Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
transcriptional repressor
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| R92H | - | increased resistance to nalidixic acid | Chromobacterium violaceum | Nalidixic acid | Reslit | Candidate |
| L113P | - | multidrug efflux transporter EmrAB transcriptional repressor EmrR | Escherichia coli | NITROXOLINE | Reference Gene Catalog | Established |
| L64R | - | multidrug efflux transporter EmrAB transcriptional repressor EmrR | Escherichia coli |
Reference Gene Catalog |
| Established |
| D109A | - | Escherichia coli | Delafloxacin | Reslit | Candidate |
| R111S | - | Escherichia coli | Delafloxacin | Reslit | Candidate |
| R111C | - | Escherichia coli | Delafloxacin | Reslit | Candidate |
| Q138K | - | Escherichia coli | Delafloxacin | Reslit | Candidate |
| R110H | - | Escherichia coli | Delafloxacin | Reslit | Candidate |
| W140R | - | Escherichia coli | Delafloxacin | Reslit | Candidate |
| L159P | - | Escherichia coli | Delafloxacin | Reslit | Candidate |
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| emrR | Card DatabaseReslit | 11 | Fluoroquinolone, Nalidixic acid +16 | Escherichia coli +7 | Shanghai, China, Balochistan, Pakistan, Germany, Hungary, Poland, Bangladesh, India | 2022, 2023, 2024, 2025 | PRJNA744405 | AAC75731.1 |
| emr R | Reslit | 1 | Fluoroquinolone | Providencia rettgeri | Colombia|USA | 2020 | VRPG00000000|VRPH00000000 | - |
Metagenomic read cloud sequencing reveals antibiotic resistance gene dynamics in the gut microbiome of a hematopoietic cell transplant patient
The study identified 46 antibiotic resistance genes in the pre-transplant E. coli strain, including genes conferring resistance to beta-lactams, aminoglycosides, polymyxins, bacitracin, and multiple drugs through efflux pumps.
Genome-based characterization of two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases.
Two Colombian clinical Providencia rettgeri isolates co-harboring NDM-1, VIM-2, and other β-lactamases were characterized. The isolates exhibited resistance to multiple antibiotics, including carbapenems, cephalosporins, and aminoglycosides.
The Genomic Characterization of KPC-Producing Klebsiella pneumoniae from the ICU of a Teaching Hospital in Shanghai, China.
The study identified the carbapenemase gene blaKPC-2 and blaKPC-24, along with fosfomycin resistance gene fosA6, and various extended-spectrum beta-lactamase genes such as blaCTX-M-15, blaCTX-M-65, and blaCTX-M-27 in KPC-producing Klebsiella pneumoniae strains. Additionally, genes associated with fluoroquinolone, macrolide, aminoglycoside, and sulfonamide resistance were also characterized.
Environmental complexity is more important than mutation in driving the evolution of latent novel traits in E. coli.
Complex antibiotic environments drive the evolution of latent novel traits in E. coli through the spread of pleiotropic mutations affecting multiple resistance mechanisms.
Taxonomic Assignment-Based Genome Reconstruction from Apical Periodontal Metagenomes to Identify Antibiotic Resistance and Virulence Factors.
The study identified several antibiotic resistance genes (ARGs) in metagenomic assemblies from apical periodontal infections, highlighting the presence of multidrug resistance mechanisms in Enterobacter and Pseudomonas species.
Virulence Factors and Antimicrobial Resistance of Uropathogenic Escherichia coli EQ101 UPEC Isolated from UTI Patient in Quetta, Balochistan, Pakistan.
The study identified multiple antimicrobial resistance genes in the E. coli EQ101 isolate, including genes involved in antibiotic efflux, inactivation, and drug replacement. Key resistance genes include TolC, emrR, evgA, qacEdelta1, H-NS, cpxA, mdtM, aadA5, mphA, CTX-M-15, sul1, and dfrA14.
Nitroxoline resistance is associated with significant fitness loss and diminishes in vivo virulence of Escherichia coli.
The study identifies mutations in efflux-related genes such as emrR, emrA, emrB, marR, ramR, oqxR, iscR, and envZ as major contributors to nitroxoline resistance in E. coli and K. pneumoniae. These mutations lead to reduced susceptibility to nitroxoline and are associated with significant fitness loss and diminished in vivo virulence.
Monitoring Changes in the Antimicrobial-Resistance Gene Set (ARG) of Raw Milk and Dairy Products in a Cattle Farm, from Production to Consumption.
The study identified 112 antibiotic-resistance genes in raw milk and dairy products, with a significant increase in resistant genes in aged cheese compared to raw milk. Key genes included OXA-662 and OXA-309, which confer resistance to beta-lactam antibiotics, and several efflux pump genes like abaQ, emrA, and acrAB-tolC, which contribute to fluoroquinolone resistance. The findings highlight the dynamic changes in the resistome during food processing and the potential public health risks associated with the spread of antibiotic resistance genes through raw dairy products.
Genomic Analysis of Cronobacter condimenti s37: Identification of Resistance and Virulence Genes and Comparison with Other Cronobacter and Closely Related Species.
The study identified 17 antimicrobial resistance genes in Cronobacter condimenti s37, including genes involved in resistance to multiple antibiotic classes such as beta-lactams, tetracyclines, macrolides, phenicols, quinolones, aminoglycosides, glycopeptides, peptide antibiotics, rifamycins, nitroimidazoles, phosphonic acid derivatives, diaminopyrimidine derivatives, and elphamycins.
Genomic Characterization of Pan-Drug Resistant Klebsiella pneumoniae KPNW Isolated From UTI Patient in Bangladesh.
The study identifies 42 antimicrobial resistance (AMR) genes in the pan-drug resistant Klebsiella pneumoniae isolate KPNW, including beta-lactamases (bla CTX-M-15, bla NDM-1, bla OXA-1, bla TEM-63, bla TEM-104, bla SHV-28), tetracycline resistance genes (tet(A)), and efflux pump genes (oqxA, oqxB, marA, marR, ompK37, pbp3, crp, h-ns, kpnG, kpnH, parC, rsmA). Additionally, the isolate shows resistance to polymyxin B and colistin through modifications in lipid A (eptB, arnT, lptD, msbA, vanG) and other mechanisms.
Genomic insights into novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae: a threat from an Indian hospital setting.
The study identifies several AMR genes and mutations in the novel ST7947 carbapenem-resistant hypervirulent Klebsiella pneumoniae isolate BB-7, including bla CTX-M-15, bla SHV-28, bla TEM-1, bla OXA-1, bla OXA-232, armA, aadA2, baeR, tetD, adeF, emrR, AAC(6')-Ib-cr6, catI, sul1, mphE, msrE, dfrA1, oqxA, and fosA, as well as mutations in GyrA, ParC, OmpA, OmpK37, and ArnT that confer resistance to multiple antibiotics.
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