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Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
membrane fusion protein
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| emrA1 | Reslit | 2 | Nalidixic acid, Neomycin +7 | Francisella tularensis LVS +1 | - | 2014, 2024 | - | - |
| EmrA1 | Reslit |
| 1 |
| Nalidixic acid |
| Francisella |
| - |
| 2021 |
| - |
| - |
EmrA1 membrane fusion protein of Francisella tularensis LVS is required for resistance to oxidative stress, intramacrophage survival and virulence in mice.
The study identifies EmrA1 as a critical component of the MFS multidrug efflux pump in Francisella tularensis LVS, necessary for resistance to oxidative stress, intramacrophage survival, and virulence in mice. Loss of EmrA1 leads to increased sensitivity to hydrogen peroxide, superoxide, and certain antibiotics.
Genetic Determinants of Antibiotic Resistance in Francisella.
The paper reviews the genetic determinants of antibiotic resistance in Francisella, focusing on intrinsic resistance mechanisms and the roles of specific genes such as beta-lactamases, efflux pumps, and LPS modification genes.
TolC and EmrA1 contribute to Francisella novicida multidrug resistance and modulation of host cell death.
TolC and EmrA1 are essential for multidrug resistance and modulation of host cell death in Francisella novicida.
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