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dfrA29

trimethoprim-resistant dihydrofolate reductase DfrA29

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to dfrA29

Browse AMR rules for dfrA29

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Purine synthesis
Validation Method: experimental characterization
Drug Classes: TRIMETHOPRIM, Trimethoprim
Organisms: uncultured bacterium, Salmonella, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli
Geographic Location: Global
Alleles: 2
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
DfrA29	Reference Gene Catalog	1	TRIMETHOPRIM	uncultured bacterium	-	2009	FM957878.1	CAX16458.1
dfrA29	Card Database

Papers3

1

High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.

PMID 20027306 · 2009

Gene Information

Gene Name: dfrA29
Allele: DfrA29
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA29
Source Database: Reference Gene Catalog
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • uncultured bacterium
Sequence Accession: FM957878.1
Protein Accession: CAX16458.1

2

Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges

PMID 22046172 · 2023

This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.

Gene Information

Gene Name: dfrA29
Allele: dfrA29
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: Trimethoprim
Organisms Tested In: • Salmonella
Geographic Location: Global
Validation Method: experimental characterization
Sequence Accession: V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013

3

PMID unpublished

Gene Information

Gene Name: dfrA29
Allele: dfrA29
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica subsp. enterica serovar Typhimurium
Sequence Accession: AM237806

4

Gene Information

Gene Name: dfrA29
Allele: dfrA29
Encodes: trimethoprim resistant dihydrofolate reductase dfr
Source Database: Card Database
Mechanism: antibiotic target replacement
Organisms Tested In: • Escherichia coli
Sequence Accession: KX118301.1
Protein Accession: ANN23980.1
Notes: ARO:3004554