eis2

aminoglycoside N-acetyltransferase

Validation StatusSupported

Overview

Mechanism: Acetylates FF-NH2 to form FF-ac, a more potent translational inhibitor
Validation Method: RNA sequencing and transcriptomic analysis
Drug Classes: Aminoglycoside
Organisms: Mycobacterium abscessus
Papers: 3
Databases: Reslit

Papers3

RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus.

PMID 34633851 · 2022

The study identifies several genes involved in antibiotic resistance in Mycobacterium abscessus, including erm(41) for macrolide resistance, WhiB7 for general resistance to ribosome-targeting antibiotics, sigH for tigecycline resistance, cydA for clofazimine tolerance, and various aminoglycoside-modifying enzymes like aac(2'), aph(3'), and eis2.

Gene Information

Gene Name: eis2
Allele: eis2
Encodes: aminoglycoside N-acetyltransferase
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Mycobacterium abscessus
Validation Method: RNA sequencing and transcriptomic analysis
Sequence Accession: PRJNA655109|GSE163621

Lsr2, a pleiotropic regulator at the core of the infectious strategy of Mycobacterium abscessus.

PMID 38353553 · 2024

Lsr2 regulates genes involved in antimicrobial resistance, including eis2, MAB_1409c, MAB_2355c, and erm41, which contribute to resistance against aminoglycosides and macrolides in Mycobacterium abscessus.

Gene Information

Gene Name: eis2
Allele: eis2
Encodes: Eis N-acetyl transferase protein
Source Database: Reslit
Confers Resistance To: Aminoglycoside
Organisms Tested In: • Mycobacterium abscessus
Validation Method: RNA-seq and RT-qPCR

Prodrug florfenicol amine is activated by intrinsic resistance to target Mycobacterium abscessus.

PMID 41168430 · 2025

The study identifies Eis2 as an aminoglycoside-modifying enzyme that activates florfenicol amine (FF-NH2) by acetylating it to form FF-ac, a more potent translational inhibitor. Mutations in whiB7 and eis2 decrease susceptibility to FF-NH2.

Gene Information

Gene Name: eis2
Allele: eis2
Encodes: N-acetyltransferase
Source Database: Reslit
Mechanism: Acetylates FF-NH2 to form FF-ac, a more potent translational inhibitor
Organisms Tested In: • Mycobacterium abscessus
Validation Method: Susceptibility testing with deletion strains and complementation experiments
Sequence Accession: NC_010397|PRJNA1141985|GSE273574|PXD059834|MSV000096854

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