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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
trimethoprim-resistant dihydrofolate reductase DfrG
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| dfrG | Card DatabaseResFinder Database | 2 | TRIMETHOPRIM | Staphylococcus aureus | - | 2005 | AB205645 | BAE15963.1 |
| DfrG |
Card DatabaseReference Gene CatalogResFinder DatabaseReslit |
| 111 |
| TRIMETHOPRIM, Trimethoprim +2 |
| Staphylococcus aureus +37 |
| United Kingdom, Switzerland, Vietnam, Europe|Africa|South Asia|Latin America|South-East Asia, Nsukka agricultural zone, Nigeria, France|United States, United States, Republic of Suriname, global, Canada|United Kingdom|Global, Italy, Australia, Guangdong Province, China, Namibia, Argentina, East London|West London, Germany, Connecticut, Denmark, Spain, Northern Province|Kigali District, India, wastewater treatment plants|Canada, Alberta, Canada, Portugal, Nigeria, Denmark|Finland|Iceland|Lithuania|Netherlands|Spain, Europe, Korea, Northern Australia, Japan, Portugal|Spain|Denmark, Estonia|swine, Thailand, Europe|Germany, Australia|New Zealand, Western Uganda, Asia|Europe|Americas|China|Taiwan, South Africa, Europe|United Kingdom, Germany|Africa, Rwanda, China, Northern Ghana, Sudan, Africa|Asia|America|Europe|Oceania|global, Russia, Canada|United Kingdom|Alberta, Somalia|Kenya|East Africa, Brazil, Kenya, Belgium, Edo, Nigeria, Japan|Denmark|Norway|China|United States|Switzerland|India|Netherlands, Algeria, Eastern Tanzania, Argentina|United States, Benin, Thuringia, Germany, Serbia, Rio de Janeiro, USA, Slovak Republic, La Rioja, Spain, Scotland, Ghana, China|New Zealand|Denmark|United Kingdom|Australia|United States, Canterbury, New Zealand, Beira, Mozambique|Mozambique, Europe|USA, Egypt, East Africa, Delhi, India |
| 2005, 2010, 2012, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 |
| AB205645.1 |
| BAE15963.1 |
| dfr(G) | Reslit | 5 | Trimethoprim | Staphylococcus pseudintermedius +2 | Switzerland, Thailand|Israel, Spain, China | 2008, 2011, 2013, 2020, 2023 | AM904732|AM904731|AM262968|AM262971|AM262969|AM262972|AM262967|AM262970 | - |
| dfr G | Reslit | 2 | Trimethoprim | Bacillus anthracis +2 | North America|South America|Europe|Asia|Africa|Oceania, Thailand | 2021, 2024 | AE017334.2|AE017336 | - |
Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).
Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).
Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).
Cloning and characterization of a novel trimethoprim-resistant dihydrofolate reductase from a nosocomial isolate of Staphylococcus aureus CM.S2 (IMCJ1454).
Characterization of new staphylococcal cassette chromosome mec (SCCmec) and topoisomerase genes in fluoroquinolone- and methicillin-resistant Staphylococcus pseudintermedius.
The study characterizes new SCCmec elements and mutations in topoisomerase genes associated with fluoroquinolone and methicillin resistance in Staphylococcus pseudintermedius.
Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).
The study identifies several AMR genes and mutations in the MRSA strain TW20, including mecA for methicillin resistance, qacA for antiseptic resistance, Tn554 and ermA1 for streptomycin and erythromycin resistance, BlaZ for beta-lactam resistance, TetM for tetracycline resistance, and DfrG for trimethoprim resistance. Additionally, a point mutation in GyrA (Ser84Leu) confers quinolone resistance.
The increase of methicillin-resistant Staphylococcus aureus (MRSA) and the presence of an unusual sequence type ST49 in slaughter pigs in Switzerland.
The study identifies the presence of methicillin-resistant Staphylococcus aureus (MRSA) in slaughter pigs in Switzerland, highlighting the emergence of the unusual sequence type ST49. It reports various AMR genes such as mecA, blaZ, tet(M), tet(K), erm(A), erm(C), ant(9)-Ia, str, dfr(G), and vga(A)v, which confer resistance to β-lactams, tetracycline, macrolides, lincosamides, streptogramins B, spectinomycin, streptomycin, trimethoprim, and tiamulin.
Identification of acquired antimicrobial resistance genes.
The study presents ResFinder, a web-based tool for identifying acquired antimicrobial resistance genes in whole-genome data. It successfully identifies resistance genes with high accuracy and agrees with phenotypic testing. The tool detects various resistance genes across different bacterial species, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others.
Novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45.
The study identifies a novel pseudo-staphylococcal cassette chromosome mec element (ψSCCmec57395) in methicillin-resistant Staphylococcus pseudintermedius CC45, along with various AMR genes such as mecA, blaZ, aac(6')-Ie–aph(2')-Ia, aph(3')-III, ant(6)-Ia, sat4, erm(B), tet(M), dfr(G), and cat pC221. Additionally, fluoroquinolone resistance was linked to specific mutations in gyrA and grlA.
Antimicrobial susceptibility and antibiotic resistance gene transfer analysis of foodborne, clinical, and environmental Listeria spp. isolates including Listeria monocytogenes.
The study identified the tet(M) gene as the primary cause of tetracycline resistance in Listeria isolates, along with dfrA, dfrD, and dfrG genes responsible for trimethoprim resistance. Additionally, the transferability of these resistance genes via conjugative transposons and plasmids was demonstrated.
Identification and Antimicrobial Resistance of Bacteria Isolated from Probiotic Products Used in Shrimp Culture.
The study identified several antimicrobial resistance genes in Bacillus spp. isolated from probiotic products used in shrimp culture, including ermD (macrolide resistance), tetL (tetracycline resistance), fexA (phenicol resistance), and dfrD, dfrG, dfrK (trimethoprim resistance). These genes were detected through whole genome sequencing of multiple antimicrobial-resistant Bacillus isolates.
Predominance of dfrG as determinant of trimethoprim resistance in imported Staphylococcus aureus.
