dfrA50

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dihydrofolate reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dfrA50

AMR Rules

Browse AMR rules for dfrA50

Validation StatusConfirmed2+ DBs

Overview

Validation Method: functional studies in E. coli
Drug Classes: Trimethoprim
Organisms: Escherichia coli, Klebsiella phage ST13-OXA48phi12.3, Klebsiella phage pJN2-26
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.

Research Article

PMID 40503927 · 2025

The study identified two novel trimethoprim resistance genes, dfrA50 and dfrA51, in phage-plasmids, which confer resistance to trimethoprim in Escherichia coli.

Gene Information

Gene Name: dfrA50
Allele: DfrA50
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Validation Method: functional studies in E. coli
Sequence Accession: NG_242637.1|NG_242639.1|NG_242636.1|WP_038694170.1|QYR06304.1|WP_040203768.1|QBP27508.1|WP_000781812.1|AFL47010.1

Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.

Research Article

PMID 40503927 · 2025

Gene Information

Gene Name: dfrA50
Allele: DfrA50
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA50
Source Database: Reference Gene Catalog
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Klebsiella phage ST13-OXA48phi12.3
Sequence Accession: MK422451.1
Protein Accession: QBP27508.1

Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.

Research Article

PMID 40503927 · 2025

Gene Information

Gene Name: dfrA50
Allele: DfrA50
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA50
Source Database: Reference Gene Catalog
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Klebsiella phage pJN2-26
Sequence Accession: MZ779062.1
Protein Accession: UAV85970.1

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dfrA50

View on PubMed

dihydrofolate reductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to dfrA50

AMR Rules

Browse AMR rules for dfrA50

Validation StatusConfirmed2+ DBs

Overview

Validation Method: functional studies in E. coli
Drug Classes: Trimethoprim
Organisms: Escherichia coli, Klebsiella phage ST13-OXA48phi12.3, Klebsiella phage pJN2-26
Papers: 1
Databases: Reference Gene CatalogReslit

Papers1

Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.

Research Article

PMID 40503927 · 2025

The study identified two novel trimethoprim resistance genes, dfrA50 and dfrA51, in phage-plasmids, which confer resistance to trimethoprim in Escherichia coli.

Gene Information

Gene Name: dfrA50
Allele: DfrA50
Encodes: dihydrofolate reductase
Source Database: Reslit
Confers Resistance To: trimethoprim
Organisms Tested In: • Escherichia coli
Validation Method: functional studies in E. coli
Sequence Accession: NG_242637.1|NG_242639.1|NG_242636.1|WP_038694170.1|QYR06304.1|WP_040203768.1|QBP27508.1|WP_000781812.1|AFL47010.1

Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.

Research Article

PMID 40503927 · 2025

Gene Information

Gene Name: dfrA50
Allele: DfrA50
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA50
Source Database: Reference Gene Catalog
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Klebsiella phage ST13-OXA48phi12.3
Sequence Accession: MK422451.1
Protein Accession: QBP27508.1

Two novel trimethoprim resistance genes, dfra50 and dfra51, identified in phage-plasmids.

Research Article

PMID 40503927 · 2025

Gene Information

Gene Name: dfrA50
Allele: DfrA50
Encodes: trimethoprim-resistant dihydrofolate reductase DfrA50
Source Database: Reference Gene Catalog
Confers Resistance To: TRIMETHOPRIM
Organisms Tested In: • Klebsiella phage pJN2-26
Sequence Accession: MZ779062.1
Protein Accession: UAV85970.1

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No comments yet. Be the first to comment!

dfrA50

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dfrA50

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