dinF

multidrug efflux pump

Validation StatusCandidate

Overview

Validation Method: mutant analysis and complementation
Drug Classes: Quinolone
Organisms: Ralstonia solanacearum, Escherichia coli, Streptococcus pneumoniae
Papers: 2
Databases: Reslit

Papers2

Two host-induced Ralstonia solanacearum genes, acrA and dinF, encode multidrug efflux pumps and contribute to bacterial wilt virulence.

PMID 17337552 · 2007

The study identifies acrA and dinF as multidrug efflux pumps in Ralstonia solanacearum that contribute to bacterial wilt virulence by conferring resistance to antibiotics, phytoalexins, and detergents.

Gene Information

Gene Name: dinF
Allele: dinF
Encodes: multidrug efflux pump
Source Database: Reslit
Organisms Tested In: • Ralstonia solanacearum
• Escherichia coli
Validation Method: mutant analysis and complementation

Functional analysis of pneumococcal drug efflux pumps associates the MATE DinF transporter with quinolone susceptibility.

PMID 23114782 · 2013

The study identifies DinF as a MATE family efflux pump involved in quinolone susceptibility in Streptococcus pneumoniae, showing that its inactivation increases susceptibility to moxifloxacin, ciprofloxacin, and levofloxacin.

Gene Information

Gene Name: dinF
Allele: dinF
Encodes: MATE family efflux pump
Source Database: Reslit
Confers Resistance To: Quinolone
Organisms Tested In: • Streptococcus pneumoniae
Validation Method: mutant construction and susceptibility testing

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dinF

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