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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
multidrug efflux MFS transporter permease subunit EmrB
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| EmrB | Reference Gene CatalogReslit | 28 | EFFLUX, Beta-lactams +34 | Stenotrophomonas maltophilia K279a +13 | Europe, Brazil, India, UK, Norway|China, Canada, Detroit, Shanghai, China, Pakistan, Lebanon, Sichuan, China, China, Germany, Danakil Depression, Afar Region, Ethiopia, South Africa, Hungary | 2013, 2016, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | AM743169.1 | CAQ45064.1 |
| emrB | Card Database | 1 | - | Escherichia coli str. K-12 substr. MG1655 | - | - | U00096.1 | AAC75733.1 |
Characterization of a major facilitator superfamily (MFS) tripartite efflux pump EmrCABsm from Stenotrophomonas maltophilia.
Enhanced Efflux Activity Facilitates Drug Tolerance in Dormant Bacterial Cells.
The study identifies multiple multi-drug efflux genes, including tolC, acrA, acrB, acrD, acrF, emrA, emrB, macA, and macB, which are significantly upregulated in persister cells, contributing to reduced antibiotic accumulation and increased drug tolerance.
Multidrug resistance operon emrAB contributes for chromate and ampicillin co-resistance in a Staphylococcus strain isolated from refinery polluted river bank.
The emrAB operon in Staphylococcus aureus LZ-01 confers co-resistance to chromate and ampicillin, as evidenced by gene knockout and complementation experiments showing reduced resistance in mutants.
An EmrB multidrug efflux pump in Burkholderia thailandensis with unexpected roles in antibiotic resistance.
The study identifies EmrB as a primary efflux pump for trimethoprim and tetracycline in Burkholderia thailandensis, demonstrating its role in antibiotic resistance through gene inactivation and MIC testing.
Extended Spectrum Beta-Lactamase-Producing Gram-Negative Bacteria Recovered From an Amazonian Lake Near the City of Belém, Brazil.
The study identified various extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-14, bla CTX-M-2, bla TEM, and bla SHV, in multidrug-resistant gram-negative bacteria from an Amazonian lake. These genes were associated with resistance to cephalosporins and other beta-lactam antibiotics.
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Phylogenetic Grouping of Human Ocular Escherichia coli Based on Whole-Genome Sequence Analysis.
The study identified 22 AMR genes in 10 ocular E. coli isolates, including bla CTX-M-15, dfrA17, aadA2, aadA5, bla OXA-1, bla NDM-5, dfrA12, bla TEM-1 B, mdfA, emrB, mphA, sul1, sul2, and aac(6')-1b-cr. Additionally, chromosomal mutations in parE, gyrA, and parC were found to confer resistance to fluoroquinolones.
Preterm infants harbour diverse Klebsiella populations, including atypical species that encode and produce an array of antimicrobial resistance- and virulence-associated factors.
The study identified various antimicrobial resistance genes in Klebsiella isolates from preterm infants, highlighting the presence of multidrug resistance mechanisms.
Fecal Klebsiella pneumoniae Carriage Is Intermittent and of High Clonal Diversity.
The study identified 25 antibiotic resistance genes in 80 Klebsiella pneumoniae isolates, primarily encoding efflux pumps and inactivating enzymes. Notably, blaSHV, emrB, emrR, marA, marR, msbA, ompK37, oqxA, oqxB, acrA, vgaC, fosA, tet(D), APH(3")-Ib, APH(6)-Id, aadA, qnrS2, rpoB2, mexF, and oprN were found to confer resistance to various antibiotics.
Antibiotic Resistance and Phylogeny of Pseudomonas spp. Isolated over Three Decades from Chicken Meat in the Norwegian Food Chain.
The study identified several AMR genes and mutations in Pseudomonas spp. isolated from chicken meat in Norway, including beta-lactamases, efflux pumps, and genes involved in resistance to aminoglycosides, fluoroquinolones, and colistin.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
The Evolution of Fluoroquinolone Resistance in Salmonella under Exposure to Sub-Inhibitory Concentration of Enrofloxacin.
Soil Bacteria in Urban Community Gardens Have the Potential to Disseminate Antimicrobial Resistance Through Horizontal Gene Transfer.
The study identified various antimicrobial resistance genes (ARGs) in soil and vegetable bacteria from urban community gardens, highlighting the potential for horizontal gene transfer of resistance traits to clinically relevant pathogens.
The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China.
