embB
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
AMR Rules
Browse AMR rules for embB
Validation StatusCandidate
Overview
- Papers
- 14
- Mutations
- 133
Mutations
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| A225S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S272I | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A281P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| F287C | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| ATGcodon306ATA | - | - | Mycobacterium tuberculosis | ethambutol | Reslit | Candidate |
| G406A | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| Q445R | - | - | Mycobacterium tuberculosis | ethambutol | Reslit | Candidate |
| G294S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G406D | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| R13L | - | - | Mycobacterium tuberculosis | ethambutol | Reslit | Candidate |
| M306I | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| G406C | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| M306V | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| G406S | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| Q497R | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| G324R | - | - | Mycobacterium tuberculosis | ethambutol | Reslit | Candidate |
| P397S | - | - | Mycobacterium tuberculosis | ethambutol | Reslit | Candidate |
| D1024N | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| F320L | - | - | Mycobacterium tuberculosis | ethambutolEthambutol | ResFinderReslit | Confirmed |
| A221G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| F287V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N296H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D299E | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| M306L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| M306T | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D311G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N318H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N318K | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Y319S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D328Y | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D328V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G331R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S347I | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A356S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G358V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| E368Q | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V377M | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S380R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| L239P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R274P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N296K | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Y319N | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| W332L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| E368A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V369A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| E378A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S380N | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P397T | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D240H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| H312R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Y319C | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D328G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Y333H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S347T | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| L359I | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V377G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| E378K | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A271V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V282L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| I293N | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D311H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N318S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S347C | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D354A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A357S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R367P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| E368D | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G374V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| W395R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P404S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S272C | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V282G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S297L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V309G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G314A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S366P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P371R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A379D | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A388G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P397Q | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G401S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V227G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| F285L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S298W | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A357V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V369L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| W395C | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N399H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R257W | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S297A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A313V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A356V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| L370R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A379T | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N400K | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S317T | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| F330V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Y334H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V360M | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Y384N | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| N399D | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P446H | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Y315C | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P375A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| F398Y | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| E405D | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P461S | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| T437A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R460L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Q497K | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G459A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Q497P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| D959A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| S412L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G448V | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R469P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A659T | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| M423I | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V452L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R471P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| G745D | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| P430L | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| Q853P | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V436G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| E504D | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| H1002R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R460C | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| M1000R | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| V435G | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| A431T | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| M482I | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| R507K | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
| T1082A | - | - | Mycobacterium tuberculosis | Ethambutol | ResFinder | Established |
Papers14
1
Tuberculosis drug resistance mutation database.
Mutation Information
embB: p.A225SembB: p.S272IembB: p.A281PembB: p.F287CembB: p.G294SembB: p.A221GembB: p.F287VembB: p.D299EembB: p.N318HembB: p.N318KembB: p.Y319SembB: p.D328VembB: p.G331RembB: p.S347IembB: p.A356SembB: p.G358VembB: p.E368QembB: p.L239PembB: p.R274PembB: p.N296KembB: p.M306LembB: p.Y319NembB: p.D328YembB: p.W332LembB: p.E368AembB: p.V369AembB: p.E378AembB: p.S380NembB: p.P397TembB: p.G406CembB: p.G406DembB: p.D240HembB: p.M306VembB: p.H312RembB: p.Y319CembB: p.D328GembB: p.Y333HembB: p.L359IembB: p.V377GembB: p.E378KembB: p.A271VembB: p.I293NembB: p.M306IembB: p.D311HembB: p.N318SembB: p.S347CembB: p.A357SembB: p.R367PembB: p.E368DembB: p.G374VembB: p.W395RembB: p.G406SembB: p.S272CembB: p.V282GembB: p.S297LembB: p.M306TembB: p.V309GembB: p.G314AembB: p.S347TembB: p.S366PembB: p.P371RembB: p.A379DembB: p.A388GembB: p.G401SembB: p.V227GembB: p.F285LembB: p.D311GembB: p.V377MembB: p.W395CembB: p.R257WembB: p.V282LembB: p.L370RembB: p.P397QembB: p.N400KembB: p.N296HembB: p.S317TembB: p.F330VembB: p.A357VembB: p.V369LembB: p.S380RembB: p.N399HembB: p.G406AembB: p.S297AembB: p.Y334HembB: p.A356VembB: p.V360MembB: p.A379TembB: p.Y384NembB: p.P446HembB: p.P375AembB: p.F398YembB: p.P461SembB: p.N399DembB: p.T437AembB: p.D1024NembB: p.G459AembB: p.Q497KembB: p.Q497PembB: p.Q497RembB: p.D959AembB: p.G448VembB: p.R469PembB: p.A659TembB: p.M423IembB: p.V452LembB: p.R471PembB: p.G745DembB: p.P430LembB: p.V436GembB: p.R460LembB: p.R460CembB: p.M1000RembB: p.V435GembB: p.A431T
- Protein Change
- A225S, S272I, A281P, F287C, G294S, A221G, F287V, D299E, N318H, N318K, Y319S, D328V, G331R, S347I, A356S, G358V, E368Q, L239P, R274P, N296K, M306L, Y319N, D328Y, W332L, E368A, V369A, E378A, S380N, P397T, G406C, G406D, D240H, M306V, H312R, Y319C, D328G, Y333H, L359I, V377G, E378K, A271V, I293N, M306I, D311H, N318S, S347C, A357S, R367P, E368D, G374V, W395R, G406S, S272C, V282G, S297L, M306T, V309G, G314A, S347T, S366P, P371R, A379D, A388G, G401S, V227G, F285L, D311G, V377M, W395C, R257W, V282L, L370R, P397Q, N400K, N296H, S317T, F330V, A357V, V369L, S380R, N399H, G406A, S297A, Y334H, A356V, V360M, A379T, Y384N, P446H, P375A, F398Y, P461S, N399D, T437A, D1024N, G459A, Q497K, Q497P, Q497R, D959A, G448V, R469P, A659T, M423I, V452L, R471P, G745D, P430L, V436G, R460L, R460C, M1000R, V435G, A431T
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
2
Transfer of embB codon 306 mutations into clinical Mycobacterium tuberculosis strains alters susceptibility to ethambutol, isoniazid, and rifampin.
embB 306 mutations alter susceptibility to ethambutol, isoniazid, and rifampin.
Mutation Information
- Protein Change
- ATGcodon306ATA
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- ethambutol
- Source Database
- Reslit
3
Allelic Exchange and Mutant Selection Demonstrate that Common Clinical embCAB Gene Mutations Only Modestly Increase Resistance to Ethambutol in Mycobacterium tuberculosis.
Mutation Information
embB: p.G406AembB: p.Q445RembB: p.G406DembB: p.R13LembB: p.G406CembB: p.G406SembB: p.Q497RembB: p.M306VembB: p.G324RembB: p.P397SembB: p.D1024NembB: p.F320L
- Protein Change
- G406A, Q445R, G406D, R13L, G406C, G406S, Q497R, M306V, G324R, P397S, D1024N, F320L
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- ethambutol
- Source Database
- Reslit
4
Convergent evolutionary analysis identifies significant mutations in drug resistance targets of Mycobacterium tuberculosis.
Mutations in embB306 were found to be associated with drug resistance.
Mutation Information
- Protein Change
- M306I
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- ethambutol
- Source Database
- Reslit
5
Genome analysis of multi- and extensively-drug-resistant tuberculosis from KwaZulu-Natal, South Africa.
Mutation Information
- Protein Change
- M306V
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- ethambutol
- Source Database
- Reslit
6
Detection by GenoType MTBDRsl test of complex mechanisms of resistance to second-line drugs and ethambutol in multidrug-resistant Mycobacterium tuberculosis complex isolates.
Mutation Information
- Protein Change
- M306V, M306I
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- ethambutol
- Source Database
- Reslit
7
[Metastases to the mediastinal lymph nodes in a series of two-hundred-consecutive operations for primary lung cancer].
