Browse AMR Genes

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA34
Source Database: Reference Gene Catalog
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065.1
Protein Accession: KTN70288.1
Notes: ARO:3005346

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA34
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065.1
Protein Accession: KTN70288.1
Notes: ARO:3005346

Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA.

Research Article

A novel trimethoprim resistance gene, dfrA34, was identified in a Salmonella Heidelberg isolate and shown to confer trimethoprim resistance when cloned into E. coli.

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Salmonella enterica serotype Heidelberg
• Escherichia coli
Geographic Location: USA
Validation Method: cloning in E. coli + broth dilution and Etest
Sequence Accession: MH760469

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA34
Source Database: Card Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065.1
Protein Accession: KTN70288.1
Notes: ARO:3005346

Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA.

Research Article

Gene Information

Gene Name: dfrA34
Allele: dfrA34
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065

Bacterial genomes carrying this gene

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: trimethoprim resistant dihydrofolate reductase dfr
Source Database: Card Database
Mechanism: antibiotic target replacement
Confers Resistance To: DIAMINOPYRIMIDINE ANTIBIOTICTRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: NG_062229.1
Protein Accession: WP_058652112.1
Notes: ARO:3005346

Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Dairy Calf Exposure, United States, 2015-2018.

Research Article

PMID 34989634 · 2022

The study identifies a multidrug-resistant (MDR) Salmonella Heidelberg outbreak linked to dairy calf exposure, highlighting the presence of plasmid-borne resistance genes such as aadA1, aph(3')-Ia, bla CMY-2, floR, fosA7, qnrB19, strA, strB, sull, sul2, tet(A), tet(B), tet(O), and a novel gene dfrA34.

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Salmonella enterica serovar Heidelberg
Geographic Location: United States
Validation Method: whole genome sequencing and antimicrobial susceptibility testing
Sequence Accession: MH760469.1

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dfrA34

trimethoprim-resistant dihydrofolate reductase DfrA34

NCBI Pathogen Isolates

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dfrA34

AMR Rules

Browse AMR rules for dfrA34

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Purine synthesis
Validation Method: cloning in E. coli + broth dilution and Etest
Drug Classes: Trimethoprim, Diaminopyrimidine antibiotic
Organisms: Salmonella enterica, Salmonella enterica serotype Heidelberg, Escherichia coli, Salmonella enterica serovar Heidelberg
Geographic Location: USA, United States
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA34
Source Database: Reference Gene Catalog
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065.1
Protein Accession: KTN70288.1
Notes: ARO:3005346

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA34
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065.1
Protein Accession: KTN70288.1
Notes: ARO:3005346

Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA.

Research Article

A novel trimethoprim resistance gene, dfrA34, was identified in a Salmonella Heidelberg isolate and shown to confer trimethoprim resistance when cloned into E. coli.

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Salmonella enterica serotype Heidelberg
• Escherichia coli
Geographic Location: USA
Validation Method: cloning in E. coli + broth dilution and Etest
Sequence Accession: MH760469

Gene Information

Gene Name: dfrA34
Allele: DfrA34
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA34
Source Database: Card Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065.1
Protein Accession: KTN70288.1
Notes: ARO:3005346

Novel trimethoprim resistance gene dfrA34 identified in Salmonella Heidelberg in the USA.

Research Article

Gene Information

Gene Name: dfrA34
Allele: dfrA34
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Salmonella enterica
Sequence Accession: JYRF01000065