The study identifies dfrG as the primary determinant of trimethoprim resistance in imported Staphylococcus aureus, accounting for 92% of all trimethoprim resistance cases.
Characterization of mannitol-fermenting methicillin-resistant staphylococci isolated from pigs in Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant staphylococci isolated from pigs in Nigeria, including mecA, blaZ, erm(C), erm(B), str, tet(K), tet(M), tet(L), dfrG, dfrK, aacA/aphD, aphA3, cat pC221, and cat pC223. Additionally, a Ser84Leu mutation in the gyrA gene was found to confer ciprofloxacin resistance.
Demography and Intercontinental Spread of the USA300 Community-Acquired Methicillin-Resistant Staphylococcus aureus Lineage.
The study characterizes the AMR genes and mutations in the USA300 CA-MRSA lineage, highlighting the presence of multiple resistance determinants including beta-lactam, aminoglycoside, macrolide, and fluoroquinolone resistance genes, as well as specific mutations in gyrA and parC contributing to fluoroquinolone resistance.
MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates.
The study identifies dfrG and dfrK as novel plasmid-encoded trimethoprim resistance genes in MRSA and MSSA isolates from the United States, demonstrating their role in conferring high-level resistance to trimethoprim.
Characterization of Multi-Drug Resistant Enterococcus faecalis Isolated from Cephalic Recording Chambers in Research Macaques (Macaca spp.).
The study identified various AMR genes and mutations in Enterococcus faecalis isolates from macaque cephalic implants, highlighting the presence of high-level aminoglycoside resistance, tetracycline resistance, and bacitracin resistance. These findings emphasize the complexity of AMR in clinical settings and the need for targeted antimicrobial strategies.
Complete-genome sequencing elucidates outbreak dynamics of CA-MRSA USA300 (ST8-spa t008) in an academic hospital of Paramaribo, Republic of Suriname.
The study identified several AMR genes, including ermC, dfrG, and qacC, which confer resistance to erythromycin, trimethoprim, and quaternary ammonium compounds, respectively, in MRSA USA300 isolates from Suriname.
RNA-seq and Tn-seq reveal fitness determinants of vancomycin-resistant Enterococcus faecium during growth in human serum.
The study identifies genes involved in nucleotide biosynthesis and carbohydrate metabolism that are essential for the growth of vancomycin-resistant Enterococcus faecium in human serum, highlighting potential targets for novel antimicrobials.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Genomic Comparison of Highly Virulent, Moderately Virulent, and Avirulent Strains From a Genetically Closely-Related MRSA ST239 Sub-lineage Provides Insights Into Pathogenesis.
The study identifies dfrG, a gene encoding a trimethoprim-resistant dihydrofolate reductase, as a factor contributing to trimethoprim resistance in TW20, CMRSA6, and CMRSA3. M92 lacks this gene and is susceptible to trimethoprim.
Occurrence and characterization of methicillin-resistant Staphylococcus pseudintermedius in successive parturitions of bitches and their puppies in two kennels in Italy.
The study identified multiple methicillin-resistant Staphylococcus pseudintermedius (MRSP) strains in two Italian kennels, highlighting the presence of various resistance mechanisms including beta-lactam, aminoglycoside, macrolide, tetracycline, and chloramphenicol resistance genes.
Remodeling of pSK1 Family Plasmids and Enhanced Chlorhexidine Tolerance in a Dominant Hospital Lineage of Methicillin-Resistant Staphylococcus aureus.
The study identifies several AMR genes, including aac(6')-aph(2"), aadD, aph(3')-IIIa, dfrA, dfrG, qacA, and qacC, associated with resistance to gentamicin, trimethoprim, and chlorhexidine in ST239 MRSA. The pSK1-like plasmids were found to contribute to enhanced resistance and tolerance through the acquisition of these genes.
Antimicrobial resistance, virulence genes profiling and molecular relatedness of methicillin-resistant Staphylococcus aureus strains isolated from hospitalized patients in Guangdong Province, China.
The study identified several AMR genes and mutations in MRSA isolates from Guangdong, China, including aac(6')-aph(2"), ermA, ermB, ermC, lnuA, dfrG, rpoB, fexA, and mutations in gyrA, gyrB, grlA, and grlB associated with resistance to various antibiotics.
FLASH: a next-generation CRISPR diagnostic for multiplexed detection of antimicrobial resistance sequences.
FLASH-NGS was developed for the detection of antimicrobial resistance genes and mutations in clinical samples, demonstrating high sensitivity and specificity for various pathogens including Staphylococcus aureus, Enterococcus faecium, and Plasmodium falciparum.
Identification and molecular epidemiology of methicillin resistant Staphylococcus pseudintermedius strains isolated from canine clinical samples in Argentina.
The study identified various AMR genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates from Argentina, including mecA, blaZ, ermB, dfrG, aph(3')-III, ant(6)-Ia, tetM, and aac(6')-Ie-aph(2')-Ia. Mutations in gyrA (S84L) and grlA (S80I) were associated with ciprofloxacin resistance.
Whole genome sequencing revealed new molecular characteristics in multidrug resistant staphylococci recovered from high frequency touched surfaces in London.
The study identified several AMR genes in multidrug-resistant staphylococci from high-frequency touched surfaces in London, including blaZ, qacA/B, dfrC, norA, ant(4')-Ib, AAC(6')-Ie-APH(2")-Ia, fusB, msrA, ermC, mphC, tetK, mupA, cat, dfrG, lnuA, fusC, aph3-IIIa, sat4A, vgaA, and others. These genes conferred resistance to various antibiotics such as penicillin, fusidic acid, mupirocin, tetracycline, erythromycin, and chloramphenicol.
Molecular Characterization of Equine Staphylococcus aureus Isolates Exhibiting Reduced Oxacillin Susceptibility.
The study identifies several AMR genes and mutations associated with reduced oxacillin susceptibility in equine Staphylococcus aureus isolates, including blaZ, aadD, dfrG, tet(L), and aacA-aphD, along with various mutations in genes such as FemA, FemB, FemX, CcpA, GdpP, and PBP1-4.
Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus.