Mutation Information
embB: p.S272IembB: p.N296HembB: p.V377MembB: p.A356SembB: p.F287VembB: p.N296KembB: p.V369AembB: p.P397TembB: p.V282LembB: p.P397QembB: p.A357VembB: p.V369LembB: p.N399HembB: p.F287CembB: p.S297AembB: p.A356VembB: p.A379TembB: p.S272CembB: p.V282GembB: p.V377GembB: p.N399DembB: p.S297LembB: p.A357SembB: p.A379DembB: p.W395RembB: p.W395CembB: p.R460LembB: p.R460C
- Protein Change
- S272I, N296H, V377M, A356S, F287V, N296K, V369A, P397T, V282L, P397Q, A357V, V369L, N399H, F287C, S297A, A356V, A379T, S272C, V282G, V377G, N399D, S297L, A357S, A379D, W395R, W395C, R460L, R460C
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
8
Evaluation of genotype MTBDRsl assay to detect drug resistance associated with fluoroquinolones, aminoglycosides and ethambutol on clinical sediments.
Mutation Information
- Protein Change
- M306L, M306V, M306T, M306I
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
9
Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing.
Mutation Information
- Protein Change
- M306V, M306T, M306I, M306L, A313V, Y315C
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
10
Evolution of high-level ethambutol-resistant tuberculosis through interacting mutations in decaprenylphosphoryl-β-D-arabinose biosynthetic and utilization pathway genes.
Mutation Information
embB: p.M306TembB: p.M306IembB: p.M306LembB: p.G406SembB: p.M306VembB: p.E378KembB: p.D354AembB: p.E378AembB: p.G406DembB: p.G406CembB: p.Q497KembB: p.G406AembB: p.Q497PembB: p.Q497RembB: p.Q853PembB: p.T1082A
- Protein Change
- M306T, M306I, M306L, G406S, M306V, E378K, D354A, E378A, G406D, G406C, Q497K, G406A, Q497P, Q497R, Q853P, T1082A
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
11
Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacterium tuberculosis.
Mutation Information
embB: p.M306IembB: p.G406SembB: p.G406CembB: p.M306LembB: p.M306TembB: p.M306VembB: p.G406AembB: p.G406DembB: p.Q497KembB: p.Q497PembB: p.Q497R
- Protein Change
- M306I, G406S, G406C, M306L, M306T, M306V, G406A, G406D, Q497K, Q497P, Q497R
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
12
A potential role for RNA turnover in the light regulation of plant gene expression: ribulose-1,5-bisphosphate carboxylase small subunit in soybean.
Mutation Information
- Protein Change
- D311G, S380R, S380N, D311H
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
13
Characterization of mutations in multi- and extensive drug resistance among strains of Mycobacterium tuberculosis clinical isolates in Republic of Korea.
Mutation Information
embB: p.D328YembB: p.S347TembB: p.D328VembB: p.D354AembB: p.P404SembB: p.Y319CembB: p.D328GembB: p.S298WembB: p.Y319SembB: p.S347IembB: p.G406CembB: p.Y319NembB: p.S347CembB: p.G406SembB: p.G406DembB: p.F320LembB: p.E405DembB: p.Q497KembB: p.Q497RembB: p.S412LembB: p.G406AembB: p.Q497PembB: p.E504DembB: p.M482IembB: p.R507K
- Protein Change
- D328Y, S347T, D328V, D354A, P404S, Y319C, D328G, S298W, Y319S, S347I, G406C, Y319N, S347C, G406S, G406D, F320L, E405D, Q497K, Q497R, S412L, G406A, Q497P, E504D, M482I, R507K
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder
14
Genome sequencing of 161 Mycobacterium tuberculosis isolates from China identifies genes and intergenic regions associated with drug resistance.
Mutation Information
embB: p.M306VembB: p.M306TembB: p.M306IembB: p.M306LembB: p.D354AembB: p.A313VembB: p.Q497PembB: p.Q497RembB: p.E504DembB: p.H1002RembB: p.Q497K
- Protein Change
- M306V, M306T, M306I, M306L, D354A, A313V, Q497P, Q497R, E504D, H1002R, Q497K
- Organisms
- Mycobacterium tuberculosis
- Confers Resistance To
- Ethambutol
- Source Database
- ResFinder