Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dihydrofolate reductase (DHFR)
Overview
Resistance to antibacterial antifolates in multidrug-resistant Staphylococcus aureus: prevalence estimates and genetic basis.
Research Article
The study identifies a novel gene, dfrL, which encodes a DHFR with ~35% identity to native and known resistant DHFRs, and is associated with high-level resistance to trimethoprim and iclaprim. Additionally, various mutations in dfrB and folP were found to confer resistance to trimethoprim and sulfamethoxazole, respectively.
Resistance to antibacterial antifolates in multidrug-resistant Staphylococcus aureus: prevalence estimates and genetic basis.
Research Article
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