The study identifies dfrA, dfrG, and dfrK genes in clinical isolates of Methicillin Resistant Staphylococcus aureus (MRSA) that confer resistance to trimethoprim and iclaprim. These genes were characterized through biochemical, structural, and computational methods, leading to the development of novel inhibitors (INCAs) with improved activity against these resistant enzymes.
International travel as source of a hospital outbreak with an unusual meticillin-resistant Staphylococcus aureus clonal complex 398, Denmark, 2016.
The study identifies the PVL-positive human variant of MRSA CC398 as the cause of an outbreak in a Danish maternity unit, highlighting the role of international travelers in introducing such strains into healthcare settings.
Antimicrobial Resistance, Virulence, and Genetic Lineages of Staphylococci from Horses Destined for Human Consumption: High Detection of S. aureus Isolates of Lineage ST1640 and Those Carrying the lukPQ Gene.
The study identified antimicrobial resistance genes such as ant(6)-Ia, blaZ, dfrA, and dfrG in Staphylococcus aureus isolates, along with the equine-adapted leukocidin gene lukPQ and the complement inhibitor gene scn-eq. These findings highlight the presence of virulence and resistance determinants in S. aureus isolates from horses.
Characterization of Antibiotic and Biocide Resistance Genes and Virulence Factors of Staphylococcus Species Associated with Bovine Mastitis in Rwanda.
The study identified several antibiotic and biocide resistance genes in Staphylococcus species associated with bovine mastitis in Rwanda, including blaZ, tet(K), erm(C), vga(A), sal(A), lnu(A), msr(A), dfrA, dfrD, dfrG, smr, qacAB, cadD, copB, and arsA. These genes conferred resistance to various antibiotics such as penicillin, tetracycline, erythromycin, clindamycin, trimethoprim, and biocides like quaternary ammonium compounds.
Antibiotic Susceptibility, Virulence Pattern, and Typing of Staphylococcus aureus Strains Isolated From Variety of Infections in India.
The study identified various AMR genes in S. aureus isolates, including mecA, pvl, czrC, qacA/B, aac(6')/aph(2), aph(3'-III), msrA, ermA, ermC, mphC, tetK, tetL, tetM, cat::pC221, cat::pC223, cat::pC194, dfrA, dfrB, and dfrG, which confer resistance to multiple antibiotics such as oxacillin, chloramphenicol, gentamicin, erythromycin, clindamycin, tetracycline, and trimethoprim.
Comparative genomics of multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants.
The study identified several AMR genes in multidrug-resistant Enterococcus spp. isolated from wastewater treatment plants, including vancomycin resistance genes (vanA, vanM, vanG, vanC), macrolide resistance genes (ermB, msrC), tetracycline resistance genes (tetL), aminoglycoside resistance genes (aad(6'), aac(6')-Ie-aph(2")-Ia, ant(9')-Ia, aph(3')-IIIa, SAT-4, ant(6')-Ia), chloramphenicol resistance gene (cat), dihydrofolate reductase genes (dfrE, dfrF, dfrG), and lincosamide resistance genes (InuB, InuG).
In Vitro Pharmacodynamic Analyses Help Guide the Treatment of Multidrug-Resistant Enterococcus faecium and Carbapenem-Resistant Enterobacter cloacae Bacteremia in a Liver Transplant Patient.
The study identifies various AMR genes and mutations in Enterococcus faecium and Enterobacter hormaechei isolates from a liver transplant patient, highlighting their roles in resistance to multiple antibiotics.
Characterization of the First mecA-Positive Multidrug-Resistant Staphylococcus pseudintermedius Isolated from an Argentinian Patient.
The study characterizes the first mecA-positive multidrug-resistant Staphylococcus pseudintermedius isolate from an Argentinean patient, identifying several AMR genes and mutations associated with resistance to multiple antibiotics.
Machine learning with random subspace ensembles identifies antimicrobial resistance determinants from pan-genomes of three pathogens.
The study identifies known and novel antimicrobial resistance genes using a machine learning approach on pan-genomes of Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli. Key findings include the detection of resistance genes such as gyrA, parC, ermC, lmrS, aac(6')-aph(2"), dfrG, tetK, and various beta-lactamases.
Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum.
The study identified several AMR genes in Enterococcus spp., including erm(B), tet(M), optrA, dfrE, lsa(A), aac(6')-Ib, eat(A), ant(6)-Ia, aph(3')-IIIa, sat4, tet(L), bcrB, bcrC, dfrF, and dfrG, which confer resistance to various antibiotics such as macrolides, tetracyclines, oxazolidinones, trimethoprim, and aminoglycosides.
Next-Generation Sequencing and MALDI Mass Spectrometry in the Study of Multiresistant Processed Meat Vancomycin-Resistant Enterococci (VRE).
The study identified multiple AMR genes in vancomycin-resistant enterococci (VRE) isolated from processed meat, including vanA, vanC1, erm(B), aac(6')-Ii, aadE, ant(9)-Ia, lsa(E), msr(C), lnu(B), tet(M)+tet(L), dfrG, dfrK, adeC, and efmA, which confer resistance to various antibiotics such as vancomycin, erythromycin, tetracycline, aminoglycosides, and trimethoprim.
Characteristics of oral methicillin-resistant Staphylococcus epidermidis isolated from dental plaque.
The study identified multiple AMR genes in methicillin-resistant Staphylococcus epidermidis (MRSE) isolates from dental plaque, including mecA, dfrA, dfrG, aacA-aphD, aadD, aphA3, ermC, msrA, tetK, norA, qacA, and qacC. These genes confer resistance to various antibiotics such as oxacillin, penicillin G, trimethoprim, gentamicin, erythromycin, tetracycline, and quaternary ammonium compounds.
Antimicrobial Resistance and Virulence of Methicillin-Resistant Staphylococcus aureus from Human, Chicken and Environmental Samples within Live Bird Markets in Three Nigerian Cities.
The study identified various antimicrobial resistance genes in MRSA isolates from human, chicken, and environmental samples in Nigerian live bird markets, highlighting the presence of multidrug-resistant strains and the potential public health risks associated with their dissemination.
Antimicrobial Resistance of Coagulase-Positive Staphylococcus Isolates Recovered in a Veterinary University Hospital.