The study identified the carbapenemase gene blaKPC-2 and blaKPC-24, along with fosfomycin resistance gene fosA6, and various extended-spectrum beta-lactamase genes such as blaCTX-M-15, blaCTX-M-65, and blaCTX-M-27 in KPC-producing Klebsiella pneumoniae strains. Additionally, genes associated with fluoroquinolone, macrolide, aminoglycoside, and sulfonamide resistance were also characterized.
Proteomic Comparison of Ivermectin Sensitive and Resistant Staphylococcus aureus Clinical Isolates Reveals Key Efflux Pumps as Possible Resistance Determinants.
The study identifies mepA, emrB, and swrC as efflux pumps that are overexpressed in ivermectin-resistant Staphylococcus aureus isolates, suggesting their role in resistance mechanisms.
Draft Genome Sequences of Multidrug-Resistant Escherichia coli Isolated from River Water.
The study reports the draft genome sequences of seven multidrug-resistant Escherichia coli strains isolated from river water, identifying various antibiotic resistance genes and mutations associated with resistance to multiple antibiotics.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Phenotypic and genotypic characterization of antimicrobial resistance profiles in Salmonella isolated from waterfowl in 2002-2005 and 2018-2020 in Sichuan, China.
The study identified multiple AMR genes and mutations in Salmonella isolates from waterfowl in Sichuan, China, including beta-lactamases, aminoglycoside-modifying enzymes, tetracycline efflux pumps, and quinolone resistance genes. Mutations in gyrA and gyrB were associated with nalidixic acid resistance.
Complete Genetic Analysis of Plasmids Carrying Multiple Resistance, Virulence, and Phage-Like Genes in Foodborne Escherichia coli Isolate.
The study identified 16 antimicrobial resistance genes in a foodborne E. coli strain, including bla NDM-1 and mcr-1, highlighting the dissemination of multidrug-resistant plasmids in food products.
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli.
The study identifies mutations in efflux-related genes such as emrR, emrA, emrB, marR, ramR, oqxR, iscR, and envZ as major contributors to nitroxoline resistance in E. coli and K. pneumoniae. These mutations lead to reduced susceptibility to nitroxoline and are associated with significant fitness loss and diminished in vivo virulence.
Shotgun Metagenomics-Guided Prediction Reveals the Metal Tolerance and Antibiotic Resistance of Microbes in Poly-Extreme Environments in the Danakil Depression, Afar Region.
The study identified numerous antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) in the metagenomes of Lake Afdera and the Assale salt plain in the Danakil Depression. Key ARGs included beta-lactamases (ACC-1, OXA-58, OXA-363, OXA-212, NDM-17, OXA-134, ACT-29, LRA-19), efflux pumps (emrB, abeM, abeS, mgrA, adeJ, MexC, adeL, adeH), sulfonamide resistance genes (sul1, sul2), tetracycline resistance genes (tet39, tetX, tetK), and others. MRGs included copper resistance genes (copC, copD), cadmium resistance gene (cadD), mercury resistance gene (merA), chromate resistance genes (chrB, chrA), nickel-cobalt-cadmium resistance genes (nccA, nccB), cobalt-zinc-cadmium resistance gene (czcD), arsenic resistance gene (arsO), lead resistance gene (pbrA), and mercury resistance genes (merB, merR, MIR).
In Vitro Microevolution and Co-Selection Assessment of Florfenicol Impact on Escherichia coli Resistance Development.
Florfenicol exposure leads to increased resistance to fluoroquinolones and cephalosporins through mutations in efflux pump genes such as acrB, acrR, emrR, and robA, as well as the presence of resistance genes like ampC, ampH, bacA, and emrB.
Genome mining of Escherichia coli WG5D from drinking water source: unraveling antibiotic resistance genes, virulence factors, and pathogenicity.
The study identifies multiple antibiotic resistance genes in E. coli WG5D, including multidrug efflux pumps and genes conferring resistance to various antibiotics such as fluoroquinolones, cephalosporins, and glycopeptides.
In Vitro Microevolution and Co-Selection Assessment of Amoxicillin and Cefotaxime Impact on Escherichia coli Resistance Development.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
Genomic Dissection of an Enteroaggregative Escherichia coli Strain Isolated from Bacteremia Reveals Insights into Its Hybrid Pathogenic Potential.
The study identifies multiple efflux pump-encoding genes in the E. coli strain EC092, which contribute to its resistance against several antibiotics including tetracycline, trimethoprim, streptomycin, and sulfamethoxazole.
Resistance evolution under potentiated sulphonamide pressure in Escherichia coli.
The study identified multiple antimicrobial resistance genes and mutations in E. coli under potentiated sulphonamide pressure, highlighting the role of efflux pumps and folate pathway modifications in resistance development.
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