and G94R, which are associated with reduced fluoroquinolone susceptibility.
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