The study identified various antimicrobial resistance genes in methicillin-resistant Staphylococcus pseudintermedius (MRSP) isolates, including blaZ, erm(B), erm(C), aph(3'), ant(6), aad(6), SAT-4, cat(pc221), dfr(G), tet(K), and tet(M). These genes were associated with resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, trimethoprim, and tetracycline.
Employing MIC Data for Mink Pathogens to Propose Tentative Epidemiological Cut-Off Values: A Step Toward Rationalizing Antimicrobial Use in Mink.
The study identified several AMR genes in mink pathogens, including beta-lactamases (blaTEM-1, blaCTX-M-1), tetracycline resistance genes (tet(A), tet(B)), aminoglycoside resistance genes (aadA5, aadA1), sulfonamide resistance genes (sul2), dihydrofolate reductase genes (dfrA1, dfrA5, dfrA8, dfrA14), macrolide/lincosamide/streptogramin B resistance genes (erm), lincomycin resistance gene (lnu(A)), spectinomycin resistance gene (spc), and additional sulfonamide and trimethoprim resistance genes (sul1, sul3, dfrK, dfrG).
Evidence for the Dissemination to Humans of Methicillin-Resistant Staphylococcus aureus ST398 through the Pork Production Chain: A Study in a Portuguese Slaughterhouse.
The study identified multiple antimicrobial resistance genes in MRSA ST398 isolates from a Portuguese slaughterhouse, highlighting the dissemination of these resistant strains through the pork production chain and their potential to colonize humans.
Antimicrobial resistance and virulence factors in livestock-associated MRSA from German dairy farms
The study identified various antimicrobial resistance genes in livestock-associated MRSA from German dairy farms, including mecA, fexA, tet(K), tet(M), vga(A), vga(E), dfrG, dfrK, aac(6')Ie-aph(2")Ia, str, spc, lsa(E), and erm(A). These genes conferred resistance to beta-lactams, chloramphenicol, tetracyclines, pleuromutilins, trimethoprim, aminoglycosides, streptomycin, spectinomycin, macrolides, lincosamides, and streptogramin B.
Integrative Analysis of Whole Genome Sequencing and Phenotypic Resistance Toward Prediction of Trimethoprim-Sulfamethoxazole Resistance in Staphylococcus aureus.
The study identified dfrA, dfrG, dfrD, and dfrK genes as conferring trimethoprim resistance in Staphylococcus aureus, and mutations in the folP gene (F17L and KE257_Dup) as responsible for sulfamethoxazole resistance.
Genome-Wide Analysis of Staphylococcus aureus Sequence Type 72 Isolates Provides Insights Into Resistance Against Antimicrobial Agents and Virulence Potential.
The study identified several AMR genes in ST72 isolates, including blaZ, aadD, ermC, msr(A), mph(C), tetK, aac(6')-aph(2'), fusC, and dfrG, which confer resistance to various antibiotics. K07-204 showed resistance to methicillin, ampicillin, erythromycin, kanamycin, and tetracycline, while K07-561 exhibited resistance to ampicillin and tetracycline. Additionally, K07-204 was found to be highly resistant to lysostaphin.
Clinical and Molecular Epidemiology of an Emerging Panton-Valentine Leukocidin-Positive ST5 Methicillin-Resistant Staphylococcus aureus Clone in Northern Australia.
The study identifies the dfrG gene as a trimethoprim resistance determinant in a ST5-MRSA-SCC mec IVo clone, which shows SXT susceptibility by Etest despite being reported as SXT resistant by Vitek 2.
Implanted Port Catheter System Infection Caused by Methicillin-resistant Staphylococcus pseudintermedius ST71-SCCmec type III.
The study reports a case of implanted port catheter system infection caused by methicillin-resistant Staphylococcus pseudintermedius ST71-SCC mec III, identifying several AMR genes and mutations including aac(6')-aph(2''), ant(6')-Ia, aph(3')-III, sat4A, mecA, blaZ, erm(B), dfrG, GyrA Ser84Leu, and GrlA Ser80Ile.
Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections.
The study identified antimicrobial resistance genes qacA, dfrG, and qacC in Staphylococcus saprophyticus isolates, highlighting their role in resistance to quaternary ammonium compounds, trimethoprim, and biocides respectively.
Clonal Diversity and Antimicrobial Resistance of Methicillin-Resistant Staphylococcus pseudintermedius Isolated from Canine Pyoderma.
All 31 MRSP isolates were multidrug-resistant, showing resistance to penicillin, macrolides, lincosamides, aminoglycosides, tetracycline, and trimethoprim-sulfamethoxazole. Key resistance genes identified include blaZ, ermB, msr(A/B), aac(6')-Ie-aph(2'')-Ia, aph(3')-IIIa, ant(4')-Ia, tetM, tetK, and dfrG.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Molecular Characterization of Enterococcus Isolates From Different Sources in Estonia Reveals Potential Transmission of Resistance Genes Among Different Reservoirs.
The study identified vanB genes in two vancomycin-resistant E. faecalis isolates and characterized various tetracycline, macrolide, lincosamide, and aminoglycoside resistance genes in E. faecalis and E. faecium isolates from different sources in Estonia.
Evaluation of commercial probiotics for antimicrobial resistance genes.
The study found that 94% of the evaluated commercial probiotics contained at least one transferable antimicrobial resistance (AMR) gene, with 82% containing two or more. The most commonly detected AMR genes were tetK (68%) and sul2 (60%).
The First Report of a Methicillin-Resistant Staphylococcus aureus Isolate Harboring Type IV SCCmec in Thailand.
The study reports the first identification of a methicillin-resistant Staphylococcus aureus (MRSA) isolate harboring type IV SCCmec in Thailand. Five acquired antimicrobial resistance genes, including blaZ, mecA, Inu(A), tet(K), and dfrG, were identified, conferring resistance to beta-lactams, lincosamides, tetracycline, and trimethoprim.
Frequency, Local Dynamics, and Genomic Characteristics of ESBL-Producing Escherichia coli Isolated From Specimens of Hospitalized Horses.
