dfrA35

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trimethoprim-resistant dihydrofolate reductase DfrA35

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dfrA35

AMR Rules

Browse AMR rules for dfrA35

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Purine synthesis
Validation Method: cloning and expression in E. coli followed by MIC testing
Drug Classes: Trimethoprim, Diaminopyrimidine antibiotic
Organisms: Escherichia coli, Klebsiella pneumoniae
Geographic Location: Switzerland
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA35
Source Database: Reference Gene Catalog
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA35
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA35
Source Database: Card Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: dfrA35
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: CP024557

PMID 30989199

Gene Information

Gene Name: dfrA35
Allele: dfrA35
Encodes: trimethoprim resistant dihydrofolate reductase dfr
Source Database: Card Database
Mechanism: antibiotic target replacement
Confers Resistance To: DIAMINOPYRIMIDINE ANTIBIOTICTRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

A Novel Trimethoprim Resistance Gene, dfrA36, Characterized from Escherichia coli from Calves.

Research Article

PMID 31068437 · 2019

The study identifies a novel trimethoprim resistance gene, dfrA35, in Escherichia coli from calves. The gene was functionally validated through cloning and expression in E. coli, demonstrating increased MIC for trimethoprim.

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: dihydrofolate reductase
Source Database: Reslit
Mechanism: confers resistance to trimethoprim by enzymatic modification of the drug target
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Geographic Location: Switzerland
Validation Method: cloning and expression in E. coli followed by MIC testing
Sequence Accession: CP038791

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dfrA35

View on PubMed

trimethoprim-resistant dihydrofolate reductase DfrA35

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dfrA35

AMR Rules

Browse AMR rules for dfrA35

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Purine synthesis
Validation Method: cloning and expression in E. coli followed by MIC testing
Drug Classes: Trimethoprim, Diaminopyrimidine antibiotic
Organisms: Escherichia coli, Klebsiella pneumoniae
Geographic Location: Switzerland
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA35
Source Database: Reference Gene Catalog
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA35
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA35
Source Database: Card Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

Novel trimethoprim resistance gene, dfrA35, in IncC plasmids from Australia.

Research Article

PMID 30989199 · 2019

Gene Information

Gene Name: dfrA35
Allele: dfrA35
Source Database: ResFinder Database
Mechanism: Purine synthesis
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Klebsiella pneumoniae
Sequence Accession: CP024557

PMID 30989199

Gene Information

Gene Name: dfrA35
Allele: dfrA35
Encodes: trimethoprim resistant dihydrofolate reductase dfr
Source Database: Card Database
Mechanism: antibiotic target replacement
Confers Resistance To: DIAMINOPYRIMIDINE ANTIBIOTICTRIMETHOPRIM
Organisms Tested In: • Escherichia coli
Sequence Accession: KY887596.1
Protein Accession: ASF80997.1
Notes: ARO:3005164

A Novel Trimethoprim Resistance Gene, dfrA36, Characterized from Escherichia coli from Calves.

Research Article

PMID 31068437 · 2019

Gene Information

Gene Name: dfrA35
Allele: DfrA35
Encodes: dihydrofolate reductase
Source Database: Reslit
Mechanism: confers resistance to trimethoprim by enzymatic modification of the drug target
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Geographic Location: Switzerland
Validation Method: cloning and expression in E. coli followed by MIC testing
Sequence Accession: CP038791

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No comments yet. Be the first to comment!

dfrA35

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