Browse AMR Genes

Explore antimicrobial resistance genes from the literature

eptA

pmr phosphoethanolamine transferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to eptA

Browse AMR rules for eptA

Validation StatusEstablished

Overview

Mechanism: antibiotic target alteration
Drug Classes: Colistin, Polymyxin b
Organisms: Escherichia coli str. K-12 substr. W3110, E. coli, Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Neisseria meningitidis
Papers: 8
Databases: Card Database
Mutations: 18

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
K233T	-	-	E. coli	Colistin	Reslit	Candidate
E244K	-	The mutation E244K in eptA confers resistance to colistin by altering the PE substrate-binding cavity, which is essential for the enzymatic activity of EptA.	Salmonella enterica, Escherichia coli	Colistin	Reslit	Candidate
T148A	-	-	E. coli	Colistin