The study identified several ESBL genes, including blaCTX-M-1, blaCTX-M-15, blaSHV-12, blaOXA-1, blaCTX-M-14, blaCTX-M-3, and blaCMY-2, along with aminoglycoside resistance genes like aac(3)-IV, sulfonamide resistance genes sul1 and sul2, and trimethoprim resistance genes dfrA and dfrG, in ESBL-producing E. coli isolates from hospitalized horses.
Characterization of methicillin-resistant Staphylococcus pseudintermedius isolates from Australian animals: discovery of novel sequence types
The study identified several AMR genes in MRSP isolates, including blaZ, mecA, cat-pC221, ermB, ermC, tetM, dfrG, aac6-aph2, ant6-Ia, aph3-III, and aadD, which confer resistance to various antibiotics such as oxacillin, penicillin, chloramphenicol, erythromycin, clindamycin, tetracycline, trimethoprim, and gentamicin.
Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda.
The study identified various AMR genes in S. aureus isolates from Fort Portal Regional Referral Hospital, including blaZ, dfrA, dfrG, ermA, ermC, msrA, tetK, and tetM, contributing to resistance against multiple antibiotics. Additionally, mecA was detected, indicating methicillin resistance.
Molecular Evolution and Adaptation of Livestock-Associated Methicillin-Resistant Staphylococcus aureus (LA-MRSA) Sequence Type 9.
The study identifies multiple AMR genes and mutations in ST9 S. aureus, including mecA, blaZ, lnu(B), lsa(E), erm(C), fexA, tet(L), dfrG, vwb, and the MDR ST9 element, highlighting their role in multidrug resistance and host adaptation.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
Whole Genome Analysis of Three Multi-Drug Resistant Listeria innocua and Genomic Insights Into Their Relatedness With Resistant Listeria monocytogenes.
The study identified multiple AMR genes in three multi-drug resistant L. innocua isolates, including tet(M), optrA, fexA, dfrG, lnu(B), lsa(E), ant(6)-Ia, erm(B), aph(3')-IIIa, catA8, lnu(A), msr(D), and mef(A). These genes confer resistance to various antibiotics such as tetracycline, oxazolidinones, fluoroquinolones, trimethoprim, lincomycin, macrolides, aminoglycosides, and chloramphenicol.
The roles of antimicrobial resistance, phage diversity, isolation source and selection in shaping the genomic architecture of Bacillus anthracis.
The study identifies ten AMR genes in B. anthracis, highlighting their distribution across global isolates and their association with population genomic structure. Key genes include mph L, bla 1, fos B, bla 2, vml R, bcII, tem -116, cfr C, dfr G, and oxa -59, each with distinct resistance mechanisms and geographic prevalence.
Genomic Analysis of Antibiotic-Resistant Staphylococcus epidermidis Isolates From Clinical Sources in the Kwazulu-Natal Province, South Africa.
The study identified multiple antibiotic resistance genes in methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, tet(K), erm(A), erm(B), erm(C), dfrG, aac(6')-aph(2''), and cat(pC221), which confer resistance to beta-lactams, tetracyclines, macrolides, lincosamides, streptogramin B, trimethoprim, aminoglycosides, and chloramphenicol.
Evaluating the potential for respiratory metagenomics to improve treatment of secondary infection and detection of nosocomial transmission on expanded COVID-19 intensive care units.
The study evaluated the use of respiratory metagenomics to detect antimicrobial resistance genes and improve treatment of secondary infections in ICU patients. It identified several beta-lactam resistance genes, macrolide resistance genes, and sulfonamide resistance genes in various bacterial species.
Characterisation and Molecular Analysis of an Unusual Chimeric Methicillin Resistant Staphylococcus Aureus Strain and its Bacteriophages.
The study identifies the trimethoprim resistance gene dfrG located on a prophage in a chimeric MRSA strain, highlighting the role of phages in the dissemination of antibiotic resistance genes.
Genetic Characterization of Staphylococcus aureus From Subclinical Mastitis Cases in Dairy Cows in Rwanda.
The study identified the blaZ gene conferring penicillin resistance in 84% of the isolates, tet(K) or tetM genes for tetracycline resistance in 20% of the isolates, and the dfrG gene for trimethoprim resistance in 28% of the isolates.
Antimicrobial and Biocide Resistance among Feline and Canine Staphylococcus aureus and Staphylococcus pseudintermedius Isolates from Diagnostic Submissions.
The study identified various antimicrobial resistance genes in feline and canine Staphylococcus aureus and Staphylococcus pseudintermedius isolates, including blaZ, mecA, mecC, tet(K), tet(M), erm(A), erm(B), erm(C), erm(T), msr(A), aadE, aacA-aphD, aphA3, aadD, dfrG, lnu(B), and lsa(E). These genes conferred resistance to multiple antibiotics such as penicillins, tetracyclines, macrolides, aminoglycosides, and others.
The Emergence of a Multidrug-Resistant and Pathogenic ST42 Lineage of Staphylococcus haemolyticus from a Hospital in China.
The study identifies the ST42 lineage of Staphylococcus haemolyticus as a multidrug-resistant and pathogenic clone with a high burden of antibiotic resistance genes (ARGs) and virulence determinants.
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Whole-Genome Sequence of Multidrug-Resistant Methicillin-Resistant Staphylococcus epidermidis Carrying Biofilm-Associated Genes and a Unique Composite of SCCmec.
The study identified multiple antimicrobial resistance genes in multidrug-resistant methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, fusB, fosB, aadD, aac(6')-aph(2"), tet(K), dfrG, msr(A), and qacA. These genes contribute to resistance against various antibiotics such as methicillin, penicillin, fusidic acid, fosfomycin, aminoglycosides, tetracycline, trimethoprim, macrolides, and chlorhexidine.
Nasal Staphylococcus aureus and S. pseudintermedius carriage in healthy dogs and cats: a systematic review of their antibiotic resistance, virulence and genetic lineages of zoonotic relevance.
The study identifies various AMR genes such as mecA, blaZ, tet(M), erm(B), aac(6')-aph(2"), aadD, ant(6)-Ia, and sat4 in Staphylococcus aureus and S. pseudintermedius isolates from healthy dogs and cats, indicating widespread antibiotic resistance.
