eat(A)

ABC transporter

Validation StatusConfirmed2+ DBs

Overview

Validation Method: allelic replacement and MIC testing
Drug Classes: Lincomycin, Clindamycin, Dalfopristin, Quinupristin, Tiamulin, Aminoglycoside, PLEUROMUTILIN, Lincomycin|Clindamycin|Dalfopristin|Quinupristin|Tiamulin
Organisms: Enterococcus faecium, Enterococcus faecium Aus0004
Geographic Location: Alberta, Canada
Papers: 2
Databases: Reference Gene CatalogReslit
Mutations: 1

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T450I	-	-	Enterococcus faecium	Lincomycin\|Clindamycin\|Dalfopristin\|Quinupristin\|Tiamulin	Reslit	Candidate

Papers2

Genetic basis for in vitro and in vivo resistance to lincosamides, streptogramins A, and pleuromutilins (LSAP phenotype) in Enterococcus faecium.

PMID 23836170 · 2013

The study identifies a single point mutation (C1349T) in the eat(A) gene, which confers resistance to lincosamides, streptogramins A, and pleuromutilins in Enterococcus faecium.

Gene Information

Gene Name: eat(A)
Allele: Eat(A)
Encodes: ABC transporter
Source Database: Reslit
Confers Resistance To: LincomycinClindamycinDalfopristinQuinupristinTiamulin
Organisms Tested In: • Enterococcus faecium
Validation Method: allelic replacement and MIC testing
Sequence Accession: KF010778|KF010779

Surveillance of Enterococcus spp. reveals distinct species and antimicrobial resistance diversity across a One-Health continuum.

PMID 32127598 · 2020

The study identified several AMR genes in Enterococcus spp., including erm(B), tet(M), optrA, dfrE, lsa(A), aac(6')-Ib, eat(A), ant(6)-Ia, aph(3')-IIIa, sat4, tet(L), bcrB, bcrC, dfrF, and dfrG, which confer resistance to various antibiotics such as macrolides, tetracyclines, oxazolidinones, trimethoprim, and aminoglycosides.

Gene Information

Gene Name: eat(A)
Allele: Eat(A)
Encodes: enterococcal antibiotic resistance protein
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Enterococcus faecium
Geographic Location: Alberta, Canada
Validation Method: whole genome sequencing
Sequence Accession: NC_004668|CP002621.1|CP003583.1

PMID N/A

Gene Information

Gene Name: eat(A)
Allele: Eat(A)
Encodes: ABC-F type ribosomal protection protein Eat(A)
Source Database: Reference Gene Catalog
Confers Resistance To: PLEUROMUTILIN
Organisms Tested In: • Enterococcus faecium Aus0004
Sequence Accession: CP003351.2
Protein Accession: AFC62715.1

Browse AMR Genes

eat(A)

Mutations

Gene Information

Gene Information

Gene Information