Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
multidrug efflux MFS transporter periplasmic adaptor subunit EmrA
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| - | - | Escherichia coli | CIP | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years |
|---|
| Sequence Accession |
|---|
| Protein Accession |
|---|
| EmrA | Reference Gene CatalogReslit | 15 | EFFLUX, Beta-lactams +12 | Stenotrophomonas maltophilia K279a +7 | Europe, Northern California|USA, Norway|China, Germany, Manitoba, Canada, South Africa, Hungary, Brazil, India | 2013, 2016, 2018, 2019, 2021, 2022, 2023, 2024, 2025 | AM743169.1 | CAQ45063.1 |
| emr A | Reslit | 1 | Fluoroquinolone | Providencia rettgeri | Colombia|USA | 2020 | VRPG00000000|VRPH00000000 | - |
| emrA | Card Database | 1 | - | Escherichia coli str. K-12 substr. W3110 | - | - | AP009048.1 | BAA16547.1 |
Characterization of a major facilitator superfamily (MFS) tripartite efflux pump EmrCABsm from Stenotrophomonas maltophilia.
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells.
The study identifies multiple multi-drug efflux genes, including tolC, acrA, acrB, acrD, acrF, emrA, emrB, macA, and macB, which are significantly upregulated in persister cells, contributing to reduced antibiotic accumulation and increased drug tolerance.
Multidrug resistance operon emrAB contributes for chromate and ampicillin co-resistance in a Staphylococcus strain isolated from refinery polluted river bank.
The emrAB operon in Staphylococcus aureus LZ-01 confers co-resistance to chromate and ampicillin, as evidenced by gene knockout and complementation experiments showing reduced resistance in mutants.
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic.
The study identifies several AMR genes involved in resistance to various antibiotics, including murA, murJ, fabI, norA, lmrB2/3, emrA, yhgE, lmrB2, fosB, uppP, vraRS, and mprF, through Tn-seq data and upregulation signatures.
Early-life gut microbiome modulation reduces the abundance of antibiotic-resistant bacteria.
The study shows that colonization of the gut of breastfed infants by B. infantis EVC001 leads to a significant reduction in antibiotic resistance genes (ARGs) compared to controls. The ARGs identified were mainly associated with Escherichia, Clostridium, and Staphylococcus, and conferred resistance to beta-lactams, fluoroquinolones, and multiple drug classes.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.
Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain.
The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli.
The study identifies mutations in efflux-related genes such as emrR, emrA, emrB, marR, ramR, oqxR, iscR, and envZ as major contributors to nitroxoline resistance in E. coli and K. pneumoniae. These mutations lead to reduced susceptibility to nitroxoline and are associated with significant fitness loss and diminished in vivo virulence.
Bacterial diversity and resistome analysis of drinking water stored in cisterns from two First Nations communities in Manitoba, Canada.
The study identified a diverse array of antimicrobial resistance genes in drinking water stored in cisterns from two First Nations communities in Manitoba, Canada. Key findings include the presence of genes such as aac(3')-Ia, aac(6')-Iia, aac(6')-Iic, aph(3')-Ia, acrD, smeB, smeR, FEZ-1, rm3, SPG-1, OXA-21, OXA-119, OXA-205, dfrA14, dfrB6, acrB, acrF, adeF, ceoB, emrA, mexE, mexF, mexI, oprN, oqxB, BRP(MBL), vanSO, axyY, CRP, efrB, macB, mexB, mexC, mexD, mexK, mexQ, mexW, mexY, mtrA, muxB, muxC, oleB, oleC, ompB, oprM, smeD, smeE, golS, mdsB, PER-2, TEM-126, msbA, arnA, bacA, bcrA, MCR-5, rosA, rosB, rpoB2, ugd, mexN, taeA, efpA, rphA, rphB, otr(A), otrC, tetA(48 ), ompH, and triC, which confer resistance to various antibiotics including aminoglycosides, beta-lactams, cephalosporins, carbapenems, fluoroquinolones, macrolides, monobactams, nitroimidazoles, peptides, phenicols, pleuromutilins, rifamycins, tetracyclines, and triclosan.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
Genomic Dissection of an Enteroaggregative Escherichia coli Strain Isolated from Bacteremia Reveals Insights into Its Hybrid Pathogenic Potential.
The study identifies multiple efflux pump-encoding genes in the E. coli strain EC092, which contribute to its resistance against several antibiotics including tetracycline, trimethoprim, streptomycin, and sulfamethoxazole.
Prevalence and genomic insights of carbapenem resistant and ESBL producing Multidrug resistant Escherichia coli in urinary tract infections.
The study identified multiple AMR genes, including NDM-5, CTX-M-15, TEM-1, and others, in carbapenem-resistant and ESBL-producing multidrug-resistant E. coli isolates from urinary tract infections.
Resistance evolution under potentiated sulphonamide pressure in Escherichia coli.
The study identified multiple antimicrobial resistance genes and mutations in E. coli under potentiated sulphonamide pressure, highlighting the role of efflux pumps and folate pathway modifications in resistance development.
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