Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim-resistant dihydrofolate reductase DfrA25
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| DfrA25 | Reference Gene Catalog | 1 | TRIMETHOPRIM | Salmonella enterica subsp. enterica serovar Agona, Escherichia coli | - | 2006 | DQ267940.1, KX118301.1 | - |
| dfrA25 | Card Database |
| 12 |
| TRIMETHOPRIM, Trimethoprim +2 |
| Salmonella enterica subsp. enterica serovar Agona +7 |
| Global, China, United States, United Kingdom, Brazil|Europe|United Kingdom|United States, Brazil, Europe |
| 2006, 2017, 2019, 2021, 2023, 2024, 2025 |
| DQ267940.1 |
| ABB71176.1 |
dfrA25, a novel trimethoprim resistance gene from Salmonella Agona isolated from a human urine sample in Brazil.
dfrA25, a novel trimethoprim resistance gene from Salmonella Agona isolated from a human urine sample in Brazil.
dfrA25, a novel trimethoprim resistance gene from Salmonella Agona isolated from a human urine sample in Brazil.
dfrA25, a novel trimethoprim resistance gene from Salmonella Agona isolated from a human urine sample in Brazil.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
A putative multi-replicon plasmid co-harboring beta-lactamase genes blaKPC-2, blaCTX-M-14 and blaTEM-1 and trimethoprim resistance gene dfrA25 from a Klebsiella pneumoniae sequence type (ST) 11 strain in China.
The study identifies a novel multi-replicon plasmid pHS091147 carrying multiple resistance genes, including blaKPC-2, blaCTX-M-14, blaTEM-1, dfrA25, and sul1, which confer resistance to various antibiotics such as carbapenems, cephalosporins, and trimethoprim.
Genomic characterization of novel IncFII-type multidrug resistant plasmids p0716-KPC and p12181-KPC from Klebsiella pneumoniae.
The study characterizes two novel IncFII-type multidrug-resistant plasmids, p0716-KPC and p12181-KPC, from Klebsiella pneumoniae. These plasmids carry multiple resistance genes, including blaKPC-2, mph(A), strAB, aacC2, qacEΔ1, sul1, sul2, dfrA25, aphA1a, and blaTEM-1, contributing to resistance against various antibiotics.
Applying Rapid Whole-Genome Sequencing To Predict Phenotypic Antimicrobial Susceptibility Testing Results among Carbapenem-Resistant Klebsiella pneumoniae Clinical Isolates.
The study identified various AMR genes and mutations in carbapenem-resistant Klebsiella pneumoniae isolates, including bla KPC-2, bla KPC-3, bla NDM-1, bla OXA-48, ampC, qnrB, qnrS, aac(6')-Ib-cr, armA, rmtB, tet(A), tet(B), tet(D), tet(G), sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, dfrA25, dfrA26, dfrA30, oqxA, oqxB, and mgrB, as well as mutations in ompK35, ompK36, gyrA, parC, phoP, phoQ, pmrA, and pmrB, which contribute to resistance against multiple antibiotics.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Genome-Scale Metabolic Models and Machine Learning Reveal Genetic Determinants of Antibiotic Resistance in Escherichia coli and Unravel the Underlying Metabolic Adaptation Mechanisms.
The study identifies 20 top-ranked genetic determinants associated with antibiotic resistance in E. coli, including genes involved in cell wall metabolism, energy metabolism, and iron metabolism, using a combination of machine learning and genome-scale metabolic models.
Genomic Features and Phylogenetic Analysis of Antimicrobial-Resistant Salmonella Mbandaka ST413 Strains.
The study identified nine resistance genes, including aac(6')-Iaa, sul1, qacE, blaOXA-129, tet(B), and aadA1, as well as a point mutation in ParC (T57S) associated with quinolone resistance in Salmonella Mbandaka ST413 strains.
Whole-Genome Analysis of Extensively Drug-Resistant Enterobacter hormaechei Isolated from a Patient with Non-Hodgkin's Lymphoma.
The study identifies an extensively drug-resistant Enterobacter hormaechei ST90 clone carrying multiple resistance genes, including bla CTX-M-15, bla GES-2, bla TEM-1A, bla OXA-1, bla NDM-1, and bla ACT-15, along with genes encoding resistance to aminoglycosides, quinolones, sulfonamides, chloramphenicol, fosfomycin, and other antibiotics.
Pan-genome analysis of the Enterobacter hormaechei complex highlights its genomic flexibility and pertinence as a multidrug resistant pathogen.
The study identifies a wide range of antibiotic resistance genes in the Enterobacter hormaechei complex, highlighting its multidrug-resistant nature and the role of mobile genetic elements in the dissemination of resistance.
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