Whole-Genome Analysis of Staphylococcus aureus Isolates from Ready-to-Eat Food in Russia.
The study identified multiple antimicrobial resistance (AMR) genes in Staphylococcus aureus isolates from ready-to-eat food in Russia, including blaZ, mecA, inuA, cat, ermC, dfrG, dfrK, aaC, aaD, ant(9)-Ia, tet(K), tet(cluster), erm(A), erm(C), cat(pC194), and fexA. These genes conferred resistance to various antibiotics such as penicillins, lincosamides, phenicols, macrolides, aminoglycosides, tetracyclines, and fluoroquinolones.
Exploring the mobilome and resistome of Enterococcus faecium in a One Health context across two continents.
The study identifies various AMR genes in Enterococcus faecium, including vanA, vanB, ermB, ermT, ermA, aad(6), aph(3')-IIIa, aac(6')-Ie-aph(2')-Ia, sat-4, tetM, tet(W/N/W), dfrG, dfrF, lnuB, optrA, and lsaE, which are associated with different habitats and geographic locations.
Genomic Characterization and Antimicrobial Susceptibility of Dromedary-Associated Staphylococcaceae from the Horn of Africa.
The study identified several antimicrobial resistance genes in Staphylococcaceae isolates from camels and cattle in East Africa, including tet(K), blaZ, blaARL, mecA, mecA1, msrA, mphC, salA, dfrG, aacA-aphD, and str. These genes were associated with resistance to tetracycline, benzylpenicillin, oxacillin, erythromycin, clindamycin, trimethoprim, gentamicin, and streptomycin.
Concordance between Antimicrobial Resistance Phenotype and Genotype of Staphylococcus pseudintermedius from Healthy Dogs.
The study identified 17 antibiotic resistance genes in Staphylococcus pseudintermedius isolates from healthy dogs, including blaZ, mecA, ermB, tetM, aac(6')-aph(2''), ant(6)-Ia, aph(3')-IIIa, spw, str, and dfrG. It also found mutations in gyrA and parC genes associated with fluoroquinolone resistance, and mutations in rpoB and clpP linked to vancomycin resistance.
Dispersion and persistence of antimicrobial resistance genes among Staphylococcus spp. and Mammaliicoccus spp. isolated along a swine manure treatment plant.
The study identified multiple antimicrobial resistance genes, including fexA, ermC, cfr, aac(6')-aph(2''), dfrG, tetK, blaZ, mecA, norA, tetM, and ermA, in Staphylococcus and Mammaliicoccus species isolated from a swine manure treatment plant, indicating widespread resistance to various antibiotics.
Plasmid-Coded Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus from Food and Livestock in Germany.
Two linezolid-resistant MRSA strains from pigs in Germany were identified, both harboring plasmid-encoded cfr genes. These strains also had additional AMR genes, indicating multidrug resistance.
Characteristics of Staphylococcus aureus Isolated from Patients in Busia County Referral Hospital, Kenya.
The study identified S. aureus isolates carrying genes conferring resistance to penicillin-G, trimethoprim, tetracycline, erythromycin, gentamicin, and other antibiotics. Key resistance genes included blaZ, tetK, tetM, dfrG, ermA, ermC, aacA-aphD, aad9, and mecA.
Genomic insights into antibiotic resistance and mobilome of lactic acid bacteria and bifidobacteria.
The study identified several acquired and intrinsic antimicrobial resistance genes in lactic acid bacteria and bifidobacteria, including tetW, ANT(6)-Ia, aac(6')-Ie-APH(2'')-Ia, erm(B), erm(49), cat, dfrG, arr-4, and fosXCC. Additionally, mutations in S12, rsmG, Lsa(A), MsrC, and PBP5 were associated with resistance to various antibiotics.
An in-house 45-plex array for the detection of antimicrobial resistance genes in Gram-positive bacteria.
The study describes an in-house 45-plex array for detecting antimicrobial resistance genes in Gram-positive bacteria, identifying optrA, poxtA, and vanA as significant resistance markers in Enterococcus and Staphylococcus isolates.
Prevalence, multiple antibiotic resistance and virulence profile of methicillin-resistant Staphylococcus aureus (MRSA) in retail poultry meat from Edo, Nigeria.
The study identified multiple antimicrobial resistance genes in methicillin-resistant Staphylococcus aureus (MRSA) isolated from retail poultry meat in Edo, Nigeria, highlighting the prevalence of multidrug-resistant MRSA and the presence of virulence factors that pose a public health concern.
Intra-host variation of genetic lineages or AMR genotypes of CoPS
The study identifies various AMR genes including blaZ, dfrA, dfrG, ermB, catA, aac6′-aph2″, tet(M), dfrK, and ant4′ in Staphylococcus aureus and Staphylococcus pseudintermedius isolates. Additionally, a mutation in grlA (S80F) was found to confer fluoroquinolone resistance.
Enterococcal Linear Plasmids Adapt to Enterococcus faecium and Spread within Multidrug-Resistant Clades.
The study identifies pELF1-like plasmids in Enterococcus faecium that carry multiple antimicrobial resistance genes, including vancomycin resistance determinants, aminoglycoside resistance genes, macrolide resistance genes, tetracycline resistance genes, and oxazolidinone resistance genes. These plasmids are associated with multidrug-resistant clades and demonstrate high stability and self-transmissibility.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcaceae (MRS) and Mammaliicocci (MRM) in Dromedary Camels from Algeria: First Detection of SCCmec-mecC Hybrid in Methicillin-Resistant Mammaliicoccus lentus.
The study identified methicillin-resistant Staphylococcus and Mammaliicoccus species in dromedary camels in Algeria, including the first detection of a SCCmec-mecC hybrid in Mammaliicoccus lentus. Key resistance genes identified include mecA, mecC, blaZ, aadD, dfrG, ermB, ermA, msrA, mphC, fosB, fusB, and tet(K).
Genomic Diversity of Methicillin-Resistant Staphylococcus aureus CC398 Isolates Collected from Diseased Swine in the German National Resistance Monitoring Program GERM-Vet from 2007 to 2019.
The study identified numerous antimicrobial resistance (AMR) genes in methicillin-resistant Staphylococcus aureus (MRSA) CC398 isolates from diseased swine in Germany, including beta-lactam, tetracycline, macrolide, lincosamide, streptogramin B, phenicol, aminoglycoside, and fluoroquinolone resistance genes. These genes were often located on small transposons or plasmids, contributing to the multidrug resistance profile of the isolates.
A Genomic Snapshot of Antibiotic-ResistantEnterococcus faecalis within Public Hospital Environments in South Africa.
The study identified tet(M) and erm(B) as the most common antibiotic-resistant genes in Enterococcus faecalis isolates from South African hospitals, along with other resistance genes such as dfrG, catA, and optrA.
Molecular Characterization of Staphylococcus aureus Isolated from Raw Milk and Humans in Eastern Tanzania: Genetic Diversity and Inter-Host Transmission.
The study identified several antimicrobial resistance genes in Staphylococcus aureus isolates from raw milk and humans in eastern Tanzania, including blaZ, dfrG, erm(C), tet(K), and str, which confer resistance to penicillin, trimethoprim, macrolides, tetracycline, and streptomycin, respectively.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Genomic Features of Antimicrobial Resistance in Staphylococcus pseudintermedius Isolated from Dogs with Pyoderma in Argentina and the United States: A Comparative Study.
The study identified various antimicrobial resistance genes and mutations in Staphylococcus pseudintermedius isolates from dogs in Argentina and the United States, highlighting differences in resistance profiles between the two regions.
Genetic characterization of MDR genomic elements carrying two aac(6')-aph(2") genes in feline-derived clinical Enterococcus faecalis isolate.
The study identified a multidrug-resistant E. faecalis isolate (ESC1) carrying a novel composite transposon with two aac(6')-aph(2") genes, along with several other resistance genes on plasmids, contributing to resistance against multiple antibiotics.
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Whole genome sequence-based analysis of Staphylococcus aureus isolated from bovine mastitis in Thuringia, Germany.
The study identified multiple AMR genes and mutations in Staphylococcus aureus isolates from bovine mastitis in Thuringia, Germany, including blaZ, blaI, blaR, blaPC, mecA, tetM, tetK, ermA, dfrG, dfrK, ant(6)-Ia, aac(6')-Ie-aph(2"), aadD1, ant(9)-Ia, ant(4')-Ia, aph(2")-Ih, gyrA_S84L, and parC_S80F/Y.
Genomic Insights into Methicillin-Resistant Staphylococci and Mammaliicocci from Bulk Tank Milk of Dairy Farms in Serbia.
The study identified multiple AMR genes in methicillin-resistant staphylococci and mammaliicocci from bulk tank milk, highlighting their role as potential reservoirs of antimicrobial resistance genes.
Antimicrobial resistance and whole genome sequencing of novel sequence types of Enterococcus faecalis, Enterococcus faecium, and Enterococcus durans isolated from livestock.
The study identifies several antimicrobial resistance genes in Enterococcus species isolated from livestock in South Africa, highlighting the presence of multidrug-resistant strains and emphasizing the need for genomic surveillance to monitor the spread of antimicrobial resistance in food chain animals.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Genomic characterization of a unique Panton-Valentine leucocidin-positive community-associated methicillin-resistant Staphylococcus aureus lineage increasingly impacting on Australian indigenous communities.
The study identifies a unique clonal lineage of PVL-positive ST5 CA-MRSA (WA121) in Australia, characterized by specific mobile genetic elements including SCC mec IVo, Tn 7491, Tn 7702, and the EDIN-A plasmid p2010-15611-2, contributing to its resistance and virulence.
High Diversity but Monodominance of Multidrug-Resistant Bacteria in Immunocompromised Pediatric Patients with Acute Lymphoblastic Leukemia Developing GVHD Are Not Associated with Changes in Gut Mycobiome.
The study identifies multiple multidrug-resistant bacteria, including Enterococcus faecium and Klebsiella pneumoniae, carrying various resistance genes such as msr(C), erm(T), aac(6')-li, dfrG, ant(6)-la, aph(3")-Ib, sul2, and aph(6)-ld, which confer resistance to multiple antibiotics.
Canine Staphylococcaceae circulating in a Kenyan animal shelter.
The study identified various AMR genes in Staphylococcaceae strains isolated from dogs in a Kenyan animal shelter, including tetracycline, beta-lactam, and aminoglycoside resistance genes.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Gut diversity and the resistome as biomarkers of febrile neutropenia outcome in paediatric oncology patients undergoing hematopoietic stem cell transplantation.
The study identifies several antibiotic-resistance genes associated with febrile neutropenia in pediatric oncology patients undergoing hematopoietic stem cell transplantation, including msr(C), dfrG, erm(T), VanHAX, aac(6')-Ib, aph(3')-III, ant(6)-Ia, and aac(6')-Ii.
Genetic Diversification and Resistome of Coagulase-Negative Staphylococci from Nostrils of Healthy Dogs and Dog-Owners in La Rioja, Spain.
The study identified various AMR genes including blaZ, mecA, erm(A), erm(C), erm(T), mph(C), msr(A), vga(A), lsaB, ant4′, aac6′-aph2″, tet(K), tet(M), dfrA, dfrG, catPC221, and mupA in CoNS isolates from healthy dogs and dog-owners. Additionally, a linezolid-resistant S. epidermidis isolate was found to have multiple amino acid substitutions in 50S ribosomal proteins L3 and L4.
Displacement of Hospital-Acquired, Methicillin-Resistant Staphylococcus aureus Clones by Heterogeneous Community Strains in Kenya over a 13-Year Period.
The study identified several AMR genes and mutations in MRSA strains from Kenya, including aac(6')-aph(2''), dfrG, tetK, gyrA (S84L), and grlA (S80Y), indicating resistance to aminoglycosides, trimethoprim, tetracycline, and fluoroquinolones.
Emergence of novel methicillin resistant Staphylococcus pseudintermedius lineages revealed by whole genome sequencing of isolates from companion animals and humans in Scotland.
The study identified novel methicillin-resistant Staphylococcus pseudintermedius (MRSP) lineages, including ST726 and ST551, and characterized antimicrobial resistance genes such as mecA, blaZ, tetK, and mupA. It also noted a high prevalence of multidrug resistance (MDR) among MRSP isolates.
Genomic characterization of multi drug resistant ESBL-producing Escherichia coli isolates from patients and patient environments in a teaching hospital in Ghana.
The study identified multiple AMR genes in ESBL-producing E. coli isolates from patients and the hospital environment, including bla CTX-M-15, bla TEM-1B, bla OXA-1, and various aminoglycoside, macrolide, tetracycline, sulfonamide, and trimethoprim resistance genes. Additionally, PMQR genes like qnrS1, qnrB19, qnrB4, and qepA4 were detected, contributing to quinolone resistance.
Investigation of antimicrobial resistance and antimicrobial resistance genes in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit.
The study identified multiple antimicrobial resistance genes, including bla Z, aac A- aph D, msr A, tet K, gyr A, grl A, dfr G, and cfr, in Staphylococcus aureus and coagulase-negative staphylococci isolated from rabbit clinical abscesses, highlighting the presence of multidrug-resistant strains.
A single amplified genome catalog reveals the dynamics of mobilome and resistome in the human microbiome.
The study identifies numerous AMR genes in oral and fecal SAGs, highlighting the presence of resistance mechanisms such as efflux pumps, quinolone resistance proteins, dihydrofolate reductases, erythromycin ribosome methyltransferases, and aminoglycoside phosphotransferases.
Dissecting the genetic features and evolution of Staphylococcus aureus sequence type 88: a global perspective.
The study identifies specific AMR genes and mutations in ST88 isolates, including dfrG, aadD, lnu(A), and dfrA, as well as mutations in grlA, gyrA, grlB, and rpoB that contribute to fluoroquinolone and rifampicin resistance.
Zoonotic transmission of asymptomatic carriage Staphylococcus aureus on dairy farms in Canterbury, New Zealand.
The study identified a bovine isolate carrying the extended-spectrum beta-lactamase gene blaTEM-116, highlighting concerns about antimicrobial resistance in dairy farm environments. Multiple antimicrobial resistance genes were detected in both bovine and human isolates, including genes conferring resistance to tetracyclines, penicillins, fosfomycin, and aminoglycosides.
The healthy human gut can take it all: vancomycin-variable, linezolid-resistant strains and specific bacteriocin-species interplay in Enterococcus spp.
The study identifies linezolid resistance genes optrA and poxtA in Enterococcus faecium and Enterococcus thailandicus isolates, along with a vancomycin-variable E. faecium strain. It also reveals the increasing prevalence of E. lactis in the healthy human gut and the complex interplay of bacteriocin gene profiles among Enterococcus species.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaOXA-51-like, and several aminoglycoside resistance genes, contributing to extensive drug resistance.
Multidrug-Resistant Staphylococcus aureus in Diabetic Foot Infections (DFI) from Beira, Mozambique: Prevalence and Virulence Profile.
The study identified high levels of multidrug resistance in Staphylococcus aureus isolates from diabetic foot infections in Beira, Mozambique, with resistance genes blaZ, mecA, vancA, vancB, ermB, ermC, dfrA, and dfrG being prevalent.
Study of lug Operon, SCCmec Elements, Antimicrobial Resistance, MGEs, and STs of Staphylococcus lugdunensis Clinical Isolates Through Whole-Genome Sequencing.
The study identified several AMR genes, including mecA, blaZ, erm(A), aac(6')-aph(2"), aph(3')-III, ant(9)-Ia, and dfrG, in S. lugdunensis isolates, which conferred resistance to various antibiotics such as penicillins, oxacillin, erythromycin, clindamycin, aminoglycosides, and trimethoprim-sulfamethoxazole.
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Staphylococcus epidermidis in Acute Myeloid Leukemia: A Comparative Genomic Study Against Non-AML Isolates.
The study identified several AMR genes in S. epidermidis isolates from AML patients, including mecA, mecR1, qacA, ermC, tetM, cfrA, ANT(4′)-Ib, blaZ, dfrG, cat, and mecI, which were associated with increased resistance to various antibiotics.
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China.
The study identified the optrA gene as the primary mechanism of linezolid resistance in Enterococcus species from cancer patients in China, along with other resistance genes such as tet(M), erm(A), and erm(B).
Isolation and Molecular Characterization of Three Staphylococcus pseudintermedius Strains from Dogs and Humans in Egypt.
Three Staphylococcus pseudintermedius isolates from dogs and humans in Egypt were characterized. The isolates showed resistance to various antibiotics, including penicillin, tetracycline, aminoglycosides, chloramphenicol, fusidic acid, macrolides, streptothricin, and trimethoprim. None of the isolates carried the mecA gene, which is associated with methicillin resistance.
Emergence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus ST398 in Wild Birds, Brazil.
The study reports the first detection of livestock-associated Methicillin-Resistant Staphylococcus aureus ST398 in wild birds in Brazil, highlighting the emergence of antimicrobial-resistant S. aureus in a protected Atlantic Forest fragment. The MRSA isolates exhibited a broad resistome, including genes for resistance to multiple antimicrobial classes.
Antimicrobial Resistance in Staphylococcus aureus at the Human-Animal-Environment Interface in East Africa: A Systematic Review and Meta-Analysis
The study identified key resistance genes including mecA, blaZ, tet(K), and erm(C) in Staphylococcus aureus isolates from East Africa, highlighting the prevalence of methicillin-resistant and multidrug-resistant strains.
Distribution and antibiotic resistance patterns of airborne staphylococci in urban environments of Delhi, India.
The study identified multiple antibiotic resistance genes (ARGs) in airborne staphylococci, including mecA, dfrS1(dfrA), dfrG, femB, blaZ, cfr, and msrA, which confer resistance to methicillin, trimethoprim, beta-lactams, chloramphenicol, and macrolides/lincosamides. High prevalence of multidrug-resistant staphylococci was observed in urban environments of Delhi, India.
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